TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T17345	Dihydrofolate reductase	D0H0KB	Riluzole	Approved	5070	C8H5F3N2OS	234.2	C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N	IC50 = 312000 nM	Non binder
T17345	Dihydrofolate reductase	D0Y7TS	Trimetrexate	Approved	5583	C19H23N5O3	369.4	CC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC	IC50 = 340000 nM	Non binder
T17345	Dihydrofolate reductase	D05AHQ	Epiroprim	Terminated	68916	C19H23N5O2	353.4	CCOC1=CC(=CC(=C1N2C=CC=C2)OCC)CC3=CN=C(N=C3N)N	IC50 = 600000 nM	Non binder
T17345	Dihydrofolate reductase	B03JIX	2,4-Diamino-5-methyl-6-(3''-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine	Investigative	46231412	C14H14N4O2S	302.35	CC1=C(OC2=NC(=NC(=C12)N)N)SC3=CC=CC(=C3)OC	IC50 > 200000 nM	Non binder
T17345	Dihydrofolate reductase	B0U8BO	5-Methyluridine 5'-monophosphate	Investigative	12803287	C10H15N2O9P	338.21	CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O	IC50 = 340000 nM	Non binder
T17345	Dihydrofolate reductase	B2E7HO	5-Methyl-6-(2-methyl-6-propan-2-ylphenyl)sulfanylfuro[2,3-d]pyrimidine-2,4-diamine	Investigative	46231414	C17H20N4OS	328.4	CC1=C(C(=CC=C1)C(C)C)SC2=C(C3=C(N=C(N=C3O2)N)N)C	IC50 > 200000 nM	Non binder
T17345	Dihydrofolate reductase	B7BVP0	2-[[4-[[(2-Amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)-methylamino]methyl]benzoyl]amino]pentanedioic acid	Investigative	135887148	C21H26N6O6	458.5	CN(CC1=CC=C(C=C1)C(=O)NC(CCC(=O)O)C(=O)O)C2CC3=C(NC2)N=C(NC3=O)N	IC50 > 1000000 nM	Non binder
T17345	Dihydrofolate reductase	B8RKU6	2,4-Diamino-5-methyl-6-(2''-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine	Investigative	46231411	C14H14N4O2S	302.35	CC1=C(OC2=NC(=NC(=C12)N)N)SC3=CC=CC=C3OC	IC50 > 200000 nM	Non binder
T17345	Dihydrofolate reductase	BB83OH	(2S)-2-{[4-({2-Amino-5-methyl-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-6-yl}sulfanyl)phenyl]formamido}pentanedioic acid	Investigative	135399760	C19H19N5O6S	445.5	CC1=C(NC2=C1C(=O)NC(=N2)N)SC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O	IC50 > 240000 nM	Non binder
T17345	Dihydrofolate reductase	BC8GT6	2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-phosphono-butyric acid	Investigative	135887106	C19H25N6O7P	480.4	C1C(CNC2=C1C(=O)NC(=N2)N)CNC3=CC=C(C=C3)C(=O)NC(CCP(=O)(O)O)C(=O)O	IC50 = 220000 nM	Non binder
T17345	Dihydrofolate reductase	BCV6T8	6-(2,5-Dimethoxyphenyl)sulfanyl-5-methylfuro[2,3-d]pyrimidine-2,4-diamine	Investigative	46231373	C15H16N4O3S	332.4	CC1=C(OC2=NC(=NC(=C12)N)N)SC3=C(C=CC(=C3)OC)OC	IC50 > 200000 nM	Non binder
T17345	Dihydrofolate reductase	BERJ32	2-[[4-[[(2-Amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)amino]methyl]benzoyl]amino]pentanedioic acid	Investigative	135887147	C20H24N6O6	444.4	C1C(CNC2=C1C(=O)NC(=N2)N)NCC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O	IC50 > 1000000 nM	Non binder
