TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T17048	DNA topoisomerase II alpha	D0O1WX	Ciprofloxacin XR	Approved	2764	C17H18FN3O3	331.34	C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O	IC50 > 256000 nM	Non binder
T17048	DNA topoisomerase II alpha	D0Q0PR	Novobiocin	Approved	54675769	C31H36N2O11	612.6	.	IC50 > 256000 nM	Non binder
T17048	DNA topoisomerase II alpha	D08BXT	Spermidine	Phase 3	1102	C7H19N3	145.25	C(CCNCCCN)CN	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	D09YDM	Camptothecin	Phase 3	24360	C20H16N2O4	348.4	CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O	IC50 > 300000 nM	Non binder
T17048	DNA topoisomerase II alpha	D0LD9S	SPERMINE	Terminated	1103	C10H26N4	202.34	C(CCNCCCN)CNCCCN	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B04KXH	6-Benzylsulfanyl-4-sulfanylidene-1H-1,3,5-triazin-2-one	Investigative	56682538	C10H9N3OS2	251.3	C1=CC=C(C=C1)CSC2=NC(=S)NC(=O)N2	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B0B7TQ	4-Benzylsulfanyl-6-[(4-nitrophenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one	Investigative	54769182	C17H14N4O3S2	386.5	C1=CC=C(C=C1)CSC2=NC(=O)NC(=N2)SCC3=CC=C(C=C3)[N+](=O)[O-]	IC50 = 358900 nM	Non binder
T17048	DNA topoisomerase II alpha	B0E1QH	4-Benzylsulfanyl-6-(cyclopropylmethylsulfanyl)-1H-1,3,5-triazin-2-one	Investigative	54769414	C14H15N3OS2	305.4	C1CC1CSC2=NC(=NC(=O)N2)SCC3=CC=CC=C3	IC50 = 481000 nM	Non binder
T17048	DNA topoisomerase II alpha	B0MSB5	3-O-beta-6-Deoxy-D-glucopyranosyl cincholic acid28-O-beta-D-glucopyranosyl ester	Investigative	46888321	C42H66O14	795	C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@@H]6[C@H]([C@@H]([C@H]([C@@H](O6)C)O)O)O)C)C)[C@@H]2[C@H]1C)C(=O)O)C(=O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B0V7NU	3-[(E)-4-Nitrobenzylidene]benzofuran-2(3H)-one	Investigative	14203214	C15H9NO4	267.24	C1=CC=C2C(=C1)/C(=C\\C3=CC=C(C=C3)[N+](=O)[O-])/C(=O)O2	IC50 > 400000 nM	Non binder
T17048	DNA topoisomerase II alpha	B19UCQ	(3E)-3-[(3,4-Dihydroxyphenyl)methylidene]-5-hydroxy-1-benzofuran-2-one	Investigative	11975877	C15H10O5	270.24	C1=CC(=C(C=C1/C=C/2\\C3=C(C=CC(=C3)O)OC2=O)O)O	IC50 = 240000 nM	Non binder
T17048	DNA topoisomerase II alpha	B1CXD0	1-Ethyl-3-[5-(2-methylpyridin-4-yl)-8-[(6-methylpyridin-3-yl)amino]isoquinolin-3-yl]urea	Investigative	67450057	C24H24N6O	412.5	CCNC(=O)NC1=CC2=C(C=CC(=C2C=N1)NC3=CN=C(C=C3)C)C4=CC(=NC=C4)C	IC50 > 256000 nM	Non binder
T17048	DNA topoisomerase II alpha	B1KO9G	Aesculioside IIId	Investigative	46888307	C57H88O24	1157.3	C/C=C(\\C)/C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H]([C@@H]([C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H]([C@]5(C)CO)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)C)C)O)O)CO)(C)C)OC(=O)/C(=C/C)/C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B1OKV0	4,6-Dichloro-N-[2-(3,4-dimethoxyphenyl)ethyl]-1,3,5-triazin-2-amine	Investigative	46179762	C13H14Cl2N4O2	329.18	COC1=C(C=C(C=C1)CCNC2=NC(=NC(=N2)Cl)Cl)OC	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B1RP5U	Quinovic acid 28-O-beta-D-glucopyranosyl ester	Investigative	46888320	C36H56O10	648.8	C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)[C@@H]2[C@H]1C)C(=O)O)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B1TR5Z	6-({[5-(Pyridin-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}methyl)-1,3,5-triazine-2,4-diamine	Investigative	17562978	C11H10N8OS	302.32	C1=CC(=CN=C1)C2=NN=C(O2)SCC3=NC(=NC(=N3)N)N	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B28CGS	(3E)-3-[(3-Hydroxy-4-methoxyphenyl)methylidene]-1-benzofuran-2-one	Investigative	11623140	C16H12O4	268.26	COC1=C(C=C(C=C1)/C=C/2\\C3=CC=CC=C3OC2=O)O	IC50 > 400000 nM	Non binder
T17048	DNA topoisomerase II alpha	B2GB1J	[2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl] 7-[[2-(4-hydroxyanilino)-2-oxoethyl]amino]-7-oxoheptanoate	Investigative	72375653	C30H28N2O11	592.5	C1=CC(=CC=C1NC(=O)CNC(=O)CCCCCC(=O)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O	IC50 > 200000 nM	Non binder
T17048	DNA topoisomerase II alpha	B2GPU8	(3E)-3-Benzylidene-5-hydroxy-1-benzofuran-2-one	Investigative	44401847	C15H10O3	238.24	C1=CC=C(C=C1)/C=C/2\\C3=C(C=CC(=C3)O)OC2=O	IC50 > 400000 nM	Non binder
T17048	DNA topoisomerase II alpha	B2IJ9K	2-[[4-Chloro-6-[(4-methoxyphenyl)methylamino]-1,3,5-triazin-2-yl]-methylamino]ethanol	Investigative	56659987	C14H18ClN5O2	323.78	CN(CCO)C1=NC(=NC(=N1)NCC2=CC=C(C=C2)OC)Cl	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B2O9LM	6-Benzylsulfanyl-4-[(3-nitrophenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one	Investigative	54769181	C17H14N4O3S2	386.5	C1=CC=C(C=C1)CSC2=NC(=NC(=O)N2)SCC3=CC(=CC=C3)[N+](=O)[O-]	IC50 = 488300 nM	Non binder
T17048	DNA topoisomerase II alpha	B2XW4K	2-((3-(1H-Imidazol-1-yl)propyl)amino)-6-methylpyrimidin-4-ol	Investigative	135611993	C11H15N5O	233.27	CC1=CC(=O)NC(=N1)NCCCN2C=CN=C2	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B2XWK5	2-[(4-Benzylsulfanyl-6-oxo-1H-1,3,5-triazin-2-yl)sulfanylmethyl]benzonitrile	Investigative	54769183	C18H14N4OS2	366.5	C1=CC=C(C=C1)CSC2=NC(=O)NC(=N2)SCC3=CC=CC=C3C#N	IC50 = 522000 nM	Non binder
