TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T08446	Na(+)/Cl(-) betaine/GABA transporter	D0ED7U	Tiagabine	Approved	60648	C20H25NO2S2	375.6	CC1=C(SC=C1)C(=CCCN2CCC[C@H](C2)C(=O)O)C3=C(C=CS3)C	IC50 = 1670000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	D08ESA	CI-966	Phase 1	198693	C23H21F6NO3	473.4	C1CN(CC(=C1)C(=O)O)CCOC(C2=CC=C(C=C2)C(F)(F)F)C3=CC=C(C=C3)C(F)(F)F	IC50 = 300000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B01XGU	2,4-Dichloro-N-{1-[(pyridin-2-yl)methyl]piperidin-4-yl}benzamide	Investigative	47058964	C18H19Cl2N3O	364.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=CC=N3	IC50 > 1000000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B04AGQ	Tert-butyl 2-[4-[(2,4-dichlorobenzoyl)amino]piperidin-1-yl]acetate	Investigative	137651374	C18H24Cl2N2O3	387.3	CC(C)(C)OC(=O)CN1CCC(CC1)NC(=O)C2=C(C=C(C=C2)Cl)Cl	IC50 > 1000000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B0ID7G	1-{2-[Tris-(4-fluoro-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid	Investigative	10050339	C27H26F3NO3	469.5	C1CC(CN(C1)CCOC(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C(=O)O	IC50 = 1270000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B0L6AI	1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid	Investigative	9983570	C30H33NO6	503.6	COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)OCCN4CCC=C(C4)C(=O)O	IC50 = 2660000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B1GKJ7	1-(2-Tritylsulfanyl-ethyl)-piperidine-3-carboxylic acid	Investigative	11743493	C27H29NO2S	431.6	C1CC(CN(C1)CCSC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)O	IC50 = 435000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B1RV5K	2,4-Dichloro-N-[1-(pyridin-3-ylmethyl)piperidin-4-yl]benzamide	Investigative	137637846	C18H19Cl2N3O	364.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CN=CC=C3	IC50 > 1000000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B1Y8RO	2,4-Dichloro-N-[1-(3-diethoxyphosphorylpropyl)piperidin-4-yl]benzamide	Investigative	137639281	C19H29Cl2N2O4P	451.3	CCOP(=O)(CCCN1CCC(CC1)NC(=O)C2=C(C=C(C=C2)Cl)Cl)OCC	IC50 > 1000000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B24HDT	(3R,8R)-8-Benzhydryl-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine-3-carboxylic acid;hydrochloride	Investigative	70689233	C23H28ClNO2	385.9	C1CC2C[C@@H](CCN2C[C@@H]1C(=O)O)C(C3=CC=CC=C3)C4=CC=CC=C4.Cl	IC50 = 2900000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B39IXZ	2,4-Dichloro-N-[1-(pyridin-4-ylmethyl)piperidin-4-yl]benzamide	Investigative	137650102	C18H19Cl2N3O	364.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=NC=C3	IC50 > 1000000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B4E2FN	1-{2-[(4-Methoxy-3-trifluoromethyl-phenyl)-phenyl-(3-trifluoromethyl-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid	Investigative	10031163	C30H29F6NO4	581.5	COC1=C(C=C(C=C1)C(C2=CC=CC=C2)(C3=CC(=CC=C3)C(F)(F)F)OCCN4CCCC(C4)C(=O)O)C(F)(F)F	IC50 = 201000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B4SNX3	1-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-piperidine-3-carboxylic acid	Investigative	10096504	C29H33NO5	475.6	COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCCN4CCCC(C4)C(=O)O	IC50 = 382000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B5EB1C	1-{2-[(4-Methoxy-phenyl)-diphenyl-methoxy]-ethyl}-piperidine-3-carboxylic acid	Investigative	10252950	C28H31NO4	445.5	COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OCCN4CCCC(C4)C(=O)O	IC50 = 655000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	B7KA4R	(R)-1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid	Investigative	6604883	C30H35NO6	505.6	COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)OCCN4CCC[C@H](C4)C(=O)O	IC50 = 630000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BA5BR3	N-(1-Benzylpiperidin-4-yl)benzamide	Investigative	40598	C19H22N2O	294.4	C1CN(CCC1NC(=O)C2=CC=CC=C2)CC3=CC=CC=C3	IC50 = 290000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BAF63S	2,4-Dichloro-N-(1-ethylpiperidin-4-yl)benzamide	Investigative	17174058	C14H18Cl2N2O	301.2	CCN1CCC(CC1)NC(=O)C2=C(C=C(C=C2)Cl)Cl	IC50 > 