TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T61622	Angiotensinogenase renin	D0CG8S	oxazine 89	Clinical trial	71305058	C19H15F4N5O2	421.3	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)F	IC50 > 200000 nM	Non binder
T61622	Angiotensinogenase renin	B1IG6M	Pro-His-Pro-Phe-His-5-amino-valeric acid-Ile-Phe-NH2	Investigative	73345600	C51H69N13O8	992.2	CCC[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NC(=O)[C@H](CC1=CC=CC=C1)N)NC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCCN6	IC50 > 1000000 nM	Non binder
T61622	Angiotensinogenase renin	B20IOX	Boc-Pro[CH2O]Phe-His-Sta-Ile-Phe-OCH3	Investigative	44373765	C49H72N8O10	933.1	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)CC(C(CC(C)CNC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC3=CC=CC=C3)OC[C@@H]4CCCN4C(=O)OC(C)(C)C)N)O	IC50 = 2500000 nM	Non binder
T61622	Angiotensinogenase renin	B23KIP	Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate	Investigative	90663498	C29H39N3O6	525.6	CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@@H](C2=CC=CC=C2)O	Ki = 980000 nM	Non binder
T61622	Angiotensinogenase renin	B2N1SL	Phenyl-substituted sulfonamides, 6a	Investigative	44236883	C30H33N3O4S2	563.7	C1=CC=C(C=C1)CN(CCNCCN(CC2=CC=CC=C2)S(=O)(=O)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4	IC50 > 250000 nM	Non binder
T61622	Angiotensinogenase renin	B2P6WY	2,3-Seco-lupa-20(29)-en-2,3,28-trioic acid	Investigative	45482029	C30H46O6	502.7	CC(=C)[C@@H]1CC[C@]2([C@@H]1[C@@H]3CC[C@H]4[C@]([C@@]3(CC2)C)(CC[C@H]([C@]4(C)CC(=O)O)C(C)(C)C(=O)O)C)C(=O)O	IC50 > 1991000 nM	Non binder
T61622	Angiotensinogenase renin	B2SP4Z	2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid methyl ester	Investigative	44370882	C22H35N3O5	421.5	CC(C)C[C@@H]([C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)O)N	Ki = 2440000 nM	Non binder
T61622	Angiotensinogenase renin	B38URC	Tert-butyl N-[(2S)-1-[[(2S,3R)-1-cyclohexyl-3-hydroxy-4-oxoheptan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamate	Investigative	44460212	C24H40N4O5	464.6	CCCC(=O)[C@@H]([C@H](CC1CCCCC1)NC(=O)[C@H](CC2=CN=CN2)NC(=O)OC(C)(C)C)O	IC50 = 420000 nM	Non binder
T61622	Angiotensinogenase renin	B3A8DG	N-Ac-Trp(CHO)-Pro[CH2O]Phe-His-Sta-Ile-Phe-OCH3	Investigative	44373976	C58H76N10O11	1089.3	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)CC(C(CC(C)CNC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC3=CC=CC=C3)OC[C@@H]4CCCN4C(=O)[C@H](CC5=CN(C6=CC=CC=C65)C=O)NC(=O)C)N)O	IC50 = 330000 nM	Non binder
T61622	Angiotensinogenase renin	B3S5UM	Boc-Trp(CHO)-Pro[CH2O]Phe-His-Sta-Ile-Phe-OCH3	Investigative	44373977	C61H82N10O12	1147.4	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)CC(C(CC(C)CNC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC3=CC=CC=C3)OC[C@@H]4CCCN4C(=O)[C@H](CC5=CN(C6=CC=CC=C65)C=O)NC(=O)OC(C)(C)C)N)O	IC50 = 1000000 nM	Non binder
