TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T13127 Farnesyl protein transferase B0H2XD 2,2'-Bipyridine Investigative 1474 C10H8N2 156.18 C1=CC=NC(=C1)C2=CC=CC=N2 IC50 = 100000000 nM Non binder T13127 Farnesyl protein transferase B0I1OZ CID 46230630 Investigative 46230630 C20H32O3 320.5 CC(=CCC/C(=C/CC/C(=C/CCC(=O)CCC(=O)O)/C)/C)C IC50 > 200000 nM Non binder T13127 Farnesyl protein transferase B0K9SP (2S)-3-Hydroxy-2-[[(2S)-4-methyl-2-[[(2S)-3-methyl-2-[[(2S)-4-[methyl(phenylmethoxy)amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxobutanoyl]amino]butanoyl]amino]pentanoyl]amino]propanoic acid Investigative 10508462 C31H49N5O10 651.7 CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)N(C)OCC1=CC=CC=C1)NC(=O)OC(C)(C)C IC50 > 360000 nM Non binder T13127 Farnesyl protein transferase B27KER 4-(4-Methylpent-3-enyl)cyclohex-4-ene-1,2-dicarboxylic acid Investigative 3768552 C14H20O4 252.31 CC(=CCCC1=CCC(C(C1)C(=O)O)C(=O)O)C IC50 > 1000000 nM Non binder T13127 Farnesyl protein transferase B2K9OX 4-(4,8,12-Trimethyltridecyl)-4-cyclohexene-1,2-dicarboxylic acid Investigative 44320678 C24H42O4 394.6 CC(C)CCCC(C)CCCC(C)CCCC1=CCC(C(C1)C(=O)O)C(=O)O IC50 > 1000000 nM Non binder T13127 Farnesyl protein transferase B2NG3X (2S)-3-Hydroxy-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-[hydroxy(methyl)amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]propanoic acid Investigative 10721615 C24H43N5O10 561.6 CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)N(C)O)NC(=O)OC(C)(C)C IC50 > 360000 nM Non binder T13127 Farnesyl protein transferase B32SWR (4E)-4-[(2E)-3,7-Dimethylocta-2,6-dienylidene]cyclohexane-1,2-dicarboxylic acid Investigative 44320873 C18H26O4 306.4 CC(=CCC/C(=C/C=C/1\\CCC(C(C1)C(=O)O)C(=O)O)/C)C IC50 > 1000000 nM Non binder T13127 Farnesyl protein transferase B40TSY [8-Amino-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-naphthalen-1-yl-methanone Investigative 10715827 C24H23N5O 397.5 C1CN(C2=C(CN1C(=O)C3=CC=CC4=CC=CC=C43)C=CC(=C2)N)CC5=CN=CN5 IC50 = 1000000 nM Non binder T13127 Farnesyl protein transferase B45FLS Tetrasodium;[2-[1-(3,7-dimethylocta-2,6-dienyl)triazol-4-yl]-1-phosphonatoethyl]-dioxido-oxo-lambda5-phosphane Investigative 73351357 C14H21N3Na4O6P2 481.24 CC(=CCCC(=CCN1C=C(N=N1)CC(P(=O)([O-])[O-])P(=O)([O-])[O-])C)C.[Na+].[Na+].[Na+].[Na+] IC50 = 500000 nM Non binder T13127 Farnesyl protein transferase B4D6PL Dodec-2-enylsuccinic acid Investigative 6026467 C16H28O4 284.39 CCCCCCCCC/C=C/CC(CC(=O)O)C(=O)O IC50 = 402000 nM Non binder T13127 Farnesyl protein transferase B4TD2O (2S)-3-Hydroxy-2-[[(2S)-4-methyl-2-[[(2S)-3-methyl-2-[(3-phenylmethoxybenzoyl)amino]butanoyl]amino]pentanoyl]amino]propanoic acid Investigative 44298887 C28H37N3O7 527.6 CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)C1=CC(=CC=C1)OCC2=CC=CC=C2 IC50 > 360000 nM Non binder T13127 Farnesyl protein transferase B53RJB 