1000000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BBA38E	2,4-Dichloro-N-(1-methylpiperidin-4-yl)benzamide	Investigative	639062	C13H16Cl2N2O	287.18	CN1CCC(CC1)NC(=O)C2=C(C=C(C=C2)Cl)Cl	IC50 > 1000000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BBH5A6	(3R)-8-Benzhydrylidene-1,2,3,4,6,7,9,9a-octahydroquinolizine-3-carboxylic acid;hydrochloride	Investigative	70691308	C23H26ClNO2	383.9	C1CC2CC(=C(C3=CC=CC=C3)C4=CC=CC=C4)CCN2C[C@@H]1C(=O)O.Cl	IC50 = 436000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BDV06W	2,4-Dichloro-N-[1-(3-cyanopropyl)piperidin-4-yl]benzamide	Investigative	137650910	C16H19Cl2N3O	340.2	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CCCC#N	IC50 > 1000000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BE8Z6U	1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxylic acid	Investigative	9797818	C22H25NO2	335.4	C1C[C@H](CN(C1)CCC=C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O	IC50 = 7210000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BF46GZ	N-(1-Benzylpiperidin-4-yl)-2,6-dichloropyridine-3-carboxamide	Investigative	137635197	C18H19Cl2N3O	364.3	C1CN(CCC1NC(=O)C2=C(N=C(C=C2)Cl)Cl)CC3=CC=CC=C3	IC50 > 1000000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BK79IQ	(3S)-8-Benzhydrylidene-1,2,3,4,6,7,9,9a-octahydroquinolizine-3-carboxylic acid;hydrochloride	Investigative	70684990	C23H26ClNO2	383.9	C1CC2CC(=C(C3=CC=CC=C3)C4=CC=CC=C4)CCN2C[C@H]1C(=O)O.Cl	IC50 = 335000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BNGJ41	1-[2-(9-Phenyl-9H-xanthen-9-yloxy)-ethyl]-piperidine-3-carboxylic acid	Investigative	10252046	C27H27NO4	429.5	C1CC(CN(C1)CCOC2(C3=CC=CC=C3OC4=CC=CC=C42)C5=CC=CC=C5)C(=O)O	IC50 = 920000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BOL61T	(3S,8R)-8-Benzhydryl-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine-3-carboxylic acid;hydrochloride	Investigative	70691306	C23H28ClNO2	385.9	C1CC2C[C@@H](CCN2C[C@H]1C(=O)O)C(C3=CC=CC=C3)C4=CC=CC=C4.Cl	IC50 = 809000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BOU75T	2,4-Dichloro-N-piperidin-4-ylbenzamide	Investigative	43345728	C12H14Cl2N2O	273.15	C1CNCCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl	IC50 > 1000000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BS1KV0	2,4-Dichloro-N-(1-propylpiperidin-4-yl)benzamide	Investigative	17173775	C15H20Cl2N2O	315.2	CCCN1CCC(CC1)NC(=O)C2=C(C=C(C=C2)Cl)Cl	IC50 > 1000000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BSN5K4	1-[2-[Tris(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acid	Investigative	4531494	C30H35NO6	505.6	COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)OCCN4CCCC(C4)C(=O)O	IC50 = 208000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BUTF86	2,4-Dichloro-N-(1-prop-2-ynylpiperidin-4-yl)benzamide	Investigative	137651669	C15H16Cl2N2O	311.2	C#CCN1CCC(CC1)NC(=O)C2=C(C=C(C=C2)Cl)Cl	IC50 > 1000000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BW3N0X	N-(1-Benzylpiperidin-4-yl)-2-methylpropanamide	Investigative	1530639	C16H24N2O	260.37	CC(C)C(=O)NC1CCN(CC1)CC2=CC=CC=C2	IC50 > 1000000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	BX5LG2	2-[4-[(2,4-Dichlorobenzoyl)amino]piperidin-1-yl]acetic acid	Investigative	137652511	C14H16Cl2N2O3	331.2	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC(=O)O	IC50 > 1000000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	D03IWW	(S)-Piperidine-3-carboxylic acid	Investigative	6575389	C6H11NO2	129.16	C1C[C@@H](CNC1)C(=O)O	IC50 = 6410000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	D08YGM	SKF89976A	Investigative	92409	C22H25NO2	335.4	C1CC(CN(C1)CCC=C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O	IC50 = 7210000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	D0D2EF	(R)-nipecotic acid	Investigative	1796510	C6H11NO2	129.16	C1C[C@H](CNC1)C(=O)O	IC50 = 2310000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	D0RF2M	NIPECOTIC ACID	Investigative	4498	C6H11NO2	129.16	C1CC(CNC1)C(=O)O	IC50 = 2370000 nM	Non binder
T08446	Na(+)/Cl(-) betaine/GABA transporter	D0V7RG	4-substituted 2,4-dioxobutanoic acids	Investigative	3532	C6H9NO2	127.14	C1CNCC(=C1)C(=O)O	IC50 = 1870000 nM	Non binder