TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T57943	Caspase-3	B01PCK	Methyl 2-(4-methyl-1,3-dioxocyclopenta[c]quinolin-2-yl)acetate	Investigative	76315606	C16H13NO4	283.28	CC1=NC2=CC=CC=C2C3=C1C(=O)C(C3=O)CC(=O)OC	IC50 = 215278173.5 nM	Non binder
T57943	Caspase-3	B0XOY4	N-(2-Hydroxy-1-methylindol-3-yl)imino-2-methyl-6-(3-methylphenyl)pyridine-3-carboxamide	Investigative	137225027	C23H20N4O2	384.4	CC1=CC(=CC=C1)C2=NC(=C(C=C2)C(=O)N=NC3=C(N(C4=CC=CC=C43)C)O)C	IC50 = 310000 nM	Non binder
T57943	Caspase-3	B13FVQ	8-Bromo-4-methyl-2-(1,3,5-trimethylpyrazol-4-yl)cyclopenta[c]quinoline-1,3-dione	Investigative	76315608	C19H16BrN3O2	398.3	CC1=C2C(=O)C(C(=O)C2=C3C=C(C=CC3=N1)Br)C4=C(N(N=C4C)C)C	IC50 = 359749335.2 nM	Non binder
T57943	Caspase-3	B16LRY	2,4-Dimethylcyclopenta[c]quinoline-1,3-dione	Investigative	76312084	C14H11NO2	225.24	CC1C(=O)C2=C(C1=O)C3=CC=CC=C3N=C2C	IC50 = 157398286.5 nM	Non binder
T57943	Caspase-3	B26LNO	(S)-3-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-5-(phenylsulfonyl)pent-4-enoic acid	Investigative	46933021	C26H23NO6S	477.5	C1=CC=C(C=C1)S(=O)(=O)/C=C/[C@H](CC(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24	IC50 = 228000 nM	Non binder
T57943	Caspase-3	B36KRQ	Methyl 3-(8-fluoro-4-methyl-1,3-dioxocyclopenta[c]quinolin-2-yl)propanoate	Investigative	76308407	C17H14FNO4	315.29	CC1=C2C(=O)C(C(=O)C2=C3C=C(C=CC3=N1)F)CCC(=O)OC	IC50 = 181970085.9 nM	Non binder
T57943	Caspase-3	B38OVC	1-Methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dione	Investigative	5288850	C20H20N2O5S	400.4	CN1C2=C(C=C(C=C2)S(=O)(=O)N3CCC[C@H]3COC4=CC=CC=C4)C(=O)C1=O	IC50 = 840000 nM	Non binder
T57943	Caspase-3	B3QZN4	N-(2-Hydroxy-1-methylindol-3-yl)imino-2-methyl-6-(3-nitrophenyl)pyridine-3-carboxamide	Investigative	137225082	C22H17N5O4	415.4	CC1=C(C=CC(=N1)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)N=NC3=C(N(C4=CC=CC=C43)C)O	IC50 = 278200 nM	Non binder
T57943	Caspase-3	B4Q1UD	5-[(2S,4S)-4-Methoxy-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione	Investigative	71698719	C15H18N2O6S	354.4	COC[C@@H]1C[C@@H](CN1S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O)OC	IC50 > 500000 nM	Non binder
T57943	Caspase-3	B4UA9Z	5-[(2S,5R)-2,5-Bis(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-(4-fluorobutyl)indole-2,3-dione	Investigative	71698978	C20H27FN2O6S	442.5	COC[C@H]1CC[C@H](N1S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CCCCF)COC	IC50 > 500000 nM	Non binder
T57943	Caspase-3	B5HI3A	4-Methyl-1,3-dioxo-2-(1,3,5-trimethylpyrazol-4-yl)cyclopenta[c]quinoline-8-sulfonamide	Investigative	76333771	C19H18N4O4S	398.4	CC1=C2C(=O)C(C(=O)C2=C3C=C(C=CC3=N1)S(=O)(=O)N)C4=C(N(N=C4C)C)C	IC50 = 33036954.1 nM	Non binder