T17345	Dihydrofolate reductase	BH0SA3	3-(2-Chloro-6-fluorophenyl)-N-(2,4-dioxo-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaen-7-yl)-5-methyl-1,2-oxazole-4-carboxamide	Investigative	71520483	C23H12ClFN2O5	450.8	CC1=C(C(=NO1)C2=C(C=CC=C2Cl)F)C(=O)NC3=CC4=C5C(=C3)C=CC=C5C(=O)OC4=O	Ki > 332000 nM	Non binder
T17345	Dihydrofolate reductase	BH38WL	1-Cyclopropyl-7-[4-[(2,4-diaminopyrimidin-5-yl)methoxymethyl]triazol-1-yl]-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid	Investigative	57404325	C20H18FN9O4	467.4	C1CC1N2C=C(C(=O)C3=CC(=C(N=C32)N4C=C(N=N4)COCC5=CN=C(N=C5N)N)F)C(=O)O	IC50 > 250000 nM	Non binder
T17345	Dihydrofolate reductase	BIW23Y	2-Amino-6-(methylsulfonyl)benzothiazole	Investigative	87152	C8H8N2O2S2	228.3	CS(=O)(=O)C1=CC2=C(C=C1)N=C(S2)N	IC50 = 1040000 nM	Non binder
T17345	Dihydrofolate reductase	BJQH82	6-(2,6-Dichlorophenyl)sulfanyl-5-methylfuro[2,3-d]pyrimidine-2,4-diamine	Investigative	46231372	C13H10Cl2N4OS	341.2	CC1=C(OC2=NC(=NC(=C12)N)N)SC3=C(C=CC=C3Cl)Cl	IC50 > 200000 nM	Non binder
T17345	Dihydrofolate reductase	BJY39G	2,4-Diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine	Investigative	46231369	C17H14N4OS	322.4	CC1=C(OC2=NC(=NC(=C12)N)N)SC3=CC=CC4=CC=CC=C43	IC50 > 200000 nM	Non binder
T17345	Dihydrofolate reductase	BM1S3H	6,7-Dimethyl-7H-pyrimido[4,5-b][1,4]oxazine-2,4-diamine	Investigative	12517703	C8H11N5O	193.21	CC1C(=NC2=C(N=C(N=C2O1)N)N)C	IC50 = 903000 nM	Non binder
T17345	Dihydrofolate reductase	BM6G2Q	1-Cyclopropyl-6-fluoro-4-oxo-7-(4-prop-2-ynylpiperazin-1-yl)-1,8-naphthyridine-3-carboxylic acid	Investigative	70687448	C19H19FN4O3	370.4	C#CCN1CCN(CC1)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F	IC50 > 250000 nM	Non binder
T17345	Dihydrofolate reductase	BNX80Q	6-(3,4-Dimethoxyphenyl)sulfanyl-5-methylfuro[2,3-d]pyrimidine-2,4-diamine	Investigative	46231413	C15H16N4O3S	332.4	CC1=C(OC2=NC(=NC(=C12)N)N)SC3=CC(=C(C=C3)OC)OC	IC50 > 200000 nM	Non binder
T17345	Dihydrofolate reductase	BOUN67	3-(5-Amino-1,3,4-Thiadiazol-2-Yl)-1-Thiophen-2-Ylpropan-1-One	Investigative	50994805	C9H9N3OS2	239.3	C1=CSC(=C1)C(=O)CCC2=NN=C(S2)N	IC50 = 300000 nM	Non binder
T17345	Dihydrofolate reductase	BP5WA2	2,4-Diamino-5-methyl-6-(4''-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine	Investigative	46231409	C14H14N4O2S	302.35	CC1=C(OC2=NC(=NC(=C12)N)N)SC3=CC=C(C=C3)OC	IC50 > 200000 nM	Non binder
T17345	Dihydrofolate reductase	BPJW67	2,4-Diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine	Investigative	46231370	C17H14N4OS	322.4	CC1=C(OC2=NC(=NC(=C12)N)N)SC3=CC4=CC=CC=C4C=C3	IC50 > 200000 nM	Non binder
