TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T67102	Cathepsin D	D0CG8S	oxazine 89	Clinical trial	71305058	C19H15F4N5O2	421.3	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)F	IC50 > 200000 nM	Non binder
T67102	Cathepsin D	B06EVY	N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-(cyclopropylethynyl)picolinamide	Investigative	86732230	C23H18F6N4O2	496.4	C1CC1C#CC2=CN=C(C=C2)C(=O)NC3=CC(=C(C(=C3)F)F)[C@@]4(C[C@H](OC(=N4)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B06FLW	N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-5-methoxypyrazine-2-carboxamide	Investigative	90372971	C17H16F4N6O3	428.3	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(N=CC(=C2)NC(=O)C3=CN=C(C=N3)OC)F	IC50 = 397000 nM	Non binder
T67102	Cathepsin D	B09CXY	(4S,6S)-4-(Fluoromethyl)-4-(2-fluoro-5-pyridin-2-yloxyphenyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373220	C17H14F5N3O2	387.3	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)OC3=CC=CC=N3)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B09RUT	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-3,5-dichloropyridine-2-carboxamide	Investigative	90413435	C19H15Cl2F3N4O2	459.2	CC1=CC(=CC(=C1F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)NC(=O)C4=C(C=C(C=N4)Cl)Cl	IC50 = 493690 nM	Non binder
T67102	Cathepsin D	B0AD9N	(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[(2-methoxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441965	C20H17F3N6O2	430.4	COC1=CN=C2C(=N1)C=CN=C2NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 500520 nM	Non binder
T67102	Cathepsin D	B0BIA6	(1S,5R,6S)-5-(5-(6-Chlorobenzo[d]oxazol-2-yl)-2-fluorophenyl)-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine	Investigative	90412941	C19H13ClF3N3O2	407.8	C1[C@@H]2[C@H]1OC(=N[C@]2(C3=C(C=CC(=C3)C4=NC5=C(O4)C=C(C=C5)Cl)F)C(F)F)N	IC50 = 240270 nM	Non binder
T67102	Cathepsin D	B0DOJ7	N-[3-[(1R,5S,6R)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-5-fluoro-4-methylsulfonylphenyl]-5-chloropyridine-2-carboxamide	Investigative	118796792	C19H17ClF2N4O4S	470.9	CS(=O)(=O)C1=C(C=C(C=C1F)NC(=O)C2=NC=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 831860 nM	Non binder
T67102	Cathepsin D	B0EHJ6	(1R,2S,6R)-2-[5-[(3-Chloro-1,7-naphthyridin-8-yl)amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441964	C20H15ClF3N5O	433.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC4=NC=CC5=CC(=CN=C54)Cl)F)C(F)F)N	IC50 = 399580 nM	Non binder
T67102	Cathepsin D	B0ELI2	N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-2-methyl-1,3-thiazole-4-carboxamide	Investigative	124222798	C25H18F2N6O3S	520.5	CC1=NC(=CS1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCOC(=N5)N)C6=CC(=CN=C6)F)F	IC50 = 361600 nM	Non binder
T67102	Cathepsin D	B0EMU2	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-methyl-5-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide	Investigative	90414018	C21H18F6N4O3	488.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)OCC(F)(F)F	IC50 = 770000 nM	Non binder
T67102	Cathepsin D	B0GXH2	(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[(7-methoxypyrido[3,2-d]pyrimidin-4-yl)amino]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441967	C20H17F3N6O2	430.4	COC1=CC2=C(C(=NC=N2)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F)N=C1	IC50 = 596240 nM	Non binder
T67102	Cathepsin D	B0JSI4	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide	Investigative	78105259	C26H22ClN5O4	503.9	C1COCC(=C1)C2=NC=C3C(=C2)C4(CCOC(=N4)N)C5=C(O3)C=CC(=C5)NC(=O)C6=NC=C(C=C6)Cl	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	B0LG4Y	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-cyanopyridine-2-carboxamide	Investigative	90414092	C19H14F3N5O2	401.3	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C(=CC(=C3)NC(=O)C4=NC=C(C=C4)C#N)F)F)N	IC50 = 364120 nM	Non binder
T67102	Cathepsin D	B0LUB2	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide	Investigative	90412798	C21H19F2N5O3	427.4	CC#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 958610 nM	Non binder
T67102	Cathepsin D	B0LYJ3	N-[5-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-6-fluoropyridin-3-yl]-5-chloropyridine-2-carboxamide	Investigative	90412680	C17H14ClF2N5O2	393.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(N=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F)N	IC50 = 389590 nM	Non binder
T67102	Cathepsin D	B0NV5J	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-cyano-3-methylpyridine-2-carboxamide	Investigative	85468830	C21H18F3N5O2	429.4	CC1=CC(=CC(=C1F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)NC(=O)C4=NC=C(C=C4C)C#N	IC50 = 725410 nM	Non binder
T67102	Cathepsin D	B0QL9I	N-[5-[(1S,5R,6S)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-6-fluoropyridin-3-yl]-5-cyanopyridine-2-carboxamide	Investigative	90441919	C18H13F3N6O2	402.3	C1[C@@H]2[C@H]1OC(=N[C@]2(C3=C(N=CC(=C3)NC(=O)C4=NC=C(C=C4)C#N)F)C(F)F)N	IC50 = 347610 nM	Non binder
T67102	Cathepsin D	B0SHT4	N-[6-[(1R,2S,6R)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoropyridin-2-yl]-3,5-dichloropyridine-2-carboxamide	Investigative	90412256	C17H14Cl2FN5O2	410.2	C[C@]1([C@H]2C[C@H]2OC(=N1)N)C3=C(C=CC(=N3)NC(=O)C4=C(C=C(C=N4)Cl)Cl)F	IC50 = 511670 nM	Non binder
T67102	Cathepsin D	B0U9NO	8-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluoroanilino]-1,7-naphthyridine-3-carbonitrile	Investigative	90372912	C21H15F5N6O	462.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC3=NC=CC4=CC(=CN=C43)C#N)F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B0XD3K	8-[[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]amino]-1,7-naphthyridine-3-carbonitrile	Investigative	78320809	C20H15F4N7O	445.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(N=CC(=C2)NC3=NC=CC4=CC(=CN=C43)C#N)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B16MGO	1,4-Di(carbazol-9-yl)butane-2,3-diol	Investigative	70688511	C28H24N2O2	420.5	C1=CC=C2C(=C1)C3=CC=CC=C3N2CC(C(CN4C5=CC=CC=C5C6=CC=CC=C64)O)O	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	B18KAN	N-[2-Amino-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-b]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide	Investigative	124222800	C26H18ClFN6O3	516.9	C1COC(=NC12C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)OC5=C2C=C(C=N5)C6=CC(=NC=C6)F)N	IC50 = 400800 nM	Non binder
T67102	Cathepsin D	B1BM5H	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	78105231	C26H23FN6O5	518.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCOC(=N5)N)C6=CCOCC6)F	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	B1BO7G	N-(6-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-5-fluoropyridin-2-yl)-3-chloro-5-(trifluoromethyl)-picolinamide	Investigative	78321446	C18H13ClF7N5O2	499.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=N2)NC(=O)C3=C(C=C(C=N3)C(F)(F)F)Cl)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B1F4MB	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3,5-dichloropyridine-2-carboxamide	Investigative	85469563	C18H13Cl2F3N4O2	445.2	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=N4)Cl)Cl)F)C(F)F)N	IC50 = 477760 nM	Non binder
T67102	Cathepsin D	B1H3SF	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide	Investigative	90413118	C21H18F3N5O3	445.4	CC#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 467370 nM	Non binder
T67102	Cathepsin D	B1H5AM	1,3-Di(9H-carbazol-9-yl)propan-2-ol	Investigative	1898613	C27H22N2O	390.5	C1=CC=C2C(=C1)C3=CC=CC=C3N2CC(CN4C5=CC=CC=C5C6=CC=CC=C64)O	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	B1HNA5	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-4-chlorothiophene-2-carboxamide	Investigative	90414800	C17H13ClF3N3O2S	415.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=CC(=CS4)Cl)F)C(F)F)N	IC50 = 762010 nM	Non binder
T67102	Cathepsin D	B1JS6E	N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-cyanopyridine-2-carboxamide	Investigative	90413220	C19H15ClFN5O2	399.8	C1[C@@H]2[C@H]1OC(=N[C@@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)C#N)Cl)N	IC50 = 904390 nM	Non binder
T67102	Cathepsin D	B1JSE8	N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-2,4-difluorophenyl]-5-methoxypyridine-2-carboxamide	Investigative	90413136	C19H17F3N4O3	406.4	COC1=CN=C(C=C1)C(=O)NC2=C(C(=C(C=C2)F)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)CF)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B1MI8H	N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-chloropyridine-2-sulfonamide	Investigative	90401360	C17H14ClF3N4O3S	446.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NS(=O)(=O)C4=NC=C(C=C4)Cl)F)C(F)F)N	IC50 = 223500 nM	Non binder
T67102	Cathepsin D	B1P3IX	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-methoxypyridine-2-carboxamide	Investigative	90416299	C19H17F3N4O3	406.4	COC1=CN=C(C=C1)C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 238440 nM	Non binder
T67102	Cathepsin D	B1Q2VH	1-(4-Benzylphenoxy)-3-(2-chlorophenyl)sulfanylpropan-2-ol	Investigative	70684290	C22H21ClO2S	384.9	C1=CC=C(C=C1)CC2=CC=C(C=C2)OCC(CSC3=CC=CC=C3Cl)O	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	B1RG4S	N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-3,5-dichloropyridine-2-carboxamide	Investigative	78321449	C17H13Cl2F4N5O2	466.2	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(N=CC(=C2)NC(=O)C3=C(C=C(C=N3)Cl)Cl)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B1T5UN	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide	Investigative	117600831	C27H24ClN5O5	534	COC1=C2C(=CC(=N1)C3=CCOCC3)C4(CCOC(=N4)N)C5=C(O2)C=CC(=C5)NC(=O)C6=NC=C(C=C6)Cl	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	B1WCS6	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-4-chloro-1-propan-2-ylpyrazole-3-carboxamide	Investigative	90414722	C19H19ClF3N5O2	441.8	CC(C)N1C=C(C(=N1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)Cl	IC50 = 294980 nM	Non binder
T67102	Cathepsin D	B1Y8LB	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	90373309	C20H16F5N5O3	469.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=CN=C(C=N3)OCC#C)F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B1Y8LG	N-(2-Amino-5'-fluoro-7'-morpholin-4-ylspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2'-yl)-5-methoxypyridine-2-carboxamide	Investigative	124222808	C27H26FN5O4S	535.6	COC1=CN=C(C=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(C35CCSC(=N5)N)C=C(C=C4F)N6CCOCC6	IC50 = 326400 nM	Non binder
T67102	Cathepsin D	B1YSR3	N-[2-Amino-3'-(3,3-dimethylbut-1-ynyl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	78104710	C27H26N6O4	498.5	CC(C)(C)C#CC1=CC2=C(C=N1)OC3=C(C24CCOC(=N4)N)C=C(C=C3)NC(=O)C5=CN=C(C=N5)OC	IC50 = 452300 nM	Non binder
T67102	Cathepsin D	B1ZU4H	N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-1-methyl-6-oxopyridin-3-yl]-5-chloropyridine-2-carboxamide	Investigative	86732216	C18H17ClF3N5O3	443.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=CC(=CN(C2=O)C)NC(=O)C3=NC=C(C=C3)Cl	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B20BIC	(4S,6S)-4-[2-Fluoro-5-[2-(1H-indol-5-yl)ethynyl]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90372918	C22H16F5N3O	433.4	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)C#CC3=CC4=C(C=C3)NC=C4)F)N)C(F)(F)F	IC50 = 381000 nM	Non binder
T67102	Cathepsin D	B23ZPL	N-[2-Amino-5'-fluoro-7'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	124222804	C27H20F2N6O4	530.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(C35CCOC(=N5)N)C=C(C=C4F)C6=CC(=NC=C6)F	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	B2EA9D	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-methoxypyridine-2-carboxamide	Investigative	90412349	C19H18ClFN4O3	404.8	COC1=CN=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 649740 nM	Non binder
T67102	Cathepsin D	B2ET9P	N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-6-chloro-3-methylimidazo[1,2-a]pyridine-2-carboxamide	Investigative	86732111	C21H17ClF5N5O2	501.8	CC1=C(N=C2N1C=C(C=C2)Cl)C(=O)NC3=CC(=C(C=C3)F)[C@@]4(C[C@H](OC(=N4)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B2G0AZ	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-isocyanopyridine-2-carboxamide	Investigative	124221534	C19H15F4N5O2	421.3	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)[N+]#[C-])F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B2H8OC	6-[2-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]ethynyl]-N-methylpyridine-3-carboxamide	Investigative	90372865	C21H17F5N4O2	452.4	CNC(=O)C1=CN=C(C=C1)C#CC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B2JUM4	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxypyrimidine-2-carboxamide	Investigative	90412694	C18H16F3N5O3	407.3	COC1=CN=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 762630 nM	Non binder
T67102	Cathepsin D	B2K3WA	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-chloropyridine-2-carboxamide	Investigative	90413160	C18H15Cl2FN4O2	409.2	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)Cl)N	IC50 = 646370 nM	Non binder
T67102	Cathepsin D	B2K6IO	N-[3-[(1S,5R,6S)-3-Amino-5-(trifluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	90441934	C18H13ClF4N4O2	428.8	C1[C@@H]2[C@H]1OC(=N[C@]2(C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F)C(F)(F)F)N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B2NU9M	N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide	Investigative	78104711	C26H17ClF2N6O3	534.9	C1COC(=NC12C3=CC(=NC(=C3OC4=C2C=C(C=C4)NC(=O)C5=NC=C(C=C5)Cl)F)C6=CC(=NC=C6)F)N	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	B2O9SV	N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	78104989	C26H19F2N7O3S	547.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCSC(=N5)N)C6=CC(=NC=C6)F)F	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	B2P5EC	N-[6-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide	Investigative	90372943	C19H17F6N5O3	477.4	CC1=CC(=CN=C1C(=O)NC2=NC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)OC(F)F	IC50 = 492000 nM	Non binder
T67102	Cathepsin D	B2P6FO	Chembl4215837	Investigative	118435363	C16H18F2N6O2S2	428.5	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC(=CS3)NC(=O)C4=NN(C=C4)C(F)F)N	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	B2PK0G	(4S,6S)-4-[5-[(3-Chloro-1,7-naphthyridin-8-yl)amino]-2,3-difluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90372805	C20H14ClF6N5O	489.8	C1[C@H](OC(=N[C@]1(CF)C2=C(C(=CC(=C2)NC3=NC=CC4=CC(=CN=C43)Cl)F)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B2QS3P	N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-chloropyrazine-2-carboxamide	Investigative	90412895	C17H13ClF3N5O2	411.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)Cl)F)C(F)F)N	IC50 = 444000 nM	Non binder
T67102	Cathepsin D	B2UB9Y	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-bromopyridine-2-carboxamide	Investigative	85468762	C18H14BrF3N4O2	455.2	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Br)F)C(F)F)N	IC50 = 282500 nM	Non binder
T67102	Cathepsin D	B2WCB3	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoro-4-methylphenyl]-5-cyano-3-methylpyridine-2-carboxamide	Investigative	90415723	C21H18F3N5O2	429.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)C)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)C#N	IC50 = 421050 nM	Non binder
T67102	Cathepsin D	B2YKB9	8-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluoroanilino]-1,7-naphthyridine-3-carbonitrile	Investigative	90372948	C21H14F6N6O	480.4	C1[C@H](OC(=N[C@]1(CF)C2=C(C(=CC(=C2)NC3=NC=CC4=CC(=CN=C43)C#N)F)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B2Z7MG	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-3-methyl-5-(trifluoromethyl)pyridine-2-carboxamide	Investigative	90412383	C20H17ClF4N4O2	456.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B30YSI	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide	Investigative	90414666	C20H17F2N5O2	397.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)C#N	IC50 = 703110 nM	Non binder
T67102	Cathepsin D	B32LRJ	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3,5-dimethylpyridine-2-carboxamide	Investigative	90413987	C20H19F3N4O2	404.4	CC1=CC(=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)C	IC50 = 752560 nM	Non binder
T67102	Cathepsin D	B36DXB	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3,5-dimethoxypyrazine-2-carboxamide	Investigative	90413990	C19H18F3N5O4	437.4	COC1=CN=C(C(=N1)OC)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B38FAL	N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-chloropyridine-2-carboxamide	Investigative	90414625	C18H14Cl2F2N4O2	427.2	C1[C@@H]2[C@H]1OC(=N[C@]2(C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)Cl)C(F)F)N	IC50 = 769500 nM	Non binder
T67102	Cathepsin D	B39BNW	N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-5-cyano-3-methylpyridine-2-carboxamide	Investigative	78321761	C19H16F4N6O2	436.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(N=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)C#N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B39SWV	N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-1-methyl-6-oxopyridin-3-yl]-5-isocyano-3-methylpyridine-2-carboxamide	Investigative	124221531	C20H19F3N6O3	448.4	CC1=CC(=CN=C1C(=O)NC2=CN(C(=O)C(=C2)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)C)[N+]#[C-]	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B3FED7	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-cyano-3-fluoropyridine-2-carboxamide	Investigative	90412624	C20H15F4N5O2	433.4	CC1=CC(=CC(=C1F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)NC(=O)C4=C(C=C(C=N4)C#N)F	IC50 = 690320 nM	Non binder