2-[1-[(1-Oxidopyridin-1-ium-4-yl)methyl]piperidin-4-ylidene]-4-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaene Investigative 44353928 C25H25N3O 383.5 C1CC2=CC=CC=C2C(=C3CCN(CC3)CC4=CC=[N+](C=C4)[O-])C5=C1C=CC=N5 IC50 = 1832000 nM Non binder T13127 Farnesyl protein transferase B5Q3CK (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-4-[hydroxy(methyl)amino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoic acid Investigative 10718836 C19H35N5O8 461.5 CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)N(C)O)N IC50 > 360000 nM Non binder T13127 Farnesyl protein transferase B67WMV Itaconic anhydride Investigative 75110 C5H4O3 112.08 C=C1CC(=O)OC1=O IC50 > 1000000 nM Non binder T13127 Farnesyl protein transferase B8O4LP 1-(3-Chlorophenyl)-4-[1-(4-cyanobenzyl)-1H-imidazole-5-ylmethyl]piperazine Investigative 44367183 C22H22ClN5 391.9 C1CN(CCN1CC2=CN=CN2CC3=CC=C(C=C3)C#N)C4=CC(=CC=C4)Cl IC50 = 250000 nM Non binder T13127 Farnesyl protein transferase B91PLB 1,10-Phenanthroline Investigative 1318 C12H8N2 180.2 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 IC50 = 4000000 nM Non binder T13127 Farnesyl protein transferase B95BHA 1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro-5-(4-methyl-3-pentenyl)- Investigative 122486 C14H18O3 234.29 CC(=CCCC1=CCC2C(C1)C(=O)OC2=O)C IC50 = 449000 nM Non binder T13127 Farnesyl protein transferase B9E5NG [1-(3H-Imidazol-4-ylmethyl)-9-methyl-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-naphthalen-1-yl-methanone Investigative 10620775 C25H24N4O 396.5 CC1=C2C(=CC=C1)CN(CCN2CC3=CN=CN3)C(=O)C4=CC=CC5=CC=CC=C54 IC50 = 350000 nM Non binder T13127 Farnesyl protein transferase B9G3NU (E)-2-(2-{(S)-1-[(S)-1-((S)-1-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-ethyl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid ethyl ester Investigative 44307001 C36H61N3O8 663.9 CCOC(=O)C(CCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)O)C/C=C(\\C)/CC/C=C(\\C)/CCC=C(C)C IC50 > 360000 nM Non binder T13127 Farnesyl protein transferase B9JXH0 (4E,8E)-5,9,13-Trimethyltetradeca-4,8,12-trienamide Investigative 46230683 C17H29NO 263.4 CC(=CCC/C(=C/CC/C(=C/CCC(=O)N)/C)/C)C IC50 > 200000 nM Non binder T13127 Farnesyl protein transferase BAN8B7 N-[1-(3H-Imidazol-4-ylmethyl)-4-(naphthalene-1-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl]-benzenesulfonamide Investigative 10650059 C30H27N5O3S 537.6 C1CN(C2=C(CN1C(=O)C3=CC=CC4=CC=CC=C43)C=CC(=C2)NS(=O)(=O)C5=CC=CC=C5)CC6=CN=CN6 IC50 = 249000 nM Non binder T13127 Farnesyl protein transferase BB5MA6 [8-Chloro-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-naphthalen-1-yl-methanone Investigative 10549858 C24H21ClN4O 416.9 C1CN(C2=C(CN1C(=O)C3=CC=CC4=CC=CC=C43)C=CC(=C2)Cl)CC5=CN=CN5 IC50 = 540000 nM Non binder T13127 Farnesyl protein transferase BBVQ31 Tetrasodium;[2-[1-[(2Z)-3,7-dimethylocta-2,6-dienyl]triazol-4-yl]-1-phosphonatoethyl]-dioxido-oxo-lambda5-phosphane Investigative 71718590 C14H21N3Na4O6P2 481.24 CC(=CCC/C(=C\\CN1C=C(N=N1)CC(P(=O)([O-])[O-])P(=O)([O-])[O-])/C)C.