T17048	DNA topoisomerase II alpha	B2YU0E	Aesculioside IIj	Investigative	46888311	C54H84O22	1085.2	C/C=C(\\C)/C(=O)O[C@H]1[C@@H]([C@@]2([C@@H](C[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@H]([C@H](O8)CO)O)O)O)C)C)[C@@H]2CC1(C)C)C)O)CO)OC(=O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B30JNQ	Methyl N-[[3-(ethylcarbamoylamino)-5-(2-methylpyridin-4-yl)isoquinolin-8-yl]methyl]carbamate	Investigative	66575905	C21H23N5O3	393.4	CCNC(=O)NC1=CC2=C(C=CC(=C2C=N1)CNC(=O)OC)C3=CC(=NC=C3)C	IC50 > 256000 nM	Non binder
T17048	DNA topoisomerase II alpha	B38GZD	[(3R,4R,4Ar,5R,6aR,6aS,6bR,8aR,10S,12aR,14bS)-5,10-dihydroxy-4a-(hydroxymethyl)-2,2,6a,6b,9,9,12a-heptamethyl-3-[(Z)-2-methylbut-2-enoyl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicen-4-yl] 2-methylbutanoate	Investigative	46888248	C40H64O7	656.9	CCC(C)C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H](C[C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)C)O)CO)(C)C)OC(=O)/C(=C\\C)/C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B3FIW9	Ginsenoside Re	Investigative	441921	C48H82O18	947.2	C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2O[C@H]3C[C@@]4([C@H](C[C@H]([C@H]5[C@]4(CC[C@@H]5[C@](C)(CCC=C(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)O)[C@@]7([C@@H]3C([C@H](CC7)O)(C)C)C)C)CO)O)O)O)O)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B3G2NA	2-[2-[[4-Chloro-6-[(4-methoxyphenyl)methylamino]-1,3,5-triazin-2-yl]amino]phenyl]ethanol	Investigative	122182575	C19H20ClN5O2	385.8	COC1=CC=C(C=C1)CNC2=NC(=NC(=N2)Cl)NC3=CC=CC=C3CCO	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B3GO9J	[(3R,4R,4Ar,5S,6R,6aR,6aS,6bR,8aR,10S,12aR,14bS)-5,6,10-trihydroxy-4a-(hydroxymethyl)-2,2,6a,6b,9,9,12a-heptamethyl-3-[(Z)-2-methylbut-2-enoyl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicen-4-yl] 2-methylbutanoate	Investigative	46888246	C40H64O8	672.9	CCC(C)C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H]([C@@H]([C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)C)O)O)CO)(C)C)OC(=O)/C(=C\\C)/C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B41ABR	4-(2,4-Dihydroxybenzoyl)oxy-2-hydroxy-6-pentylbenzoic acid	Investigative	76318541	C19H20O7	360.4	CCCCCC1=C(C(=CC(=C1)OC(=O)C2=C(C=C(C=C2)O)O)O)C(=O)O	IC50 = 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B4O1CG	2-[(2-Methylpyridin-4-yl)methylamino]pyridine-3-carboxamide	Investigative	39794232	C13H14N4O	242.28	CC1=NC=CC(=C1)CNC2=C(C=CC=N2)C(=O)N	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B4SZ1M	Aesculioside IV-23E	Investigative	24970451	C57H88O23	1141.3	C/C=C(/C)\\C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H]([C@@H]([C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@H]([C@H](O8)CO)O)O)O)C)C)C)O)O)CO)(C)C)OC(=O)/C(=C\\C)/C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B54JCM	Ethyl 2-[4-[(E)-(2-oxo-1-benzofuran-3-ylidene)methyl]phenyl]acetate	Investigative	44401288	C19H16O4	308.3	CCOC(=O)CC1=CC=C(C=C1)/C=C/2\\C3=CC=CC=C3OC2=O	IC50 > 400000 nM	Non binder
T17048	DNA topoisomerase II alpha	B58DJK	{4-Amino-6-[(4-fluorophenyl)amino]-1,3,5-triazin-2-yl}methyl 4-methylpiperazine-1-carbodithioate	Investigative	1319814	C16H20FN7S2	393.5	CN1CCN(CC1)C(=S)SCC2=NC(=NC(=N2)NC3=CC=C(C=C3)F)N	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B59MAD	20(S)-Ginsenoside Rg2	Investigative	12912322	C42H72O13	785	C[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2O[C@H]3C[C@@]4([C@H](C[C@H]([C@H]5[C@]4(CC[C@@H]5[C@](C)(CCC=C(C)C)O)C)O)[C@@]6([C@@H]3C([C@H](CC6)O)(C)C)C)C)CO)O)O)O)O)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B5D3VB	Gypenoside VIII	Investigative	11679800	C48H82O18	947.2	CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B5OGC8	Ginsenoside F2	Investigative	9918692	C42H72O13	785	CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)C)C)O)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B5WZN1	9-Amino-5,6-difluoro-3-oxo-3H-pyrido[3,2,1-kl]phenoxazine-2-carboxylic acid	Investigative	372621	C16H8F2N2O4	330.24	C1=CC2=C(C=C1N)OC3=C4N2C=C(C(=O)C4=CC(=C3F)F)C(=O)O	IC50 > 500000 nM	Non binder
T17048	DNA topoisomerase II alpha	B63ZPM	[(3R,4R,4Ar,5R,6aR,6aS,6bR,8aR,9S,10S,12aR,14bS)-4,5,10-trihydroxy-4a,9-bis(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicen-3-yl] (Z)-2-methylbut-2-enoate	Investigative	46888299	C35H56O7	588.8	C/C=C(/C)\\C(=O)O[C@H]1[C@@H]([C@@]2([C@@H](C[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H]([C@]5(C)CO)O)C)C)[C@@H]2CC1(C)C)C)O)CO)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B68FMR	2, 3-Dihydroxy-12-ursen-28-oic acid	Investigative	46887586	C30H46O6	502.7	C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(C[C@H]([C@@H](C5(C)C)O)O)C)C)[C@@H]2[C@H]1C)C(=O)O)C(=O)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B69MFH	2-[4-Chloro-6-[methyl(2-hydroxyethyl)amino]-1,3,5-triazine-2-ylamino]phenethyl alcohol	Investigative	56680463	C14H18ClN5O2	323.78	CN(CCO)C1=NC(=NC(=N1)NC2=CC=CC=C2CCO)Cl	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B6SBY8	Eryngioside 94A	Investigative	46888260	C52H82O22	1059.2	C/C=C(/C)\\C(=O)O[C@H]1[C@@H]([C@]2([C@@H](CC1(C)C)C3=CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3([C@H]([C@H]2O)O)C)C)(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](CO7)O)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)CO)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B6ZDK3	4-Benzylsulfanyl-6-(cyclobutylmethylsulfanyl)-1H-1,3,5-triazin-2-one	Investigative	54769628	C15H17N3OS2	319.4	C1CC(C1)CSC2=NC(=NC(=O)N2)SCC3=CC=CC=C3	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B70DIC	