T67102	Cathepsin D	B3GF8N	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide	Investigative	90413674	C21H18F3N5O3	445.4	CC#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 255770 nM	Non binder
T67102	Cathepsin D	B3JB9F	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-prop-1-ynylpyridine-2-carboxamide	Investigative	90413827	C21H17F3N4O2	414.4	CC#CC1=CN=C(C=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 420550 nM	Non binder
T67102	Cathepsin D	B3KQR0	N-(2-Amino-3'-bromospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-b]pyridine]-7'-yl)-4-chloro-2-fluorobenzamide	Investigative	78105121	C22H15BrClFN4O3	517.7	C1COC(=NC12C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=C4)Cl)F)OC5=C2C=C(C=N5)Br)N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B3LNP9	Schembl20590941	Investigative	118796791	C18H16ClFN4O2	374.8	C1C2C1OC(=NC2(CF)C3=CC(=CC=C3)NC(=O)C4=NC=C(C=C4)Cl)N	IC50 = 591980 nM	Non binder
T67102	Cathepsin D	B3MEZ2	N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-2,4,6-trifluorobenzamide	Investigative	90412491	C19H13F6N3O2	429.3	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=C4F)F)F)F)C(F)F)N	IC50 = 959560 nM	Non binder
T67102	Cathepsin D	B3NZD8	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]phenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90413125	C18H17F2N5O3	389.4	COC1=NC=C(N=C1)C(=O)NC2=CC=CC(=C2)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 792770 nM	Non binder
T67102	Cathepsin D	B3O6VN	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-3,6-dihydro-2H-pyridine-1-carboxamide	Investigative	90373375	C18H20F4N4O2	400.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=C2)NC(=O)N3CCC=CC3)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B3PLY2	N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-3-chloro-5-methoxypyridine-2-carboxamide	Investigative	78321760	C18H16ClF4N5O3	461.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(N=CC(=C2)NC(=O)C3=C(C=C(C=N3)OC)Cl)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B3Q0XP	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-1-(4-chlorophenyl)cyclopropane-1-carboxamide	Investigative	90414087	C22H19ClF3N3O2	449.9	C1CC1(C2=CC=C(C=C2)Cl)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 447240 nM	Non binder
T67102	Cathepsin D	B3QZ8U	N-[5-[(1S,2R,6S)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-6-fluoropyridin-3-yl]-5-chloropyridine-2-carboxamide	Investigative	90441944	C17H15ClFN5O2	375.8	C[C@@]1([C@@H]2C[C@@H]2OC(=N1)N)C3=C(N=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B3RK9J	N-[6-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoropyridin-2-yl]-5-chloropyridine-2-carboxamide	Investigative	90414819	C17H13ClF3N5O2	411.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=N3)NC(=O)C4=NC=C(C=C4)Cl)F)C(F)F)N	IC50 = 212500 nM	Non binder
T67102	Cathepsin D	B3XS2N	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-methyl-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide	Investigative	90412843	C20H17F6N5O3	489.4	CC1=NC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)OCC(F)(F)F	IC50 = 351420 nM	Non binder
T67102	Cathepsin D	B40ODW	N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-(3-cyclopropylprop-2-ynoxy)pyrazine-2-carboxamide	Investigative	118232927	C23H20F3N5O3	471.4	C1CC1C#CCOC2=NC=C(N=C2)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 359770 nM	Non binder
T67102	Cathepsin D	B41AZJ	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-chloro-4-fluorophenyl]-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide	Investigative	90412200	C19H15ClF5N5O3	491.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C(=CC(=C3)NC(=O)C4=CN=C(C=N4)OCC(F)(F)F)Cl)F)N	IC50 = 913000 nM	Non binder
T67102	Cathepsin D	B45WNF	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide	Investigative	90373136	C21H19F7N4O3	508.4	CC1=CC(=CC(=C1F)[C@@]2(C[C@H](OC(=N2)N)C(F)(F)F)CF)NC(=O)C3=NC=C(C=C3C)OC(F)F	IC50 = 775000 nM	Non binder
T67102	Cathepsin D	B45WUT	N-[3-[(1S,2R,6S)-4-Amino-2-(methoxymethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	90412850	C19H18ClFN4O3	404.8	COC[C@@]1([C@@H]2C[C@@H]2OC(=N1)N)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B46MXT	(4S,6S)-4-[5-[[3-(2-Cyclopropylethynyl)-1,7-naphthyridin-8-yl]amino]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373138	C25H20F5N5O	501.5	C1CC1C#CC2=CN=C3C(=C2)C=CN=C3NC4=CC(=C(C=C4)F)[C@@]5(C[C@H](OC(=N5)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B47DAH	N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-fluoropyridine-2-carboxamide	Investigative	78105035	C26H17F3N6O3	518.4	C1COC(=NC12C3=CC(=NC(=C3OC4=C2C=C(C=C4)NC(=O)C5=NC=C(C=C5)F)F)C6=CC(=NC=C6)F)N	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	B47YFC	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide	Investigative	90372938	C20H17F7N4O3	494.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF)OC(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B47ZHY	N-(2-Amino-3'-cyclopropylspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-methoxypyrazine-2-carboxamide	Investigative	78104892	C24H22N6O4	458.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=CN=C(C=C4C35CCOC(=N5)N)C6CC6	IC50 = 962700 nM	Non binder
T67102	Cathepsin D	B49MBO	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90373102	C18H16ClF4N5O3	461.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=CN=C(C=N3)OC)Cl)F	IC50 = 393600 nM	Non binder
T67102	Cathepsin D	B4A5ID	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-cyano-3-methylpyridine-2-carboxamide	Investigative	90413178	C20H16ClF2N5O2	431.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)C#N	IC50 = 541280 nM	Non binder
T67102	Cathepsin D	B4BF2G	2-N'-(3-Ethoxypyridin-2-yl)-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2,2'-diamine	Investigative	123165838	C24H23FN4O4	450.5	CCOC1=C(N=CC=C1)NC2=CC3=C(C=C2)OC4=C(C35CCOC(=N5)N)C=C(C=C4F)OC	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	B4FWO6	(4Ar,10R,10aR)-8-pyrimidin-5-ylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine	Investigative	67971074	C18H18N4O3	338.4	C1COC[C@@H]2[C@@H]1OC3=C([C@@]24COC(=N4)N)C=C(C=C3)C5=CN=CN=C5	IC50 > 200000 nM	Non binder
T67102	Cathepsin D	B4GB0Y	N-[3-[(1S,5R,6S)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-6-chloro-3-methylpyrazine-2-carboxamide	Investigative	90441916	C18H15ClF3N5O2	425.8	CC1=NC=C(N=C1C(=O)NC2=CC(=C(C=C2)F)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)C(F)F)Cl	IC50 = 459520 nM	Non binder
T67102	Cathepsin D	B4ILN3	N-(2-Amino-1'-fluoro-3'-pyridin-3-ylspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-fluoropyrazine-2-carboxamide	Investigative	124222792	C25H17F2N7O3	501.4	C1COC(=NC12C3=CC(=NC(=C3OC4=C2C=C(C=C4)NC(=O)C5=CN=C(C=N5)F)F)C6=CN=CC=C6)N	IC50 = 357900 nM	Non binder
T67102	Cathepsin D	B4JM2Q	(1R,5S,6R)-5-[5-[4-(2-Cyclopropylethynyl)pyrazol-1-yl]-2-fluorophenyl]-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine	Investigative	90441997	C20H17F3N4O	386.4	C1CC1C#CC2=CN(N=C2)C3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 315500 nM	Non binder
T67102	Cathepsin D	B4K8QR	8-[[6-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]amino]-5-fluoro-1,7-naphthyridine-3-carbonitrile	Investigative	78320807	C20H14F5N7O	463.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=N2)NC3=NC=C(C4=C3N=CC(=C4)C#N)F)F	IC50 = 229000 nM	Non binder
T67102	Cathepsin D	B4LT8B	N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide	Investigative	90413586	C20H17ClF4N4O3	472.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)Cl)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)CF)OC(F)F	IC50 = 395990 nM	Non binder
T67102	Cathepsin D	B4MDA7	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-3-chloro-5-(trifluoromethyl)pyridine-2-carboxamide	Investigative	90372975	C19H13ClF8N4O2	516.799	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=C(C=C(C=N3)C(F)(F)F)Cl)F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B4PRQ5	N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-methoxypyridine-2-carboxamide	Investigative	90441923	C19H16F4N4O3	424.3	COC1=CN=C(C=C1)C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 206000 nM	Non binder
T67102	Cathepsin D	B4S5TJ	(4S,6S)-4-[5-(4-Bromo-6-chloropyridin-2-yl)oxy-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90380069	C17H12BrClF5N3O2	500.6	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)OC3=NC(=CC(=C3)Br)Cl)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B4WJ9X	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-methylphenyl]-5-chloropyridine-2-carboxamide	Investigative	90413872	C19H17ClF2N4O2	406.8	CC1=C(C=C(C=C1)NC(=O)C2=NC=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 464360 nM	Non binder
T67102	Cathepsin D	B4YK6B	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-chloro-5-methoxypyridine-2-carboxamide	Investigative	85468892	C19H17ClF2N4O3	422.8	COC1=CC(=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)Cl	IC50 = 956160 nM	Non binder
T67102	Cathepsin D	B50OHQ	(1R,5S,6R)-5-[2-Chloro-5-[(2-methoxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine	Investigative	118796787	C20H18ClFN6O2	428.8	COC1=CN=C2C(=N1)C=CN=C2NC3=CC(=C(C=C3)Cl)[C@@]4([C@H]5C[C@H]5OC(=N4)N)CF	IC50 = 843040 nM	Non binder
T67102	Cathepsin D	B53DXH	N-(5-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-6-fluoropyridin-3-yl)-3-chloro-5-cyanopicolinamide	Investigative	86732133	C18H13ClF4N6O2	456.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(N=CC(=C2)NC(=O)C3=C(C=C(C=N3)C#N)Cl)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B53WYP	(8R)-8-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoroanilino]-5,6,7,8-tetrahydroquinoline-3-carbonitrile	Investigative	90413221	C22H20F3N5O	427.4	C1C[C@H](C2=C(C1)C=C(C=N2)C#N)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 468840 nM	Non binder
T67102	Cathepsin D	B53YAK	(2R)-1-Carbazol-9-yl-3-naphthalen-2-ylsulfanylpropan-2-ol	Investigative	70690563	C25H21NOS	383.5	C1=CC=C2C=C(C=CC2=C1)SC[C@@H](CN3C4=CC=CC=C4C5=CC=CC=C53)O	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	B57RSP	N-(2-Amino-4a,5,6,7,8,8a-hexahydro-4H-3,1-benzothiazin-6-yl)-5-fluoropyridine-2-carboxamide;hydrochloride	Investigative	122180114	C14H18ClFN4OS	344.8	C1CC2C(CC1NC(=O)C3=NC=C(C=C3)F)CSC(=N2)N.Cl	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	B58LOP	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	78105197	C26H24N6O5	500.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=CN=C(C=C4C35CCOC(=N5)N)C6=CCCOC6	IC50 = 480000 nM	Non binder
T67102	Cathepsin D	B59EUS	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-but-2-ynoxypyridine-2-carboxamide	Investigative	78322704	C22H18F6N4O3	500.4	CC#CCOC1=CN=C(C=C1)C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B5H0BR	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-chloro-5-cyanopyridine-2-carboxamide	Investigative	85469561	C19H13ClF3N5O2	435.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=N4)C#N)Cl)F)C(F)F)N	IC50 = 825020 nM	Non binder
T67102	Cathepsin D	B5HXW4	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(1,3-thiazol-2-ylmethoxy)pyrazine-2-carboxamide	Investigative	90412940	C21H17F3N6O3S	490.5	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OCC5=NC=CS5)F)C(F)F)N	IC50 = 383220 nM	Non binder
T67102	Cathepsin D	B5IV6W	N-[6-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	90372933	C19H16F4N6O3	452.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=N2)NC(=O)C3=CN=C(C=N3)OCC#C)F	IC50 = 609000 nM	Non binder
T67102	Cathepsin D	B5KN7Q	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-cyano-3-methoxypyridine-2-carboxamide	Investigative	90373088	C20H16F5N5O3	469.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=C(C=C(C=N3)C#N)OC)F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B5O2XV	N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	124222801	C26H19F2N7O4	531.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCOC(=N5)N)C6=CC(=NC=C6)F)F	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	B5SLB1	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloro-3-fluoropyridine-2-carboxamide	Investigative	124222811	C26H20ClF2N5O3S	556	C1COCC=C1C2=NC(=C3C(=C2)C4(CCSC(=N4)N)C5=C(O3)C=CC(=C5)NC(=O)C6=C(C=C(C=N6)Cl)F)F	IC50 = 311000 nM	Non binder
T67102	Cathepsin D	B5T1VQ	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-cyano-3-fluoropyridine-2-carboxamide	Investigative	90413021	C19H14ClF2N5O2	417.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=N4)C#N)F)Cl)N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B5T8YN	N-[3-[(1S,5R,6S)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide	Investigative	90441913	C17H13ClF5N5O2	449.8	C1[C@@H]2[C@H]1OC(=N[C@@]2(CF)C3=C(C(=CC(=C3)NC(=O)C4=NN(C=C4Cl)C(F)F)F)F)N	IC50 = 967700 nM	Non binder
T67102	Cathepsin D	B5T9SA	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-(difluoromethyl)pyridine-2-carboxamide	Investigative	71668199	C19H15F7N4O2	464.3	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)C(F)F)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B5WH9D	2-[2-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]ethynyl]-N-methylpyridine-4-carboxamide	Investigative	90373014	C21H17F5N4O2	452.4	CNC(=O)C1=CC(=NC=C1)C#CC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B5WNC1	N-[2-Amino-5'-fluoro-7'-(oxan-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	117600872	C27H26FN5O5	519.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(C35CCOC(=N5)N)C=C(C=C4F)C6CCOCC6	IC50 = 378500 nM	Non binder
T67102	Cathepsin D	B5WT3K	N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-fluoropyridine-2-carboxamide	Investigative	124222799	C26H17F3N6O3	518.4	C1COC(=NC12C3=CC(=NC(=C3OC4=C2C=C(C=C4)NC(=O)C5=NC=C(C=C5)F)F)C6=CC(=CN=C6)F)N	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	B5XR9U	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3,5-dichloropyridine-2-carboxamide	Investigative	90412683	C18H14Cl2F2N4O2	427.2	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=N4)Cl)Cl)F)N	IC50 = 875420 nM	Non binder
T67102	Cathepsin D	B5Y4CN	N-[6-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-bromo-3-chloropyridine-2-carboxamide	Investigative	90372823	C17H13BrClF4N5O2	510.7	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=N2)NC(=O)C3=C(C=C(C=N3)Br)Cl)F	IC50 = 636000 nM	Non binder
T67102	Cathepsin D	B5Y7GX	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-3-chloro-5-(trifluoromethyl)pyridine-2-carboxamide	Investigative	90373024	C19H13ClF8N4O2	516.799	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC(=O)C3=C(C=C(C=N3)C(F)(F)F)Cl)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B5YO9E	(7S)-7-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoroanilino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile	Investigative	90414650	C21H18F3N5O	413.4	C1CC2=C([C@H]1NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F)N=CC(=C2)C#N	IC50 = 205500 nM	Non binder
T67102	Cathepsin D	B5ZI8S	(4S,6S)-4-[5-[2-[5-(Difluoromethoxy)pyridin-2-yl]ethynyl]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90372770	C20H14F7N3O2	461.3	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)C#CC3=NC=C(C=C3)OC(F)F)F)N)C(F)(F)F	IC50 = 605000 nM	Non binder
T67102	Cathepsin D	B5ZR8N	N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-5-methylphenyl)-5-(difluoromethyl)-3-methylpicolinamide	Investigative	86732264	C21H19F7N4O2	492.4	CC1=CC(=CC(=C1F)[C@@]2(C[C@H](OC(=N2)N)C(F)(F)F)CF)NC(=O)C3=NC=C(C=C3C)C(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B61LSJ	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide	Investigative	90415325	C20H17ClF4N4O3	472.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)OC(F)F	IC50 = 928320 nM	Non binder
T67102	Cathepsin D	B67KYF	N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-1-methyl-6-oxopyridin-3-yl]-5-isocyanopyridine-2-carboxamide	Investigative	124221530	C19H17F3N6O3	434.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=CC(=CN(C2=O)C)NC(=O)C3=NC=C(C=C3)[N+]#[C-]	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B68CXW	[4-[3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-5-fluoro-2-(5-fluoropyridin-3-yl)phenyl]methanol	Investigative	118796794	C18H16F3N3O2	363.3	C1C2C1OC(=NC2(CF)C3=C(C=C(C(=C3)C4=CC(=CN=C4)F)CO)F)N	IC50 = 612810 nM	Non binder
T67102	Cathepsin D	B69MUR	(4S,6S)-4-(5-((7-Chloropyrido[3,2-d]pyrimidin-4-yl)amino)-2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine	Investigative	86732265	C20H16ClF5N6O	486.8	CC1=CC(=CC(=C1F)[C@@]2(C[C@H](OC(=N2)N)C(F)(F)F)CF)NC3=NC=NC4=C3N=CC(=C4)Cl	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B6A5OS	N-[(2S,3R)-4-[[1-(4-Tert-butyl-1,3-oxazol-2-yl)cyclopropyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide	Investigative	52949259	C22H29F2N3O3	421.5	CC(=O)N[C@@H](CC1=CC(=CC(=C1)F)F)[C@@H](CNC2(CC2)C3=NC(=CO3)C(C)(C)C)O	IC50 > 200000 nM	Non binder