T61622	Angiotensinogenase renin	B3TOU8	Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-hydroxy-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate	Investigative	118718871	C26H41N3O6	491.6	CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@@H](C(C)C)O	Ki = 1780000 nM	Non binder
T61622	Angiotensinogenase renin	B42EKB	(2R,3R,4S)-N-Butyl-5-cyclohexyl-2,3-dihydroxy-4-[3-(1H-imidazol-5-yl)propylamino]pentane-1-sulfonamide	Investigative	44325168	C21H40N4O4S	444.6	CCCCNS(=O)(=O)C[C@@H]([C@@H]([C@H](CC1CCCCC1)NCCCC2=CN=CN2)O)O	IC50 = 310000 nM	Non binder
T61622	Angiotensinogenase renin	B4GO5I	Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-hydroxy-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride	Investigative	73345714	C27H44ClN3O6	542.1	CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](CC(C)C)O.Cl	Ki = 230000 nM	Non binder
T61622	Angiotensinogenase renin	B5EHK2	(3S)-4-Acetyl-3-hydroxy-6-methyl-N-[(2R)-1-(3-methylbutylamino)-1-oxopropan-2-yl]heptanamide	Investigative	44340280	C18H34N2O4	342.5	C[C@H](C(=O)NCCC(C)C)NC(=O)C[C@@H](C(CC(C)C)C(=O)C)O	IC50 > 330000 nM	Non binder
T61622	Angiotensinogenase renin	B69JFM	(3S,4S)-4-(4-Chloro-phenyl)-3-(4-methoxy-benzyloxy)-piperidine	Investigative	44279247	C19H22ClNO2	331.8	COC1=CC=C(C=C1)CO[C@@H]2CNCC[C@H]2C3=CC=C(C=C3)Cl	IC50 = 1200000 nM	Non binder
T61622	Angiotensinogenase renin	B6LS5T	(S)-2-Amino-N-[4-((S,R,R)-butylsulfamoyl)-1-cyclohexylmethyl-2,3-dihydroxy-butyl]-3-(3H-imidazol-4-yl)-propionamide	Investigative	44325466	C21H39N5O5S	473.6	CCCCNS(=O)(=O)C[C@@H]([C@@H]([C@H](CC1CCCCC1)NC(=O)[C@H](CC2=CN=CN2)N)O)O	IC50 > 1000000 nM	Non binder
T61622	Angiotensinogenase renin	B6XW4P	Chembl539498	Investigative	90664754	C30H48Cl2N6O6	659.6	CC(C)CC(CC(CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)O)NC(=O)[C@H](CC2=CN=CN2)N.Cl.Cl	Ki = 900000 nM	Non binder
T61622	Angiotensinogenase renin	B7FX0G	(3S)-3-Hydroxy-6-methyl-4-(3-methylbutanoylamino)-N-[(2R)-1-(3-methylbutylamino)-1-oxopropan-2-yl]heptanamide	Investigative	44340295	C21H41N3O4	399.6	C[C@H](C(=O)NCCC(C)C)NC(=O)C[C@@H](C(CC(C)C)NC(=O)CC(C)C)O	IC50 > 330000 nM	Non binder
T61622	Angiotensinogenase renin	B85OFI	N-((1S,2R,3R)-4-Butylsulfamoyl-1-cyclohexylmethyl-2,3-dihydroxy-butyl)-3-(3H-imidazol-4-yl)-propionamide	Investigative	44325167	C21H38N4O5S	458.6	CCCCNS(=O)(=O)C[C@@H]([C@@H]([C@H](CC1CCCCC1)NC(=O)CCC2=CN=CN2)O)O	IC50 > 1000000 nM	Non binder
T61622	Angiotensinogenase renin	B8FYG4	2-{2-[2-(2-Hydroxy-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester	Investigative	73350150	C26H41N3O6	491.6	CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](C(C)C)O	Ki = 300000 nM	Non binder
T61622	Angiotensinogenase renin	B8GB4H	Methyl (2R)-2-[[(2R)-2-[(5-amino-3-hydroxy-7-methyloctanoyl)amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride	Investigative	45264156	C24H40ClN3O5	486	CC(C)CC(CC(CC(=O)N[C@H](C(C)C)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)OC)O)N.Cl	Ki = 1180000 nM	Non binder