4-Benzylsulfanyl-6-propylsulfanyl-1H-1,3,5-triazin-2-one	Investigative	54769410	C13H15N3OS2	293.4	CCCSC1=NC(=NC(=O)N1)SCC2=CC=CC=C2	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B73JBR	20(R)-Ginsenoside Rg2	Investigative	46887679	C42H72O13	785	C[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2O[C@H]3C[C@@]4([C@H](C[C@H]([C@H]5[C@]4(CC[C@@H]5[C@@](C)(CCC=C(C)C)O)C)O)[C@@]6([C@@H]3C([C@H](CC6)O)(C)C)C)C)CO)O)O)O)O)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B73QUJ	Quinovic acid 3-O-beta-D-glucoside	Investigative	14194006	C36H56O10	648.8	C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)[C@@H]2[C@H]1C)C(=O)O)C(=O)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B76GRM	(2,2-Dimethyl-4-oxo-5-pentyl-1,3-benzodioxin-7-yl) 2,4-dihydroxy-6-pentylbenzoate	Investigative	76325813	C27H34O7	470.6	CCCCCC1=C(C(=CC(=C1)O)O)C(=O)OC2=CC(=C3C(=C2)OC(OC3=O)(C)C)CCCCC	IC50 = 500000 nM	Non binder
T17048	DNA topoisomerase II alpha	B7F4BO	6-{[(1-Cyclopentyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-N2-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine	Investigative	9208033	C16H18FN9S	387.4	C1CCC(C1)N2C(=NN=N2)SCC3=NC(=NC(=N3)NC4=CC=C(C=C4)F)N	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B7P2IQ	Aesculioside IV-23D1	Investigative	11788101	C57H88O22	1125.3	C/C=C(/C)\\C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H](C[C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@H]([C@H](O8)CO)O)O)O)C)C)C)O)CO)(C)C)OC(=O)/C(=C\\C)/C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B7SJF3	Aesculioside IIIf	Investigative	44479228	C57H88O23	1141.3	C/C=C(\\C)/C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H]([C@@H]([C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)C)C)O)O)CO)(C)C)OC(=O)/C(=C/C)/C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B7UB9W	2-[(4-Benzylsulfanyl-6-oxo-2,5-dihydro-1H-1,3,5-triazin-2-yl)sulfanyl]acetic acid	Investigative	122182573	C12H13N3O3S2	311.4	C1=CC=C(C=C1)CSC2=NC(NC(=O)N2)SCC(=O)O	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B7X8ST	10-O-[2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl] 1-O-methyl decanedioate	Investigative	72375544	C26H28O10	500.5	COC(=O)CCCCCCCCC(=O)OC1=C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(C=C3)O)O	IC50 > 200000 nM	Non binder
T17048	DNA topoisomerase II alpha	B8I7CF	Eryngioside E	Investigative	46888301	C52H82O22	1059.2	C/C=C(/C)\\C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H]([C@@H]([C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](CO7)O)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)C)C)O)O)CO)(C)C)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B8VL6E	Eryngiioside L	Investigative	46888255	C54H84O22	1085.2	C/C=C(/C)\\C(=O)O[C@H]1[C@@H]([C@@]2([C@@H](C[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@H](CO7)O)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)C)[C@@H]2CC1(C)C)C)O)CO)OC(=O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B8ZK4M	AesculiosideIV-23C1	Investigative	21580556	C57H88O23	1141.3	C/C=C(/C)\\C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H](C[C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H]([C@]5(C)CO)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)C)C)O)CO)(C)C)OC(=O)/C(=C\\C)/C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B97HEF	2-N-(4-Fluorophenyl)-6-[(1-propylimidazol-2-yl)sulfanylmethyl]-1,3,5-triazine-2,4-diamine	Investigative	17506081	C16H18FN7S	359.4	CCCN1C=CN=C1SCC2=NC(=NC(=N2)NC3=CC=C(C=C3)F)N	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B97INB	Gypenoside XVII	Investigative	44584555	C48H82O18	947.2	CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)C)C)O)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)O)O)O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	B98FEG	4-Benzylsulfanyl-6-[(4-methoxyphenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one	Investigative	54768946	C18H17N3O2S2	371.5	COC1=CC=C(C=C1)CSC2=NC(=NC(=O)N2)SCC3=CC=CC=C3	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B9A6KH	2-(4,6-Dichloro-1,3,5-triazine-2-ylamino)phenethyl alcohol	Investigative	46179761	C11H10Cl2N4O	285.13	C1=CC=C(C(=C1)CCO)NC2=NC(=NC(=N2)Cl)Cl	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	B9AV3R	[(3R,4S,5R)-3,4-Dihydroxy-5-[5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-7-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-3-yl]oxyoxolan-3-yl]methyl acetate	Investigative	25067894	C28H30O15	606.5	C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=CC(=C3C(=C2)OC(=C(C3=O)O[C@@H]4[C@H]([C@@](CO4)(COC(=O)C)O)O)C5=CC=C(C=C5)O)O)O)O)O	IC50 = 240000 nM	Non binder
T17048	DNA topoisomerase II alpha	B9CSD8	4-Benzylsulfanyl-6-[(4-chlorophenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one	Investigative	54578709	C17H14ClN3OS2	375.9	C1=CC=C(C=C1)CSC2=NC(=O)NC(=N2)SCC3=CC=C(C=C3)Cl	IC50 = 219300 nM	Non binder
T17048	DNA topoisomerase II alpha	B9GWE4	{4-Amino-6-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}methyl morpholine-4-carbodithioate	Investigative	1554842	C16H20N6O2S2	392.5	COC1=CC=C(C=C1)NC2=NC(=NC(=N2)N)CSC(=S)N3CCOCC3	IC50 = 229000 nM	Non binder
