TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T39523 Phosphodiesterase 7A D0T5PO ROLIPRAM Phase 2 5092 C16H21NO3 275.34 COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3 IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A D0DF2M PMID28870136-Compound-48 Patented 2153 C7H8N4O2 180.16 CN1C2=C(C(=O)N(C1=O)C)NC=N2 IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A B16QKI Chembl4284046 Investigative 145992787 C16H16ClN5O4 377.78 CN1C2=C(C(=O)N(C1=O)C)N(C(=N2)OC)CC(=O)NC3=CC(=CC=C3)Cl IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A B1M6DQ Chembl4294138 Investigative 145994146 C20H25N5O4 399.4 CCOC1=NC2=C(N1CC(=O)NC3=CC=C(C=C3)C(C)C)C(=O)N(C(=O)N2C)C IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A B43MWN Chembl4276743 Investigative 145982932 C20H25N5O4 399.4 CC(C)(C)C1=CC=C(C=C1)NC(=O)CN2C3=C(N=C2OC)N(C(=O)N(C3=O)C)C IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A B4CMX3 Chembl4290575 Investigative 145988021 C21H27N5O4 413.5 CCOC1=NC2=C(N1CC(=O)NC3=CC=C(C=C3)C(C)(C)C)C(=O)N(C(=O)N2C)C IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A B4D1VJ Chembl4290979 Investigative 145989570 C18H20ClN5O4 405.8 CN1C2=C(C(=O)N(C1=O)C)N(C(=N2)OC)CCCC(=O)NC3=CC=C(C=C3)Cl IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A B54YGB Chembl4216676 Investigative 145974692 C21H26N6O6 458.5 CCOC1=NC2=C(N1CCCC(=O)N/N=C/C3=C(C=C(C=C3)OC)O)C(=O)N(C(=O)N2C)C IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A B5VX6Q Chembl4294370 Investigative 145993704 C21H27N5O4 413.5 CC(C)C1=CC=C(C=C1)NC(=O)CCCN2C3=C(N=C2OC)N(C(=O)N(C3=O)C)C IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A B6XMH3 Chembl4214541 Investigative 145972042 C24H26N8O4 490.5 CN1C2=C(C(=O)N(C1=O)C)N(C(=N2)NCC3=CC=CC=N3)CCCC(=O)N/N=C/C4=CC=CC=C4O IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A B72AOE Chembl4213058 Investigative 145964412 C18H20N6O4 384.4 CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CCCC(=O)N/N=C/C3=CC=CC=C3O IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A BBK7U5 Chembl4280678 Investigative 145981946 C18H20ClN5O4 405.8 CCOC1=NC2=C(N1CC(=O)NCC3=CC=CC=C3Cl)C(=O)N(C(=O)N2C)C IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A BD72GP Chembl4279233 Investigative 145980304 C17H18ClN5O4 391.8 CCOC1=NC2=C(N1CC(=O)NC3=CC(=CC=C3)Cl)C(=O)N(C(=O)N2C)C IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A BEN29A Chembl4207716 Investigative 145975232 C21H26N6O5 442.5 CCOC1=NC2=C(N1CCCC(=O)N/N=C/C3=CC=CC=C3OC)C(=O)N(C(=O)N2C)C IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A BK2EB7 Chembl4290814 Investigative 145987119 C18H20ClN5O4 405.8 CN1C2=C(C(=O)N(C1=O)C)N(C(=N2)OC)CCCC(=O)NC3=CC(=CC=C3)Cl IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A BK6E5V Chembl4280173 Investigative 145978996 C17H18ClN5O4 391.8 CN1C2=C(C(=O)N(C1=O)C)N(C(=N2)OC)CC(=O)NCC3=CC=CC=C3Cl IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A BM2NE9 Chembl4214592 Investigative 145974127 C23H25N7O5 479.5 CN1C2=C(C(=O)N(C1=O)C)N(C(=N2)NCC3=CC=CO3)CCCC(=O)N/N=C/C4=CC=CC=C4O IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A BPZ74F Chembl4218669 Investigative 145967554 C18H20N6O5 400.4 CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CCCC(=O)N/N=C/C3=C(C=C(C=C3)O)O IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A BSQ98G Chembl4283794 Investigative 145992781 C19H22ClN5O4 419.9 CN1C2=C(C(=O)N(C1=O)C)N(C(=N2)OC)CCCC(=O)NCC3=CC=CC=C3Cl IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A BY7X9D Chembl4287403 Investigative 145990687 C19H23N5O4 385.4 CC(C)C1=CC=C(C=C1)NC(=O)CN2C3=C(N=C2OC)N(C(=O)N(C3=O)C)C IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A BZ43WY Chembl4287148 Investigative 145990259 C17H18ClN5O4 391.8 CCOC1=NC2=C(N1CC(=O)NC3=CC=C(C=C3)Cl)C(=O)N(C(=O)N2C)C IC50 > 200000 nM Non binder T39523 Phosphodiesterase 7A D0D6MC HC-030031 Investigative 1150897 C18H21N5O3 355.4 CC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)C IC50 > 200000 nM Non binder