T61622	Angiotensinogenase renin	B8GQ3C	Methyl (2S)-2-[[(2S)-2-[[(2S,3S,8S)-3,8-diamino-2-hydroxy-5,10-dimethyl-7-oxoundecanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride	Investigative	49861042	C28H47ClN4O6	571.1	CC(C)C[C@@H](C(=O)CC(C)C[C@@H]([C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)O)N)N.Cl	Ki = 520000 nM	Non binder
T61622	Angiotensinogenase renin	B8KYV1	3-{2-[(5-Aminopentyl)amino]-2-oxoethoxy}-5-({[1-(4-fluorophenyl)ethyl]amino}carbonyl)phenyl phenylmethanesulfonate	Investigative	448772	C29H34FN3O6S	571.7	C[C@H](C1=CC=C(C=C1)F)NC(=O)C2=CC(=CC(=C2)OS(=O)(=O)CC3=CC=CC=C3)OCC(=O)NCCCCCN	IC50 > 500000 nM	Non binder
T61622	Angiotensinogenase renin	B8MY3C	N-((1S,2R,3R)-4-Butylsulfamoyl-1-cyclohexylmethyl-2,3-dihydroxy-butyl)-acetamide	Investigative	44325330	C17H34N2O5S	378.5	CCCCNS(=O)(=O)C[C@@H]([C@@H]([C@H](CC1CCCCC1)NC(=O)C)O)O	IC50 > 1000000 nM	Non binder
T61622	Angiotensinogenase renin	B98TYE	(2S)-N-[(2R)-1-(2,2-Dimethylpropylamino)-1-oxo-3-phenylpropan-2-yl]-N'-[(2S)-1-hydroxy-4-methylpentan-2-yl]-2-(1H-imidazol-5-ylmethyl)propanediamide	Investigative	44267824	C27H41N5O4	499.6	CC(C)C[C@@H](CO)NC(=O)[C@H](CC1=CN=CN1)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)NCC(C)(C)C	IC50 = 1200000 nM	Non binder
T61622	Angiotensinogenase renin	B9BFJ8	4-Methyl-pentanoic acid ((1S,2R,3S)-4-butylsulfamoyl-1-cyclohexylmethyl-2,3-dihydroxy-butyl)-amide	Investigative	44325127	C21H42N2O5S	434.6	CCCCNS(=O)(=O)C[C@H]([C@@H]([C@H](CC1CCCCC1)NC(=O)CCC(C)C)O)O	IC50 > 1000000 nM	Non binder
T61622	Angiotensinogenase renin	B9EX8Q	Boc-His-Pro[CH2O]Phe-His-Sta-Ile-Phe-OCH3	Investigative	44373752	C55H79N11O11	1070.3	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)CC(C(CC(C)CNC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC3=CC=CC=C3)OC[C@@H]4CCCN4C(=O)[C@H](CC5=CN=CN5)NC(=O)OC(C)(C)C)N)O	IC50 = 440000 nM	Non binder
T61622	Angiotensinogenase renin	B9TVS4	Iso-butyl-substituted sulfonamide, 9a	Investigative	44236888	C24H37N3O4S2	495.7	CC(C)CN(CCNCCN(CC(C)C)S(=O)(=O)C1=CC=CC=C1)S(=O)(=O)C2=CC=CC=C2	IC50 > 250000 nM	Non binder
T61622	Angiotensinogenase renin	BA5V1R	(2S)-N-[(2S,3R,4R)-5-(Butylsulfamoyl)-1-cyclohexyl-3,4-dihydroxypentan-2-yl]-2-hydroxy-4-methylpentanamide	Investigative	44325307	C21H42N2O6S	450.6	CCCCNS(=O)(=O)C[C@@H]([C@@H]([C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)O)O)O	IC50 > 1000000 nM	Non binder
T61622	Angiotensinogenase renin	BARB73	His-Sta-Leu-Phe-NH2	Investigative	44332794	C29H45N7O5	571.7	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)NC(=O)CC(C(CC(C)C)NC(=O)[C@H](CC2=CN=CN2)N)O	IC50 = 370000 nM	Non binder
T61622	Angiotensinogenase renin	BB57RQ	3-Hydroxy-6-methyl-4-{3-methyl-2-[3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-butyrylamino}-heptanoic acid amide	Investigative	44340351	C23H44N4O5	456.6	CC(C)CC([C@H](CC(=O)N)O)NC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)CC(C)C	IC50 > 330000 nM	Non binder