T67102	Cathepsin D	B6AKI9	N-(3-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-chloro-3-fluoropicolinamide	Investigative	90373416	C18H13ClF6N4O2	466.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=C(C=C(C=N3)Cl)F)F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B6BAD7	N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-(cyclopropylethynyl)picolinamide	Investigative	90413279	C23H19F3N4O2	440.4	C1CC1C#CC2=CN=C(C=C2)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 398530 nM	Non binder
T67102	Cathepsin D	B6BQE1	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-chloro-4-fluorophenyl]-5-cyanopyridine-2-carboxamide	Investigative	90413537	C19H14ClF2N5O2	417.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C(=CC(=C3)NC(=O)C4=NC=C(C=C4)C#N)Cl)F)N	IC50 = 301500 nM	Non binder
T67102	Cathepsin D	B6BT2E	N-[2-Amino-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	124222802	C26H20FN7O4	513.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=CN=C(C=C4C35CCOC(=N5)N)C6=CC(=NC=C6)F	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	B6C9VH	Chembl4294221	Investigative	137348437	C25H20ClN5O4	489.9	C1COCC(=C1)C2=NC=C3C(=C2)[C@]4(COC(=N4)N)C5=C(O3)C=CC(=C5)NC(=O)C6=NC=C(C=C6)Cl	IC50 = 480000 nM	Non binder
T67102	Cathepsin D	B6DQH9	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide	Investigative	90412674	C20H17ClF4N4O3	472.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)OC(F)F	IC50 = 230500 nM	Non binder
T67102	Cathepsin D	B6F2UY	N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	78105230	C26H19F2N7O4	531.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCOC(=N5)N)C6=CC(=CN=C6)F)F	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	B6GE3I	2-Amino-7-phenyl-3-[(4-phenyloxolan-2-yl)methyl]quinazolin-4-one	Investigative	127038526	C25H23N3O2	397.5	C1C(COC1CN2C(=O)C3=C(C=C(C=C3)C4=CC=CC=C4)N=C2N)C5=CC=CC=C5	IC50 > 200000 nM	Non binder
T67102	Cathepsin D	B6HAK5	(4S)-4-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluoroanilino]-3,4-dihydro-2H-pyrano[3,2-b]pyridine-7-carbonitrile	Investigative	118796788	C21H18F3N5O2	429.4	C1COC2=C([C@H]1NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F)N=CC(=C2)C#N	IC50 = 206000 nM	Non binder
T67102	Cathepsin D	B6KU4R	(1R,2S,6R)-2-[3-Chloro-2-fluoro-5-[(2-propan-2-yloxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90413146	C22H21ClF2N6O2	474.9	CC(C)OC1=CN=C2C(=N1)C=CN=C2NC3=CC(=C(C(=C3)Cl)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)CF	IC50 = 322620 nM	Non binder
T67102	Cathepsin D	B6LWV3	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90416108	C18H16F3N5O3	407.3	COC1=NC=C(N=C1)C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 529160 nM	Non binder
T67102	Cathepsin D	B6N9BO	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide	Investigative	90372797	C17H13ClF7N5O2	487.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=NN(C=C3Cl)C(F)F)F)F	IC50 = 627600 nM	Non binder
T67102	Cathepsin D	B6NRK0	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(difluoromethyl)-3-methylpyridine-2-carboxamide	Investigative	90413928	C20H18F4N4O2	422.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)C(F)F	IC50 = 515090 nM	Non binder
T67102	Cathepsin D	B6RDT5	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-3,5-dichloropyridine-2-carboxamide	Investigative	90413224	C18H13Cl3F2N4O2	461.7	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=N4)Cl)Cl)Cl)C(F)F)N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B6WPQ3	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-ethynylpyridine-2-carboxamide	Investigative	90412855	C20H15F3N4O2	400.4	C#CC1=CN=C(C=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 466880 nM	Non binder
T67102	Cathepsin D	B6XP4J	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90413129	C18H16ClF2N5O3	423.8	COC1=NC=C(N=C1)C(=O)NC2=CC(=C(C(=C2)F)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 896760 nM	Non binder
T67102	Cathepsin D	B6YU3Q	(1R,2S,6R)-2-[5-[(3-Chloro-5-fluoro-1,7-naphthyridin-8-yl)amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441963	C20H14ClF4N5O	451.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC4=NC=C(C5=C4N=CC(=C5)Cl)F)F)C(F)F)N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B6ZVF1	N-[2-Amino-5'-fluoro-7'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl]-5-cyanopyridine-2-carboxamide	Investigative	124222809	C28H18F2N6O3	524.5	C1COC(=NC12C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)C#N)OC5=C2C=C(C=C5F)C6=CC(=NC=C6)F)N	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	B6ZWO3	(4S,6S)-4-[5-(4-Bromopyridin-2-yl)oxy-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90372839	C17H13BrF5N3O2	466.2	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)OC3=NC=CC(=C3)Br)F)N)C(F)(F)F	IC50 = 557000 nM	Non binder
T67102	Cathepsin D	B75WNT	N-[6-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoropyridin-2-yl]-5-chloropyridine-2-carboxamide	Investigative	90414882	C17H14ClF2N5O2	393.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=N3)NC(=O)C4=NC=C(C=C4)Cl)F)N	IC50 = 216000 nM	Non binder
T67102	Cathepsin D	B78BZV	N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-5-fluoropyridine-2-carboxamide	Investigative	90372851	C17H14F5N5O2	415.32	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(N=CC(=C2)NC(=O)C3=NC=C(C=C3)F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B78CYX	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	90373160	C20H16ClF4N5O3	485.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=CN=C(C=N3)OCC#C)Cl)F	IC50 = 554000 nM	Non binder
T67102	Cathepsin D	B7HZ2L	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide	Investigative	90372894	C20H17F7N4O3	494.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)OC(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B7I1GX	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-but-2-ynoxypyridine-2-carboxamide	Investigative	90412840	C22H19F3N4O3	444.4	CC#CCOC1=CN=C(C=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 243500 nM	Non binder
T67102	Cathepsin D	B7IWU1	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-chloro-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide	Investigative	90413082	C20H16ClF2N5O2	431.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)Cl)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)C#N	IC50 = 260000 nM	Non binder
T67102	Cathepsin D	B7K0PC	N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	90401352	C18H14ClF3N4O2	410.8	C1[C@@H]2[C@H]1OC(=N[C@@]2(CF)C3=C(C(=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F)F)N	IC50 = 339220 nM	Non binder
T67102	Cathepsin D	B7K6FU	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-fluoropyridine-2-carboxamide	Investigative	78105036	C27H24FN5O5	517.5	COC1=C2C(=CC(=N1)C3=CCOCC3)C4(CCOC(=N4)N)C5=C(O2)C=CC(=C5)NC(=O)C6=NC=C(C=C6)F	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	B7KOY0	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-4-methylthiophene-2-carboxamide	Investigative	90412958	C18H16F3N3O2S	395.4	CC1=CSC(=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 834710 nM	Non binder
T67102	Cathepsin D	B7LG2E	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-cyano-3-methylpyridine-2-carboxamide	Investigative	90373412	C21H18F5N5O2	467.4	CC1=CC(=CC(=C1F)[C@@]2(C[C@H](OC(=N2)N)C(F)(F)F)CF)NC(=O)C3=NC=C(C=C3C)C#N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B7M6LR	N-[3-[(1S,2S,6S)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90412860	C18H18FN5O3	371.4	C[C@]1([C@@H]2C[C@@H]2OC(=N1)N)C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OC)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B7N5AQ	(1R,2S,6R)-2-[3-Chloro-2-fluoro-5-[(2-methoxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90413619	C20H17ClF2N6O2	446.8	COC1=CN=C2C(=N1)C=CN=C2NC3=CC(=C(C(=C3)Cl)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)CF	IC50 = 725380 nM	Non binder
T67102	Cathepsin D	B7OY4C	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-4-prop-2-ynoxypiperidine-1-carboxamide	Investigative	90372991	C21H24F4N4O3	456.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)OCC#C)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B7RE0K	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-3-methyl-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide	Investigative	90412996	C20H17ClF5N5O3	505.8	CC1=NC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)OCC(F)(F)F	IC50 = 556390 nM	Non binder
T67102	Cathepsin D	B7VZ8A	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxy-3-methylpyridine-2-carboxamide	Investigative	90413583	C20H19F3N4O3	420.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)OC	IC50 = 342490 nM	Non binder
T67102	Cathepsin D	B7XC5A	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-chloro-4-fluorophenyl]-5-cyano-3-methoxypyridine-2-carboxamide	Investigative	90413171	C20H16ClF2N5O3	447.8	COC1=C(N=CC(=C1)C#N)C(=O)NC2=CC(=C(C(=C2)Cl)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 891600 nM	Non binder
T67102	Cathepsin D	B7YBR6	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-[2-(3-methyloxetan-3-yl)ethynyl]pyridine-2-carboxamide	Investigative	90417761	C24H21F3N4O3	470.4	CC1(COC1)C#CC2=CN=C(C=C2)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 748150 nM	Non binder
T67102	Cathepsin D	B7YSE9	N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-5-chloro-3-methylpyridine-2-carboxamide	Investigative	78322074	C18H16ClF4N5O2	445.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(N=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)Cl	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B80DFQ	2-N'-(3-Ethoxypyridin-2-yl)-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2,2'-diamine	Investigative	123400481	C24H23FN4O3S	466.5	CCOC1=C(N=CC=C1)NC2=CC3=C(C=C2)OC4=C(C35CCSC(=N5)N)C=C(C=C4F)OC	IC50 = 262500 nM	Non binder
T67102	Cathepsin D	B82CZK	N-(2-Amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2'-yl)-5-chloropyridine-2-carboxamide	Investigative	78105159	C23H18ClFN4O3S	484.9	COC1=CC2=C(C(=C1)F)OC3=C(C24CCSC(=N4)N)C=C(C=C3)NC(=O)C5=NC=C(C=C5)Cl	IC50 = 350200 nM	Non binder
T67102	Cathepsin D	B84TFM	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide	Investigative	71666292	C21H18F5N5O3	483.4	CC#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B86QPR	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide	Investigative	78105081	C27H24FN5O4S	533.6	COC1=CN=C(C=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCSC(=N5)N)C6=CCCOC6)F	IC50 = 569000 nM	Non binder
T67102	Cathepsin D	B89YNK	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-methylphenyl]-5-cyanopyridine-2-carboxamide	Investigative	90401358	C20H17F2N5O2	397.4	CC1=C(C=C(C=C1)NC(=O)C2=NC=C(C=C2)C#N)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 715760 nM	Non binder
T67102	Cathepsin D	B8BVA7	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-methoxypyridine-2-carboxamide	Investigative	90373358	C19H17F5N4O3	444.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=NC=C(C=C3)OC)F)F	IC50 = 761600 nM	Non binder
T67102	Cathepsin D	B8E2BU	N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide	Investigative	78322384	C16H13ClF6N6O2	470.76	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(N=CC(=C2)NC(=O)C3=NN(C=C3Cl)C(F)F)F	IC50 = 844000 nM	Non binder
T67102	Cathepsin D	B8HCB2	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-prop-2-ynoxypyridine-2-carboxamide	Investigative	90373328	C21H18F4N4O3	450.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)OCC#C)F	IC50 = 666000 nM	Non binder
T67102	Cathepsin D	B8IF3K	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-cyanopyridine-2-carboxamide	Investigative	86732252	C19H14ClF4N5O2	455.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)Cl)F	IC50 = 487900 nM	Non binder
T67102	Cathepsin D	B8J6WR	(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441952	C21H18F3N5O2	429.4	COC1=CN=C2C(=C1)C=CN=C2NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 738320 nM	Non binder
T67102	Cathepsin D	B8KYV1	3-{2-[(5-Aminopentyl)amino]-2-oxoethoxy}-5-({[1-(4-fluorophenyl)ethyl]amino}carbonyl)phenyl phenylmethanesulfonate	Investigative	448772	C29H34FN3O6S	571.7	C[C@H](C1=CC=C(C=C1)F)NC(=O)C2=CC(=CC(=C2)OS(=O)(=O)CC3=CC=CC=C3)OCC(=O)NCCCCCN	IC50 > 500000 nM	Non binder
T67102	Cathepsin D	B8OL4A	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-methoxypyridine-2-carboxamide	Investigative	90413157	C20H19F3N4O3	420.4	CC1=CC(=CC(=C1F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)NC(=O)C4=NC=C(C=C4)OC	IC50 = 354980 nM	Non binder
T67102	Cathepsin D	B8PR1W	N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-chloropicolinamide	Investigative	85468763	C18H14ClF3N4O2	410.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F)C(F)F)N	IC50 = 684310 nM	Non binder
T67102	Cathepsin D	B8RF2D	(2R)-N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]oxolane-2-carboxamide	Investigative	90412554	C17H18F3N3O3	369.34	C1C[C@@H](OC1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 318540 nM	Non binder
T67102	Cathepsin D	B8RFY6	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-6-methoxypyridazine-3-carboxamide	Investigative	90415593	C18H16F3N5O3	407.3	COC1=NN=C(C=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 667110 nM	Non binder
T67102	Cathepsin D	B8S7FG	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-methylphenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90412784	C19H19F2N5O3	403.4	CC1=C(C=C(C=C1)NC(=O)C2=CN=C(C=N2)OC)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 684340 nM	Non binder
T67102	Cathepsin D	B8SEY7	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoro-4-methoxyphenyl]-5-chloropyridine-2-carboxamide	Investigative	90412901	C19H17ClF2N4O3	422.8	COC1=C(C=C(C=C1F)NC(=O)C2=NC=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 220000 nM	Non binder
T67102	Cathepsin D	B8SJ1H	8-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoroanilino]-1,7-naphthyridine-3-carbonitrile	Investigative	90441971	C21H15F3N6O	424.4	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC4=NC=CC5=CC(=CN=C54)C#N)F)C(F)F)N	IC50 = 657710 nM	Non binder
T67102	Cathepsin D	B8X1GH	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-chloro-3-methylpyridine-2-carboxamide	Investigative	90413184	C19H17Cl2FN4O2	423.3	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)Cl	IC50 = 517380 nM	Non binder
T67102	Cathepsin D	B8XUH1	N-(2-Amino-3'-chloro-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-cyanopyridine-2-carboxamide	Investigative	78104889	C22H14ClFN6O3	464.8	C1COC(=NC12C3=CC(=NC(=C3OC4=C2C=C(C=C4)NC(=O)C5=NC=C(C=C5)C#N)F)Cl)N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B8YCB0	N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-2-(2-cyclopropylethynyl)-1,3-oxazole-4-carboxamide	Investigative	90413622	C21H17F3N4O3	430.4	C1CC1C#CC2=NC(=CO2)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 302500 nM	Non binder
T67102	Cathepsin D	B8ZW6M	N-(2-Amino-3'-cyclopropyl-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-methoxypyrazine-2-carboxamide	Investigative	78105263	C24H21FN6O4	476.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCOC(=N5)N)C6CC6)F	IC50 = 269400 nM	Non binder
T67102	Cathepsin D	B90XNW	N-[3-[(1R,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-chlorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide	Investigative	90441929	C20H17ClF4N4O3	472.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)Cl)C3([C@H]4C[C@H]4OC(=N3)N)C(F)F)OC(F)F	IC50 = 958310 nM	Non binder
T67102	Cathepsin D	B91KCA	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloro-3-methoxypyridine-2-carboxamide	Investigative	78321764	C19H16ClF5N4O3	478.8	COC1=C(N=CC(=C1)Cl)C(=O)NC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B92RXF	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-fluoro-3-methoxypyridine-2-carboxamide	Investigative	90413662	C19H16F4N4O3	424.3	COC1=C(N=CC(=C1)F)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B93TOV	N-[5-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-6-fluoropyridin-3-yl]-5-cyanopyridine-2-carboxamide	Investigative	90413094	C18H14F2N6O2	384.3	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(N=CC(=C3)NC(=O)C4=NC=C(C=C4)C#N)F)N	IC50 = 293500 nM	Non binder
T67102	Cathepsin D	B95GFY	N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-5-methoxypyridine-2-carboxamide	Investigative	90373127	C18H17F4N5O3	427.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(N=CC(=C2)NC(=O)C3=NC=C(C=C3)OC)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B95HER	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-4-cyanothiophene-2-carboxamide	Investigative	90414328	C18H13F3N4O2S	406.4	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=CC(=CS4)C#N)F)C(F)F)N	IC50 = 534110 nM	Non binder
T67102	Cathepsin D	B96ZIU	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-cyanopyridine-2-carboxamide	Investigative	90373287	C20H16F5N5O2	453.4	CC1=CC(=CC(=C1F)[C@@]2(C[C@H](OC(=N2)N)C(F)(F)F)CF)NC(=O)C3=NC=C(C=C3)C#N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B98OEW	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-(difluoromethyl)pyrazine-2-carboxamide	Investigative	90373163	C18H14ClF6N5O2	481.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=NC=C(N=C3)C(F)F)Cl)F	IC50 = 604000 nM	Non binder
T67102	Cathepsin D	B9C6XR	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-2-phenoxyacetamide	Investigative	90413353	C20H18F3N3O3	405.4	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)COC4=CC=CC=C4)F)C(F)F)N	IC50 = 331000 nM	Non binder