[Na+].[Na+].[Na+].[Na+] IC50 = 400000 nM Non binder T13127 Farnesyl protein transferase BC56UY Tetrasodium;[2-[1-[(2E)-3,7-dimethylocta-2,6-dienyl]triazol-4-yl]-1-phosphonatoethyl]-dioxido-oxo-lambda5-phosphane Investigative 71521669 C14H21N3Na4O6P2 481.24 CC(=CCC/C(=C/CN1C=C(N=N1)CC(P(=O)([O-])[O-])P(=O)([O-])[O-])/C)C.[Na+].[Na+].[Na+].[Na+] IC50 > 500000 nM Non binder T13127 Farnesyl protein transferase BCQ2D8 Acetic acid (3S,4aR,6aS,12aR,12bS)-8,9-diformyl-11-hydroxy-4,4,6a,12b-tetramethyl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H-benzo[a]xanthen-3-yl ester Investigative 10455264 C25H32O6 428.5 CC(=O)O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@]3([C@@H]2CC4=C(C=C(C(=C4O3)C=O)C=O)O)C)C IC50 = 560000 nM Non binder T13127 Farnesyl protein transferase BD3U1B 7-Bromo-4-(1-naphthylcarbonyl)-1-(1H-imidazole-5-ylmethyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine Investigative 10790170 C24H21BrN4O 461.4 C1CN(C2=C(CN1C(=O)C3=CC=CC4=CC=CC=C43)C=C(C=C2)Br)CC5=CN=CN5 IC50 = 228000 nM Non binder T13127 Farnesyl protein transferase BEC5H4 (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-hydroxypropanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoic acid Investigative 44299016 C17H32N4O7 404.5 CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)N IC50 > 360000 nM Non binder T13127 Farnesyl protein transferase BK6BF3 1-(3H-Imidazol-4-ylmethyl)-7-phenyl-4-(1-phenyl-1H-tetrazol-5-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine Investigative 10718316 C26H24N8 448.5 C1CN(C2=C(CN1C3=NN=NN3C4=CC=CC=C4)C=C(C=C2)C5=CC=CC=C5)CC6=CN=CN6 IC50 = 702000 nM Non binder T13127 Farnesyl protein transferase BKB2V3 (4-Chloro-phenylamino)-[1-(3H-imidazol-4-ylmethyl)-7-phenyl-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-methyl-cyanamide Investigative 10743390 C27H24ClN7 482 C1CN(C2=C(CN1C(=NC3=CC=C(C=C3)Cl)NC#N)C=C(C=C2)C4=CC=CC=C4)CC5=CN=CN5 IC50 = 1423000 nM Non binder T13127 Farnesyl protein transferase BKJD93 (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-4-[methyl(phenylmethoxy)amino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoic acid Investigative 10626514 C26H41N5O8 551.6 CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)N(C)OCC1=CC=CC=C1)N IC50 > 360000 nM Non binder T13127 Farnesyl protein transferase BKUA52 1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-ylmethyl-7-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine Investigative 10551282 C30H28N4 444.6 C1CN(C2=C(CN1CC3=CC=CC4=CC=CC=C43)C=C(C=C2)C5=CC=CC=C5)CC6=CN=CN6 IC50 = 2968000 nM Non binder T13127 Farnesyl protein transferase BKZG79 (2S)-3-Hydroxy-2-[[(2S)-2-[[(2S)-2-[(2-hydroxy-3-phenylmethoxybenzoyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]propanoic