T17048	DNA topoisomerase II alpha	B9QK7P	Aesculioside IIIb	Investigative	46888251	C56H88O24	1145.3	C/C=C(/C)\\C(=O)O[C@H]1[C@@H]([C@]2([C@@H](CC1(C)C)C3=CC[C@@H]4[C@]5(CC[C@@H]([C@]([C@@H]5CC[C@]4([C@@]3([C@H]([C@H]2O)O)C)C)(C)CO)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)CO)OC(=O)C(C)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BA8TK3	2-[(3,4-Dimethoxyphenyl)methylamino]pyridine-3-carboxamide	Investigative	39997960	C15H17N3O3	287.31	COC1=C(C=C(C=C1)CNC2=C(C=CC=N2)C(=O)N)OC	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BAV8P1	3-[(E)-4-Hydroxybenzylidene]benzofuran-2(3H)-one	Investigative	44401681	C15H10O3	238.24	C1=CC=C2C(=C1)/C(=C\\C3=CC=C(C=C3)O)/C(=O)O2	IC50 = 327000 nM	Non binder
T17048	DNA topoisomerase II alpha	BB3YO0	Olivetolic acid	Investigative	2826719	C12H16O4	224.25	CCCCCC1=C(C(=CC(=C1)O)O)C(=O)O	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BB6P8L	4-Benzylsulfanyl-6-butylsulfanyl-1H-1,3,5-triazin-2-one	Investigative	54769411	C14H17N3OS2	307.4	CCCCSC1=NC(=NC(=O)N1)SCC2=CC=CC=C2	IC50 = 234700 nM	Non binder
T17048	DNA topoisomerase II alpha	BB8RF9	6-{[(5-Cyclopropyl-1,3,4-oxadiazol-2-yl)sulfanyl]methyl}-N2-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine	Investigative	17478154	C15H14FN7OS	359.4	C1CC1C2=NN=C(O2)SCC3=NC(=NC(=N3)NC4=CC=C(C=C4)F)N	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BBG46M	(3E)-5-Hydroxy-3-[(4-hydroxyphenyl)methylidene]-1-benzofuran-2-one	Investigative	14804068	C15H10O4	254.24	C1=CC(=CC=C1/C=C/2\\C3=C(C=CC(=C3)O)OC2=O)O	IC50 > 400000 nM	Non binder
T17048	DNA topoisomerase II alpha	BBM18F	(1S,2R,4As,6aR,6bR,8aR,10S,12aR,12bR,14bS)-1,2,6b,9,9,12a-hexamethyl-10-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-4a-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-6a-carboxylic acid	Investigative	14194010	C42H66O15	811	C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)[C@@H]2[C@H]1C)C(=O)O)C(=O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BBW70J	Dibenzyl (2R)-2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)amino]pentanedioate	Investigative	46179869	C24H26N4O6	466.5	COC1=NC(=NC(=N1)N[C@H](CCC(=O)OCC2=CC=CC=C2)C(=O)OCC3=CC=CC=C3)OC	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BBW75R	Eryngioside F	Investigative	46888300	C52H82O21	1043.2	C/C=C(/C)\\C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H](C[C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](CO7)O)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)C)C)O)CO)(C)C)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BC2DF1	4-Amino-2-[(2S)-1-morpholin-4-yl-1-oxopropan-2-yl]sulfanyl-1H-pyrimidin-6-one	Investigative	135874968	C11H16N4O3S	284.34	C[C@@H](C(=O)N1CCOCC1)SC2=NC(=CC(=O)N2)N	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BD7U5Z	24-Hydroxy-beta-amyrin	Investigative	14167253	C30H50O2	442.7	C[C@@]12CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H]([C@]5(C)CO)O)C)C)[C@@H]1CC(CC2)(C)C)C	IC50 > 200000 nM	Non binder
T17048	DNA topoisomerase II alpha	BDF9X7	6-Methyl-2-{[(2-methyl-4-pyridinyl)methyl]amino}nicotinamide	Investigative	39818372	C14H16N4O	256.3	CC1=NC(=C(C=C1)C(=O)N)NCC2=CC(=NC=C2)C	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BDHZ67	4-Methyl-2-[(2Z)-2-(pyridin-4-ylmethylidene)hydrazinyl]-1H-pyrimidin-6-one	Investigative	135887676	C11H11N5O	229.24	CC1=CC(=O)NC(=N1)N/N=C\\C2=CC=NC=C2	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BDN5Z4	2-[2-[[4-(Benzylamino)-6-chloro-1,3,5-triazin-2-yl]amino]phenyl]ethanol	Investigative	122182574	C18H18ClN5O	355.8	C1=CC=C(C=C1)CNC2=NC(=NC(=N2)Cl)NC3=CC=CC=C3CCO	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BDR1V8	Aesculioside IIk	Investigative	46888257	C54H84O22	1085.2	C/C=C(/C)\\C(=O)O[C@H]1[C@@H]([C@@]2([C@@H](C[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@H]([C@H](O8)CO)O)O)O)C)C)[C@@H]2CC1(C)C)C)O)CO)OC(=O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BDYX53	4-Benzylsulfanyl-2-phenylsulfanyl-2,5-dihydro-1H-1,3,5-triazin-6-one	Investigative	122182572	C16H15N3OS2	329.4	C1=CC=C(C=C1)CSC2=NC(NC(=O)N2)SC3=CC=CC=C3	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BE1I5X	Aesculioside IIIa	Investigative	46888258	C54H84O23	1101.2	C/C=C(/C)\\C(=O)O[C@H]1[C@@H]([C@@]2([C@@H](C[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H]([C@]5(C)CO)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)C)[C@@H]2CC1(C)C)C)O)COC(=O)C)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BE2XK5	(E)-3-Benzylidenebenzofuran-2(3H)-one	Investigative	10933039	C15H10O2	222.24	C1=CC=C(C=C1)/C=C/2\\C3=CC=CC=C3OC2=O	IC50 > 400000 nM	Non binder
T17048	DNA topoisomerase II alpha	BE5G8B	Aesculioside IVc	Investigative	46888247	C57H90O22	1127.3	CCC(C)C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H](C[C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@H]([C@H](O8)CO)O)O)O)C)C)C)O)CO)(C)C)OC(=O)/C(=C\\C)/C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BE8Q1V	{4-Amino-6-[(4-fluorophenyl)amino]-1,3,5-triazin-2-yl}methyl cyclohexyl(methyl)carbamodithioate	Investigative	3758536	C18H23FN6S2	406.5	CN(C1CCCCC1)C(=S)SCC2=NC(=NC(=N2)NC3=CC=C(C=C3)F)N	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BEAV61	(3E)-3-[(4-Hydroxy-3-methoxyphenyl)methylidene]-1-benzofuran-2-one	Investigative	44401925	C16H12O4	268.26	COC1=C(C=CC(=C1)/C=C/2\\C3=CC=CC=C3OC2=O)O	IC50 = 351000 nM	Non binder