T57943	Caspase-3	B5N2FQ	N-(2-Hydroxy-1-methylindol-3-yl)imino-6-(3-methoxyphenyl)-2-methylpyridine-3-carboxamide	Investigative	137225013	C23H20N4O3	400.4	CC1=C(C=CC(=N1)C2=CC(=CC=C2)OC)C(=O)N=NC3=C(N(C4=CC=CC=C43)C)O	IC50 = 547000 nM	Non binder
T57943	Caspase-3	B5XRT1	N-(2-Hydroxy-1-methylindol-3-yl)imino-2-methyl-6-(4-nitrophenyl)pyridine-3-carboxamide	Investigative	137225081	C22H17N5O4	415.4	CC1=C(C=CC(=N1)C2=CC=C(C=C2)[N+](=O)[O-])C(=O)N=NC3=C(N(C4=CC=CC=C43)C)O	IC50 = 202400 nM	Non binder
T57943	Caspase-3	B61FGN	8-Bromo-4-methylcyclopenta[c]quinoline-1,3-dione	Investigative	76330152	C13H8BrNO2	290.11	CC1=C2C(=O)CC(=O)C2=C3C=C(C=CC3=N1)Br	IC50 = 26977394.32 nM	Non binder
T57943	Caspase-3	B6P3VT	N-(2-Hydroxy-1-methylindol-3-yl)imino-2-methyl-6-phenylpyridine-3-carboxamide	Investigative	137225080	C22H18N4O2	370.4	CC1=C(C=CC(=N1)C2=CC=CC=C2)C(=O)N=NC3=C(N(C4=CC=CC=C43)C)O	IC50 = 456100 nM	Non binder
T57943	Caspase-3	B7T8AK	4-Methyl-8-[2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl-2-(1,3,5-trimethylpyrazol-4-yl)cyclopenta[c]quinoline-1,3-dione	Investigative	76326505	C30H30N4O5S	558.6	CC1=C2C(=O)C(C(=O)C2=C3C=C(C=CC3=N1)S(=O)(=O)N4CCCC4COC5=CC=CC=C5)C6=C(N(N=C6C)C)C	IC50 = 54954087.39 nM	Non binder
T57943	Caspase-3	B8A9TN	Chembl4129140	Investigative	46830074	C20H16BrCl2NO3	469.2	CC(=O)C1=C(C(=O)N(C1C2=CC=C(C=C2)Br)CCC3=CC(=C(C=C3)Cl)Cl)O	IC50 > 200000 nM	Non binder
T57943	Caspase-3	B8XBO9	5-[(2R,5S)-2,5-Bis(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione	Investigative	71698716	C16H20N2O6S	368.4	COC[C@H]1CC[C@H](N1S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O)COC	IC50 > 500000 nM	Non binder
T57943	Caspase-3	B94HQN	8-Bromo-2,4-dimethylcyclopenta[c]quinoline-1,3-dione	Investigative	76326506	C14H10BrNO2	304.14	CC1C(=O)C2=C(N=C3C=CC(=CC3=C2C1=O)Br)C	IC50 = 632411851.4 nM	Non binder
T57943	Caspase-3	B9KCM3	Methyl 3-(8-bromo-4-methyl-1,3-dioxocyclopenta[c]quinolin-2-yl)propanoate	Investigative	76326490	C17H14BrNO4	376.2	CC1=C2C(=O)C(C(=O)C2=C3C=C(C=CC3=N1)Br)CCC(=O)OC	IC50 = 926829823.4 nM	Non binder
T57943	Caspase-3	B9XAK1	(S)-3-((S)-2-(Benzyloxycarbonylamino)propanamido)-5-(phenylsulfonyl)pent-4-enoic acid	Investigative	46933318	C22H24N2O7S	460.5	C[C@@H](C(=O)N[C@@H](CC(=O)O)/C=C/S(=O)(=O)C1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2	IC50 = 343000 nM	Non binder
T57943	Caspase-3	BA4IG6	2,4-Dimethyl-8-morpholin-4-ylsulfonylcyclopenta[c]quinoline-1,3-dione	Investigative	76308427	C18H18N2O5S	374.4	CC1C(=O)C2=C(N=C3C=CC(=CC3=C2C1=O)S(=O)(=O)N4CCOCC4)C	IC50 = 43954161.54 nM	Non binder
