TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T60693	Opioid receptor kappa	BAN8J1	Ethyl 2-[(1R,9R,10S,12R)-10-hydroxy-4-methoxy-17-methyl-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]acetate	Investigative	77107153	C22H29NO5	387.5	CCOC(=O)C[C@H]1C[C@]2([C@H]3CC4=C([C@@]2(CCN3C)CC1=O)C=C(C=C4)OC)O	EC50 > 200000 nM	Non binder
T60693	Opioid receptor kappa	BD3ZN8	(1R,9R,10S,12R)-10-Hydroxy-4-methoxy-17-methyl-12-(2-oxo-2-piperidin-1-ylethyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one	Investigative	90255932	C25H34N2O4	426.5	CN1CC[C@]23CC(=O)[C@H](C[C@]2([C@H]1CC4=C3C=C(C=C4)OC)O)CC(=O)N5CCCCC5	EC50 > 200000 nM	Non binder
T60693	Opioid receptor kappa	BE8Y7H	(2S)-1-[2-[(1R,9R,10S,12R)-17-(Cyclopropylmethyl)-4,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]acetyl]pyrrolidine-2-carboxylic acid	Investigative	77106954	C27H34N2O6	482.6	C1C[C@H](N(C1)C(=O)C[C@H]2C[C@]3([C@H]4CC5=C([C@@]3(CCN4CC6CC6)CC2=O)C=C(C=C5)O)O)C(=O)O	EC50 > 200000 nM	Non binder
T60693	Opioid receptor kappa	BJ3SU9	(2S)-2-Amino-N-[(2R)-1-[[(4S)-2-(2-amino-2-oxoethyl)-3-oxo-4,5-dihydro-1H-2-benzazepin-4-yl]amino]-1-oxopropan-2-yl]-3-(4-hydroxy-2,6-dimethylphenyl)-N-methylpropanamide	Investigative	54669894	C27H35N5O5	509.6	CC1=CC(=CC(=C1C[C@@H](C(=O)N(C)[C@H](C)C(=O)N[C@H]2CC3=CC=CC=C3CN(C2=O)CC(=O)N)N)C)O	Ki > 1000000 nM	Non binder
T60693	Opioid receptor kappa	BLI7J9	(1R,9R,10S,12R)-10-Hydroxy-12-[2-(4-hydroxypiperidin-1-yl)-2-oxoethyl]-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one	Investigative	90255817	C25H34N2O5	442.5	CN1CC[C@]23CC(=O)[C@H](C[C@]2([C@H]1CC4=C3C=C(C=C4)OC)O)CC(=O)N5CCC(CC5)O	EC50 > 200000 nM	Non binder
T60693	Opioid receptor kappa	BP69UG	(4As,5R,10bR)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[h]isoquinoline-7,8-diol	Investigative	46869265	C19H21NO2	295.4	C1CNC[C@@H]2[C@@H]1[C@@H](CC3=C2C=CC(=C3O)O)C4=CC=CC=C4	Ki = 820000 nM	Non binder
T60693	Opioid receptor kappa	BS5Z4K	(2S)-2-[[(2R)-2-[[(2S)-2-Amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-methylamino]propanoyl]amino]-N-(2-amino-2-oxoethyl)-N-methyl-3-phenylpropanamide	Investigative	56834761	C27H37N5O5	511.6	CC1=CC(=CC(=C1C[C@@H](C(=O)N(C)[C@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N(C)CC(=O)N)N)C)O	Ki > 1000000 nM	Non binder
T60693	Opioid receptor kappa	BS8IP9	(1R,9R,10S,12R)-10-Hydroxy-4-methoxy-17-methyl-12-(2-oxo-2-pyrrolidin-1-ylethyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one	Investigative	90256146	C24H32N2O4	412.5	CN1CC[C@]23CC(=O)[C@H](C[C@]2([C@H]1CC4=C3C=C(C=C4)OC)O)CC(=O)N5CCCC5	EC50 > 200000 nM	Non binder
T60693	Opioid receptor kappa	BUO4M6	(2S)-2-Amino-N-[(2R)-1-[[(4S)-2-(2-amino-2-oxoethyl)-3-oxo-4,5-dihydro-1H-2-benzazepin-4-yl]amino]-1-oxopropan-2-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide	Investigative	54757387	C26H33N5O5	495.6	CC1=CC(=CC(=C1C[C@@H](C(=O)N[C@H](C)C(=O)N[C@H]2CC3=CC=CC=C3CN(C2=O)CC(=O)N)N)C)O	Ki > 1000000 nM	Non binder
T60693	Opioid receptor kappa	BV4E8Y	(1R,9R,10S,12R)-10-Hydroxy-4-methoxy-17-methyl-12-(2-morpholin-4-yl-2-oxoethyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one	Investigative	90255665	C24H32N2O5	428.5	CN1CC[C@]23CC(=O)[C@H](C[C@]2([C@H]1CC4=C3C=C(C=C4)OC)O)CC(=O)N5CCOCC5	EC50 > 200000 nM	Non binder
T60693	Opioid receptor kappa	D08LIT	SB-0304	Investigative	11641503	C25H29N5O5	479.5	C[C@H](C(=O)N[C@H]1CC2=CC=CC=C2CN(C1=O)CC(=O)N)N3CC4=C(C[C@@H](C3=O)N)C=CC(=C4)O	Ki > 1000000 nM	Non binder
T60693	Opioid receptor kappa	D0A3YH	H-Tyr-NMe-D-Ala-Phe-Sar-NH2	Investigative	24853671	C25H33N5O5	483.6	C[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N(C)CC(=O)N)N(C)C(=O)[C@H](CC2=CC=C(C=C2)O)N	Ki > 1000000 nM	Non binder