T17345	Dihydrofolate reductase	BQTI62	2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid	Investigative	136046152	C21H29N6O7P	508.5	CCOP(=O)(CCC(C(=O)O)NC(=O)C1=CC=C(C=C1)NCC2CC3=C(NC2)N=C(NC3=O)N)O	IC50 = 950000 nM	Non binder
T17345	Dihydrofolate reductase	BR5Z1A	2-Amino-6,7-dimethyl-3,7-dihydropyrimido[4,5-b][1,4]oxazin-4-one	Investigative	12242319	C8H10N4O2	194.19	CC1C(=NC2=C(O1)N=C(NC2=O)N)C	IC50 = 377000 nM	Non binder
T17345	Dihydrofolate reductase	BS0KO4	6-(2,6-Dimethylphenyl)sulfanyl-5-methylfuro[2,3-d]pyrimidine-2,4-diamine	Investigative	46231371	C15H16N4OS	300.4	CC1=C(C(=CC=C1)C)SC2=C(C3=C(N=C(N=C3O2)N)N)C	IC50 > 200000 nM	Non binder
T17345	Dihydrofolate reductase	BSJ5K2	3-[3-Benzyl-4-[[[3-benzyl-4-(carboxymethoxy)benzoyl]-(2-methylpropyl)carbamoyl]amino]phenyl]propanoic acid	Investigative	76325779	C37H38N2O7	622.7	CC(C)CN(C(=O)C1=CC(=C(C=C1)OCC(=O)O)CC2=CC=CC=C2)C(=O)NC3=C(C=C(C=C3)CCC(=O)O)CC4=CC=CC=C4	IC50 > 1000000 nM	Non binder
T17345	Dihydrofolate reductase	BUL63B	2-Amino-6-methyl-7-phenyl-3,7-dihydropyrimido[4,5-b][1,4]oxazin-4-one	Investigative	12242324	C13H12N4O2	256.26	CC1=NC2=C(N=C(NC2=O)N)OC1C3=CC=CC=C3	IC50 = 740000 nM	Non binder
T17345	Dihydrofolate reductase	BW30ZA	1-Cyclopropyl-6-fluoro-4-oxo-7-(prop-2-ynylamino)-1,8-naphthyridine-3-carboxylic acid	Investigative	70689505	C15H12FN3O3	301.27	C#CCNC1=C(C=C2C(=O)C(=CN(C2=N1)C3CC3)C(=O)O)F	IC50 > 250000 nM	Non binder
T17345	Dihydrofolate reductase	BW9S7G	5-Methyl-6-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]sulfanylfuro[2,3-d]pyrimidine-2,4-diamine	Investigative	46231410	C14H7F7N4OS	412.29	CC1=C(OC2=NC(=NC(=C12)N)N)SC3=C(C(=C(C(=C3F)F)C(F)(F)F)F)F	IC50 > 200000 nM	Non binder
T17345	Dihydrofolate reductase	BX07EK	2-(4-{[(2,4-Diamino-furo[2,3-d]pyrimidin-5-ylmethyl)-amino]-methyl}-benzoylamino)-pentanedioic acid	Investigative	9889551	C20H22N6O6	442.4	C1=CC(=CC=C1CNCC2=COC3=NC(=NC(=C23)N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O	IC50 > 200000 nM	Non binder
T17345	Dihydrofolate reductase	BY2WM1	2-Amino-6-methyl-3,7-dihydropyrimido[4,5-b][1,4]oxazin-4-one	Investigative	12242320	C7H8N4O2	180.16	CC1=NC2=C(N=C(NC2=O)N)OC1	IC50 = 242000 nM	Non binder
T17345	Dihydrofolate reductase	BZH85M	Methyl 2-(2-(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)acryloyl)-1,2-dihydrophthalazin-1-yl)-2-methylpropanoate	Investigative	45272213	C29H32N6O5	544.6	CC(C)(C1C2=CC=CC=C2C=NN1C(=O)/C=C/C3=C(C(=CC(=C3)CC4=CN=C(N=C4N)N)OC)OC)C(=O)OC	IC50 = 813000 nM	Non binder
T17345	Dihydrofolate reductase	D00IBG	flavin mononucleotide	Investigative	643976	C17H21N4O9P	456.3	CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)C[C@@H]([C@@H]([C@@H](COP(=O)(O)O)O)O)O	IC50 = 325000 nM	Non binder