Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 2-(2,4-Dichloro-benzenesulfinyl)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-((R)-8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid pyridin-3-ylamide | Drug Info |
| Ftase --- FPTase | ethyl 2-(3-(3-(1H-imidazol-4-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetate | Drug Info |
| Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-1-(3-chlorobenzyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
| Ftase --- FPTase | 4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-2-(5,6,7,8-tetrahydro-naphthalen-2-yloxy)-benzonitrile | Drug Info |
| Ftase --- FPTase | N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)-N-(4-phenoxyphenyl)quinoline-2-carboxamide | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| Ftase --- FPTase | 2-[2-(3-Chloro-phenyl)-1H-indol-3-yl]-N-isopropyl-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| Ftase --- FPTase | 4-{(S)-1-[(S)-1-((S)-1-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienoylamino)-butyric acid | Drug Info |
| Ftase --- FPTase | 3-alFPP | Drug Info |
| Ftase --- FPTase | N-(4-bromophenethyl)-N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)quinoline-2-carboxamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid tert-butyl ester | Drug Info |
| Ftase --- FPTase | 1-((2R,3R)-3-Allyloxy-6-chloro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl)-1H-imidazole | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(2-Methyl-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | (2E,6E)-3-ethyl-7,11-dimethyldodeca-2,6,10-trienyl trihydrogen diphosphate | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | 2-(3-Benzoyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | N-Isopropyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-2-ylmethyl-acetamide | Drug Info |
| Ftase --- FPTase | (+)4-{2-[4-(4-chloro-3,6,7,12-tetrahydropyrido[2',3':4,5]cyclohepta[e]indol-12-yl)hexahydro-1-pyridinyl]-2-oxoethyl}-1-pyridiniumolate | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{Benzyl-[(S)-2-(3-mercapto-propionylamino)-3-methyl-pentyl]-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4'-{[3-(4-Amino-benzyl)-3H-imidazol-4-ylmethyl]-amino}-[1,1';2',1'']terphenyl-3-carboxylic 28 (FTI-2347) | Drug Info |
| Ftase --- FPTase | Chaetomellic acid B | Drug Info |
| Ftase --- FPTase | (S)-4-{1-[1-((S)-1-(S)-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienylcarbamoyl)-butyric acid | Drug Info |
| Ftase --- FPTase | 6-[Amino-(4-chloro-phenyl)-(4-methyl-4H-[1,2,4]triazol-3-yl)-methyl]-4-(3-chloro-phenyl)-1-methyl-1H-quinolin-2-one | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-[1-(1-oxy-pyridine-3-carbonyl)-piperidin-4-yl]-ethanone | Drug Info |
| Ftase --- FPTase | Isobutyric acid 2-((10R,13S)-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl ester | Drug Info |
| Ftase --- FPTase | (+/-)4-{2-[4-(9-bromo-4-chloro-1-methyl-3,6,7,12-tetrahydropyrido[2',3':4,5]cyclohepta[e]indol-12-yliden)hexahydro-1-pyridinyl]-2-oxoethyl}-1-pyridiniumolate | Drug Info |
| Ftase --- FPTase | N-(4-bromophenethyl)-N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)furan-2-carboxamide | Drug Info |
| Ftase --- FPTase | [4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-imidazol-1-yl-methanone | Drug Info |
| Ftase --- FPTase | NA | Drug Info |
| Ftase --- FPTase | 2-Benzyloxy-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-iodo-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | 2-(1-Acetyl-piperidin-3-yl)-1-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-ethanone | Drug Info |
| Ftase --- FPTase | 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-[1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-benzonitrile | Drug Info |
| Ftase --- FPTase | N-Isobutyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| Ftase --- FPTase | Pyridine-3-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(2-methyl-allyl)-amide | Drug Info |
| Ftase --- FPTase | 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-4-carboxylic acid | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(3-hydroxy-phenylethynyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | (4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a]quinazolin-7-yl)(1-methyl-1H-imidazol-5-yl)methanamine | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[(E)-4-(Cyclohexyl-hydroxy-methyl)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (S)-3-Hydroxy-2-{(S)-2-[(S)-2-(3-mercapto-propionylamino)-3-methyl-butyrylamino]-4-methyl-pentanoylamino}-propionic acid | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(2,4-Dichloro-benzyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | Lonafarnib | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid pyrazin-2-ylamide | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-dimethylcarbamoyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((R)-3,7-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-(1-oxy-pyridin-3-ylmethyl)-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | 1-[4-Chloro-3-(4-chloro-benzyloxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | 4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-2-phenylsulfanyl-benzonitrile | Drug Info |
| Ftase --- FPTase | (Z)-Octadec-9-enoic acid {2-[3-(2,3-dimethyl-phenylsulfamoyl)-phenylcarbamoyl]-ethyl}-amide | Drug Info |
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