TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T56367	Phosphodiesterase 1	D03VPC	Cilostazol	Approved	2754	C20H27N5O2	369.5	C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	D0E0SW	Enoximone	Approved	53708	C12H12N2O2S	248.3	CC1=C(NC(=O)N1)C(=O)C2=CC=C(C=C2)SC	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	D0R6TI	Inamrinone Lactate	Approved	3698	C10H9N3O	187.2	C1=CN=CC=C1C2=CNC(=O)C(=C2)N	IC50 > 300000 nM	Non binder
T56367	Phosphodiesterase 1	D0DF2M	PMID28870136-Compound-48	Patented	2153	C7H8N4O2	180.16	CN1C2=C(C(=O)N(C1=O)C)NC=N2	IC50 = 320000 nM	Non binder
T56367	Phosphodiesterase 1	D07FHZ	Ro 20-1724	Terminated	5087	C15H22N2O3	278.35	CCCCOC1=C(C=CC(=C1)CC2CNC(=O)N2)OC	IC50 = 250000 nM	Non binder
T56367	Phosphodiesterase 1	B06ZML	4-Acetyl-1-methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)-isoquinolinone	Investigative	129517	C17H18N2O2	282.34	CC1=C2CC(CCC2=C(C(=O)N1)C(=O)C)C3=CC=NC=C3	IC50 = 409000 nM	Non binder
T56367	Phosphodiesterase 1	B0GE4Y	4,5-Dihydro-6-[4-(4-hydroxymethyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone	Investigative	14099426	C14H14N4O2	270.29	C1CC(=O)NN=C1C2=CC=C(C=C2)N3C=C(N=C3)CO	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	B15ULR	6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one	Investigative	14099444	C13H12N4O	240.26	C1CC(=O)NN=C1C2=CC(=CC=C2)N3C=CN=C3	IC50 = 930000 nM	Non binder
T56367	Phosphodiesterase 1	B1ANS6	Sulmazole	Investigative	5353	C14H13N3O2S	287.34	COC1=C(C=CC(=C1)S(=O)C)C2=NC3=C(N2)C=CC=N3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	B4B5KL	3-Cyclopentyloxy-4-methoxy-N-(2-nitrophenyl)benzamide	Investigative	10089597	C19H20N2O5	356.4	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2[N+](=O)[O-])OC3CCCC3	IC50 = 400000 nM	Non binder
T56367	Phosphodiesterase 1	B4CD2Z	3-(Cyclopentyloxy)-N-(2-fluorophenyl)-4-methoxybenzamide	Investigative	10087963	C19H20FNO3	329.4	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2F)OC3CCCC3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	B4Q7RS	Benzamide,n-(2-chlorophenyl)-3-(cyclopentyloxy)-4-methoxy-	Investigative	10450290	C19H20ClNO3	345.8	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2Cl)OC3CCCC3	IC50 > 200000 nM	Non binder
T56367	Phosphodiesterase 1	B5W8PZ	3-Cyclopentyloxy-N-(2,5-dichloro-phenyl)-4-methoxy-benzamide	Investigative	10091146	C19H19Cl2NO3	380.3	COC1=C(C=C(C=C1)C(=O)NC2=C(C=CC(=C2)Cl)Cl)OC3CCCC3	IC50 > 200000 nM	Non binder
T56367	Phosphodiesterase 1	B68FGQ	N-(2-Hydroxybutyl)-5-[(2-oxo-3,4-dihydro-1H-quinolin-6-yl)oxy]-N-phenylpentanamide	Investigative	44367386	C24H30N2O4	410.5	CCC(CN(C1=CC=CC=C1)C(=O)CCCCOC2=CC3=C(C=C2)NC(=O)CC3)O	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	B8F0HW	4,5-Dihydro-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone	Investigative	13233889	C14H14N4O	254.29	CC1=NC=CN1C2=CC=C(C=C2)C3=NNC(=O)CC3	IC50 = 530000 nM	Non binder