T67102	Cathepsin D	B9FPX2	N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-(oxolan-3-ylmethoxy)pyrazine-2-carboxamide	Investigative	118359398	C22H22F3N5O4	477.4	C1COCC1COC2=NC=C(N=C2)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B9HBL8	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-(1,3-oxazol-2-ylmethoxy)pyrazine-2-carboxamide	Investigative	90372802	C21H17F5N6O4	512.4	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC(=O)C3=CN=C(C=N3)OCC4=NC=CO4)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B9HZG7	N-[6-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3-chloro-5-cyanopyridine-2-carboxamide	Investigative	78321445	C18H13ClF4N6O2	456.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=N2)NC(=O)C3=C(C=C(C=N3)C#N)Cl)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B9I7WZ	Methyl 4-[[3-[(1S,5R,6S)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]carbamoyl]benzoate	Investigative	118361795	C21H17F4N3O4	451.4	COC(=O)C1=CC=C(C=C1)C(=O)NC2=CC(=C(C(=C2)F)F)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)C(F)F	IC50 = 343180 nM	Non binder
T67102	Cathepsin D	B9KU6E	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloro-3-methylpyridine-2-carboxamide	Investigative	90413745	C19H17ClF2N4O2	406.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)Cl	IC50 = 348840 nM	Non binder
T67102	Cathepsin D	B9LHA7	N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-chloro-3-(hydroxymethyl)picolinamide	Investigative	90413325	C19H16ClF3N4O3	440.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=N4)Cl)CO)F)C(F)F)N	IC50 = 275500 nM	Non binder
T67102	Cathepsin D	B9M5PK	N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide	Investigative	90412264	C17H13Cl2F4N5O2	466.2	C1[C@@H]2[C@H]1OC(=N[C@]2(C3=C(C=CC(=C3)NC(=O)C4=NN(C=C4Cl)C(F)F)Cl)C(F)F)N	IC50 = 690710 nM	Non binder
T67102	Cathepsin D	B9RU2Y	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-cyano-3-fluoropyridine-2-carboxamide	Investigative	90372807	C19H12F7N5O2	475.3	C1[C@H](OC(=N[C@]1(CF)C2=C(C(=CC(=C2)NC(=O)C3=C(C=C(C=N3)C#N)F)F)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B9TA3Y	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-chloro-3-fluoropyridine-2-carboxamide	Investigative	90372911	C18H12ClF7N4O2	484.8	C1[C@H](OC(=N[C@]1(CF)C2=C(C(=CC(=C2)NC(=O)C3=C(C=C(C=N3)Cl)F)F)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B9VRF5	(4S,6S)-4-(5-(6-Ethynylpyridin-3-yl)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine	Investigative	86732154	C19H14F5N3O	395.3	C#CC1=NC=C(C=C1)C2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	B9WG5I	1-Carbazol-9-yl-4-naphthalen-2-ylsulfanylbutan-2-ol	Investigative	70684257	C26H23NOS	397.5	C1=CC=C2C=C(C=CC2=C1)SCCC(CN3C4=CC=CC=C4C5=CC=CC=C53)O	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	B9Y2DN	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	85468827	C18H15ClF2N4O2	392.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F)N	IC50 = 471710 nM	Non binder
T67102	Cathepsin D	B9ZD6F	(1R,2S,6R)-2-[5-[(3-Chloro-1,7-naphthyridin-8-yl)amino]-2-fluorophenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90418103	C20H16ClF2N5O	415.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC4=NC=CC5=CC(=CN=C54)Cl)F)N	IC50 = 282000 nM	Non binder
T67102	Cathepsin D	BA1N8S	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-chloropyridine-2-carboxamide	Investigative	90413687	C19H16ClF3N4O2	424.8	CC1=CC(=CC(=C1F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)NC(=O)C4=NC=C(C=C4)Cl	IC50 = 257250 nM	Non binder
T67102	Cathepsin D	BA5PG2	N-[6-[(1S,2R,6S)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoropyridin-2-yl]-5-methoxypyrazine-2-carboxamide	Investigative	90414903	C17H17FN6O3	372.4	C[C@@]1([C@@H]2C[C@@H]2OC(=N1)N)C3=C(C=CC(=N3)NC(=O)C4=CN=C(C=N4)OC)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BA79XE	N-[5-[(1S,5R,6S)-3-Amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-6-fluoropyridin-3-yl]-5-methoxypyrazine-2-carboxamide	Investigative	90441946	C17H17FN6O3	372.4	C[C@@]1([C@@H]2C[C@@H]2OC(=N1)N)C3=C(N=CC(=C3)NC(=O)C4=CN=C(C=N4)OC)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BA8BQ6	N-(5-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-6-fluoropyridin-3-yl)-5-cyano-3-methylpicolinamide	Investigative	86732198	C19H15F5N6O2	454.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(N=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF)C#N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BA9S1G	N-(5-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-6-fluoropyridin-3-yl)-5-chloropicolinamide	Investigative	86732197	C17H13ClF5N5O2	449.8	C1[C@H](OC(=N[C@]1(CF)C2=C(N=CC(=C2)NC(=O)C3=NC=C(C=C3)Cl)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BA9X4D	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-2-(difluoromethyl)-1,3-oxazole-4-carboxamide	Investigative	90441926	C17H13F5N4O3	416.3	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=COC(=N4)C(F)F)F)C(F)F)N	IC50 = 238370 nM	Non binder
T67102	Cathepsin D	BAD2I6	N-[3-[(1S,5R,6S)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-cyanopyridine-2-carboxamide	Investigative	90441921	C19H13F4N5O2	419.3	C1[C@@H]2[C@H]1OC(=N[C@]2(C3=C(C(=CC(=C3)NC(=O)C4=NC=C(C=C4)C#N)F)F)C(F)F)N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BAF6L2	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(difluoromethyl)-2-methylpyrazole-3-carboxamide	Investigative	90412938	C18H16F5N5O2	429.3	CN1C(=CC(=N1)C(F)F)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 514640 nM	Non binder
T67102	Cathepsin D	BAP6M7	N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-chloro-3-methylpicolinamide	Investigative	86732142	C19H16ClF5N4O2	462.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF)Cl	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BAT3I6	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-methoxy-3-methylpyrazine-2-carboxamide	Investigative	90373110	C19H18F5N5O3	459.4	CC1=NC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)OC	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BAT40U	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	71667462	C18H14ClF5N4O2	448.8	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)Cl)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BAWZ59	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-3-chloro-5-cyanopyridine-2-carboxamide	Investigative	85468831	C20H15ClF3N5O2	449.8	CC1=CC(=CC(=C1F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)NC(=O)C4=C(C=C(C=N4)C#N)Cl	IC50 = 558460 nM	Non binder
T67102	Cathepsin D	BAZK98	N-[(4S)-2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	71542873	C26H24N6O5	500.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=CN=C(C=C4[C@]35CCOC(=N5)N)C6=CCCOC6	IC50 = 480000 nM	Non binder
T67102	Cathepsin D	BB1A6R	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	90413600	C18H13ClF4N4O2	428.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C(=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F)F)C(F)F)N	IC50 = 213000 nM	Non binder
T67102	Cathepsin D	BB6RL7	6-((3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)ethynyl)nicotinonitrile	Investigative	86279155	C20H13F5N4O	420.3	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)C#CC3=NC=C(C=C3)C#N)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BBIR60	N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide	Investigative	90415821	C21H18ClF2N5O3	461.8	CC#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)Cl)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)C(F)F	IC50 = 500140 nM	Non binder
T67102	Cathepsin D	BBLM73	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(difluoromethyl)-3-methylpyridine-2-carboxamide	Investigative	90413229	C20H17F5N4O2	440.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)C(F)F	IC50 = 767700 nM	Non binder
T67102	Cathepsin D	BBZY28	N-[3-[(4S,6R)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90372856	C18H16F5N5O3	445.3	COC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3(C[C@@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BC0I7U	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-methoxy-3-methylpyrazine-2-carboxamide	Investigative	90413128	C19H19ClFN5O3	419.8	CC1=NC(=CN=C1C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)OC	IC50 = 714940 nM	Non binder
T67102	Cathepsin D	BC10DQ	N-(2-Amino-5'-fluoro-7'-morpholin-4-ylspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2'-yl)-5-methoxypyrazine-2-carboxamide	Investigative	124222810	C26H25FN6O4S	536.6	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(C35CCSC(=N5)N)C=C(C=C4F)N6CCOCC6	IC50 = 229500 nM	Non binder
T67102	Cathepsin D	BC6M2G	N-(2-Amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl)-5-chloropyridine-2-carboxamide	Investigative	117600814	C23H18ClFN4O4	468.9	COC1=CC2=C(C(=C1)F)OC3=C(C24CCOC(=N4)N)C=C(C=C3)NC(=O)C5=NC=C(C=C5)Cl	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BC87GN	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-2-methyl-1,3-thiazole-4-carboxamide	Investigative	124222797	C25H22FN5O4S	507.5	CC1=NC(=CS1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCOC(=N5)N)C6=CCCOC6)F	IC50 = 411100 nM	Non binder
T67102	Cathepsin D	BC87KD	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxypyridine-2-carboxamide	Investigative	90412791	C19H17F3N4O3	406.4	COC1=CN=C(C=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 987710 nM	Non binder
T67102	Cathepsin D	BC8R1H	(1S,2R,6S)-2-[2,6-Difluoro-3-[(2-methoxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441954	C20H17F3N6O2	430.4	COC1=CN=C2C(=N1)C=CN=C2NC3=C(C(=C(C=C3)F)[C@]4([C@@H]5C[C@@H]5OC(=N4)N)CF)F	IC50 = 292000 nM	Non binder
T67102	Cathepsin D	BCH90R	N-Phenyl-2-(1-(3,4,5-trimethoxybenzoyl)naphthalen-2-yloxy)acetamide	Investigative	44415718	C28H25NO6	471.5	COC1=CC(=CC(=C1OC)OC)C(=O)C2=C(C=CC3=CC=CC=C32)OCC(=O)NC4=CC=CC=C4	IC50 = 231500 nM	Non binder
T67102	Cathepsin D	BCJ1F5	1-(2-Chlorophenyl)sulfanyl-3-(7-ethylindol-1-yl)propan-2-ol	Investigative	70694765	C19H20ClNOS	345.9	CCC1=CC=CC2=C1N(C=C2)CC(CSC3=CC=CC=C3Cl)O	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	BCN89R	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-chloro-3-methoxypyridine-2-carboxamide	Investigative	90412249	C19H17Cl2FN4O3	439.3	COC1=C(N=CC(=C1)Cl)C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 834640 nM	Non binder
T67102	Cathepsin D	BCX73G	(1S,2R,6S)-2-[2-Fluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90401371	C21H20FN5O2	393.4	C[C@@]1([C@@H]2C[C@@H]2OC(=N1)N)C3=C(C=CC(=C3)NC4=NC=CC5=CC(=CN=C54)OC)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BCZ69W	(4S,6S)-4-[2,3-Difluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90382575	C21H18F5N5O2	467.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC3=NC=CC4=CC(=CN=C43)OC)F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BD16NL	(1R,5S,6R)-5-(Difluoromethyl)-5-[2-fluoro-5-[(2-methylpyrazolo[3,4-c]pyridin-7-yl)amino]phenyl]-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine	Investigative	90441957	C19H17F3N6O	402.4	CN1C=C2C=CN=C(C2=N1)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BD1GL7	(1R,2S,6R)-2-[2-Fluoro-5-[(5-fluoro-3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441951	C21H18F3N5O2	429.4	COC1=CC2=C(C(=NC=C2F)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)CF)N=C1	IC50 = 596190 nM	Non binder
T67102	Cathepsin D	BD2EW3	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-3-methyl-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide	Investigative	90372862	C20H17F8N5O3	527.4	CC1=NC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)OCC(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BD3SH6	N'-(1-Carbazol-9-yl-3-naphthalen-2-ylsulfanylpropan-2-yl)ethane-1,2-diamine	Investigative	70686411	C27H27N3S	425.6	C1=CC=C2C=C(C=CC2=C1)SCC(CN3C4=CC=CC=C4C5=CC=CC=C53)NCCN	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	BD8GC0	(4S,6S)-4-[5-(5-Chloro-3-fluoropyridin-2-yl)oxy-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90372915	C17H12ClF6N3O2	439.7	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)OC3=C(C=C(C=N3)Cl)F)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BD9GF6	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(1,3-thiazol-2-ylmethoxy)pyridine-2-carboxamide	Investigative	90413524	C22H18F3N5O3S	489.5	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)OCC5=NC=CS5)F)C(F)F)N	IC50 = 360350 nM	Non binder
T67102	Cathepsin D	BD9JE6	N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90391043	C18H16ClF2N5O3	423.8	COC1=NC=C(N=C1)C(=O)NC2=CC(=C(C(=C2)F)Cl)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)CF	IC50 = 403830 nM	Non binder
T67102	Cathepsin D	BDF6Q7	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-chloro-4-fluorophenyl]-5-methoxy-3-methylpyrazine-2-carboxamide	Investigative	90413207	C19H18ClF2N5O3	437.8	CC1=NC(=CN=C1C(=O)NC2=CC(=C(C(=C2)Cl)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)OC	IC50 = 574200 nM	Non binder
T67102	Cathepsin D	BDI1H7	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-methoxy-3-methylpyrazine-2-carboxamide	Investigative	90373505	C19H18ClF4N5O3	475.8	CC1=NC(=CN=C1C(=O)NC2=CC(=C(C(=C2)Cl)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)OC	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BDN29Y	N-[3-[(1S,5R,6S)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-chloro-3-methylpyrazine-2-carboxamide	Investigative	90441917	C18H15ClF3N5O2	425.8	CC1=NC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)C(F)F)Cl	IC50 = 577310 nM	Non binder
T67102	Cathepsin D	BDQ12Y	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-(cyclopropylmethoxy)-3-methylpyridine-2-carboxamide	Investigative	90373221	C23H23F5N4O3	498.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF)OCC4CC4	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BDQ81V	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-2-methyl-1,3-oxazole-4-carboxamide	Investigative	90413526	C17H15F3N4O3	380.32	CC1=NC(=CO1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 372960 nM	Non binder
T67102	Cathepsin D	BDR9I4	(1S,2S,6S)-2-[2-Fluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90391030	C21H20FN5O2	393.4	C[C@]1([C@@H]2C[C@@H]2OC(=N1)N)C3=C(C=CC(=C3)NC4=NC=CC5=CC(=CN=C54)OC)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BDRI46	4-[[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]amino]pyrido[3,2-d]pyrimidine-7-carbonitrile	Investigative	78320810	C19H14F4N8O	446.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(N=CC(=C2)NC3=NC=NC4=C3N=CC(=C4)C#N)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BDS1U8	N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-(methylamino)pyrimidine-2-carboxamide	Investigative	90414947	C18H17F3N6O2	406.4	CNC1=CN=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 489920 nM	Non binder
T67102	Cathepsin D	BDW64I	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-(difluoromethyl)pyrazine-2-carboxamide	Investigative	90373194	C18H14F7N5O2	465.3	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=NC=C(N=C3)C(F)F)F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BE49GL	N-[(4S)-2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide	Investigative	71542874	C26H21ClFN5O4	521.9	C1COCC=C1C2=NC(=C3C(=C2)[C@]4(CCOC(=N4)N)C5=C(O3)C=CC(=C5)NC(=O)C6=NC=C(C=C6)Cl)F	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BE7CH0	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-chloro-3-(hydroxymethyl)pyridine-2-carboxamide	Investigative	90413150	C19H17Cl2FN4O3	439.3	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=N4)Cl)CO)Cl)N	IC50 = 532830 nM	Non binder
T67102	Cathepsin D	BE9JT7	N-(2-Amino-3'-cyclopropyl-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide	Investigative	78105262	C24H19ClFN5O3	479.9	C1CC1C2=NC(=C3C(=C2)C4(CCOC(=N4)N)C5=C(O3)C=CC(=C5)NC(=O)C6=NC=C(C=C6)Cl)F	IC50 = 360000 nM	Non binder
T67102	Cathepsin D	BEA1U3	N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-fluoropyridine-2-carboxamide	Investigative	78104987	C26H17F3N6O2S	534.5	C1CSC(=NC12C3=CC(=NC(=C3OC4=C2C=C(C=C4)NC(=O)C5=NC=C(C=C5)F)F)C6=CC(=NC=C6)F)N	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BEC8I2	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-but-2-ynoxypyridine-2-carboxamide	Investigative	90372756	C22H19F5N4O3	482.4	CC#CCOC1=CN=C(C=C1)C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C	IC50 = 783800 nM	Non binder
T67102	Cathepsin D	BEIR54	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide	Investigative	85468893	C20H17F5N4O3	456.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)OC(F)F	IC50 = 326910 nM	Non binder
T67102	Cathepsin D	BEJ06C	N-[3-[(1S,6S)-3-Amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-(4-hydroxy-4-methylpent-2-ynoxy)-3-methylpyridine-2-carboxamide	Investigative	118796782	C25H27FN4O4	466.5	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)C3([C@@H]4C[C@@H]4OC(=N3)N)C)OCC#CC(C)(C)O	IC50 = 462460 nM	Non binder
T67102	Cathepsin D	BEM39K	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-3-methyl-5-(trifluoromethyl)pyridine-2-carboxamide	Investigative	90413138	C20H16ClF5N4O2	474.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)C(F)(F)F	IC50 = 206030 nM	Non binder
T67102	Cathepsin D	BER76G	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide	Investigative	90373224	C20H16ClF4N5O2	469.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)Cl)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)C#N	IC50 = 416000 nM	Non binder