T17048	DNA topoisomerase II alpha	BELT36	(1S,2R,4As,6aR,6aR,6bR,8aR,10S,12aR,14bS)-10-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-1,2,6b,9,9,12a-hexamethyl-4a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-6a-carboxylic acid	Investigative	46888323	C48H76O19	957.1	C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O[C@@H]7[C@@H]([C@@H]([C@H]([C@@H](O7)C)O)O)O)O)O)C)C)[C@@H]2[C@H]1C)C(=O)O)C(=O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BF7P4U	4-[(4-Benzylsulfanyl-6-oxo-1H-1,3,5-triazin-2-yl)sulfanylmethyl]-3-fluorobenzonitrile	Investigative	54769408	C18H13FN4OS2	384.5	C1=CC=C(C=C1)CSC2=NC(=O)NC(=N2)SCC3=C(C=C(C=C3)C#N)F	IC50 = 485800 nM	Non binder
T17048	DNA topoisomerase II alpha	BFCJ50	(2S)-2-[2-[4-Methoxy-6-[[(1S)-1-methyl-2-oxo-2-(benzyloxy)ethyl]amino]-1,3,5-triazine-2-ylamino]benzoylamino]propionic acid benzyl ester	Investigative	46179870	C31H32N6O6	584.6	C[C@@H](C(=O)OCC1=CC=CC=C1)NC2=NC(=NC(=N2)NC3=CC=CC=C3C(=O)N[C@@H](C)C(=O)OCC4=CC=CC=C4)OC	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BFCN89	4,6-Dichloro-[1,3,5]triazin-2-yl-4-methoxy-benzyl-amine	Investigative	11300612	C11H10Cl2N4O	285.13	COC1=CC=C(C=C1)CNC2=NC(=NC(=N2)Cl)Cl	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BFV7K6	Aesculioside IVb	Investigative	46888249	C58H92O23	1157.3	CCC(C)C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H]([C@@H]([C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H]([C@]5(C)CO)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)C)C)C)O)CO)(C)C)OC(=O)/C(=C\\C)/C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BFZ2W3	Saniculasaponin III	Investigative	46888254	C55H86O23	1115.3	CC/C(=C/C)/C(=O)O[C@H]1[C@@H]([C@]2([C@@H](CC1(C)C)C3=CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3([C@H]([C@H]2O)O)C)C)(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@H](CO7)O)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)CO)OC(=O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BG1QF4	2-[(4,6-Dimethoxy-1,3,5-triazin-2-yl)thio]benzoic acid	Investigative	56683793	C12H11N3O4S	293.3	COC1=NC(=NC(=N1)SC2=CC=CC=C2C(=O)O)OC	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BG3N6L	Aesculioside IIf	Investigative	46888312	C54H84O23	1101.2	C/C=C(\\C)/C(=O)O[C@H]1[C@@H]([C@]2([C@@H](CC1(C)C)C3=CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3([C@H]([C@H]2O)O)C)C)(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@H]([C@H](O8)CO)O)O)O)C)CO)OC(=O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BGS90I	4-Benzylsulfanyl-6-[(2-methoxyphenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one	Investigative	56680462	C18H17N3O2S2	371.5	COC1=CC=CC=C1CSC2=NC(=NC(=O)N2)SCC3=CC=CC=C3	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BH0BX4	Aesculioside IIIe	Investigative	46888308	C57H88O24	1157.3	C/C=C(/C)\\C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H]([C@@H]([C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H]([C@]5(C)CO)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)C)C)O)O)CO)(C)C)OC(=O)/C(=C/C)/C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BH0ZK7	Ginsenoside F3	Investigative	46887678	C41H70O13	771	CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(C[C@@H]([C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)O)C)O)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO[C@H]6[C@@H]([C@H]([C@H](CO6)O)O)O)O)O)O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BHL3F8	4-Benzylsulfanyl-6-[(2-nitrophenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one	Investigative	54768950	C17H14N4O3S2	386.5	C1=CC=C(C=C1)CSC2=NC(=O)NC(=N2)SCC3=CC=CC=C3[N+](=O)[O-]	IC50 = 376700 nM	Non binder
T17048	DNA topoisomerase II alpha	BI32YC	N-(2-Ethylphenyl)-2-amino-4,6-dichloro-1,3,5-triazine	Investigative	19420351	C11H10Cl2N4	269.13	CCC1=CC=CC=C1NC2=NC(=NC(=N2)Cl)Cl	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BI5M3Y	Kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside	Investigative	57401109	C26H28O14	564.5	C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=CC(=C3C(=C2)OC(=C(C3=O)O[C@H]4[C@@H]([C@H]([C@H](CO4)O)O)O)C5=CC=C(C=C5)O)O)O)O)O	IC50 = 330000 nM	Non binder
T17048	DNA topoisomerase II alpha	BIC5L6	(3E)-3-[(4-Fluorophenyl)methylidene]-1-benzofuran-2-one	Investigative	44401260	C15H9FO2	240.23	C1=CC=C2C(=C1)/C(=C\\C3=CC=C(C=C3)F)/C(=O)O2	IC50 > 400000 nM	Non binder
T17048	DNA topoisomerase II alpha	BID2X0	2-Fluoro-N-((4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide	Investigative	3332833	C16H12F2N4OS	346.4	C1=CC=C(C(=C1)C(=O)NCC2=NNC(=S)N2C3=CC=C(C=C3)F)F	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BIE25F	(2S)-2-[(4,6-Diamino-1,3,5-triazin-2-yl)sulfanyl]-1-morpholin-4-ylpropan-1-one	Investigative	40789334	C10H16N6O2S	284.34	C[C@@H](C(=O)N1CCOCC1)SC2=NC(=NC(=N2)N)N	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BIFJ14	21beta-O,22alpha-O-Diangeloylbarringtogenol C	Investigative	21636448	C40H62O7	654.9	C/C=C(/C)\\C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H](C[C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)C)O)CO)(C)C)OC(=O)/C(=C\\C)/C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BIL1D6	(1S,2R,4As,6aR,6aR,6bR,8aR,10S,12aR,14bS)-4a-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxycarbonyl-1,2,6b,9,9,12a-hexamethyl-10-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-6a-carboxylic acid	Investigative	46888324	C47H74O19	943.1	C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)[C@@H]2[C@H]1C)C(=O)O)C(=O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@H](CO8)O)O)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BJ0N3Q	