T56367	Phosphodiesterase 1	B8Y4LK	3(2H)-Pyridazinone, 5-ethyl-4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-	Investigative	13233885	C15H16N4O	268.31	CCC1CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	B9DQS1	3-(Cyclopentyloxy)-N-(2,6-dichlorophenyl)-4-methoxybenzamide	Investigative	10249183	C19H19Cl2NO3	380.3	COC1=C(C=C(C=C1)C(=O)NC2=C(C=CC=C2Cl)Cl)OC3CCCC3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	B9XEJ4	6-(4-(1H-Imidazol-1-yl)phenyl)-5-methylpyridazin-3(2H)-one	Investigative	14099446	C14H12N4O	252.27	CC1=CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3	IC50 = 660000 nM	Non binder
T56367	Phosphodiesterase 1	BC9ML7	3-Cyclopentyloxy-N-(2,6-dibromo-phenyl)-4-methoxy-benzamide	Investigative	10434818	C19H19Br2NO3	469.2	COC1=C(C=C(C=C1)C(=O)NC2=C(C=CC=C2Br)Br)OC3CCCC3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	BCO56F	N-(6-Methyl-8-propyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)acetamide	Investigative	205981	C11H15N5O	233.27	CCCC1=NC(=CN2C1=NN=C2NC(=O)C)C	Ki = 717000 nM	Non binder
T56367	Phosphodiesterase 1	BE8J5Y	N-(2-Chloro-6-methyl-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide	Investigative	10067044	C20H22ClNO3	359.8	CC1=C(C(=CC=C1)Cl)NC(=O)C2=CC(=C(C=C2)OC)OC3CCCC3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	BF4YQ2	N-(4-Chloro-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide	Investigative	10043209	C19H20ClNO3	345.8	COC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)Cl)OC3CCCC3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	BF51SU	3-(Cyclopentyloxy)-N-(2,6-difluorophenyl)-4-methoxybenzamide	Investigative	9798336	C19H19F2NO3	347.4	COC1=C(C=C(C=C1)C(=O)NC2=C(C=CC=C2F)F)OC3CCCC3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	BFAK10	6-(4-Imidazol-1-yl-phenyl)-2-methyl-4,5-dihydro-2H-pyridazin-3-one	Investigative	13233881	C14H14N4O	254.29	CN1C(=O)CCC(=N1)C2=CC=C(C=C2)N3C=CN=C3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	BG8MJ2	3-Cyclopentyloxy-N-(2-hydroxy-phenyl)-4-methoxy-benzamide	Investigative	10359077	C19H21NO4	327.4	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2O)OC3CCCC3	IC50 > 200000 nM	Non binder
T56367	Phosphodiesterase 1	BI9ZN4	3-Cyclopentyloxy-N-(2,3-dichloro-phenyl)-4-methoxy-benzamide	Investigative	10385088	C19H19Cl2NO3	380.3	COC1=C(C=C(C=C1)C(=O)NC2=C(C(=CC=C2)Cl)Cl)OC3CCCC3	IC50 > 200000 nM	Non binder
T56367	Phosphodiesterase 1	BJI62E	3-Cyclopentyloxy-N-(4-fluoro-phenyl)-4-methoxy-benzamide	Investigative	10404302	C19H20FNO3	329.4	COC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)F)OC3CCCC3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	BM65YG	6-(4-Benzoimidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one	Investigative	14099427	C17H14N4O	290.32	C1CC(=O)NN=C1C2=CC=C(C=C2)N3C=NC4=CC=CC=C43	IC50 = 220000 nM	Non binder
T56367	Phosphodiesterase 1	BN2MO7	6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one	Investigative	13887375	C13H10N4O	238.24	C1=CC(=CC=C1C2=NNC(=O)C=C2)C3=NC=CN3	IC50 = 330000 nM	Non binder