T57943	Caspase-3	BAFT60	(2E)-3-[(4-Methoxyphenyl)amino]-2-[4-(6-nitro-2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile	Investigative	2856462	C22H14N4O5S	446.4	COC1=CC=C(C=C1)N/C=C(\\C#N)/C2=NC(=CS2)C3=CC4=C(C=CC(=C4)[N+](=O)[O-])OC3=O	IC50 > 1000000 nM	Non binder
T57943	Caspase-3	BAUE15	6-(3,4-Dimethoxyphenyl)-N-(2-hydroxy-1-methylindol-3-yl)imino-2-methylpyridine-3-carboxamide	Investigative	137225015	C24H22N4O4	430.5	CC1=C(C=CC(=N1)C2=CC(=C(C=C2)OC)OC)C(=O)N=NC3=C(N(C4=CC=CC=C43)C)O	IC50 = 598600 nM	Non binder
T57943	Caspase-3	BB30AO	2-Hydroxy-5-methylsulfamoyl-benzoic acid	Investigative	14490061	C8H9NO5S	231.23	CNS(=O)(=O)C1=CC(=C(C=C1)O)C(=O)O	Ki > 1000000 nM	Non binder
T57943	Caspase-3	BBC37U	N-(2-Hydroxy-1-methylindol-3-yl)imino-6-(2-methoxyphenyl)-2-methylpyridine-3-carboxamide	Investigative	137225014	C23H20N4O3	400.4	CC1=C(C=CC(=N1)C2=CC=CC=C2OC)C(=O)N=NC3=C(N(C4=CC=CC=C43)C)O	IC50 = 551500 nM	Non binder
T57943	Caspase-3	BBM94F	(S)-3-(Benzyloxycarbonylamino)-5-(phenylsulfonyl)pent-4-enoic acid	Investigative	46933019	C19H19NO6S	389.4	C1=CC=C(C=C1)COC(=O)N[C@@H](CC(=O)O)/C=C/S(=O)(=O)C2=CC=CC=C2	IC50 = 453000 nM	Non binder
T57943	Caspase-3	BG7R2X	5-[(2S,5S)-2,5-Bis(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione	Investigative	71698717	C16H20N2O6S	368.4	COC[C@@H]1CC[C@H](N1S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O)COC	IC50 > 500000 nM	Non binder
T57943	Caspase-3	BG86EI	(S)-3-((S)-2-(Benzyloxycarbonylamino)-3-methylbutanamido)-5-(phenylsulfonyl)pent-4-enoic acid	Investigative	46933459	C24H28N2O7S	488.6	CC(C)[C@@H](C(=O)N[C@@H](CC(=O)O)/C=C/S(=O)(=O)C1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2	IC50 = 387900 nM	Non binder
T57943	Caspase-3	BG8T9L	4-Methyl-2-(2-methylphenyl)cyclopenta[c]quinoline-1,3-dione	Investigative	76308408	C20H15NO2	301.3	CC1=CC=CC=C1C2C(=O)C3=C(C2=O)C4=CC=CC=C4N=C3C	IC50 = 123310483.3 nM	Non binder
T57943	Caspase-3	BGPH84	5-[(2S,4R)-4-Methoxy-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione	Investigative	71698718	C15H18N2O6S	354.4	COC[C@@H]1C[C@H](CN1S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O)OC	IC50 > 500000 nM	Non binder
T57943	Caspase-3	BH0Z5J	4-Methyl-1,3-dioxo-2-(1,3,5-trimethylpyrazol-4-yl)cyclopenta[c]quinoline-8-carbonitrile	Investigative	76333784	C20H16N4O2	344.4	CC1=C2C(=O)C(C(=O)C2=C3C=C(C=CC3=N1)C#N)C4=C(N(N=C4C)C)C	IC50 = 15995580.29 nM	Non binder
T57943	Caspase-3	BIL7V2	4-Methyl-8-morpholin-4-ylsulfonyl-2-(1,3,5-trimethylpyrazol-4-yl)cyclopenta[c]quinoline-1,3-dione	Investigative	76322948	C23H24N4O5S	468.5	CC1=C2C(=O)C(C(=O)C2=C3C=C(C=CC3=N1)S(=O)(=O)N4CCOCC4)C5=C(N(N=C5C)C)C	IC50 = 3999447.5 nM	Non binder
