TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T40694	Polo-like kinase 1	B09CJR	(R)-3-(1-(2-Chloro-4-((4-fluoropiperidin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide	Investigative	45269431	C26H26ClFN4O2S	513	C[C@H](C1=C(C=C(C=C1)CN2CCC(CC2)F)Cl)OC3=C(SC(=C3)C4=CN=C5N4C=CC=C5)C(=O)N	EC50 = 400000 nM	Non binder
T40694	Polo-like kinase 1	B1O9RE	N-Methyl-2-[5-(4-methylphenyl)-2-oxopyrazin-1-yl]acetamide	Investigative	68178483	C14H15N3O2	257.29	CC1=CC=C(C=C1)C2=CN(C(=O)C=N2)CC(=O)NC	IC50 = 250000 nM	Non binder
T40694	Polo-like kinase 1	B1UKM3	3-((1R)-1-(2-Chloro-4-((3-hydroxypyrrolidin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide	Investigative	45271970	C25H25ClN4O3S	497	C[C@H](C1=C(C=C(C=C1)CN2CCC(C2)O)Cl)OC3=C(SC(=C3)C4=CN=C5N4C=CC=C5)C(=O)N	EC50 = 227000 nM	Non binder
T40694	Polo-like kinase 1	B4G0PO	N~1~-Methyl-2-(6-methyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetamide	Investigative	53016051	C12H14N2O3	234.25	CC1=CC2=C(C=C1)OCC(=O)N2CC(=O)NC	IC50 = 350000 nM	Non binder
T40694	Polo-like kinase 1	B5BFJ9	3-[(1R)-1-[2-Chloro-4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]ethoxy]-5-imidazo[1,2-a]pyridin-3-ylthiophene-2-carboxamide	Investigative	45271975	C25H25ClN4O4S2	545.1	C[C@H](C1=C(C=C(C=C1)CN2CCS(=O)(=O)CC2)Cl)OC3=C(SC(=C3)C4=CN=C5N4C=CC=C5)C(=O)N	EC50 = 400000 nM	Non binder
T40694	Polo-like kinase 1	B5XC8S	(R)-3-(1-(2-Chloro-4-((4-hydroxypiperidin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide	Investigative	45271969	C26H27ClN4O3S	511	C[C@H](C1=C(C=C(C=C1)CN2CCC(CC2)O)Cl)OC3=C(SC(=C3)C4=CN=C5N4C=CC=C5)C(=O)N	EC50 = 390000 nM	Non binder
T40694	Polo-like kinase 1	B63AQB	(R)-3-(1-(2-Chloro-4-((3-oxopiperazin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide	Investigative	45271090	C25H24ClN5O3S	510	C[C@H](C1=C(C=C(C=C1)CN2CCNC(=O)C2)Cl)OC3=C(SC(=C3)C4=CN=C5N4C=CC=C5)C(=O)N	EC50 = 1700000 nM	Non binder
T40694	Polo-like kinase 1	B8E4RQ	(R)-3-(1-(2-Chloro-4-((3-hydroxypropylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide	Investigative	45271168	C24H25ClN4O3S	485	C[C@H](C1=C(C=C(C=C1)CNCCCO)Cl)OC2=C(SC(=C2)C3=CN=C4N3C=CC=C4)C(=O)N	EC50 = 219000 nM	Non binder
T40694	Polo-like kinase 1	BBPS02	5-Methoxy-N-methyl-2,3-dihydro-1,4-benzodioxine-7-carboxamide	Investigative	39969430	C11H13NO4	223.22	CNC(=O)C1=CC2=C(C(=C1)OC)OCCO2	IC50 = 300000 nM	Non binder
T40694	Polo-like kinase 1	BCP72R	N,5-Dimethyl-2-(3-morpholin-4-ylpropyl)-1-phenyl-2H-pyrrol-1-ium-4-carboxamide	Investigative	121493729	C20H28N3O2+	342.5	CC1=[N+](C(C=C1C(=O)NC)CCCN2CCOCC2)C3=CC=CC=C3	IC50 = 550000 nM	Non binder
T40694	Polo-like kinase 1	BEC2B7	N-Methylquinoline-6-carboxamide	Investigative	59810763	C11H10N2O	186.21	CNC(=O)C1=CC2=C(C=C1)N=CC=C2	IC50 = 400000 nM	Non binder
