TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T55956	Metabotropic glutamate receptor 6	D00ENY	L-Glutamic Acid	Approved	33032	C5H9NO4	147.13	C(CC(=O)O)[C@@H](C(=O)O)N	EC50 = 270000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	B2RYP6	2-Aminooctanedioic acid	Investigative	77937	C8H15NO4	189.21	C(CCC(C(=O)O)N)CCC(=O)O	EC50 > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	B3HQT6	(2S)-2-Amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-4-yl)-2-methylpropanoic acid	Investigative	44322745	C6H9N3O5	203.15	C[C@](CN1C(=O)NOC1=O)(C(=O)O)N	Ki > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	B3O1FQ	(RS)-Apica	Investigative	4694355	C10H12NO5P	257.18	C1CC(C2=C1C=C(C=C2)P(=O)(O)O)(C(=O)O)N	Ki > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	B7FBR0	Kainic acid	Investigative	10255	C10H15NO4	213.23	CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O	EC50 = 299000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	B7GRY1	(2S,3S)-3-(Carboxymethyl)azetidine-2-carboxylic acid	Investigative	2733519	C6H9NO4	159.14	C1[C@@H]([C@H](N1)C(=O)O)CC(=O)O	IC50 > 300000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	B96LOR	D-2-Aminoadipic acid	Investigative	165627	C6H11NO4	161.16	C(C[C@H](C(=O)O)N)CC(=O)O	EC50 > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	BC96JQ	(2R,4R)-1,4-Diamino-pyrrolidine-2,4-dicarboxylic acid	Investigative	10330132	C6H11N3O4	189.17	C1[C@@H](N(C[C@]1(C(=O)O)N)N)C(=O)O	Ki > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	BFLU56	(R)-Ampa	Investigative	6604707	C7H10N2O4	186.17	CC1=C(C(=O)NO1)C[C@H](C(=O)O)N	EC50 > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	BH41XD	2-Aminoheptanedioic acid	Investigative	101122	C7H13NO4	175.18	C(CCC(=O)O)CC(C(=O)O)N	EC50 > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	BIGT98	(1R,2S,4R,5R)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid	Investigative	10775369	C8H11NO4	185.18	C1[C@@H]2C[C@]([C@H]1[C@@H]2C(=O)O)(C(=O)O)N	EC50 = 800000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	BJNB38	(1S,2S,4S,5R)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid	Investigative	10560963	C8H11NO4	185.18	C1[C@H]2C[C@]([C@@H]1[C@@H]2C(=O)O)(C(=O)O)N	EC50 > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	BK1E2B	alpha-Amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid	Investigative	173564	C6H8N2O4	172.14	CC1=C(C(=O)NO1)C(C(=O)O)N	EC50 > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	BP9I2D	(1R,2S,4R,5S)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid	Investigative	10465017	C8H11NO4	185.18	C1[C@@H]2C[C@]([C@H]1[C@H]2C(=O)O)(C(=O)O)N	EC50 > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	BQIC40	2-Amino-2,3-methano-4-phosphonobutanoic acid	Investigative	125799	C5H10NO5P	195.11	C1[C@H]([C@]1(C(=O)O)N)CP(=O)(O)O	EC50 > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	BWC90O	2-Amino-bicyclo[3.2.0]heptane-2,7-dicarboxylic acid	Investigative	44322843	C9H13NO4	199.2	C1C[C@](C2C1C[C@@H]2C(=O)O)(C(=O)O)N	Ki > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	BXIR36	2-Amino-6-(3-hydroxy-5-methylisoxazol-4-yl)hexanoic acid	Investigative	10609381	C10H16N2O4	228.24	CC1=C(C(=O)NO1)CCCCC(C(=O)O)N	EC50 > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	BZ67QI	2-Amino-5-(3-hydroxy-5-methyl-isoxazol-4-yl)-pentanoic acid	Investigative	44338561	C9H14N2O4	214.22	CC1=C(C(=O)NO1)CCCC(C(=O)O)N	EC50 = 410000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	D06DUE	[3H]quisqualate	Investigative	40539	C5H7N3O5	189.13	C([C@@H](C(=O)O)N)N1C(=O)NC(=O)O1	Ki = 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	D08CAB	D-aspartic acid	Investigative	83887	C4H7NO4	133.1	C([C@H](C(=O)O)N)C(=O)O	EC50 > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	D0O1AK	D-glutamic acid	Investigative	23327	C5H9NO4	147.13	C(CC(=O)O)[C@H](C(=O)O)N	EC50 > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	D0OT9B	L-aspartic acid	Investigative	5960	C4H7NO4	133.1	C([C@@H](C(=O)O)N)C(=O)O	EC50 > 1000000 nM	Non binder
T55956	Metabotropic glutamate receptor 6	D0T5SU	(S)-AMPA	Investigative	158397	C7H10N2O4	186.17	CC1=C(C(=O)NO1)C[C@@H](C(=O)O)N	EC50 = 220000 nM	Non binder