T57943	Caspase-3	BISM19	5-[(2S,4R)-2-(Methoxymethyl)-4-(trifluoromethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione	Investigative	71698803	C15H15F3N2O5S	392.4	COC[C@@H]1C[C@H](CN1S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O)C(F)(F)F	IC50 > 500000 nM	Non binder
T57943	Caspase-3	BK5SJ6	7-Chloro-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione	Investigative	118723326	C14H15ClN2O5S	358.8	COC[C@@H]1CCCN1S(=O)(=O)C2=CC3=C(C(=C2)Cl)NC(=O)C3=O	IC50 = 500000 nM	Non binder
T57943	Caspase-3	BKX43R	2-(2,3-Dihydro-1,4-benzodioxin-2-YL)-1,3-thiazole-4-carboxylic acid	Investigative	2821593	C12H9NO4S	263.27	C1C(OC2=CC=CC=C2O1)C3=NC(=CS3)C(=O)O	IC50 > 200000 nM	Non binder
T57943	Caspase-3	BLA1Y0	N-(2-Hydroxyethyl)-4-methyl-1,3-dioxo-2-(1,3,5-trimethylpyrazol-4-yl)cyclopenta[c]quinoline-8-sulfonamide	Investigative	76319293	C21H22N4O5S	442.5	CC1=C2C(=O)C(C(=O)C2=C3C=C(C=CC3=N1)S(=O)(=O)NCCO)C4=C(N(N=C4C)C)C	IC50 = 19998618.7 nM	Non binder
T57943	Caspase-3	BLGA14	(4S)-4,8-Dihydroxy-3,4-dihydro-2H-naphthalen-1-one	Investigative	13369486	C10H10O3	178.18	C1CC(=O)C2=C([C@H]1O)C=CC=C2O	Ki = 732120 nM	Non binder
T57943	Caspase-3	BM5DK4	5-[(2S,4S)-4-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione	Investigative	73347421	C22H32N2O10S	516.6	COC[C@@H]1C[C@@H](CN1S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O)OCCOCCOCCOCCO	IC50 > 500000 nM	Non binder
T57943	Caspase-3	BMN95C	Ethyl (2R,3R)-3-[[(1-acetylpyrrolidine-2-carbonyl)amino]-(2-amino-2-oxoethyl)carbamoyl]oxirane-2-carboxylate	Investigative	127053771	C15H22N4O7	370.36	CCOC(=O)[C@H]1[C@@H](O1)C(=O)N(CC(=O)N)NC(=O)C2CCCN2C(=O)C	IC50 = 890000 nM	Non binder
T57943	Caspase-3	BN02SK	N-(2-Hydroxy-1-methylindol-3-yl)imino-2-methyl-6-(2-methylphenyl)pyridine-3-carboxamide	Investigative	137225052	C23H20N4O2	384.4	CC1=CC=CC=C1C2=NC(=C(C=C2)C(=O)N=NC3=C(N(C4=CC=CC=C43)C)O)C	IC50 = 350600 nM	Non binder
T57943	Caspase-3	BN3A8L	Methyl 2-(8-fluoro-4-methyl-1,3-dioxocyclopenta[c]quinolin-2-yl)acetate	Investigative	76330132	C16H12FNO4	301.27	CC1=C2C(=O)C(C(=O)C2=C3C=C(C=CC3=N1)F)CC(=O)OC	IC50 = 399944749.8 nM	Non binder
T57943	Caspase-3	BN5PS9	Methyl 3-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxocyclopenta[c]quinolin-2-yl)propanoate	Investigative	76322928	C21H22N2O7S	446.5	CC1=C2C(=O)C(C(=O)C2=C3C=C(C=CC3=N1)S(=O)(=O)N4CCOCC4)CCC(=O)OC	IC50 = 36982817.98 nM	Non binder
T57943	Caspase-3	BN76PC	Methyl 2-(8-bromo-4-methyl-1,3-dioxocyclopenta[c]quinolin-2-yl)acetate	Investigative	76333770	C16H12BrNO4	362.17	CC1=C2C(=O)C(C(=O)C2=C3C=C(C=CC3=N1)Br)CC(=O)OC	IC50 = 460256573.6 nM	Non binder