acid Investigative 44299002 C28H37N3O8 543.6 CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)C1=C(C(=CC=C1)OCC2=CC=CC=C2)O IC50 > 360000 nM Non binder T13127 Farnesyl protein transferase BL7TK9 (2R,3R)-2-Imidazol-1-ylmethyl-4-methyl-2,3-dihydro-benzo[b]thiophen-3-ol Investigative 10752959 C13H14N2OS 246.33 CC1=C2[C@H]([C@H](SC2=CC=C1)CN3C=CN=C3)O IC50 = 266000 nM Non binder T13127 Farnesyl protein transferase BLQ78H [(3S,4Ar,6aS,12aR,12bS)-11-hydroxy-8,9-bis(hydroxymethyl)-4,4,6a,12b-tetramethyl-1,2,3,4a,5,6,12,12a-octahydrobenzo[a]xanthen-3-yl] acetate Investigative 44305558 C25H36O6 432.5 CC(=O)O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@]3([C@@H]2CC4=C(C=C(C(=C4O3)CO)CO)O)C)C IC50 = 460000 nM Non binder T13127 Farnesyl protein transferase BMO4N7 2-[[4-(Dimethylamino)-6-[(2-sulfanylethylamino)methyl]-2-pyridyl]methylamino]ethanethiol Investigative 390610 C13H24N4S2 300.5 CN(C)C1=CC(=NC(=C1)CNCCS)CNCCS IC50 = 620000 nM Non binder T13127 Farnesyl protein transferase BN6B4T (4E,8E)-N-(Benzenesulfonyl)-5,9,13-trimethyltetradeca-4,8,12-trienamide Investigative 46230686 C23H33NO3S 403.6 CC(=CCC/C(=C/CC/C(=C/CCC(=O)NS(=O)(=O)C1=CC=CC=C1)/C)/C)C IC50 > 200000 nM Non binder T13127 Farnesyl protein transferase BNQ9R8 (S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldisulfanyl-propionylamino)-methyl]-3-benzyloxy-tetrahydro-pyran-2-carbonyl}-amino)-4-methyl-pentanoic acid Investigative 11376536 C27H43N3O6S2 569.8 CC(C)C[C@@H](C(=O)O)NC(=O)[C@@H]1[C@H](CC[C@H](O1)CNC(=O)[C@H](CSSC(C)(C)C)N)OCC2=CC=CC=C2 IC50 = 321000 nM Non binder T13127 Farnesyl protein transferase BO2U6Y (2S)-3-Hydroxy-2-[[(2S)-2-[[(2S)-2-[(4-hydroxybenzoyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]propanoic acid Investigative 44298915 C21H31N3O7 437.5 CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)C1=CC=C(C=C1)O IC50 > 360000 nM Non binder T13127 Farnesyl protein transferase BOUZ75 (2S)-3-Hydroxy-2-[[(2S)-2-[[(2S)-2-[(2-hydroxybenzoyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]propanoic acid Investigative 44298951 C21H31N3O7 437.5 CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)C1=CC=CC=C1O IC50 > 360000 nM Non binder T13127 Farnesyl protein transferase BP9AO6 (3,4-Dihydro-2H-quinolin-1-yl)-[1-(3H-imidazol-4-ylmethyl)-7-phenyl-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-methanone Investigative 10647793 C29H29N5O 463.6 C1CC2=CC=CC=C2N(C1)C(=O)N3CCN(C4=C(C3)C=C(C=C4)C5=CC=CC=C5)CC6=CN=CN6 IC50 = 205000 nM Non binder T13127 Farnesyl protein transferase BR3B6W [2-Hydroxy-3-sulfanyl-1-(sulfanylmethyl)propyl] 2-(2,3-dihydro-1,4-benzodioxin-3-yl)thiazole-4-carboxylate Investigative 493392 C16H17NO5S3 399.5 C1C(OC2=CC=CC=C2O1)C3=NC(=CS3)C(=O)OC(CS)C(CS)O IC50 > 1000000 nM Non binder T13127 Farnesyl protein transferase BS50AW 1-(3H-Imidazol-4-ylmethyl)-4-(naphthalene-1-sulfonyl)-7-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine Investigative 10815067 C29H26N4O2S 494.6 C1CN(C2=C(CN1S(=O)(=O)C3=CC=CC4=CC=CC=C43)C=C(C=C2)C5=CC=CC=C5)CC6=CN=CN6 IC50 = 426000 nM Non binder T13127 Farnesyl protein transferase BSQ7Z1 1-Phenyl-4-[1-(4-cyanobenzyl)-1H-imidazole-5-ylmethyl]piperazine-2,5-dione Investigative 15410947 C22H19N5O2 385.4 C1C(=O)N(CC(=O)N1CC2=CN=CN2CC3=CC=C(C=C3)C#N)C4=CC=CC=C4 IC50 = 950000 nM Non binder T13127 Farnesyl protein transferase BTA56P 2-Methyl-3-(acetylthio)-9-methoxy-1,2,3,4-tetrahydropyrazino[1,2-a]indole-1,4-dione Investigative 10403581 C15H14N2O4S 318.3 CC(=O)SC1C(=O)N2C3=C(C=C2C(=O)N1C)C(=CC=C3)OC IC50 = 748000 nM Non binder T13127 Farnesyl protein transferase BTA5X6 Lauric anhydride Investigative 69527 C24H46O3 382.6 CCCCCCCCCCCC(=O)OC(=O)CCCCCCCCCCC IC50 = 854000 nM Non binder T13127 Farnesyl protein transferase BU5XQ9 Tetrasodium;[2-[1-[[(2R,3R)-3-methyl-3-(4-methylpent-3-enyl)oxiran-2-yl]methyl]triazol-4-yl]-1-phosphonatoethyl]-dioxido-oxo-lambda5-phosphane Investigative 90656272 C14H21N3Na4O7P2 497.24 CC(=CCC[C@@]1([C@H](O1)CN2C=C(N=N2)CC(P(=O)([O-])[O-])P(=O)([O-])[O-])C)C.[Na+].[Na+].[Na+].[Na+] IC50 = 400000 nM Non binder T13127 Farnesyl protein transferase BWJO10 (S)-3-Hydroxy-2-{(S)-4-methyl-2-[(S)-3-methyl-2-((10E,14E)-7,11,15-trimethyl-hexadeca-6,10,14-trienoylamino)-butyrylamino]-pentanoylamino}-propionic acid Investigative 44307003 C33H57N3O6 591.8 CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)CCCC/C=C(\\C)/CC/C=C(\\C)/CCC=C(C)C IC50 > 360000 nM Non binder T13127 Farnesyl protein transferase BWYT08 5-(4,8,12-Trimethyl-tridecyl)-3a,4,7,7a-tetrahydro-isobenzofuran-1,3-dione Investigative 10362198 C24H40O3 376.6 CC(C)CCCC(C)CCCC(C)CCCC1=CCC2C(C1)C(=O)OC2=O IC50 > 1000000 nM Non binder T13127 Farnesyl protein transferase BXZO34 4-Oxo-4-[[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]amino]butyric acid Investigative 10448769 C19H31NO3 321.5 CC(=CCC/C(=C/CC/C(=C/CNC(=O)CCC(=O)O)/C)/C)C IC50 = 220000 nM Non binder T13127 Farnesyl protein transferase BZ4GP0 11-(1-Methylpiperidin-4-yl)-6,11-dihydro-5H-benzo[1,2]cyclohepta[3,4-b]pyridine Investigative 18715403 C20H24N2 292.4 CN1CCC(CC1)C2C3=CC=CC=C3CCC4=C2N=CC=C4 IC50 = 724000 nM Non binder T13127 Farnesyl protein transferase BZ74QH Tetrasodium;[2-[1-[[(2R,3S)-3-methyl-3-(4-methylpent-3-enyl)oxiran-2-yl]methyl]triazol-4-yl]-1-phosphonatoethyl]-dioxido-oxo-lambda5-phosphane Investigative 90656274 C14H21N3Na4O7P2 497.24 CC(=CCC[C@]1([C@H](O1)CN2C=C(N=N2)CC(P(=O)([O-])[O-])P(=O)([O-])[O-])C)C.[Na+].[Na+].[Na+].[Na+] IC50 = 340000 nM Non binder T13127 Farnesyl protein transferase BZ76PR 2-Dodecen-1-ylsuccinic anhydride Investigative 5362708 C16H26O3 266.38 CCCCCCCCC/C=C/CC1CC(=O)OC1=O IC50 > 1000000 nM Non binder T13127 Farnesyl protein transferase D0WT6A Ethylene diamine Investigative 3301 C2H8N2 60.1 C(CN)N IC50 = 15500000 nM Non binder