{4-Amino-6-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}methyl piperidine-1-carbodithioate	Investigative	1332897	C17H22N6OS2	390.5	COC1=CC=C(C=C1)NC2=NC(=NC(=N2)N)CSC(=S)N3CCCCC3	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BJ5T8Z	[(3R,4R,4Ar,5R,6aR,6aS,6bR,8aR,9S,10S,12aR,14bS)-5,10-dihydroxy-4a,9-bis(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-4-(2-methylpropanoyloxy)-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicen-3-yl] (Z)-2-methylbut-2-enoate	Investigative	46888250	C39H62O8	658.9	C/C=C(/C)\\C(=O)O[C@H]1[C@@H]([C@@]2([C@@H](C[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H]([C@]5(C)CO)O)C)C)[C@@H]2CC1(C)C)C)O)CO)OC(=O)C(C)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BJ8RC4	2-[4-[[2-[[7-[2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl]oxy-7-oxoheptanoyl]amino]acetyl]amino]phenyl]acetic acid	Investigative	72375655	C32H30N2O12	634.6	C1=CC(=CC=C1CC(=O)O)NC(=O)CNC(=O)CCCCCC(=O)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O	IC50 > 200000 nM	Non binder
T17048	DNA topoisomerase II alpha	BJM4G0	Aesculioside IIa	Investigative	46888259	C52H82O22	1059.2	C/C=C(/C)\\C(=O)O[C@H]1[C@@H]([C@]2([C@@H](CC1(C)C)C3=CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3([C@H]([C@H]2O)O)C)C)(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@H]([C@H](O8)CO)O)O)O)C)CO)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BJZ4B3	(E)-3-(3,4-Dihydroxybenzylidene)benzofuran-2(3H)-one	Investigative	44401682	C15H10O4	254.24	C1=CC=C2C(=C1)/C(=C\\C3=CC(=C(C=C3)O)O)/C(=O)O2	IC50 = 272000 nM	Non binder
T17048	DNA topoisomerase II alpha	BK1U8N	Prop-2-ynyl N-[[3-(ethylcarbamoylamino)-5-(2-methylpyridin-4-yl)isoquinolin-8-yl]methyl]carbamate	Investigative	88962303	C23H23N5O3	417.5	CCNC(=O)NC1=CC2=C(C=CC(=C2C=N1)CNC(=O)OCC#C)C3=CC(=NC=C3)C	IC50 > 256000 nM	Non binder
T17048	DNA topoisomerase II alpha	BK6P7L	N-[6-[[2-[(8R,9S,13S,14S,17R)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]acetyl]amino]hexyl]-5,11-dimethyl-6H-pyrido[4,3-b]carbazole-9-carboxamide	Investigative	10747298	C44H52N4O4	700.9	CC1=C2C=CN=CC2=C(C3=C1NC4=C3C=C(C=C4)C(=O)NCCCCCCNC(=O)C[C@@]5(CC[C@@H]6[C@@]5(CC[C@H]7[C@H]6CCC8=C7C=CC(=C8)O)C)O)C	IC50 > 200000 nM	Non binder
T17048	DNA topoisomerase II alpha	BKWY05	Methyl 2-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzoate	Investigative	617467	C11H8Cl2N4O2	299.11	COC(=O)C1=CC=CC=C1NC2=NC(=NC(=N2)Cl)Cl	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BL7EP3	Kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside	Investigative	21606527	C27H30O15	594.5	C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=CC(=C3C(=C2)OC(=C(C3=O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C5=CC=C(C=C5)O)O)O)O)O	IC50 = 600000 nM	Non binder
T17048	DNA topoisomerase II alpha	BL8JR0	Unii-W6V49A8fjq	Investigative	12912363	C53H90O22	1079.3	CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)O)O)O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BLKT28	(5S)-4-[2-(3,4-Dimethoxyphenyl)-1,3-dithian-2-yl]-5-(hydroxymethyl)oxolan-2-one	Investigative	137639369	C17H22O5S2	370.5	COC1=C(C=C(C=C1)C2(SCCCS2)C3CC(=O)O[C@@H]3CO)OC	IC50 > 200000 nM	Non binder
T17048	DNA topoisomerase II alpha	BLZ4Q3	N-((4-(2-Chlorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3-methoxybenzamide	Investigative	5098538	C17H15ClN4O2S	374.8	COC1=CC=CC(=C1)C(=O)NCC2=NNC(=S)N2C3=CC=CC=C3Cl	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BM16ZP	Propan-2-yl 2-[[4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzoyl]amino]propanoate	Investigative	75164138	C16H17Cl2N5O3	398.2	CC(C)OC(=O)C(C)NC(=O)C1=CC=C(C=C1)NC2=NC(=NC(=N2)Cl)Cl	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BN6Z5F	11-Fluoro-10-(4-methylpiperazin-1-yl)-5-nitro-14-oxo-8-oxa-1-azatetracyclo[7.7.1.02,7.013,17]heptadeca-2(7),3,5,9(17),10,12,15-heptaene-15-carboxylic acid	Investigative	14316872	C21H17FN4O6	440.4	CN1CCN(CC1)C2=C(C=C3C4=C2OC5=C(N4C=C(C3=O)C(=O)O)C=CC(=C5)[N+](=O)[O-])F	IC50 = 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BN84AM	6-[(Cyclopentylsulfanyl)methyl]-N2-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine	Investigative	33499296	C15H18FN5S	319.4	C1CCC(C1)SCC2=NC(=NC(=N2)NC3=CC=C(C=C3)F)N	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BN8X4G	Ginsenoside-F5	Investigative	46224647	C41H70O13	771	CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(C[C@@H]([C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)O)C)O)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO[C@@H]6[C@H]([C@@H]([C@H](O6)CO)O)O)O)O)O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BO4RI0	N-(2-Tert-butylphenyl)-4,6-dichloro-1,3,5-triazin-2-amine	Investigative	46179760	C13H14Cl2N4	297.18	CC(C)(C)C1=CC=CC=C1NC2=NC(=NC(=N2)Cl)Cl	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BOC2M4	Aesculioside IId	Investigative	46888298	C46H72O17	897.1	C/C=C(/C)\\C(=O)O[C@H]1[C@@H]([C@@]2([C@@H](C[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H]([C@]5(C)CO)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O)C)C)[C@@H]2CC1(C)C)C)O)CO)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BOGJ59	2-N-(4-Fluorophenyl)-6-(2H-tetrazol-5-ylsulfanylmethyl)-1,3,5-triazine-2,4-diamine	Investigative	118724649	C11H10FN9S	319.32	C1=CC(=CC=C1NC2=NC(=NC(=N2)N)CSC3=NNN=N3)F	IC50 = 337000 nM	Non binder
