TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T63414 P2X purinoceptor 7 D02LMZ ATPase Phase 2 5957 C10H16N5O13P3 507.18 C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N EC50 = 780000 nM Non binder T63414 P2X purinoceptor 7 B3PYB9 N'-(2-Chlorophenyl)pentacyclo[6.4.0.02,10.03,7.04,9]dodecane-8-carbohydrazide Investigative 137644370 C19H21ClN2O 328.8 C1CC2C3C1C4C2(C5C3C4CC5)C(=O)NNC6=CC=CC=C6Cl IC50 = 933000 nM Non binder T63414 P2X purinoceptor 7 BHS4I3 N'-[2-(Trifluoromethyl)phenyl]pentacyclo[6.4.0.02,10.03,7.04,9]dodecane-8-carbohydrazide Investigative 137652052 C20H21F3N2O 362.4 C1CC2C3C1C4C2(C5C3C4CC5)C(=O)NNC6=CC=CC=C6C(F)(F)F IC50 = 366000 nM Non binder T63414 P2X purinoceptor 7 BW0CZ4 N'-[2-Chloro-4-(trifluoromethyl)phenyl]pentacyclo[6.4.0.02,10.03,7.04,9]dodeca-5,11-diene-8-carbohydrazide Investigative 137632064 C20H16ClF3N2O 392.8 C1=CC2C3C1C4C2(C5C3C4C=C5)C(=O)NNC6=C(C=C(C=C6)C(F)(F)F)Cl IC50 = 1557000 nM Non binder