T67102	Cathepsin D	BET0P6	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(1,3-oxazol-5-ylmethoxy)pyrazine-2-carboxamide	Investigative	90412788	C21H17F3N6O4	474.4	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OCC5=CN=CO5)F)C(F)F)N	IC50 = 845840 nM	Non binder
T67102	Cathepsin D	BEV9N7	(4S,6S)-4-(2-Fluoro-5-((4-phenylpyridin-2-yl)amino)phenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine	Investigative	86732155	C23H19F5N4O	462.4	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC3=NC=CC(=C3)C4=CC=CC=C4)F)N)C(F)(F)F	IC50 = 316000 nM	Non binder
T67102	Cathepsin D	BF0ST1	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-chloro-3-methoxypyridine-2-carboxamide	Investigative	90372989	C20H18ClF5N4O3	492.8	CC1=CC(=CC(=C1F)[C@@]2(C[C@H](OC(=N2)N)C(F)(F)F)CF)NC(=O)C3=C(C=C(C=N3)Cl)OC	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BF48PJ	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloro-3-methylpyridine-2-carboxamide	Investigative	78322073	C19H17ClF4N4O2	444.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)Cl	IC50 = 202000 nM	Non binder
T67102	Cathepsin D	BF4NR9	N-[6-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3-chloro-5-methoxypyridine-2-carboxamide	Investigative	90373241	C18H16ClF4N5O3	461.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=N2)NC(=O)C3=C(C=C(C=N3)OC)Cl)F	IC50 = 658000 nM	Non binder
T67102	Cathepsin D	BF6AN7	N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-2-methyl-1,3-thiazole-4-carboxamide	Investigative	78104935	C25H18F2N6O3S	520.5	CC1=NC(=CS1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCOC(=N5)N)C6=CC(=NC=C6)F)F	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BF6T9D	N-(2-Amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2'-yl)-5-methoxypyrazine-2-carboxamide	Investigative	78105163	C23H20FN5O4S	481.5	COC1=CC2=C(C(=C1)F)OC3=C(C24CCSC(=N4)N)C=C(C=C3)NC(=O)C5=CN=C(C=N5)OC	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BF8I5B	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-but-2-ynoxypyridine-2-carboxamide	Investigative	90415322	C22H20F2N4O3	426.4	CC#CCOC1=CN=C(C=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 303020 nM	Non binder
T67102	Cathepsin D	BF9N7S	(1R,2S,6R)-2-[5-[[(8S)-3-Bromo-5,6,7,8-tetrahydroquinolin-8-yl]amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90414728	C21H20BrF3N4O	481.3	C1C[C@@H](C2=C(C1)C=C(C=N2)Br)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 263000 nM	Non binder
T67102	Cathepsin D	BFDP56	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide	Investigative	90411972	C20H16ClF2N5O2	431.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)C#N	IC50 = 662080 nM	Non binder
T67102	Cathepsin D	BFG23H	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-[(2R)-but-3-yn-2-yl]oxypyrazine-2-carboxamide	Investigative	90414443	C21H18F3N5O3	445.4	C[C@H](C#C)OC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 848580 nM	Non binder
T67102	Cathepsin D	BFH30O	(1R,2S,6R)-2-[5-[[4-Chloro-1-(difluoromethyl)pyrazol-3-yl]methylamino]-2-fluorophenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441969	C17H16ClF4N5O	417.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NCC4=NN(C=C4Cl)C(F)F)F)N	IC50 = 234000 nM	Non binder
T67102	Cathepsin D	BFLW17	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide	Investigative	90373270	C20H15F6N5O2	471.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF)C#N	IC50 = 568100 nM	Non binder
T67102	Cathepsin D	BFPV34	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90413700	C18H16ClF2N5O3	423.8	COC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 363000 nM	Non binder
T67102	Cathepsin D	BFUC21	(4S,6S)-4-(2,3-Difluoro-5-((2-methoxypyrido[3,4-b]pyrazin-5-yl)amino)phenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine	Investigative	86732247	C20H17F5N6O2	468.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC3=NC=CC4=NC(=CN=C43)OC)F)F	IC50 = 519000 nM	Non binder
T67102	Cathepsin D	BFWJ43	N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-chloro-3-methoxypicolinamide	Investigative	118232930	C19H16ClF3N4O3	440.8	COC1=C(N=CC(=C1)Cl)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 907850 nM	Non binder
T67102	Cathepsin D	BG0B1J	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-fluoropyridine-2-carboxamide	Investigative	78105293	C26H21F2N5O4	505.5	C1COCC(=C1)C2=NC(=C3C(=C2)C4(CCOC(=N4)N)C5=C(O3)C=CC(=C5)NC(=O)C6=NC=C(C=C6)F)F	IC50 = 255000 nM	Non binder
T67102	Cathepsin D	BG1J6K	(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-(4-prop-1-ynylpyrazol-1-yl)phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90413304	C18H15F3N4O	360.3	CC#CC1=CN(N=C1)C2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 385600 nM	Non binder
T67102	Cathepsin D	BGJT97	(4S,6S)-4-(Fluoromethyl)-4-[2-fluoro-5-[5-(1,3,4-oxadiazol-2-yl)pyridin-3-yl]phenyl]-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373258	C19H14F5N5O2	439.3	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)C3=CC(=CN=C3)C4=NN=CO4)F)N)C(F)(F)F	IC50 = 454000 nM	Non binder
T67102	Cathepsin D	BGK72V	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-methoxy-3-methylpyrazine-2-carboxamide	Investigative	90414094	C20H20F3N5O3	435.4	CC1=CC(=CC(=C1F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)NC(=O)C4=NC=C(N=C4C)OC	IC50 = 447110 nM	Non binder
T67102	Cathepsin D	BGLC34	N-[3-[(1R,5S,6R)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-5-fluoro-4-methylsulfanylphenyl]-5-chloropyridine-2-carboxamide	Investigative	118796784	C19H17ClF2N4O2S	438.9	CSC1=C(C=C(C=C1F)NC(=O)C2=NC=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 654540 nM	Non binder
T67102	Cathepsin D	BGWX86	(4S,6S)-4-[5-[(3-Chloro-1,7-naphthyridin-8-yl)amino]-2-fluoropyridin-3-yl]-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	78321122	C19H15ClF4N6O	454.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(N=CC(=C2)NC3=NC=CC4=CC(=CN=C43)Cl)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BGY20R	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-cyano-3-(hydroxymethyl)pyridine-2-carboxamide	Investigative	90415711	C20H17ClFN5O3	429.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=N4)C#N)CO)Cl)N	IC50 = 352100 nM	Non binder
T67102	Cathepsin D	BH08FP	N-[6-[(1R,2S,6R)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoropyridin-2-yl]-5-chloropyridine-2-carboxamide	Investigative	90412917	C17H15ClFN5O2	375.8	C[C@]1([C@H]2C[C@H]2OC(=N1)N)C3=C(C=CC(=N3)NC(=O)C4=NC=C(C=C4)Cl)F	IC50 = 279000 nM	Non binder
T67102	Cathepsin D	BH0S7X	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-methoxy-3-methylpyridine-2-carboxamide	Investigative	90373497	C21H21F5N4O3	472.4	CC1=CC(=CC(=C1F)[C@@]2(C[C@H](OC(=N2)N)C(F)(F)F)CF)NC(=O)C3=NC=C(C=C3C)OC	IC50 = 780500 nM	Non binder
T67102	Cathepsin D	BH0X3B	N-(2-Amino-4a,5,6,7,8,8a-hexahydro-4H-3,1-benzothiazin-6-yl)benzamide;hydrochloride	Investigative	122180116	C15H20ClN3OS	325.9	C1CC2C(CC1NC(=O)C3=CC=CC=C3)CSC(=N2)N.Cl	IC50 = 797000 nM	Non binder
T67102	Cathepsin D	BH1J4G	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide	Investigative	78090782	C26H21ClFN5O4	521.9	C1COCC(=C1)C2=NC(=C3C(=C2)C4(CCOC(=N4)N)C5=C(O3)C=CC(=C5)NC(=O)C6=NC=C(C=C6)Cl)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BH1ZF4	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-2-(2-methoxyethoxy)acetamide	Investigative	90412189	C17H20F3N3O4	387.4	COCCOCC(=O)NC1=CC(=C(C=C1)F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F	IC50 = 666150 nM	Non binder
T67102	Cathepsin D	BH39ZQ	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-chloro-5-fluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	86732276	C18H14Cl2F4N4O2	465.2	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=NC=C(C=C3)Cl)F)Cl	IC50 = 407900 nM	Non binder
T67102	Cathepsin D	BH50VR	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	90373092	C20H16F5N5O3	469.4	C#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BH52QR	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-3-chloro-5-methoxypyridine-2-carboxamide	Investigative	90412959	C19H17Cl2FN4O3	439.3	COC1=CC(=C(N=C1)C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)Cl	IC50 = 752050 nM	Non binder
T67102	Cathepsin D	BH52XN	N-[3-[(1R,2S,6R)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	90412818	C18H16ClFN4O2	374.8	C[C@]1([C@H]2C[C@H]2OC(=N1)N)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F	IC50 = 476180 nM	Non binder
T67102	Cathepsin D	BH63GW	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-bromopyridine-2-carboxamide	Investigative	86732231	C18H13BrF6N4O2	511.2	C1[C@H](OC(=N[C@]1(CF)C2=C(C(=CC(=C2)NC(=O)C3=NC=C(C=C3)Br)F)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BH73SE	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-3-chloro-5-cyanopyridine-2-carboxamide	Investigative	85468828	C19H14Cl2FN5O2	434.2	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=N4)C#N)Cl)Cl)N	IC50 = 996820 nM	Non binder
T67102	Cathepsin D	BH9DV5	N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-bromopicolinamide	Investigative	78322077	C18H14BrF5N4O2	493.2	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)Br)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BHE3S1	N-{3-[(4s,6s)-2-Amino-4-(Fluoromethyl)-6-(Trifluoromethyl)-5,6-Dihydro-4h-1,3-Oxazin-4-Yl]-4-Fluorophenyl}-5-Cyanopyridine-2-Carboxamide	Investigative	71305057	C19H14F5N5O2	439.3	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BHO6A1	N-[3-[(1R,5S,6R)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-chlorophenyl]-5-chloro-3-(fluoromethyl)pyridine-2-carboxamide	Investigative	90414355	C19H16Cl2F2N4O2	441.3	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=N4)Cl)CF)Cl)N	IC50 = 444190 nM	Non binder
T67102	Cathepsin D	BHVD43	N-[(1R,4S,6S,7S)-9-Amino-12-oxa-8-thia-10-azatricyclo[5.3.3.01,6]tridec-9-en-4-yl]-3-chlorobenzamide;hydrochloride	Investigative	122180109	C17H21Cl2N3O2S	402.3	C1C[C@]23COC[C@H]([C@H]2C[C@H]1NC(=O)C4=CC(=CC=C4)Cl)SC(=N3)N.Cl	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	BHXR41	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-3-chloro-5-methoxypyridine-2-carboxamide	Investigative	78322709	C19H16ClF5N4O3	478.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=C(C=C(C=N3)OC)Cl)F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BI0X9L	N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide	Investigative	90413617	C20H16ClF2N5O2	431.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)Cl)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)CF)C#N	IC50 = 539090 nM	Non binder
T67102	Cathepsin D	BI6S8W	N-(2-Amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl)-4-chloro-2-fluorobenzamide	Investigative	124222795	C24H18ClF2N3O4	485.9	COC1=CC2=C(C(=C1)F)OC3=C(C24CCOC(=N4)N)C=C(C=C3)NC(=O)C5=C(C=C(C=C5)Cl)F	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BI7LT6	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-chloropyridine-2-carboxamide	Investigative	90373023	C19H16ClF5N4O2	462.8	CC1=CC(=CC(=C1F)[C@@]2(C[C@H](OC(=N2)N)C(F)(F)F)CF)NC(=O)C3=NC=C(C=C3)Cl	IC50 = 515200 nM	Non binder
T67102	Cathepsin D	BI80EJ	N-[3-[(6S)-2-Amino-4-(difluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	124221529	C18H13ClF6N4O2	466.8	C1[C@H](OC(=NC1(C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)Cl)F)C(F)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BID41E	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90372867	C19H18F5N5O3	459.4	CC1=CC(=CC(=C1F)[C@@]2(C[C@H](OC(=N2)N)C(F)(F)F)CF)NC(=O)C3=CN=C(C=N3)OC	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BIE6N1	N-(2-Amino-3'-bromospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-b]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide	Investigative	78104844	C21H15BrClN5O3	500.7	C1COC(=NC12C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)OC5=C2C=C(C=N5)Br)N	IC50 = 245100 nM	Non binder
T67102	Cathepsin D	BIGS81	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-propan-2-yloxypyrazine-2-carboxamide	Investigative	90413319	C20H20F3N5O3	435.4	CC(C)OC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 706050 nM	Non binder
T67102	Cathepsin D	BIHM08	N-(2-Amino-3'-cyclopropylspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-b]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide	Investigative	78105082	C24H20ClN5O3	461.9	C1CC1C2=CC3=C(N=C2)OC4=C(C35CCOC(=N5)N)C=C(C=C4)NC(=O)C6=NC=C(C=C6)Cl	IC50 = 432500 nM	Non binder
T67102	Cathepsin D	BIJ5F2	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-bromopyridine-2-carboxamide	Investigative	90413253	C18H14BrClF2N4O2	471.7	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Br)Cl)C(F)F)N	IC50 = 459300 nM	Non binder
T67102	Cathepsin D	BIO16V	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-cyano-3-(difluoromethyl)pyridine-2-carboxamide	Investigative	90441979	C20H14F5N5O2	451.3	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=N4)C#N)C(F)F)F)C(F)F)N	IC50 = 476950 nM	Non binder
T67102	Cathepsin D	BIX32W	N-[2-Amino-7'-(3,6-dihydro-2H-pyran-5-yl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2'-yl]-5-chloropyridine-2-carboxamide	Investigative	127044896	C26H21ClN4O4	488.9	C1COCC(=C1)C2=CC3=C(C=C2)OC4=C(C35COC(=N5)N)C=C(C=C4)NC(=O)C6=NC=C(C=C6)Cl	IC50 = 470000 nM	Non binder
T67102	Cathepsin D	BIY4V7	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-1-(4-chlorophenyl)cyclobutane-1-carboxamide	Investigative	90413306	C23H21ClF3N3O2	463.9	C1CC(C1)(C2=CC=C(C=C2)Cl)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 323700 nM	Non binder
T67102	Cathepsin D	BJ19CN	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyano-3-methoxypyridine-2-carboxamide	Investigative	90373184	C20H16F5N5O3	469.4	COC1=C(N=CC(=C1)C#N)C(=O)NC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BJ4X5K	2-Amino-7-[4-(2-phenylethyl)phenyl]-3-[[(2S,5R)-5-phenyloxolan-2-yl]methyl]quinazolin-4-one	Investigative	127028711	C33H31N3O2	501.6	C1C[C@@H](O[C@@H]1CN2C(=O)C3=C(C=C(C=C3)C4=CC=C(C=C4)CCC5=CC=CC=C5)N=C2N)C6=CC=CC=C6	IC50 = 220000 nM	Non binder
T67102	Cathepsin D	BJ5ZV3	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-bromopyridine-2-carboxamide	Investigative	90412662	C18H15BrClFN4O2	453.7	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Br)Cl)N	IC50 = 537750 nM	Non binder
T67102	Cathepsin D	BJ6D1Q	N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	90414468	C20H16ClF2N5O3	447.8	C#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C(=C2)F)Cl)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)CF	IC50 = 370020 nM	Non binder
T67102	Cathepsin D	BJ7U6L	N-(2-Amino-3'-chlorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide	Investigative	78105084	C21H15Cl2N5O3	456.3	C1COC(=NC12C3=CC(=NC=C3OC4=C2C=C(C=C4)NC(=O)C5=NC=C(C=C5)Cl)Cl)N	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BJ87BS	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-bromo-3-fluoropyridine-2-carboxamide	Investigative	90382583	C18H13BrF6N4O2	511.2	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=C(C=C(C=N3)Br)F)F)F	IC50 = 928000 nM	Non binder
T67102	Cathepsin D	BJ8AR4	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-(difluoromethyl)pyridine-2-carboxamide	Investigative	90372979	C20H17F7N4O2	478.4	CC1=CC(=CC(=C1F)[C@@]2(C[C@H](OC(=N2)N)C(F)(F)F)CF)NC(=O)C3=NC=C(C=C3)C(F)F	IC50 = 991700 nM	Non binder
T67102	Cathepsin D	BJD76M	(4S,6S)-4-(2-Fluoro-5-(pyrazin-2-yloxy)phenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine	Investigative	86732148	C16H13F5N4O2	388.29	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)OC3=NC=CN=C3)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BJQ19C	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-(fluoromethoxy)pyridine-2-carboxamide	Investigative	90412848	C19H17ClF2N4O3	422.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)OCF)Cl)N	IC50 = 882020 nM	Non binder
T67102	Cathepsin D	BJS03O	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]phenyl]-5-chloropyridine-2-carboxamide	Investigative	90413257	C18H15ClF2N4O2	392.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=CC(=CC=C3)NC(=O)C4=NC=C(C=C4)Cl)C(F)F)N	IC50 = 397000 nM	Non binder
T67102	Cathepsin D	BJW94N	(1R,2S,6R)-2-[2-Fluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90412776	C21H20FN5O2	393.4	C[C@]1([C@H]2C[C@H]2OC(=N1)N)C3=C(C=CC(=C3)NC4=NC=CC5=CC(=CN=C54)OC)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BJY30Z	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide	Investigative	90372970	C19H15ClF7N5O3	529.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=CN=C(C=N3)OCC(F)(F)F)Cl)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BK06NA	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carbothioamide	Investigative	90373107	C18H14ClF5N4OS	464.8	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC(=S)C3=NC=C(C=C3)Cl)F)N)C(F)(F)F	IC50 = 805000 nM	Non binder
T67102	Cathepsin D	BK3A7Q	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-6-chloropyridine-2-carboxamide	Investigative	90412204	C18H14ClF3N4O2	410.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=NC(=CC=C4)Cl)F)C(F)F)N	IC50 = 724590 nM	Non binder
T67102	Cathepsin D	BK4GP8	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide	Investigative	90413009	C19H14F3N5O2	401.3	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)C#N)F)C(F)F)N	IC50 = 697750 nM	Non binder