T40694	Polo-like kinase 1	BF91HJ	N-Methyl-2-(6-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetamide	Investigative	68178481	C10H11N3OS2	253.3	CC1=CC2=C(S1)N=CN=C2SCC(=O)NC	IC50 = 475000 nM	Non binder
T40694	Polo-like kinase 1	BG2L8V	1-(Benzenesulfonyl)-N-methylindole-3-carboxamide	Investigative	14943552	C16H14N2O3S	314.4	CNC(=O)C1=CN(C2=CC=CC=C21)S(=O)(=O)C3=CC=CC=C3	IC50 = 375000 nM	Non binder
T40694	Polo-like kinase 1	BGTI78	N,2-Dimethyl-1,5-diphenylpyrrole-3-carboxamide	Investigative	68178482	C19H18N2O	290.4	CC1=C(C=C(N1C2=CC=CC=C2)C3=CC=CC=C3)C(=O)NC	IC50 = 600000 nM	Non binder
T40694	Polo-like kinase 1	BJ57YZ	N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine	Investigative	50908681	C19H16N2O2	304.3	COC1=CC=C(C=C1)CNC2=C3C4=CC=CC=C4OC3=NC=C2	IC50 = 271000 nM	Non binder
T40694	Polo-like kinase 1	BM2E4X	N-Methyl-4-phenyl-5-(trifluoromethyl)thiophene-2-carboxamide	Investigative	121494135	C13H10F3NOS	285.29	CNC(=O)C1=CC(=C(S1)C(F)(F)F)C2=CC=CC=C2	IC50 = 500000 nM	Non binder
T40694	Polo-like kinase 1	BRP50M	(R)-3-(1-(2-Chloro-4-((cyclopropylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide	Investigative	45267772	C24H23ClN4O2S	467	C[C@H](C1=C(C=C(C=C1)CNC2CC2)Cl)OC3=C(SC(=C3)C4=CN=C5N4C=CC=C5)C(=O)N	EC50 = 220000 nM	Non binder
T40694	Polo-like kinase 1	BS78AQ	9-Chloro-2-[2-chloro-5-[3-(dimethylamino)propyl]anilino]-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione	Investigative	56945172	C23H23Cl2N5S	472.4	CN(C)CCCC1=CC(=C(C=C1)Cl)NC2=NC=C3CC(=S)NC4=C(C3=N2)C=CC(=C4)Cl	EC50 = 440000 nM	Non binder
T40694	Polo-like kinase 1	BTF35R	(R)-3-(1-(4-((Tert-butylamino)methyl)-2-fluorophenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide	Investigative	45267711	C25H27FN4O2S	466.6	C[C@H](C1=C(C=C(C=C1)CNC(C)(C)C)F)OC2=C(SC(=C2)C3=CN=C4N3C=CC=C4)C(=O)N	EC50 = 290000 nM	Non binder
T40694	Polo-like kinase 1	BW8JD9	3-Amino-N-methyl-4-phenyl-5-(trifluoromethyl)thiophene-2-carboxamide	Investigative	121494136	C13H11F3N2OS	300.3	CNC(=O)C1=C(C(=C(S1)C(F)(F)F)C2=CC=CC=C2)N	IC50 > 600000 nM	Non binder
T40694	Polo-like kinase 1	BXF7S8	N~1~-Methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)benzamide	Investigative	53015124	C11H11N3O2	217.22	CC1=NC(=NO1)C2=CC=C(C=C2)C(=O)NC	IC50 = 320000 nM	Non binder
T40694	Polo-like kinase 1	BYG16O	Schembl20920285	Investigative	49873221	C26H43N8O11P	674.6	C[C@H]([C@@H](C(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCN2C(=O)C)OP(=O)(O)O	IC50 > 300000 nM	Non binder
T40694	Polo-like kinase 1	BZ2I9N	3-(3-Methoxyphenyl)-N-methyl-1H-pyrazole-5-carboxamide	Investigative	19509877	C12H13N3O2	231.25	CNC(=O)C1=CC(=NN1)C2=CC(=CC=C2)OC	IC50 = 380000 nM	Non binder