T57943	Caspase-3	BO36HM	8-Bromo-4-methyl-2-(2-methylphenyl)cyclopenta[c]quinoline-1,3-dione	Investigative	76330134	C20H14BrNO2	380.2	CC1=CC=CC=C1C2C(=O)C3=C(N=C4C=CC(=CC4=C3C2=O)Br)C	IC50 = 393550075.5 nM	Non binder
T57943	Caspase-3	BO3K2C	1-Benzyl-3,7-dimethyl-8-sulfanylidene-9H-purine-2,6-dione	Investigative	3708081	C14H14N4O2S	302.35	CN1C2=C(NC1=S)N(C(=O)N(C2=O)CC3=CC=CC=C3)C	IC50 > 200000 nM	Non binder
T57943	Caspase-3	BOE8F7	Methyl 3-(4-methyl-1,3-dioxocyclopenta[c]quinolin-2-yl)propanoate	Investigative	76330133	C17H15NO4	297.3	CC1=NC2=CC=CC=C2C3=C1C(=O)C(C3=O)CCC(=O)OC	IC50 = 42953642.68 nM	Non binder
T57943	Caspase-3	BP48MJ	N-(2-Hydroxy-1-methylindol-3-yl)imino-6-(4-methoxyphenyl)-2-methylpyridine-3-carboxamide	Investigative	137225012	C23H20N4O3	400.4	CC1=C(C=CC(=N1)C2=CC=C(C=C2)OC)C(=O)N=NC3=C(N(C4=CC=CC=C43)C)O	IC50 = 487200 nM	Non binder
T57943	Caspase-3	BP6WT3	(S)-3-(Benzyloxycarbonylamino)-5-(methylsulfonyl)pent-4-enoic acid	Investigative	46933020	C14H17NO6S	327.35	CS(=O)(=O)/C=C/[C@H](CC(=O)O)NC(=O)OCC1=CC=CC=C1	IC50 = 434600 nM	Non binder
T57943	Caspase-3	BQDY01	7-Fluoro-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione	Investigative	118723329	C14H15FN2O5S	342.34	COC[C@@H]1CCCN1S(=O)(=O)C2=CC3=C(C(=C2)F)NC(=O)C3=O	IC50 = 500000 nM	Non binder
T57943	Caspase-3	BQP5Z4	(S)-3-((S)-2-(Benzyloxycarbonylamino)propanamido)-5-(methylsulfonyl)pent-4-enoic acid	Investigative	52943262	C17H22N2O7S	398.4	C[C@@H](C(=O)N[C@@H](CC(=O)O)/C=C/S(=O)(=O)C)NC(=O)OCC1=CC=CC=C1	IC50 = 655800 nM	Non binder
T57943	Caspase-3	BRZG05	Methyl 2-[[4-methyl-1,3-dioxo-2-(1,3,5-trimethylpyrazol-4-yl)cyclopenta[c]quinolin-8-yl]sulfonylamino]-3-phenylpropanoate	Investigative	76326504	C29H28N4O6S	560.6	CC1=C2C(=O)C(C(=O)C2=C3C=C(C=CC3=N1)S(=O)(=O)NC(CC4=CC=CC=C4)C(=O)OC)C5=C(N(N=C5C)C)C	IC50 = 23014418.17 nM	Non binder
T57943	Caspase-3	BS53KT	(3S)-4-Oxo-3-(pyridin-4-ylformamido)butanoic acid	Investigative	23645258	C10H10N2O4	222.2	C1=CN=CC=C1C(=O)N[C@@H](CC(=O)O)C=O	IC50 > 200000 nM	Non binder
T57943	Caspase-3	BS9E0W	N-(2-Hydroxy-1-methylindol-3-yl)imino-2-methyl-6-(2-nitrophenyl)pyridine-3-carboxamide	Investigative	137225083	C22H17N5O4	415.4	CC1=C(C=CC(=N1)C2=CC=CC=C2[N+](=O)[O-])C(=O)N=NC3=C(N(C4=CC=CC=C43)C)O	IC50 = 296500 nM	Non binder
T57943	Caspase-3	BSUF75	N-(2-Methoxyethyl)-4-methyl-1,3-dioxo-2-(1,3,5-trimethylpyrazol-4-yl)cyclopenta[c]quinoline-8-sulfonamide	Investigative	76315609	C22H24N4O5S	456.5	CC1=C2C(=O)C(C(=O)C2=C3C=C(C=CC3=N1)S(=O)(=O)NCCOC)C4=C(N(N=C4C)C)C	IC50 = 20989398.84 nM	Non binder
T57943	Caspase-3	BT6K4U	N-(2-Hydroxy-1-methylindol-3-yl)imino-2-methyl-6-(4-methylphenyl)pyridine-3-carboxamide	Investigative	137225016	C23H20N4O2	384.4	CC1=CC=C(C=C1)C2=NC(=C(C=C2)C(=O)N=NC3=C(N(C4=CC=CC=C43)C)O)C	IC50 = 375300 nM	Non binder