T17048	DNA topoisomerase II alpha	BOR9A1	(20R)-Ginsenoside Rg3	Investigative	46887680	C42H72O13	785	CC(=CCC[C@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BP2J0C	4-Methyl-2-[(2Z)-2-(pyridin-3-ylmethylidene)hydrazinyl]-1H-pyrimidin-6-one	Investigative	135883794	C11H11N5O	229.24	CC1=CC(=O)NC(=N1)N/N=C\\C2=CN=CC=C2	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BPAD85	Bakuchicin	Investigative	3083848	C11H6O3	186.16	C1=CC2=C(C=CC(=O)O2)C3=C1C=CO3	IC50 = 404000 nM	Non binder
T17048	DNA topoisomerase II alpha	BQ61WC	(3E)-3-[(4-Methoxyphenyl)methylidene]-1-benzofuran-2-one	Investigative	21350957	C16H12O3	252.26	COC1=CC=C(C=C1)/C=C/2\\C3=CC=CC=C3OC2=O	IC50 > 400000 nM	Non binder
T17048	DNA topoisomerase II alpha	BQ8T2D	[(3R,4R,4Ar,5R,6aR,6aS,6bR,8aR,9S,10S,12aR,14bS)-5,10-dihydroxy-4a,9-bis(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-4-[(Z)-2-methylbut-2-enoyl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicen-3-yl] (Z)-2-methylbut-2-enoate	Investigative	46888244	C40H62O8	670.9	C/C=C(/C)\\C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H](C[C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H]([C@]5(C)CO)O)C)C)C)O)CO)(C)C)OC(=O)/C(=C\\C)/C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BQN8R9	alpha-Amyrin	Investigative	73170	C30H50O	426.7	C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)[C@@H]2[C@H]1C)C)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BQO86X	6-(4-Aminophenyl)-4-sulfanylidene-1H-1,3,5-triazin-2-one	Investigative	46179700	C9H8N4OS	220.25	C1=CC(=CC=C1C2=NC(=S)NC(=O)N2)N	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BQX6U2	Lupeol	Investigative	259846	C30H50O	426.7	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BR3Y7T	2-[(4,6-Dimethoxy-1,3,5-triazin-2-yl)amino]benzoic acid	Investigative	46179765	C12H12N4O4	276.25	COC1=NC(=NC(=N1)NC2=CC=CC=C2C(=O)O)OC	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BR4T1A	2-N-(4-Fluorophenyl)-6-[(1-methyltetrazol-5-yl)sulfanylmethyl]-1,3,5-triazine-2,4-diamine	Investigative	27213568	C12H12FN9S	333.35	CN1C(=NN=N1)SCC2=NC(=NC(=N2)NC3=CC=C(C=C3)F)N	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BR6F4W	Methyl 2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoate	Investigative	4159286	C13H13N3O5	291.26	COC1=NC(=NC(=N1)OC2=CC=CC=C2C(=O)OC)OC	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BR84PE	Benzyl 4-[2,4-bis(phenylmethoxy)benzoyl]oxy-2-hydroxybenzoate	Investigative	76329404	C35H28O7	560.6	C1=CC=C(C=C1)COC2=CC(=C(C=C2)C(=O)OC3=CC(=C(C=C3)C(=O)OCC4=CC=CC=C4)O)OCC5=CC=CC=C5	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BR8B2W	Aesculioside IIc	Investigative	46888296	C52H82O21	1043.2	C/C=C(/C)\\C(=O)O[C@H]1[C@@H]([C@@]2([C@@H](C[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@H]([C@H](O8)CO)O)O)O)C)C)[C@@H]2CC1(C)C)C)O)CO)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BRU0D6	Lupeol 3-acetate	Investigative	46887587	C32H52O2	468.8	CC(=C)[C@@H]1CC[C@]2([C@@H]1[C@@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OC(=O)C)C)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BS18ZL	2-[(2-Methylpyridin-4-yl)methylamino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxamide	Investigative	39794153	C16H18N4O	282.34	CC1=NC=CC(=C1)CNC2=C(C=C3CCCC3=N2)C(=O)N	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BS26AO	4-(2,4-Dihydroxybenzoyloxy)-2-hydroxybenzoic acid	Investigative	54210863	C14H10O7	290.22	C1=CC(=C(C=C1O)O)C(=O)OC2=CC(=C(C=C2)C(=O)O)O	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BS53ML	3-[(E)-4-Hydroxybenzylidene]-6-hydroxybenzofuran-2(3H)-one	Investigative	9837937	C15H10O4	254.24	C1=CC(=CC=C1/C=C/2\\C3=C(C=C(C=C3)O)OC2=O)O	IC50 > 400000 nM	Non binder
T17048	DNA topoisomerase II alpha	BSV8K2	N-(2-Bromophenyl)-4,6-dichloro-1,3,5-triazin-2-amine	Investigative	35296	C9H5BrCl2N4	319.97	C1=CC=C(C(=C1)NC2=NC(=NC(=N2)Cl)Cl)Br	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BSX60Q	4-Benzylsulfanyl-6-(cyclohexylmethylsulfanyl)-1H-1,3,5-triazin-2-one	Investigative	54579405	C17H21N3OS2	347.5	C1CCC(CC1)CSC2=NC(=NC(=O)N2)SCC3=CC=CC=C3	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BT9G2D	3-[(2R,3S,4S)-3,4-Dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-7-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one	Investigative	25067849	C26H28O14	564.5	C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=CC(=C3C(=C2)OC(=C(C3=O)O[C@@H]4[C@H]([C@@](CO4)(CO)O)O)C5=CC=C(C=C5)O)O)O)O)O	IC50 = 550000 nM	Non binder
T17048	DNA topoisomerase II alpha	BTA1V9	Damara-20(22), 24-dien-3, 6, 12-trine	Investigative	46887682	C30H50O3	458.7	CC(=CC/C=C(/C)\\[C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(C[C@@H]([C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)O)C)O)C)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BTB48Q	Aesculioside IVa	Investigative	46888245	C57H90O23	1143.3	CCC(C)C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H]([C@@H]([C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@H]([C@H](O8)CO)O)O)O)C)C)C)O)O)CO)(C)C)OC(=O)/C(=C\\C)/C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BTI42V	Aesculioside IIg	Investigative	46888256	C54H84O23	1101.2	C/C=C(/C)\\C(=O)O[C@H]1[C@@H]([C@]2([C@@H](CC1(C)C)C3=CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3([C@H]([C@H]2O)O)C)C)(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@H]([C@H](O8)CO)O)O)O)C)CO)OC(=O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BTQ14V	2-Pentyl-4-[2,4-bis(benzyloxy)-6-pentylbenzoyloxy]-6-hydroxybenzoic acid benzyl ester	Investigative	76314922	C45H48O7	700.9	CCCCCC1=C(C(=CC(=C1)OC(=O)C2=C(C=C(C=C2OCC3=CC=CC=C3)OCC4=CC=CC=C4)CCCCC)O)C(=O)OCC5=CC=CC=C5	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BTZ3Y8	N-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-D-glutamic acid	Investigative	46179812	C10H14N4O6	286.24	COC1=NC(=NC(=N1)N[C@H](CCC(=O)O)C(=O)O)OC	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BU95HS	3-[(2-Benzylsulfanyl-6-oxo-1H-1,3,5-triazin-4-yl)sulfanylmethyl]benzonitrile	Investigative	54769184	C18H14N4OS2	366.5	C1=CC=C(C=C1)CSC2=NC(=NC(=O)N2)SCC3=CC(=CC=C3)C#N	IC50 = 528000 nM	Non binder