T61622	Angiotensinogenase renin	BC07PA	(2R,3R,4S)-N-Butyl-5-cyclohexyl-2,3-dihydroxy-4-(4-methylpentylamino)pentane-1-sulfonamide	Investigative	44325315	C21H44N2O4S	420.7	CCCCNS(=O)(=O)C[C@@H]([C@@H]([C@H](CC1CCCCC1)NCCCC(C)C)O)O	IC50 = 680000 nM	Non binder
T61622	Angiotensinogenase renin	BC09YT	3-Hydroxy-6-methyl-4-[3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-heptanoic acid amide	Investigative	44340320	C18H35N3O4	357.5	CC(C)C[C@@H](C(CC(=O)N)O)NC(=O)[C@@H](C(C)C)NC(=O)CC(C)C	IC50 > 330000 nM	Non binder
T61622	Angiotensinogenase renin	BC10GD	Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-3-amino-2-hydroxy-5-methylhexanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride	Investigative	49861037	C28H47ClN4O6	571.1	CC(C)C[C@@H]([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)O)N.Cl	Ki = 960000 nM	Non binder
T61622	Angiotensinogenase renin	BC24LK	(1R,2R,4Ar,4bS,6aS,9R,10S,10aS,12aR)-1-(carboxymethyl)-2-(2-carboxypropan-2-yl)-1,4a,4b,9,10-pentamethyl-2,3,4,5,6,7,8,9,10,10a,12,12a-dodecahydrochrysene-6a-carboxylic acid	Investigative	44244046	C30H46O6	502.7	C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@H]([C@]4(C)CC(=O)O)C(C)(C)C(=O)O)C)[C@@H]2[C@H]1C)C)C(=O)O	IC50 > 1991000 nM	Non binder
T61622	Angiotensinogenase renin	BD69GE	Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride	Investigative	52942941	C27H45ClN4O5	541.1	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)N.Cl	Ki = 1140000 nM	Non binder
T61622	Angiotensinogenase renin	BD91YV	Phenyl-substituted sulfonamides, 6c	Investigative	44236885	C32H37N3O4S2	591.8	C1=CC=C(C=C1)CN(CCCNCCCN(CC2=CC=CC=C2)S(=O)(=O)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4	IC50 > 250000 nM	Non binder
T61622	Angiotensinogenase renin	BE5Q9M	(2R,3R,4S)-4-Amino-N-butyl-5-cyclohexyl-2,3-dihydroxypentane-1-sulfonamide	Investigative	44324881	C15H32N2O4S	336.5	CCCCNS(=O)(=O)C[C@@H]([C@@H]([C@H](CC1CCCCC1)N)O)O	IC50 = 470000 nM	Non binder
T61622	Angiotensinogenase renin	BER2I9	Methyl (2R)-2-[[(2R)-2-[[5-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-7-methyloctanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;dihydrochloride	Investigative	90664755	C30H48Cl2N6O6	659.6	CC(C)CC(CC(CC(=O)N[C@H](C(C)C)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)OC)O)NC(=O)[C@H](CC2=CN=CN2)N.Cl.Cl	Ki = 740000 nM	Non binder
T61622	Angiotensinogenase renin	BF6D0P	Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-hydroxy-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate	Investigative	90663501	C30H41N3O6	539.7	CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](CC2=CC=CC=C2)O	Ki = 670000 nM	Non binder