T67102	Cathepsin D	BK78DM	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-3-methyl-5-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide	Investigative	90372973	C22H20F8N4O3	540.4	CC1=CC(=CC(=C1F)[C@@]2(C[C@H](OC(=N2)N)C(F)(F)F)CF)NC(=O)C3=NC=C(C=C3C)OCC(F)(F)F	IC50 = 263000 nM	Non binder
T67102	Cathepsin D	BK78NY	Chembl4289749	Investigative	145986616	C21H16ClN5O3	421.8	CC1=CC2=C(C=N1)OC3=C([C@@]24COC(=N4)N)C=C(C=C3)NC(=O)C5=NC=C(C=C5)Cl	IC50 = 640000 nM	Non binder
T67102	Cathepsin D	BKE6A5	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-bromopyridine-2-carboxamide	Investigative	90372854	C18H14BrF5N4O2	493.2	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=NC=C(C=C3)Br)F)F	IC50 = 424000 nM	Non binder
T67102	Cathepsin D	BKOG46	N-[6-[(1R,2S,6R)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoropyridin-2-yl]-5-methoxypyrazine-2-carboxamide	Investigative	90412952	C17H17FN6O3	372.4	C[C@]1([C@H]2C[C@H]2OC(=N1)N)C3=C(C=CC(=N3)NC(=O)C4=CN=C(C=N4)OC)F	IC50 = 521420 nM	Non binder
T67102	Cathepsin D	BKQ5J9	N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-cyanopyridine-2-carboxamide	Investigative	78104936	C27H17F2N7O3	525.5	C1COC(=NC12C3=CC(=NC(=C3OC4=C2C=C(C=C4)NC(=O)C5=NC=C(C=C5)C#N)F)C6=CC(=NC=C6)F)N	IC50 = 517700 nM	Non binder
T67102	Cathepsin D	BKT68Y	N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyano-2-pyridinecarboxamide	Investigative	71668048	C19H13ClF5N5O2	473.8	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC(=O)C3=C(C=C(C=N3)C#N)Cl)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BKTP18	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-3-methyl-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide	Investigative	90373296	C20H17F8N5O3	527.4	CC1=NC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF)OCC(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BKX6N2	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(cyclopentylmethoxy)pyrazine-2-carboxamide	Investigative	90412704	C23H24F3N5O3	475.5	C1CCC(C1)COC2=NC=C(N=C2)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 890720 nM	Non binder
T67102	Cathepsin D	BL01OU	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloro-3-propan-2-ylpyridine-2-carboxamide	Investigative	90414815	C21H20ClF3N4O2	452.9	CC(C)C1=C(N=CC(=C1)Cl)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 699950 nM	Non binder
T67102	Cathepsin D	BL1G2H	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(1,3-oxazol-2-ylmethoxy)pyrazine-2-carboxamide	Investigative	90412867	C21H17F3N6O4	474.4	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OCC5=NC=CO5)F)C(F)F)N	IC50 = 767260 nM	Non binder
T67102	Cathepsin D	BL1MD7	N-[5-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-6-fluoropyridin-3-yl]-5-chloropyridine-2-carboxamide	Investigative	90412352	C17H14ClF2N5O2	393.8	C1[C@@H]2[C@H]1OC(=N[C@@]2(CF)C3=C(N=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F)N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BL27JC	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide	Investigative	90414794	C17H13Cl2F4N5O2	466.2	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=NN(C=C4Cl)C(F)F)Cl)C(F)F)N	IC50 = 509920 nM	Non binder
T67102	Cathepsin D	BL28WX	N-[6-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-chloropyridine-2-carboxamide	Investigative	90373218	C17H13ClF5N5O2	449.8	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=N2)NC(=O)C3=NC=C(C=C3)Cl)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BL2OH7	N-[3-[(1S,5R,6S)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-bromopyridine-2-carboxamide	Investigative	90441911	C18H14BrF3N4O2	455.2	C1[C@@H]2[C@H]1OC(=N[C@@]2(CF)C3=C(C(=CC(=C3)NC(=O)C4=NC=C(C=C4)Br)F)F)N	IC50 = 516140 nM	Non binder
T67102	Cathepsin D	BL3WB1	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-cyanopyridine-2-carboxamide	Investigative	85468826	C19H13F4N5O2	419.3	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C(=CC(=C3)NC(=O)C4=NC=C(C=C4)C#N)F)F)C(F)F)N	IC50 > 618000 nM	Non binder
T67102	Cathepsin D	BL4MU5	(4S,6S)-4-(Fluoromethyl)-4-(2-fluoro-5-pyrimidin-2-yloxyphenyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373212	C16H13F5N4O2	388.29	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)OC3=NC=CC=N3)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BL82QK	Chembl4204163	Investigative	118435382	C17H18F2N6O3S2	456.5	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC(=CS3)NC(=O)C4=CN=C(C=N4)OC(F)F)N	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	BLJV42	N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide	Investigative	90413014	C19H14F3N5O2	401.3	C1[C@@H]2[C@H]1OC(=N[C@]2(C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)C#N)F)C(F)F)N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BLK8S7	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	71667461	C18H15ClF4N4O2	430.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)Cl)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BLM6X3	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-methoxy-3-methylpyridine-2-carboxamide	Investigative	90412765	C20H19ClF2N4O3	436.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)OC	IC50 = 258460 nM	Non binder
T67102	Cathepsin D	BLOT59	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-but-2-ynoxy-3-methylpyridine-2-carboxamide	Investigative	90373248	C23H21F5N4O3	496.4	CC#CCOC1=CN=C(C(=C1)C)C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C	IC50 = 286000 nM	Non binder
T67102	Cathepsin D	BLR0T3	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-2-cyclohexylacetamide	Investigative	90413678	C20H24F3N3O2	395.4	C1CCC(CC1)CC(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BLTQ42	N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-[(1R)-1-cyanoethoxy]pyridine-2-carboxamide	Investigative	90441938	C21H18F3N5O3	445.4	C[C@H](C#N)OC1=CN=C(C=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 668250 nM	Non binder
T67102	Cathepsin D	BLW63Z	N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-cyano-3-(dimethylamino)pyridine-2-carboxamide	Investigative	90413017	C21H19F3N6O2	444.4	CN(C)C1=C(N=CC(=C1)C#N)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 732460 nM	Non binder
T67102	Cathepsin D	BLXA94	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-(cyclopropylmethoxy)-3-methylpyridine-2-carboxamide	Investigative	90372920	C23H23F5N4O3	498.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)OCC4CC4	IC50 = 510800 nM	Non binder
T67102	Cathepsin D	BM4X9K	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-chloro-5-methoxypyridine-2-carboxamide	Investigative	85469562	C19H16ClF3N4O3	440.8	COC1=CC(=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)Cl	IC50 = 378870 nM	Non binder
T67102	Cathepsin D	BM7K6G	2-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenoxy]-N-methylpyridine-4-carboxamide	Investigative	90373057	C19H17F5N4O3	444.4	CNC(=O)C1=CC(=NC=C1)OC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BM8C6U	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloro-3-fluoropyridine-2-carboxamide	Investigative	90372960	C18H13ClF6N4O2	466.8	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC(=O)C3=C(C=C(C=N3)Cl)F)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BM8NQ3	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-3-chloro-5-(difluoromethyl)pyridine-2-carboxamide	Investigative	90372778	C19H14ClF7N4O2	498.8	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC(=O)C3=C(C=C(C=N3)C(F)F)Cl)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BM8RX1	N-[2-Amino-5'-fluoro-7'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl]-5-fluoropyridine-2-carboxamide	Investigative	124222805	C27H18F3N5O3	517.5	C1COC(=NC12C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)F)OC5=C2C=C(C=C5F)C6=CC(=NC=C6)F)N	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BMD0B4	(4S,6S)-4-(2,3-Difluoro-5-((3-methoxypyridin-2-yl)amino)phenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine	Investigative	86732266	C18H17F5N4O2	416.3	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC3=C(C=CC=N3)OC)F)F	IC50 = 282000 nM	Non binder
T67102	Cathepsin D	BME6D8	N-[5-[(1R,2S,6R)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-6-fluoropyridin-3-yl]-5-chloropyridine-2-carboxamide	Investigative	90441945	C17H15ClFN5O2	375.8	C[C@]1([C@H]2C[C@H]2OC(=N1)N)C3=C(N=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F	IC50 = 401920 nM	Non binder
T67102	Cathepsin D	BMGT28	N-[3-[(1S,5R,6S)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide	Investigative	90441912	C21H18F3N5O3	445.4	CC#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C(=C2)F)F)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)CF	IC50 = 526500 nM	Non binder
T67102	Cathepsin D	BMI54Y	Chembl4279064	Investigative	145980299	C23H18ClN5O3	447.9	C1CC1C2=NC=C3C(=C2)[C@]4(COC(=N4)N)C5=C(O3)C=CC(=C5)NC(=O)C6=NC=C(C=C6)Cl	IC50 = 310000 nM	Non binder
T67102	Cathepsin D	BMLY34	N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]phenyl]-5-chloropyridine-2-carboxamide	Investigative	90413260	C18H15ClF2N4O2	392.8	C1[C@@H]2[C@H]1OC(=N[C@]2(C3=CC(=CC=C3)NC(=O)C4=NC=C(C=C4)Cl)C(F)F)N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BMP43N	N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	90412759	C18H13ClF4N4O2	428.8	C1[C@@H]2[C@H]1OC(=N[C@]2(C3=C(C(=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F)F)C(F)F)N	IC50 = 471870 nM	Non binder
T67102	Cathepsin D	BMY0B9	(S)-3-Chloro-1-fluoro-N7-(3-methylpyridin-2-yl)-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazine]-2',7-diamine	Investigative	89473231	C21H17ClFN5O2	425.8	CC1=C(N=CC=C1)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4[C@]35CCOC(=N5)N)Cl)F	IC50 = 386300 nM	Non binder
T67102	Cathepsin D	BMZ6K9	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxypyridine-2-carboxamide	Investigative	90412185	C19H18F2N4O3	388.4	COC1=CN=C(C=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 759190 nM	Non binder
T67102	Cathepsin D	BN27XY	1-Naphthalen-2-ylsulfanyl-3-(2-phenylindol-1-yl)propan-2-ol	Investigative	70682176	C27H23NOS	409.5	C1=CC=C(C=C1)C2=CC3=CC=CC=C3N2CC(CSC4=CC5=CC=CC=C5C=C4)O	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	BN2Q8G	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-b]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide	Investigative	78105085	C26H22ClN5O4	503.9	C1COCC=C1C2=CC3=C(N=C2)OC4=C(C35CCOC(=N5)N)C=C(C=C4)NC(=O)C6=NC=C(C=C6)Cl	IC50 = 341500 nM	Non binder
T67102	Cathepsin D	BN74LK	Methyl 2-[3-[(4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenoxy]pyridine-4-carboxylate	Investigative	90372961	C19H16F5N3O4	445.3	COC(=O)C1=CC(=NC=C1)OC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BN76QZ	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chlorothiophene-2-carboxamide	Investigative	90413317	C17H13ClF3N3O2S	415.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=CC=C(S4)Cl)F)C(F)F)N	IC50 = 474390 nM	Non binder
T67102	Cathepsin D	BN7PA5	N-[3-[(1R,2S,6R)-4-Amino-2-(methoxymethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	90413130	C19H18ClFN4O3	404.8	COC[C@]1([C@H]2C[C@H]2OC(=N1)N)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BN95TI	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-methoxypyridine-2-carboxamide	Investigative	90372905	C19H16F6N4O3	462.3	COC1=CN=C(C=C1)C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BNF25X	8-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoroanilino]-1,7-naphthyridine-3-carbonitrile	Investigative	90413216	C21H16F2N6O	406.4	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC4=NC=CC5=CC(=CN=C54)C#N)F)N	IC50 = 204890 nM	Non binder
T67102	Cathepsin D	BNH97I	N-(2-Aminospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-b]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide	Investigative	78105120	C21H16ClN5O3	421.8	C1COC(=NC12C3=C(N=CC=C3)OC4=C2C=C(C=C4)NC(=O)C5=NC=C(C=C5)Cl)N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BNRO03	N-(6-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-5-fluoropyridin-2-yl)-5-chloropicolinamide	Investigative	78321127	C17H14ClF4N5O2	431.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=N2)NC(=O)C3=NC=C(C=C3)Cl)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BNUI16	5'-Fluoro-7'-methoxy-2-N'-(3-phenylmethoxypyridin-2-yl)spiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2,2'-diamine	Investigative	124222790	C29H25FN4O4	512.5	COC1=CC2=C(C(=C1)F)OC3=C(C24CCOC(=N4)N)C=C(C=C3)NC5=C(C=CC=N5)OCC6=CC=CC=C6	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BNYM07	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	90413271	C20H17F2N5O3	413.4	C#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 260500 nM	Non binder
T67102	Cathepsin D	BNZ1K5	N-[5-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-6-fluoropyridin-3-yl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	90413246	C19H16F2N6O3	414.4	C#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(N=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 310790 nM	Non binder
T67102	Cathepsin D	BO03UP	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-3-methyl-5-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide	Investigative	90373125	C21H18F8N4O3	526.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)OCC(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BO09NR	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-bromo-3-chloropyridine-2-carboxamide	Investigative	78321125	C18H13BrClF5N4O2	527.7	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC(=O)C3=C(C=C(C=N3)Br)Cl)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BO14AQ	N-[5-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-6-fluoropyridin-3-yl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide	Investigative	90413235	C16H13ClF4N6O2	432.76	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(N=CC(=C3)NC(=O)C4=NN(C=C4Cl)C(F)F)F)N	IC50 = 370200 nM	Non binder
T67102	Cathepsin D	BO14PD	N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-chloro-3-(methoxymethyl) picolinamide	Investigative	90414451	C20H18ClF3N4O3	454.8	COCC1=C(N=CC(=C1)Cl)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 735560 nM	Non binder
T67102	Cathepsin D	BO1VA8	(1R,5S,6R)-5-(Difluoromethyl)-5-[2-fluoro-5-[[(7R)-3-isocyano-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]amino]phenyl]-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine	Investigative	118796790	C21H18F3N5O	413.4	[C-]#[N+]C1=CC2=C([C@@H](CC2)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F)N=C1	IC50 = 555020 nM	Non binder
T67102	Cathepsin D	BO67UY	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	78105118	C26H23FN6O5	518.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCOC(=N5)N)C6=CCCOC6)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BO7BJ4	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-methoxypyridine-2-carboxamide	Investigative	71668050	C19H17F5N4O3	444.4	COC1=CN=C(C=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BO7DL8	6-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-3-chloro-5H-pyrrolo[3,4-b]pyridin-7(6H)-one	Investigative	90413553	C19H14ClF3N4O2	422.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)N4CC5=C(C4=O)N=CC(=C5)Cl)F)C(F)F)N	IC50 = 659310 nM	Non binder
T67102	Cathepsin D	BO9EV7	(4S,6S)-4-[2-Fluoro-5-[(7-isocyanopyrido[3,2-d]pyrimidin-4-yl)amino]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	124221527	C20H14F5N7O	463.4	[C-]#[N+]C1=CC2=C(C(=NC=N2)NC3=CC(=C(C=C3)F)[C@@]4(C[C@H](OC(=N4)N)C(F)(F)F)CF)N=C1	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BO9L5Q	9-(3-Naphthalen-2-ylsulfanylpropyl)carbazole	Investigative	70688505	C25H21NS	367.5	C1=CC=C2C=C(C=CC2=C1)SCCCN3C4=CC=CC=C4C5=CC=CC=C53	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	BOAX58	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-cyanopyrimidine-2-carboxamide	Investigative	90412652	C19H15F3N6O2	416.4	CC1=CC(=CC(=C1F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)NC(=O)C4=NC=C(C=N4)C#N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BOB59E	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chlorothiophene-3-carboxamide	Investigative	90412071	C17H13ClF3N3O2S	415.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=CSC(=C4)Cl)F)C(F)F)N	IC50 = 580110 nM	Non binder
T67102	Cathepsin D	BOD3F0	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-methoxy-3-methylpyrazine-2-carboxamide	Investigative	90373037	C20H20F5N5O3	473.4	CC1=CC(=CC(=C1F)[C@@]2(C[C@H](OC(=N2)N)C(F)(F)F)CF)NC(=O)C3=NC=C(N=C3C)OC	IC50 = 634000 nM	Non binder
T67102	Cathepsin D	BORB72	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-3,5-dichloropyridine-2-carboxamide	Investigative	90373010	C18H13Cl2F5N4O2	483.2	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=C(C=C(C=N3)Cl)Cl)F)F	IC50 = 394000 nM	Non binder