T17048	DNA topoisomerase II alpha	BU9HR8	3'-(3,4-Dimethoxybenzyl)-3'-deoxythymidine	Investigative	102350366	C19H24N2O6	376.4	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)CC3=CC(=C(C=C3)OC)OC	IC50 > 200000 nM	Non binder
T17048	DNA topoisomerase II alpha	BV65GQ	Aesculioside IIIc	Investigative	46888313	C57H90O23	1143.3	CCC(C)C(=O)O[C@H]1[C@@H](C(C[C@@H]2[C@]1([C@@H]([C@@H]([C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@H]([C@H](O8)CO)O)O)O)C)C)C)O)O)CO)(C)C)OC(=O)/C(=C/C)/C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BV70SR	Eryngiioside J	Investigative	46888253	C54H84O23	1101.2	C/C=C(/C)\\C(=O)O[C@H]1[C@@H]([C@]2([C@@H](CC1(C)C)C3=CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3([C@H]([C@H]2O)O)C)C)(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](CO7)O)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)CO)OC(=O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BVM1C0	(3E)-3-[(3-Hydroxyphenyl)methylidene]-1-benzofuran-2-one	Investigative	44401784	C15H10O3	238.24	C1=CC=C2C(=C1)/C(=C\\C3=CC(=CC=C3)O)/C(=O)O2	IC50 > 400000 nM	Non binder
T17048	DNA topoisomerase II alpha	BW79FP	4-Phenyl-6-thioxo-5,6-dihydro-1,3,5-triazin-2(1H)-one	Investigative	2818525	C9H7N3OS	205.24	C1=CC=C(C=C1)C2=NC(=S)NC(=O)N2	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BW7MX2	[2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl] 7-[[2-[4-(hydroxymethyl)anilino]-2-oxoethyl]amino]-7-oxoheptanoate	Investigative	72375654	C31H30N2O11	606.6	C1=CC(=CC=C1CO)NC(=O)CNC(=O)CCCCCC(=O)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O	IC50 > 200000 nM	Non binder
T17048	DNA topoisomerase II alpha	BX49PT	2-[(8R,9S,13S,14S,17R)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-N-[6-[[2-(5,11-dimethylpyrido[4,3-b]carbazol-6-yl)acetyl]amino]hexyl]acetamide	Investigative	10676329	C45H54N4O4	714.9	CC1=C2C=CN=CC2=C(C3=C1N(C4=CC=CC=C43)CC(=O)NCCCCCCNC(=O)C[C@@]5(CC[C@@H]6[C@@]5(CC[C@H]7[C@H]6CCC8=C7C=CC(=C8)O)C)O)C	IC50 > 200000 nM	Non binder
T17048	DNA topoisomerase II alpha	BX4MK0	Dibenzyl (2R)-2-[[2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)sulfanyl]benzoyl]amino]pentanedioate	Investigative	46179814	C31H30N4O7S	602.7	COC1=NC(=NC(=N1)SC2=CC=CC=C2C(=O)N[C@H](CCC(=O)OCC3=CC=CC=C3)C(=O)OCC4=CC=CC=C4)OC	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BX9PI4	2-Pentyl-4,6-dihydroxybenzoic acid 3-pentyl-5-hydroxyphenyl ester	Investigative	76329405	C23H30O5	386.5	CCCCCC1=CC(=CC(=C1)OC(=O)C2=C(C=C(C=C2O)O)CCCCC)O	IC50 = 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BXDY27	1-Ethyl-3-(8-methyl-5-pyridin-4-ylisoquinolin-3-yl)urea	Investigative	67449276	C18H18N4O	306.4	CCNC(=O)NC1=CC2=C(C=CC(=C2C=N1)C)C3=CC=NC=C3	IC50 > 256000 nM	Non binder
T17048	DNA topoisomerase II alpha	BXF7N3	N-((4-Phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-(trifluoromethyl)benzamide	Investigative	4245203	C17H13F3N4OS	378.4	C1=CC=C(C=C1)N2C(=NNC2=S)CNC(=O)C3=CC=CC=C3C(F)(F)F	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BXO30Z	Ginsenoside rb1	Investigative	9898279	C54H92O23	1109.3	CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)O)O)O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BXS89G	Aesculioside III	Investigative	46888252	C54H84O23	1101.2	C/C=C(/C)\\C(=O)O[C@H]1[C@@H]([C@@]2([C@@H](C[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H]([C@]5(C)CO)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)C)[C@@H]2CC1(C)C)C)O)CO)OC(=O)C	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BYPR86	6-Benzylsulfanyl-4-[(3-methoxyphenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one	Investigative	54768945	C18H17N3O2S2	371.5	COC1=CC=CC(=C1)CSC2=NC(=O)NC(=N2)SCC3=CC=CC=C3	IC50 = 485300 nM	Non binder
T17048	DNA topoisomerase II alpha	BZ4MT1	N-[[4-(3,4-Dichlorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3-methoxybenzamide	Investigative	4289636	C17H14Cl2N4O2S	409.3	COC1=CC=CC(=C1)C(=O)NCC2=NNC(=S)N2C3=CC(=C(C=C3)Cl)Cl	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	BZ6EK3	3-O-alpha-L-Rhamnopyranosyl quinovic acid	Investigative	46888322	C36H56O9	632.8	C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O[C@@H]6[C@@H]([C@@H]([C@H]([C@@H](O6)C)O)O)O)C)C)[C@@H]2[C@H]1C)C(=O)O)C(=O)O	IC50 > 250000 nM	Non binder
T17048	DNA topoisomerase II alpha	BZ6T9M	2-(4,6-Dichloro-1,3,5-triazine-2-ylthio)benzoic acid	Investigative	46179703	C10H5Cl2N3O2S	302.14	C1=CC=C(C(=C1)C(=O)O)SC2=NC(=NC(=N2)Cl)Cl	IC50 > 1000000 nM	Non binder
T17048	DNA topoisomerase II alpha	D01BKS	ginsenoside Rg3	Investigative	9918693	C42H72O13	785	CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O)C	IC50 > 250000 nM	Non binder