TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T24982 Ileal sodium/bile acid cotransporter B1IT3Y 2-[[(4R)-4-[(2S,18R)-6-(2-Hydroxyethyl)-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4,7-dien-17-yl]pentanoyl]amino]acetic acid Investigative 44392375 C29H45N3O4 499.7 C[C@H](CCC(=O)NCC(=O)O)C1CCC2[C@@]1(CCC3C2CCC4[C@@]3(CC5=CN(N=C5C4)CCO)C)C IC50 > 300000 nM Non binder T24982 Ileal sodium/bile acid cotransporter B40BDA 2-[(4R)-4-[(2S,18R)-6-[(3-{[(2S)-2-(6-Methoxynaphthalen-2-yl)propanoyl]oxy}phenyl)methyl]-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4,7-dien-17-yl]pentanamido]acetic acid Investigative 44392324 C48H59N3O6 774 C[C@H](CCC(=O)NCC(=O)O)C1CCC2[C@@]1(CCC3C2CCC4[C@@]3(CC5=CN(N=C5C4)CC6=CC(=CC=C6)OC(=O)[C@@H](C)C7=CC8=C(C=C7)C=C(C=C8)OC)C)C IC50 > 300000 nM Non binder T24982 Ileal sodium/bile acid cotransporter B7PTQ3 2-[(4R)-4-[(2S,12R,18R)-12-Hydroxy-6-[(3-{[(2S)-2-(6-methoxynaphthalen-2-yl)propanoyl]oxy}phenyl)methyl]-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4,7-dien-17-yl]pentanamido]acetic acid Investigative 44392345 C48H59N3O7 790 C[C@H](CCC(=O)NCC(=O)O)C1CCC2[C@@]1(CCC3C2[C@@H](CC4[C@@]3(CC5=CN(N=C5C4)CC6=CC(=CC=C6)OC(=O)[C@@H](C)C7=CC8=C(C=C7)C=C(C=C8)OC)C)O)C IC50 > 300000 nM Non binder T24982 Ileal sodium/bile acid cotransporter BY9V6W 2-[[(4R)-4-[(2S,12R,18R,19S)-12,19-Dihydroxy-6-[(3-hydroxyphenyl)methyl]-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4,7-dien-17-yl]pentanoyl]amino]acetic acid Investigative 44392323 C34H47N3O6 593.8 C[C@H](CCC(=O)NCC(=O)O)C1CCC2[C@@]1([C@H](CC3C2[C@@H](CC4[C@@]3(CC5=CN(N=C5C4)CC6=CC(=CC=C6)O)C)O)O)C IC50 > 300000 nM Non binder