T67102	Cathepsin D	BOW60X	N-[(4S)-2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methylpyridine-2-carboxamide	Investigative	117624181	C27H25N5O4	483.5	CC1=CN=C(C=C1)C(=O)NC2=CC3=C(C=C2)OC4=CN=C(C=C4[C@]35CCOC(=N5)N)C6=CCCOC6	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BOYA80	N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	90413256	C18H14ClF3N4O2	410.8	C1[C@@H]2[C@H]1OC(=N[C@]2(C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F)C(F)F)N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BP29QM	1-Carbazol-9-yl-3-(2-fluorophenyl)sulfanylpropan-2-ol	Investigative	70686436	C21H18FNOS	351.4	C1=CC=C2C(=C1)C3=CC=CC=C3N2CC(CSC4=CC=CC=C4F)O	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	BP3B5K	(4S,6S)-4-[2-Fluoro-5-[3-fluoro-4-(trifluoromethyl)pyridin-2-yl]oxyphenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373043	C18H12F9N3O2	473.3	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)OC3=NC=CC(=C3F)C(F)(F)F)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BP6Z5O	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-methoxypyrimidine-2-carboxamide	Investigative	90412634	C18H16ClF2N5O3	423.8	COC1=CN=C(N=C1)C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 374140 nM	Non binder
T67102	Cathepsin D	BP74VR	N-(3-((1S,5R,6S)-3-Amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide	Investigative	90412858	C18H18FN5O3	371.4	C[C@@]1([C@@H]2C[C@@H]2OC(=N1)N)C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OC)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BP75IZ	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-chloro-3-methylpyridine-2-carboxamide	Investigative	90372965	C19H16ClF5N4O2	462.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)Cl	IC50 = 733000 nM	Non binder
T67102	Cathepsin D	BP9GL8	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide	Investigative	90415303	C17H13ClF5N5O2	449.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=NN(C=C4Cl)C(F)F)F)C(F)F)N	IC50 = 464440 nM	Non binder
T67102	Cathepsin D	BPKL97	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-fluoropyridine-2-carboxamide	Investigative	90372913	C19H16F6N4O2	446.3	CC1=CC(=CC(=C1F)[C@@]2(C[C@H](OC(=N2)N)C(F)(F)F)CF)NC(=O)C3=NC=C(C=C3)F	IC50 = 832900 nM	Non binder
T67102	Cathepsin D	BPLX72	N-[(5R,14R)-5-Amino-5-methyl-16-oxo-14-phenyl-3-oxa-15-azatricyclo[15.3.1.17,11]docosa-1(21),7,9,11(22),17,19-hexaen-19-yl]-N-propylmethanesulfonamide	Investigative	44441701	C31H39N3O4S	549.7	CCCN(C1=CC2=CC(=C1)C(=O)N[C@H](CCC3=CC(=CC=C3)C[C@@](COC2)(C)N)C4=CC=CC=C4)S(=O)(=O)C	IC50 = 275000 nM	Non binder
T67102	Cathepsin D	BPQ4Z8	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-chloro-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90413665	C18H16ClF2N5O3	423.8	COC1=NC=C(N=C1)C(=O)NC2=CC(=C(C(=C2)Cl)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 373100 nM	Non binder
T67102	Cathepsin D	BPU86A	N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide	Investigative	78104671	C27H20F2N6O4	530.5	COC1=CN=C(C=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCOC(=N5)N)C6=CC(=CN=C6)F)F	IC50 = 256400 nM	Non binder
T67102	Cathepsin D	BPW4S2	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90415579	C19H18F3N5O3	421.4	CC1=CC(=CC(=C1F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)NC(=O)C4=CN=C(C=N4)OC	IC50 = 465440 nM	Non binder
T67102	Cathepsin D	BQ14GS	N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-5-cyanopyridine-2-carboxamide	Investigative	78321762	C18H14F4N6O2	422.3	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(N=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BQ2G5T	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide	Investigative	78104669	C27H24FN5O5	517.5	COC1=CN=C(C=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCOC(=N5)N)C6=CCCOC6)F	IC50 = 312700 nM	Non binder
T67102	Cathepsin D	BQ31AV	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide	Investigative	85469560	C20H16F3N5O2	415.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)C#N	IC50 = 376160 nM	Non binder
T67102	Cathepsin D	BQ4CV7	(4S,6S)-4-[5-[[2-(Difluoromethyl)-[1,3]thiazolo[5,4-d]pyrimidin-7-yl]amino]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373222	C18H13F7N6OS	494.4	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC3=C4C(=NC=N3)SC(=N4)C(F)F)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BQ7A1T	(4S,6S)-4-[2-Fluoro-5-[(7-methoxypyrido[3,2-d]pyrimidin-4-yl)amino]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373214	C20H17F5N6O2	468.4	COC1=CC2=C(C(=NC=N2)NC3=CC(=C(C=C3)F)[C@@]4(C[C@H](OC(=N4)N)C(F)(F)F)CF)N=C1	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BQ89AN	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-fluoropyridine-2-carboxamide	Investigative	78104988	C26H21F2N5O3S	521.5	C1COCC=C1C2=NC(=C3C(=C2)C4(CCSC(=N4)N)C5=C(O3)C=CC(=C5)NC(=O)C6=NC=C(C=C6)F)F	IC50 = 210700 nM	Non binder
T67102	Cathepsin D	BQE97T	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-2,4-difluorophenyl]-5-methoxypyridine-2-carboxamide	Investigative	90412795	C19H17F3N4O3	406.4	COC1=CN=C(C=C1)C(=O)NC2=C(C(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)F	IC50 = 941650 nM	Non binder
T67102	Cathepsin D	BQK31G	N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide	Investigative	78105034	C27H20F2N6O4	530.5	COC1=CN=C(C=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCOC(=N5)N)C6=CC(=NC=C6)F)F	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BQMX07	(4S,6S)-4-[2-Fluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373140	C21H18F5N5O2	467.4	COC1=CN=C2C(=C1)C=CN=C2NC3=CC(=C(C=C3)F)[C@@]4(C[C@H](OC(=N4)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BQN96Z	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-cyanopyridine-2-carboxamide	Investigative	78105200	C27H21FN6O4	512.5	C1COCC=C1C2=NC(=C3C(=C2)C4(CCOC(=N4)N)C5=C(O3)C=CC(=C5)NC(=O)C6=NC=C(C=C6)C#N)F	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BQP5E7	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(1,3-oxazol-4-ylmethoxy)pyrazine-2-carboxamide	Investigative	90413278	C21H17F3N6O4	474.4	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OCC5=COC=N5)F)C(F)F)N	IC50 = 925020 nM	Non binder
T67102	Cathepsin D	BQT9C6	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]pyridine-2-carboxamide	Investigative	90413218	C18H15F3N4O2	376.3	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=CC=CC=N4)F)C(F)F)N	IC50 = 689700 nM	Non binder
T67102	Cathepsin D	BQTW34	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide	Investigative	71668200	C20H16F8N4O3	512.4	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)OCC(F)(F)F)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BQU32J	(4S,6S)-4-[5-[(2-Bromopyridin-4-yl)amino]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373053	C17H14BrF5N4O	465.2	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC3=CC(=NC=C3)Br)F)N)C(F)(F)F	IC50 = 469000 nM	Non binder
T67102	Cathepsin D	BR0AC4	N-(6-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-5-fluoropyridin-2-yl)-5-cyano-3-methylpicolinamide	Investigative	78321126	C19H16F4N6O2	436.4	CC1=CC(=CN=C1C(=O)NC2=NC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)C#N	IC50 = 900000 nM	Non binder
T67102	Cathepsin D	BR1F8N	N-[3-[(1S,5R,6S)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-chloro-5-fluorophenyl]-5-cyanopyridine-2-carboxamide	Investigative	90441924	C19H14ClF2N5O2	417.8	C1[C@@H]2[C@H]1OC(=N[C@@]2(CF)C3=C(C(=CC(=C3)NC(=O)C4=NC=C(C=C4)C#N)F)Cl)N	IC50 = 490740 nM	Non binder
T67102	Cathepsin D	BR4SH2	N-(2-Amino-3'-chloro-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-methoxypyrazine-2-carboxamide	Investigative	78105162	C21H16ClFN6O4	470.8	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCOC(=N5)N)Cl)F	IC50 = 334900 nM	Non binder
T67102	Cathepsin D	BR6C2T	N-[2-Amino-3'-(3,3-dimethylbut-1-ynyl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide	Investigative	78105292	C27H24ClN5O3	502	CC(C)(C)C#CC1=CC2=C(C=N1)OC3=C(C24CCOC(=N4)N)C=C(C=C3)NC(=O)C5=NC=C(C=C5)Cl	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BRA28X	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-6-chloro-3-methylimidazo[1,2-a]pyridine-2-carboxamide	Investigative	90413604	C21H18ClF2N5O2	445.8	CC1=C(N=C2N1C=C(C=C2)Cl)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)CF	IC50 = 464930 nM	Non binder
T67102	Cathepsin D	BRD2U8	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-methoxy-3-methylpyridine-2-carboxamide	Investigative	90413176	C21H21F3N4O3	434.4	CC1=CC(=CC(=C1F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)NC(=O)C4=NC=C(C=C4C)OC	IC50 = 287990 nM	Non binder
T67102	Cathepsin D	BRH85B	N-(3-Amino-12-oxa-4-thia-2-azatricyclo[4.4.3.01,6]tridec-2-en-8-yl)-3-chlorobenzamide;hydrochloride	Investigative	122180110	C17H21Cl2N3O2S	402.3	C1CC23COCC2(CC1NC(=O)C4=CC(=CC=C4)Cl)CSC(=N3)N.Cl	IC50 = 277000 nM	Non binder
T67102	Cathepsin D	BRL12F	N-[2-Amino-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide	Investigative	124222803	C26H18ClFN6O3	516.9	C1COC(=NC12C3=CC(=NC=C3OC4=C2C=C(C=C4)NC(=O)C5=NC=C(C=C5)Cl)C6=CC(=NC=C6)F)N	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BRN7M5	(2S)-1-Carbazol-9-yl-3-naphthalen-2-ylsulfanylpropan-2-ol	Investigative	70696798	C25H21NOS	383.5	C1=CC=C2C=C(C=CC2=C1)SC[C@H](CN3C4=CC=CC=C4C5=CC=CC=C53)O	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	BRN9Q0	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloro-3-methylpyridine-2-carboxamide	Investigative	85469559	C19H16ClF3N4O2	424.8	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F)Cl	IC50 = 595960 nM	Non binder
T67102	Cathepsin D	BRSA56	(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[5-(4-fluorophenyl)-1H-1,2,4-triazol-3-yl]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90401190	C20H15F4N5O	417.4	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)C4=NNC(=N4)C5=CC=C(C=C5)F)F)C(F)F)N	IC50 = 249590 nM	Non binder
T67102	Cathepsin D	BRU59A	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)spiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	78105033	C26H24N6O4S	516.6	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=CN=C(C=C4C35CCSC(=N5)N)C6=CCOCC6	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BRZ0X7	N-[2-[(4Ar,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-(trifluoromethyl)pyridine-2-carboxamide	Investigative	118435560	C18H18F3N5O2S2	457.5	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC(=CS3)NC(=O)C4=NC=C(C=C4)C(F)(F)F)N	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	BRZ6P5	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(1,3-thiazol-4-ylmethoxy)pyrazine-2-carboxamide	Investigative	90412846	C21H17F3N6O3S	490.5	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OCC5=CSC=N5)F)C(F)F)N	IC50 = 581850 nM	Non binder
T67102	Cathepsin D	BS3WR4	N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoro-4-methoxyphenyl]-5-chloropyridine-2-carboxamide	Investigative	90414897	C19H17ClF2N4O3	422.8	COC1=C(C=C(C=C1F)NC(=O)C2=NC=C(C=C2)Cl)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)CF	IC50 = 768310 nM	Non binder
T67102	Cathepsin D	BS7U0D	N-(2-Amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl)-5-methoxypyrazine-2-carboxamide	Investigative	124222794	C23H20FN5O5	465.4	COC1=CC2=C(C(=C1)F)OC3=C(C24CCOC(=N4)N)C=C(C=C3)NC(=O)C5=CN=C(C=N5)OC	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BS8V4G	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-bromo-3-(difluoromethyl)pyridine-2-carboxamide	Investigative	90413693	C19H14BrF5N4O2	505.2	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=C(C=C(C=N4)Br)C(F)F)F)C(F)F)N	IC50 = 251500 nM	Non binder
T67102	Cathepsin D	BSAU84	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]isoquinoline-3-carboxamide	Investigative	90414762	C22H18F2N4O2	408.4	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=CC5=CC=CC=C5C=N4)F)N	IC50 = 430210 nM	Non binder
T67102	Cathepsin D	BSHO62	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methylsulfonylpyridine-2-carboxamide	Investigative	90412942	C19H17F3N4O4S	454.4	CS(=O)(=O)C1=CN=C(C=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 565490 nM	Non binder
T67102	Cathepsin D	BSQA79	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyridine-2-carboxamide	Investigative	78322387	C21H16F6N4O3	486.4	C#CCOC1=CN=C(C=C1)C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BSRE90	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(cyclopropylmethoxy)pyrazine-2-carboxamide	Investigative	90412660	C21H20F3N5O3	447.4	C1CC1COC2=NC=C(N=C2)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 747300 nM	Non binder
T67102	Cathepsin D	BSTZ27	N-(2-Amino-3'-chloro-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-chloropyrazine-2-carboxamide	Investigative	78105161	C20H13Cl2FN6O3	475.3	C1COC(=NC12C3=CC(=NC(=C3OC4=C2C=C(C=C4)NC(=O)C5=CN=C(C=N5)Cl)F)Cl)N	IC50 = 323000 nM	Non binder
T67102	Cathepsin D	BSY0K8	(4Ar,10R,10aR)-8-(2-fluoropyridin-3-yl)-10a-methylspiro[1,3,4,4a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine	Investigative	67970675	C20H20FN3O3	369.4	C[C@@]12COCC[C@H]1OC3=C([C@@]24COC(=N4)N)C=C(C=C3)C5=C(N=CC=C5)F	IC50 > 200000 nM	Non binder
T67102	Cathepsin D	BT26SK	N-[3-[(1S,2R,6S)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-but-2-ynoxy-3-methylpyridine-2-carboxamide	Investigative	90412645	C23H23FN4O3	422.5	CC#CCOC1=CN=C(C(=C1)C)C(=O)NC2=CC(=C(C=C2)F)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)C	IC50 = 332730 nM	Non binder
T67102	Cathepsin D	BT4CJ9	(4S,6S)-4-[2-Fluoro-5-[2-(1H-indol-4-yl)ethynyl]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373003	C22H16F5N3O	433.4	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)C#CC3=C4C=CNC4=CC=C3)F)N)C(F)(F)F	IC50 = 578000 nM	Non binder
T67102	Cathepsin D	BT50GZ	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-prop-2-ynoxypyridine-2-carboxamide	Investigative	90413750	C21H17F3N4O3	430.4	C#CCOC1=CN=C(C=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 587650 nM	Non binder
T67102	Cathepsin D	BT5IZ9	(1R,2S,6R)-2-[5-[[3-(2-Cyclopropylethynyl)-5-fluoro-1,7-naphthyridin-8-yl]amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90413254	C25H19F4N5O	481.4	C1CC1C#CC2=CC3=C(C(=NC=C3F)NC4=CC(=C(C=C4)F)[C@@]5([C@H]6C[C@H]6OC(=N5)N)C(F)F)N=C2	IC50 = 346950 nM	Non binder
T67102	Cathepsin D	BT6GK3	N-[3-[(1S,5R,6S)-3-Amino-5-(trifluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]phenyl]-5-chloropyridine-2-carboxamide	Investigative	90441930	C18H14ClF3N4O2	410.8	C1[C@@H]2[C@H]1OC(=N[C@]2(C3=CC(=CC=C3)NC(=O)C4=NC=C(C=C4)Cl)C(F)(F)F)N	IC50 = 489480 nM	Non binder
T67102	Cathepsin D	BT8YZ5	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide	Investigative	78105228	C26H21ClFN5O3S	538	C1COCC(=C1)C2=NC(=C3C(=C2)C4(CCSC(=N4)N)C5=C(O3)C=CC(=C5)NC(=O)C6=NC=C(C=C6)Cl)F	IC50 = 217000 nM	Non binder
T67102	Cathepsin D	BT96EW	N-(3-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-6-chlorobenzo[d]oxazol-2-amine	Investigative	86732124	C19H15ClF4N4O2	442.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=C2)NC3=NC4=C(O3)C=C(C=C4)Cl)F	IC50 = 210000 nM	Non binder
T67102	Cathepsin D	BT9G3X	(4S,6S)-4-(2-Fluoro-5-(6-((trimethylsilyl)ethynyl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine	Investigative	86732153	C22H22F5N3OSi	467.5	C[Si](C)(C)C#CC1=NC=C(C=C1)C2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BTEY35	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-isocyanopyridine-2-carboxamide	Investigative	124221533	C19H14F5N5O2	439.3	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=NC=C(C=C3)[N+]#[C-])F)F	IC50 = 901000 nM	Non binder
T67102	Cathepsin D	BTL3S5	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]cyclohexanecarboxamide	Investigative	90412074	C19H22F3N3O2	381.4	C1CCC(CC1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BTS9F7	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-cyanopyridine-2-carboxamide	Investigative	90415337	C20H16F3N5O2	415.4	CC1=CC(=CC(=C1F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)NC(=O)C4=NC=C(C=C4)C#N	IC50 = 441280 nM	Non binder
T67102	Cathepsin D	BTX23I	(4S,6S)-4-[3-[(3-Chloro-1,7-naphthyridin-8-yl)amino]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373045	C20H16ClF4N5O	453.8	C1[C@H](OC(=N[C@]1(CF)C2=CC(=CC=C2)NC3=NC=CC4=CC(=CN=C43)Cl)N)C(F)(F)F	IC50 = 733000 nM	Non binder
T67102	Cathepsin D	BTZ6B5	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-(difluoromethyl)pyridine-2-carboxamide	Investigative	90373290	C19H15F7N4O2	464.3	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=NC=C(C=C3)C(F)F)F)F	IC50 = 997300 nM	Non binder
T67102	Cathepsin D	BU0XI3	1-Carbazol-9-yl-3-naphthalen-2-ylsulfanylpropan-2-ol	Investigative	56944167	C25H21NOS	383.5	C1=CC=C2C=C(C=CC2=C1)SCC(CN3C4=CC=CC=C4C5=CC=CC=C53)O	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	BU5ZE4	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-methoxypyridine-2-carboxamide	Investigative	90372830	C19H17ClF4N4O3	460.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=NC=C(C=C3)OC)Cl)F	IC50 = 622000 nM	Non binder
T67102	Cathepsin D	BU7M3B	N-{3-[(1R,5S,6R)-3-Amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide	Investigative	90411858	C18H18FN5O3	371.4	C[C@]1([C@H]2C[C@H]2OC(=N1)N)C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OC)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BU7S4P	N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-4-chloro-1-propan-2-ylpyrazole-3-carboxamide	Investigative	90373233	C18H19ClF4N6O2	462.8	CC(C)N1C=C(C(=N1)C(=O)NC2=CC(=C(N=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)C)Cl	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BU86ZQ	N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-chloropyridine-2-carboxamide	Investigative	90413523	C18H15Cl2FN4O2	409.2	C1[C@@H]2[C@H]1OC(=N[C@@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)Cl)N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BU9Z7C	(4S,6S)-4-(2-Fluoro-5-(5-(prop-1-yn-1-yl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine	Investigative	86732150	C20H16F5N3O	409.4	CC#CC1=CC(=CN=C1)C2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 = 220000 nM	Non binder