T61622	Angiotensinogenase renin	BG5S6W	Phenyl-substituted sulfonamides, 6f	Investigative	44236887	C32H39N5O4S2	621.8	C1=CC=C(C=C1)CN(CCCNCCCN(CC2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)N)S(=O)(=O)C4=CC=C(C=C4)N	IC50 > 250000 nM	Non binder
T61622	Angiotensinogenase renin	BH5PO4	2-{2-[2-(2-Hydroxy-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester	Investigative	73345715	C27H43N3O6	505.6	CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](CC(C)C)O	Ki = 230000 nM	Non binder
T61622	Angiotensinogenase renin	BHCD75	5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine	Investigative	258149	C10H11N3S	205.28	C1CCC2=C(C1)C3=C(N=CN=C3S2)N	IC50 > 300000 nM	Non binder
T61622	Angiotensinogenase renin	BI3KQ5	(1R,2R,4Ar,4bS,6aS,10aR,12aR)-1-(carboxymethyl)-2-(2-carboxypropan-2-yl)-1,4a,4b,9,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2H-chrysene-6a-carboxylic acid	Investigative	45482036	C30H46O6	502.7	C[C@@]12CC[C@H]([C@]([C@H]1CC=C3[C@]2(CC[C@@]4([C@@H]3CC(CC4)(C)C)C(=O)O)C)(C)CC(=O)O)C(C)(C)C(=O)O	IC50 > 1990000 nM	Non binder
T61622	Angiotensinogenase renin	BJ1DG3	4-Methoxy-N-{4-[(3R,4R)-3-(naphthalen-2-ylmethoxy)-piperidin-4-yl]-benzyl}-benzamide	Investigative	44278948	C31H32N2O3	480.6	COC1=CC=C(C=C1)C(=O)NCC2=CC=C(C=C2)[C@H]3CCNC[C@@H]3OCC4=CC5=CC=CC=C5C=C4	IC50 > 1000000 nM	Non binder
T61622	Angiotensinogenase renin	BJ5G2X	Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-hydroxy-2-phenylacetyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate	Investigative	90663499	C29H39N3O6	525.6	CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](C2=CC=CC=C2)O	Ki = 530000 nM	Non binder
T61622	Angiotensinogenase renin	BK05PB	Methyl (2S)-2-[[(2S)-2-[[(2R,3S,8S)-3,8-diamino-2-hydroxy-5,10-dimethyl-7-oxoundecanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride	Investigative	49861038	C28H47ClN4O6	571.1	CC(C)C[C@@H](C(=O)CC(C)C[C@@H]([C@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)O)N)N.Cl	Ki = 440000 nM	Non binder
T61622	Angiotensinogenase renin	BKB4G5	Leu-Leu-Val-Phe-OCH3	Investigative	13334744	C27H44N4O5	504.7	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)N	Ki = 500000 nM	Non binder
T61622	Angiotensinogenase renin	BKM97U	Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-hydroxy-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate	Investigative	118718870	C27H43N3O6	505.6	CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@@H](CC(C)C)O	Ki = 600000 nM	Non binder
T61622	Angiotensinogenase renin	BL93TQ	Methyl (2S)-2-[[(2S)-2-[[(2R)-2-[[(2R,3S)-3-amino-2-hydroxy-5-methylhexanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride	Investigative	49861043	C28H47ClN4O6	571.1	CC(C)C[C@@H]([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)O)N.Cl	Ki = 1520000 nM	Non binder
T61622	Angiotensinogenase renin	BM05LX	N-((1S,2R,3S)-4-Butylsulfamoyl-1-cyclohexylmethyl-2,3-dihydroxy-butyl)-acetamide	Investigative	44324882	C17H34N2O5S	378.5	CCCCNS(=O)(=O)C[C@H]([C@@H]([C@H](CC1CCCCC1)NC(=O)C)O)O	IC50 > 1000000 nM	Non binder