T56367	Phosphodiesterase 1	BO5Q4C	Benzamide,n-(2-bromophenyl)-3-(cyclopentyloxy)-4-methoxy-	Investigative	9977675	C19H20BrNO3	390.3	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2Br)OC3CCCC3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	BOU0X1	3-Cyclopentyloxy-4-methoxy-N-phenyl-benzamide	Investigative	10448177	C19H21NO3	311.4	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2)OC3CCCC3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	BPH9A4	Imazodan	Investigative	55918	C13H12N4O	240.26	C1CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	BQ4CU7	(2R,3S)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol	Investigative	149784	C14H23N5O	277.37	CCCCCC[C@@H]([C@@H](C)O)N1C=NC2=C(N=CN=C21)N	Ki > 200000 nM	Non binder
T56367	Phosphodiesterase 1	BQGB96	3-Cyclopentyloxy-4-methoxy-N-(2-methylsulfanylphenyl)benzamide	Investigative	10338401	C20H23NO3S	357.5	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2SC)OC3CCCC3	IC50 > 200000 nM	Non binder
T56367	Phosphodiesterase 1	BR5D0B	1H-Imidazo(4,5-b)pyridine, 2-(2,4-dimethoxyphenyl)-	Investigative	156890	C14H13N3O2	255.27	COC1=CC(=C(C=C1)C2=NC3=C(N2)C=CC=N3)OC	IC50 = 265000 nM	Non binder
T56367	Phosphodiesterase 1	BSD2W8	4-(4-Imidazol-1-yl-phenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one	Investigative	44279839	C17H18N4O	294.35	C1CCC2C(C1)C(=NNC2=O)C3=CC=C(C=C3)N4C=CN=C4	IC50 = 380000 nM	Non binder
T56367	Phosphodiesterase 1	BSR18M	4-Amino-6-(4-imidazol-1-ylphenyl)-2H-pyridazin-3-one	Investigative	14099449	C13H11N5O	253.26	C1=CC(=CC=C1C2=NNC(=O)C(=C2)N)N3C=CN=C3	IC50 > 500000 nM	Non binder
T56367	Phosphodiesterase 1	BV1YD3	3-Cyclopentyloxy-4-methoxy-N-(2-trifluoromethyl-phenyl)-benzamide	Investigative	10339653	C20H20F3NO3	379.4	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2C(F)(F)F)OC3CCCC3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	BW6ZJ3	N-(2-Chloro-6-fluoro-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide	Investigative	10248176	C19H19ClFNO3	363.8	COC1=C(C=C(C=C1)C(=O)NC2=C(C=CC=C2Cl)F)OC3CCCC3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	BWK5P8	3-Cyclopentyloxy-N-(2,6-dimethyl-phenyl)-4-methoxy-benzamide	Investigative	10472374	C21H25NO3	339.4	CC1=C(C(=CC=C1)C)NC(=O)C2=CC(=C(C=C2)OC)OC3CCCC3	IC50 = 250000 nM	Non binder
T56367	Phosphodiesterase 1	BXS7T4	3-Cyclopentyloxy-4-methoxy-N-o-tolyl-benzamide	Investigative	10449000	C20H23NO3	325.4	CC1=CC=CC=C1NC(=O)C2=CC(=C(C=C2)OC)OC3CCCC3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	BY06RU	3-Cyclopentyloxy-4-methoxy-N-p-tolyl-benzamide	Investigative	9973597	C20H23NO3	325.4	CC1=CC=C(C=C1)NC(=O)C2=CC(=C(C=C2)OC)OC3CCCC3	IC50 > 200000 nM	Non binder
T56367	Phosphodiesterase 1	BY74RZ	6-(4-Imidazol-1-yl-phenyl)-4-methyl-4,5-dihydro-2H-pyridazin-3-one	Investigative	13233882	C14H14N4O	254.29	CC1CC(=NNC1=O)C2=CC=C(C=C2)N3C=CN=C3	IC50 > 1000000 nM	Non binder
T56367	Phosphodiesterase 1	BYW6B1	6-(4-Imidazol-1-yl-phenyl)-2H-pyridazin-3-one	Investigative	13059432	C13H10N4O	238.24	C1=CC(=CC=C1C2=NNC(=O)C=C2)N3C=CN=C3	IC50 = 580000 nM	Non binder