T67102	Cathepsin D	BUA27X	(4S,6S)-4-[2-Fluoro-5-[(3-fluoropyridin-2-yl)amino]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90372859	C17H14F6N4O	404.31	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC3=C(C=CC=N3)F)F)N)C(F)(F)F	IC50 = 879000 nM	Non binder
T67102	Cathepsin D	BUG01M	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	78322386	C20H15F6N5O3	487.4	C#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BUKZ03	(2S)-N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-2-(4-chlorophenyl)propanamide	Investigative	90441936	C21H19ClF3N3O2	437.8	C[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 270500 nM	Non binder
T67102	Cathepsin D	BUL61G	N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-methylimidazo[1,2-a]pyridine-2-carboxamide	Investigative	78320808	C21H18F5N5O2	467.4	CC1=C(N=C2N1C=CC=C2)C(=O)NC3=CC(=C(C=C3)F)[C@@]4(C[C@H](OC(=N4)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BUR07J	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide	Investigative	90412793	C17H14ClF4N5O2	431.8	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=NN(C=C4Cl)C(F)F)F)N	IC50 = 949930 nM	Non binder
T67102	Cathepsin D	BUT8B7	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-prop-2-ynoxypyridine-2-carboxamide	Investigative	90413636	C21H18F2N4O3	412.4	C#CCOC1=CN=C(C=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 = 820880 nM	Non binder
T67102	Cathepsin D	BUV0D8	(4S,6S)-4-(5-((7-Chloropyrido[3,2-d]pyrimidin-4-yl)amino)-2-fluoropyridin-3-yl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine	Investigative	78320811	C18H14ClF4N7O	455.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(N=CC(=C2)NC3=NC=NC4=C3N=CC(=C4)Cl)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BUX7Z8	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide	Investigative	71668202	C18H16F5N5O3	445.3	COC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BV0L8F	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-cyano-3-methoxypyridine-2-carboxamide	Investigative	90414789	C20H17ClFN5O3	429.8	COC1=C(N=CC(=C1)C#N)C(=O)NC2=CC(=C(C=C2)Cl)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BV4LX2	N-(2-Amino-5'-fluoro-7'-hydroxyspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2'-yl)-5-methoxypyrazine-2-carboxamide	Investigative	117600873	C22H18FN5O4S	467.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(C35CCSC(=N5)N)C=C(C=C4F)O	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BV6L7A	N-(3-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-4-methoxypiperidine-1-carboxamide	Investigative	86732158	C19H24F4N4O3	432.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)OC)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BVD79H	3-((1S,5R,6S)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluoro-N-((S)-1-methoxypropan-2-yl)benzamide	Investigative	90414773	C17H20F3N3O3	371.35	C[C@@H](COC)NC(=O)C1=CC(=C(C=C1)F)[C@]2([C@@H]3C[C@@H]3OC(=N2)N)C(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BVI3C0	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-methoxypropanamide	Investigative	90412785	C16H18F3N3O3	357.33	COCCC(=O)NC1=CC(=C(C=C1)F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F	IC50 = 486400 nM	Non binder
T67102	Cathepsin D	BVP6X3	(4S,6S)-4-[5-[[2-(Difluoromethyl)pyrazolo[3,4-c]pyridin-7-yl]amino]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90372847	C19H15F7N6O	476.4	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)NC3=NC=CC4=CN(N=C43)C(F)F)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BVP96Q	(1R,2S,6R)-2-[2-Chloro-5-[(3-chloro-1,7-naphthyridin-8-yl)amino]phenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine	Investigative	90441958	C20H16Cl2FN5O	432.3	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC4=NC=CC5=CC(=CN=C54)Cl)Cl)N	IC50 = 251180 nM	Non binder
T67102	Cathepsin D	BVRT60	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-phenylprop-2-ynamide	Investigative	90413072	C21H16F3N3O2	399.4	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C#CC4=CC=CC=C4)F)C(F)F)N	IC50 = 203500 nM	Non binder
T67102	Cathepsin D	BVW91H	NB-360 free base	Investigative	66665322	C21H19F4N5O2	449.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3(CO[C@@](C(=N3)N)(C)C(F)(F)F)C)C#N	IC50 > 250000 nM	Non binder
T67102	Cathepsin D	BVZ05E	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide	Investigative	85468888	C19H15F2N5O2	383.4	C1[C@H]2[C@@H]1OC(=N[C@]2(CF)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)C#N)F)N	IC50 = 590780 nM	Non binder
T67102	Cathepsin D	BW14QD	N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide	Investigative	90414093	C20H16F3N5O2	415.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)CF)C#N	IC50 = 202000 nM	Non binder
T67102	Cathepsin D	BW1Y0N	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-methoxy-3-methylpyrazine-2-carboxamide	Investigative	78321765	C19H18F5N5O3	459.4	CC1=NC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF)OC	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BW2ZM5	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-bromopyridine-2-carboxamide	Investigative	90373201	C18H14BrClF4N4O2	509.7	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=NC=C(C=C3)Br)Cl)F	IC50 = 739000 nM	Non binder
T67102	Cathepsin D	BW3J0H	N-[3-[(4S,6S)-2-Benzamido-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90372784	C25H21F4N5O4	531.5	C[C@]1(C[C@H](OC(=N1)NC(=O)C2=CC=CC=C2)C(F)(F)F)C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OC)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BW7T2A	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-chloro-3-fluoropyridine-2-carboxamide	Investigative	90413989	C19H15ClF4N4O2	442.8	CC1=CC(=CC(=C1F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)NC(=O)C4=C(C=C(C=N4)Cl)F	IC50 = 810690 nM	Non binder
T67102	Cathepsin D	BW8D1E	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]phenyl]-5-cyanopyridine-2-carboxamide	Investigative	90372984	C19H15F4N5O2	421.3	C1[C@H](OC(=N[C@]1(CF)C2=CC(=CC=C2)NC(=O)C3=NC=C(C=C3)C#N)N)C(F)(F)F	IC50 = 665000 nM	Non binder
T67102	Cathepsin D	BW8R6P	N-[3-[(1S,5R,6S)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide	Investigative	90441909	C20H16F3N5O3	431.4	C#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C(=C2)F)F)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)CF	IC50 = 622600 nM	Non binder
T67102	Cathepsin D	BWB54H	N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyrazine-2-carboxamide	Investigative	124222791	C25H16ClF2N7O3	535.9	C1COC(=NC12C3=CC(=NC(=C3OC4=C2C=C(C=C4)NC(=O)C5=CN=C(C=N5)Cl)F)C6=CC(=CN=C6)F)N	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BWD4O9	N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	78104938	C26H19F2N7O3S	547.5	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(N=C(C=C4C35CCSC(=N5)N)C6=CC(=CN=C6)F)F	IC50 = 223500 nM	Non binder
T67102	Cathepsin D	BWG60M	(4S,6S)-4-(5-Amino-2-fluoropyridin-3-yl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine	Investigative	86732195	C11H11F5N4O	310.22	C1[C@H](OC(=N[C@]1(CF)C2=C(N=CC(=C2)N)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BWL91M	N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)spiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide	Investigative	78104937	C26H24N6O4S	516.6	COC1=NC=C(N=C1)C(=O)NC2=CC3=C(C=C2)OC4=CN=C(C=C4C35CCSC(=N5)N)C6=CCCOC6	IC50 = 294500 nM	Non binder
T67102	Cathepsin D	BWR3D2	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-6-chloro-3-methylimidazo[1,2-a]pyridine-2-carboxamide	Investigative	90413333	C21H17ClF3N5O2	463.8	CC1=C(N=C2N1C=C(C=C2)Cl)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 439580 nM	Non binder
T67102	Cathepsin D	BWT9J8	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-(1,3-oxazol-4-ylmethoxy)pyrazine-2-carboxamide	Investigative	85468766	C21H17ClF2N6O4	490.8	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OCC5=COC=N5)Cl)C(F)F)N	IC50 = 591850 nM	Non binder
T67102	Cathepsin D	BX16PZ	N-(2-Amino-5'-fluoro-7'-hydroxyspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2'-yl)-5-methoxypyridine-2-carboxamide	Investigative	124222806	C23H19FN4O4S	466.5	COC1=CN=C(C=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(C35CCSC(=N5)N)C=C(C=C4F)O	IC50 = 225000 nM	Non binder
T67102	Cathepsin D	BX3L7J	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-3-chloro-5-(difluoromethyl)pyridine-2-carboxamide	Investigative	90373055	C19H14ClF7N4O2	498.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=C(C=C(C=N3)C(F)F)Cl)F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BX4Z8S	N-[6-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide	Investigative	86296218	C16H13ClF6N6O2	470.76	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=N2)NC(=O)C3=NN(C=C3Cl)C(F)F)F	IC50 = 712000 nM	Non binder
T67102	Cathepsin D	BX86MB	4-Carbazol-9-yl-1-naphthalen-2-ylsulfanylbutan-2-ol	Investigative	70690565	C26H23NOS	397.5	C1=CC=C2C=C(C=CC2=C1)SCC(CCN3C4=CC=CC=C4C5=CC=CC=C53)O	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	BX9LH4	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide	Investigative	90372817	C19H15F8N5O3	513.299	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=CN=C(C=N3)OCC(F)(F)F)F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BXE13Q	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloro-3-methylpyridine-2-carbothioamide	Investigative	78321448	C19H16ClF5N4OS	478.9	CC1=CC(=CN=C1C(=S)NC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF)Cl	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BXTS15	N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoro-4-methylphenyl]-5-cyano-3-methylpyridine-2-carboxamide	Investigative	90412238	C21H18F3N5O2	429.4	CC1=CC(=CN=C1C(=O)NC2=CC(=C(C(=C2)F)C)[C@]3([C@@H]4C[C@@H]4OC(=N3)N)C(F)F)C#N	IC50 = 293790 nM	Non binder
T67102	Cathepsin D	BXTW85	N-(2-Amino-3'-chloro-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide	Investigative	78104890	C21H14Cl2FN5O3	474.3	C1COC(=NC12C3=CC(=NC(=C3OC4=C2C=C(C=C4)NC(=O)C5=NC=C(C=C5)Cl)F)Cl)N	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BY2CS0	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(1,3-thiazol-5-ylmethoxy)pyrazine-2-carboxamide	Investigative	90415296	C21H17F3N6O3S	490.5	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OCC5=CN=CS5)F)C(F)F)N	IC50 = 444850 nM	Non binder
T67102	Cathepsin D	BY3S5J	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-chloro-3-methylpyridine-2-carboxamide	Investigative	90413234	C20H18ClF3N4O2	438.8	CC1=CC(=CC(=C1F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)NC(=O)C4=NC=C(C=C4C)Cl	IC50 = 334880 nM	Non binder
T67102	Cathepsin D	BY42IC	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-chloropyridine-2-carboxamide	Investigative	90373230	C18H14Cl2F4N4O2	465.2	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=NC=C(C=C3)Cl)Cl)F	IC50 = 385600 nM	Non binder
T67102	Cathepsin D	BY42JL	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(cyclohexylmethoxy)pyrazine-2-carboxamide	Investigative	90413838	C24H26F3N5O3	489.5	C1CCC(CC1)COC2=NC=C(N=C2)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 228150 nM	Non binder
T67102	Cathepsin D	BY4T8K	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-3-chloro-5-methoxypyridine-2-carboxamide	Investigative	78321124	C19H16ClF5N4O3	478.8	COC1=CC(=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF)Cl	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BY50UZ	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-chloro-3-methoxypyridine-2-carboxamide	Investigative	90372990	C19H16ClF5N4O3	478.8	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C(=CC(=C2)NC(=O)C3=C(C=C(C=N3)Cl)OC)F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BYAD26	1-(2-Chlorophenyl)sulfanyl-3-(1,2,3,4-tetrahydrocarbazol-9-yl)propan-2-ol	Investigative	70690592	C21H22ClNOS	371.9	C1CCC2=C(C1)C3=CC=CC=C3N2CC(CSC4=CC=CC=C4Cl)O	IC50 > 300000 nM	Non binder
T67102	Cathepsin D	BYI6B9	N-(2-Amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl)-2-fluoro-4-methoxybenzamide	Investigative	124222796	C25H21F2N3O5	481.4	COC1=CC(=C(C=C1)C(=O)NC2=CC3=C(C=C2)OC4=C(C35CCOC(=N5)N)C=C(C=C4F)OC)F	IC50 = 331100 nM	Non binder
T67102	Cathepsin D	BYJS12	N-[3-[(1R,2S,6R)-4-Amino-2-(methoxymethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90412945	C19H20FN5O4	401.4	COC[C@]1([C@H]2C[C@H]2OC(=N1)N)C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OC)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BYK21T	(4S,6S)-4-(Fluoromethyl)-4-[2-fluoro-5-[4-(trifluoromethyl)pyridin-2-yl]oxyphenyl]-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90372937	C18H13F8N3O2	455.3	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)OC3=NC=CC(=C3)C(F)(F)F)F)N)C(F)(F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BYN1T0	N-(2-Amino-3'-cyclopropylspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide	Investigative	78104893	C24H20ClN5O3	461.9	C1CC1C2=NC=C3C(=C2)C4(CCOC(=N4)N)C5=C(O3)C=CC(=C5)NC(=O)C6=NC=C(C=C6)Cl	IC50 = 400000 nM	Non binder
T67102	Cathepsin D	BYQ4B8	N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-(difluoromethoxy)pyridine-2-carboxamide	Investigative	90412358	C19H15F5N4O3	442.3	C1[C@H]2[C@@H]1OC(=N[C@@]2(C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)OC(F)F)F)C(F)F)N	IC50 = 441810 nM	Non binder
T67102	Cathepsin D	BYTA48	N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-4-(2-cyclopropylethynyl)-3,6-dihydro-2H-pyridine-1-carboxamide	Investigative	90372844	C23H24F4N4O2	464.5	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=C2)NC(=O)N3CCC(=CC3)C#CC4CC4)F	IC50 = 810000 nM	Non binder
T67102	Cathepsin D	BZ29TM	(4As,10R,10aS)-4a-methyl-8-pyrimidin-5-ylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine	Investigative	67970973	C19H20N4O3	352.4	C[C@]12CCOC[C@@H]1[C@]3(COC(=N3)N)C4=C(O2)C=CC(=C4)C5=CN=CN=C5	IC50 > 200000 nM	Non binder
T67102	Cathepsin D	BZ2OI1	(4S,6S)-4-[2-Fluoro-5-[(2-methoxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373087	C20H17F5N6O2	468.4	COC1=CN=C2C(=N1)C=CN=C2NC3=CC(=C(C=C3)F)[C@@]4(C[C@H](OC(=N4)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BZ47EM	N-[5-[(1S,5R,6S)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-6-fluoropyridin-3-yl]-5-chloropyridine-2-carboxamide	Investigative	90441920	C17H13ClF3N5O2	411.8	C1[C@@H]2[C@H]1OC(=N[C@]2(C3=C(N=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F)C(F)F)N	IC50 = 274500 nM	Non binder
T67102	Cathepsin D	BZ6W5O	(4S,6S)-4-[2-Fluoro-5-[2-(1H-indol-6-yl)ethynyl]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90373126	C22H16F5N3O	433.4	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)C#CC3=CC4=C(C=C3)C=CN4)F)N)C(F)(F)F	IC50 = 721000 nM	Non binder
T67102	Cathepsin D	BZ89UA	N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(oxan-4-ylmethoxy)pyrazine-2-carboxamide	Investigative	90413156	C23H24F3N5O4	491.5	C1COCCC1COC2=NC=C(N=C2)C(=O)NC3=CC(=C(C=C3)F)[C@@]4([C@H]5C[C@H]5OC(=N4)N)C(F)F	IC50 = 640340 nM	Non binder
T67102	Cathepsin D	BZ8XL5	(2R)-N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-2-methoxypropanamide	Investigative	90412345	C16H18F3N3O3	357.33	C[C@H](C(=O)NC1=CC(=C(C=C1)F)[C@@]2([C@H]3C[C@H]3OC(=N2)N)C(F)F)OC	IC50 = 376540 nM	Non binder
T67102	Cathepsin D	BZ91CJ	N-[3-[(1R,2S,6R)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-but-2-ynoxy-3-methylpyridine-2-carboxamide	Investigative	90413286	C23H23FN4O3	422.5	CC#CCOC1=CN=C(C(=C1)C)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C	IC50 = 302760 nM	Non binder
T67102	Cathepsin D	BZG81B	(4S,6S)-4-[2-Fluoro-5-(6-fluoroquinazolin-2-yl)phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine	Investigative	90372801	C20H14F6N4O	440.3	C1[C@H](OC(=N[C@]1(CF)C2=C(C=CC(=C2)C3=NC=C4C=C(C=CC4=N3)F)F)N)C(F)(F)F	IC50 = 758000 nM	Non binder
T67102	Cathepsin D	BZJ4A5	N-(2-Amino-3'-cyclopropyl-1'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide	Investigative	78105122	C25H22ClN5O4	491.9	COC1=C2C(=CC(=N1)C3CC3)C4(CCOC(=N4)N)C5=C(O2)C=CC(=C5)NC(=O)C6=NC=C(C=C6)Cl	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BZJW04	8-((5-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-6-fluoropyridin-3-yl)amino)-5-fluoro-1,7-naphthyridine-3-carbonitrile	Investigative	86732134	C20H14F5N7O	463.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(N=CC(=C2)NC3=NC=C(C4=C3N=CC(=C4)C#N)F)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BZQF45	N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-prop-2-enoxypyrazine-2-carboxamide	Investigative	90418556	C20H18F3N5O3	433.4	C=CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C=C2)F)[C@@]3([C@H]4C[C@H]4OC(=N3)N)C(F)F	IC50 = 924060 nM	Non binder
T67102	Cathepsin D	BZVA85	N-[3-[(1S,2R,6S)-4-Amino-2-(methoxymethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide	Investigative	90413499	C19H20FN5O4	401.4	COC[C@@]1([C@@H]2C[C@@H]2OC(=N1)N)C3=C(C=CC(=C3)NC(=O)C4=CN=C(C=N4)OC)F	IC50 > 400000 nM	Non binder
T67102	Cathepsin D	BZW1Y0	N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide	Investigative	78322385	C21H17F6N5O3	501.4	CC#CCOC1=NC=C(N=C1)C(=O)NC2=CC(=C(C(=C2)F)F)[C@@]3(C[C@H](OC(=N3)N)C(F)(F)F)CF	IC50 > 400000 nM	Non binder