T61622	Angiotensinogenase renin	BN7D3G	4-Methyl-pentanoic acid ((1S,2R,3R)-4-butylsulfamoyl-1-cyclohexylmethyl-2,3-dihydroxy-butyl)-amide	Investigative	44325314	C21H42N2O5S	434.6	CCCCNS(=O)(=O)C[C@@H]([C@@H]([C@H](CC1CCCCC1)NC(=O)CCC(C)C)O)O	IC50 > 1000000 nM	Non binder
T61622	Angiotensinogenase renin	BN8T1H	Methyl (2S)-2-[[(2S)-2-[[(2R,3S)-3-amino-2-hydroxy-5-methylhexanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate	Investigative	44370946	C22H35N3O5	421.5	CC(C)C[C@@H]([C@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)O)N	Ki = 1010000 nM	Non binder
T61622	Angiotensinogenase renin	BOA1D6	2,3-Seco-lup-20(29)-en-2,3-dioic acid	Investigative	45482030	C30H48O4	472.7	CC(=C)[C@@H]1CC[C@]2([C@@H]1[C@@H]3CC[C@H]4[C@]([C@@]3(CC2)C)(CC[C@H]([C@]4(C)CC(=O)O)C(C)(C)C(=O)O)C)C	IC50 > 2117000 nM	Non binder
T61622	Angiotensinogenase renin	BOH94P	(2S)-N-[(2S,3R,4S)-5-(Butylsulfamoyl)-1-cyclohexyl-3,4-dihydroxypentan-2-yl]-2-hydroxy-4-methylpentanamide	Investigative	44325306	C21H42N2O6S	450.6	CCCCNS(=O)(=O)C[C@H]([C@@H]([C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)O)O)O	IC50 > 1000000 nM	Non binder
T61622	Angiotensinogenase renin	BP8VI6	2-{2-[2-(2-Amino-4-methyl-pentanoylamino)-acetylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester	Investigative	44276829	C23H36N4O5	448.6	CC(C)C[C@@H](C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)N	Ki = 1000000 nM	Non binder
T61622	Angiotensinogenase renin	BS1E0D	N,N'-(Iminodiethane-2,1-Diyl)bis[4-Amino-N-(2-Methylpropyl)benzenesulfonamide]	Investigative	24883482	C24H39N5O4S2	525.7	CC(C)CN(CCNCCN(CC(C)C)S(=O)(=O)C1=CC=C(C=C1)N)S(=O)(=O)C2=CC=C(C=C2)N	IC50 > 250000 nM	Non binder
T61622	Angiotensinogenase renin	BS93VY	Furfurylamine	Investigative	3438	C5H7NO	97.12	C1=COC(=C1)CN	IC50 > 300000 nM	Non binder
T61622	Angiotensinogenase renin	BSR5I1	2-[(5R,14R)-5-Amino-5-methyl-4,16-dioxo-14-phenyl-3-oxa-15-azatricyclo[15.3.1.17,11]docosa-1(20),7,9,11(22),17(21),18-hexaen-19-yl]benzonitrile	Investigative	44441743	C34H31N3O3	529.6	C[C@]1(CC2=CC=CC(=C2)CC[C@@H](NC(=O)C3=CC(=CC(=C3)C4=CC=CC=C4C#N)COC1=O)C5=CC=CC=C5)N	IC50 = 275000 nM	Non binder
T61622	Angiotensinogenase renin	BT5W3P	N-((1S,2R,3S)-4-Butylsulfamoyl-1-cyclohexylmethyl-2,3-dihydroxy-butyl)-3-(3H-imidazol-4-yl)-propionamide	Investigative	44325481	C21H38N4O5S	458.6	CCCCNS(=O)(=O)C[C@H]([C@@H]([C@H](CC1CCCCC1)NC(=O)CCC2=CN=CN2)O)O	IC50 > 1000000 nM	Non binder
T61622	Angiotensinogenase renin	BU9P1E	Phenyl-substituted sulfonamides, 6e	Investigative	44236886	C31H37N5O4S2	607.8	C1=CC=C(C=C1)CN(CCCNCCN(CC2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)N)S(=O)(=O)C4=CC=C(C=C4)N	IC50 > 250000 nM	Non binder
T61622	Angiotensinogenase renin	BV1T8H	2-[2-(5-Amino-7-methyl-oct-3-enoylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid methyl ester	Investigative	44276843	C24H37N3O4	431.6	CC(C)C[C@@H](/C=C/CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)N	Ki = 400000 nM	Non binder