T57943	Caspase-3	BTG42I	5-[(2R,5S)-2,5-Bis(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-butylindole-2,3-dione	Investigative	71698976	C20H28N2O6S	424.5	CCCCN1C2=C(C=C(C=C2)S(=O)(=O)N3[C@H](CC[C@H]3COC)COC)C(=O)C1=O	IC50 > 500000 nM	Non binder
T57943	Caspase-3	BTO3J2	7-Bromo-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione	Investigative	118723318	C14H15BrN2O5S	403.25	COC[C@@H]1CCCN1S(=O)(=O)C2=CC3=C(C(=C2)Br)NC(=O)C3=O	IC50 = 500000 nM	Non binder
T57943	Caspase-3	BU80DS	5-[(2S,4R)-4-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione	Investigative	73354985	C22H32N2O10S	516.6	COC[C@@H]1C[C@H](CN1S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O)OCCOCCOCCOCCO	IC50 > 500000 nM	Non binder
T57943	Caspase-3	BUY3N7	1-Ethyl-8-mercapto-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione	Investigative	45496892	C9H12N4O2S	240.28	CCN1C(=O)C2=C(NC(=S)N2C)N(C1=O)C	IC50 > 200000 nM	Non binder
T57943	Caspase-3	BV13BP	N-(2-Hydroxy-1-methylindol-3-yl)imino-2-methyl-6-(3,4,5-trimethoxyphenyl)pyridine-3-carboxamide	Investigative	137225026	C25H24N4O5	460.5	CC1=C(C=CC(=N1)C2=CC(=C(C(=C2)OC)OC)OC)C(=O)N=NC3=C(N(C4=CC=CC=C43)C)O	IC50 = 674300 nM	Non binder
T57943	Caspase-3	BV6C9Z	8-Fluoro-4-methylcyclopenta[c]quinoline-1,3-dione	Investigative	76333785	C13H8FNO2	229.21	CC1=C2C(=O)CC(=O)C2=C3C=C(C=CC3=N1)F	IC50 = 15922087.27 nM	Non binder
T57943	Caspase-3	BWK9Q1	Methyl 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxocyclopenta[c]quinolin-2-yl)acetate	Investigative	76319292	C20H20N2O7S	432.4	CC1=C2C(=O)C(C(=O)C2=C3C=C(C=CC3=N1)S(=O)(=O)N4CCOCC4)CC(=O)OC	IC50 = 15995580.29 nM	Non binder
T57943	Caspase-3	BWN3C1	4-Methyl-8-morpholin-4-ylsulfonylcyclopenta[c]quinoline-1,3-dione	Investigative	76333786	C17H16N2O5S	360.4	CC1=C2C(=O)CC(=O)C2=C3C=C(C=CC3=N1)S(=O)(=O)N4CCOCC4	IC50 = 209893988.4 nM	Non binder
T57943	Caspase-3	BXPQ21	1-Butyl-5-[(2S,4S)-4-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione	Investigative	73353489	C26H40N2O10S	572.7	CCCCN1C2=C(C=C(C=C2)S(=O)(=O)N3C[C@H](C[C@H]3COC)OCCOCCOCCOCCO)C(=O)C1=O	IC50 > 500000 nM	Non binder
T57943	Caspase-3	BXRI91	4-Methyl-2-(2-methylphenyl)-8-morpholin-4-ylsulfonylcyclopenta[c]quinoline-1,3-dione	Investigative	76315607	C24H22N2O5S	450.5	CC1=CC=CC=C1C2C(=O)C3=C(N=C4C=CC(=CC4=C3C2=O)S(=O)(=O)N5CCOCC5)C	IC50 = 14996848.36 nM	Non binder
T57943	Caspase-3	BYE6C7	7-Iodo-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione	Investigative	118723310	C14H15IN2O5S	450.25	COC[C@@H]1CCCN1S(=O)(=O)C2=CC3=C(C(=C2)I)NC(=O)C3=O	IC50 = 500000 nM	Non binder