T61622	Angiotensinogenase renin	BV3T0B	16beta-Hydroxy-2,3-seco-lup-20(29)-en-2,3-dioic acid	Investigative	45482028	C30H48O5	488.7	CC(=C)[C@@H]1CC[C@]2([C@@H]1[C@@H]3CC[C@H]4[C@]([C@@]3(C[C@@H]2O)C)(CC[C@H]([C@]4(C)CC(=O)O)C(C)(C)C(=O)O)C)C	IC50 > 2046000 nM	Non binder
T61622	Angiotensinogenase renin	BVMX31	(2S)-2-Amino-N-[(2S,3R,4R)-5-(butylsulfamoyl)-1-cyclohexyl-3,4-dihydroxypentan-2-yl]-4-methylpentanamide	Investigative	44325308	C21H43N3O5S	449.7	CCCCNS(=O)(=O)C[C@@H]([C@@H]([C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)N)O)O	IC50 > 1000000 nM	Non binder
T61622	Angiotensinogenase renin	BVXU07	N-Ac-His-Pro[CH2O]Phe-His-Sta-Ile-Phe-OCH3	Investigative	44373871	C52H73N11O10	1012.2	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)CC(C(CC(C)CNC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC3=CC=CC=C3)OC[C@@H]4CCCN4C(=O)[C@H](CC5=CN=CN5)NC(=O)C)N)O	IC50 = 550000 nM	Non binder
T61622	Angiotensinogenase renin	BWDH91	Carboxamide, 12b	Investigative	44236890	C35H39N3O2	533.7	C1=CC=C(C=C1)CC(=O)N(CCCNCCN(CC2=CC=CC=C2)C(=O)CC3=CC=CC=C3)CC4=CC=CC=C4	IC50 > 250000 nM	Non binder
T61622	Angiotensinogenase renin	BWE7S2	(3S,4As,6aR,7S,8R,10aR,10bS,12aS)-7-(carboxymethyl)-8-(2-carboxypropan-2-yl)-3,7,10a,10b,12a-pentamethyl-6-oxo-1,2,4,4a,6a,8,9,10,11,12-decahydrochrysene-3-carboxylic acid	Investigative	45482033	C30H44O7	516.7	C[C@]12CC[C@](C[C@@H]1C3=CC(=O)[C@H]4[C@]([C@@]3(CC2)C)(CC[C@H]([C@]4(C)CC(=O)O)C(C)(C)C(=O)O)C)(C)C(=O)O	IC50 > 1935000 nM	Non binder
T61622	Angiotensinogenase renin	BWG18Y	N-(2,3-Seco-olean-12-en-28-oyl)-D-valine acid	Investigative	45482037	C35H55NO7	601.8	CC(C)[C@H](C(=O)O)NC(=O)[C@@]12CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@H]([C@]4(C)CC(=O)O)C(C)(C)C(=O)O)C)[C@H]1CC(CC2)(C)C)C	IC50 > 1663000 nM	Non binder
T61622	Angiotensinogenase renin	BX1P0S	N,N'-(Iminodiethane-2,1-diyl)bis(4-amino-N-benzylbenzenesulfonamide)	Investigative	24883483	C30H35N5O4S2	593.8	C1=CC=C(C=C1)CN(CCNCCN(CC2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)N)S(=O)(=O)C4=CC=C(C=C4)N	IC50 > 250000 nM	Non binder
T61622	Angiotensinogenase renin	BXJ2U1	Phenyl-substituted sulfonamides, 6b	Investigative	44236884	C31H35N3O4S2	577.8	C1=CC=C(C=C1)CN(CCCNCCN(CC2=CC=CC=C2)S(=O)(=O)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4	IC50 > 250000 nM	Non binder
T61622	Angiotensinogenase renin	BXU8Y2	4-(2-{4-[2-(2-Tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(3H-imidazol-4-yl)-propionylamino]-3-hydroxy-6-methyl-heptanoylamino}-propionylamino)-3-hydroxy-6-methyl-heptanoic acid methyl ester	Investigative	44325065	C40H63N7O10	802	C[C@@H](C(=O)N[C@@H](CC(C)C)C(CC(=O)OC)O)NC(=O)CC([C@H](CC(C)C)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OC(C)(C)C)O	IC50 = 270000 nM	Non binder