Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 3-Ethylsulfanyl-5-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one | Drug Info |
| MMP1 --- MMP3 | 10-Isobutyl-6,11-dioxo-6,7,9,10,11,12,13,14-octahydro-5H-8-oxa-15-thia-5,12-diaza-benzocyclotridecene-9,13-dicarboxylic acid 9-hydroxyamide 13-methylamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid benzhydryl-amide | Drug Info |
| Erbeta --- ER | 2-(2-chloro-4-hydroxyphenyl)benzo[d]oxazol-5-ol | Drug Info |
| MMP1 --- MMP3 | (2R,3R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-1-(2-methoxy-ethyl)-2-oxo-azepan-3-yl]-3-propyl-succinamide | Drug Info |
| S5AR --- SRD5A2 | 4-[2-(6-{[Bis-(4-fluoro-phenyl)-methyl]-carbamoyl}-benzofuran-2-yl)-phenoxy]-butyric acid | Drug Info |
| Erbeta --- ER | (3S,4R)-3-Phenyl-4-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-isothiochroman-7-ol | Drug Info |
| MMP1 --- MMP9 | (3R,6S)-3-(mercaptomethyl)-6-(4-nitrobenzyl)-1-propylpiperazine-2,5-dione | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (3-bromo-phenyl)-amide | Drug Info |
| Erbeta --- ER | (2S,3R)-7-Hydroxy-3-methyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| MMP13 --- MMP1 | 2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)carbamoyl)-5,5,5-trifluoropentyl(4-benzylbenzyl)phosphinic acid | Drug Info |
| S5AR --- SRD5A2 | 3-(1-Methyl-1H-indol-3-yl)-1-phenyl-4-(1-(3-(1H-1,2,4-triazol-1-yl)propyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1Hpyrrole-2,5-dione | Drug Info |
| Erbeta --- ER | (13S,17S)-4-(2-Amino-ethyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol | Drug Info |
| MMP13 --- MMP1 | (S)-1-((2S,3R)-4-(hydroxyamino)-3-(hydroxymethyl)-2-(4-methoxyphenyl)-4-oxobutanoyl)-N-methylpiperidine-2-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (3-chloro-phenyl)-amide | Drug Info |
| Erbeta --- ER | 4-(2-{4-[(3-Benzo[1,3]dioxol-5-yl-propyl)-methyl-amino]-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino}-ethyl)-phenol | Drug Info |
| MMP13 --- MMP1 | 1-Acetyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-8-dimethylaminomethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (17-Diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)-oxo-acetic acid | Drug Info |
| Erbeta --- ER | [6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(3-piperidin-1-yl-propyl)-phenyl]-methanone | Drug Info |
| MMP13 --- MMP1 | 4-acetyl-1-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-1,4-diazepane-2-carboxamide | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-ethoxy-phenyl ester | Drug Info |
| Erbeta --- ER | (2S,3S)-7-Hydroxy-3-isopropyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| MMP13 --- MMP1 | 4-[4-(3-Chloro-benzyloxy)-benzenesulfonyl]-3-hydroxy-tetrahydro-pyran-3-carboxylic acid hydroxyamide | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-phenylamino)-6,7-dimethoxy-quinoline-3-carbaldehyde | Drug Info |
| Erbeta --- ER | (2S,3R)-7-Hydroxy-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-[4-(4-chloro-phenoxy)-phenoxy]-3-(2-ethoxy-ethyl)-piperidine-2,4,6-trione | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-[3-(4-methyl-[1,4]diazepan-1-yl)-propoxy]-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 9a-benzyl-6-methyl-8,9,9a,10-tetrahydrofluoreno[1,2-d][1,2,3]triazol-7(3H)-one | Drug Info |
| MMP13 --- MMP9 | N-hydroxy-2-(4-methoxyphenylsulfonyl)-2-propylpentanamide | Drug Info |
| PDGFR --- Src | 8-Methyl-2-(pyridin-4-ylamino)-6-thiophen-3-yl-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| Erbeta --- ER | CHEMBL2135534 | Drug Info |
| MMP2 --- HER2 | (1S,2S,5RS)-N-hydroxy-5-(2-((R)-3-hydroxypyrrolidin-1-yl)-2-oxoethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-Phenyl-3-benzyl-6-(morphilin-4-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Erbeta --- ER | (6-hydroxy-2-(4-hydroxyphenyl)-5,7-dimethylbenzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone | Drug Info |
| MMP2 --- MMP1 | N-Hydroxy-N-[1-(4-thiophen-2-yl-phenoxymethyl)-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-yl)-ethyl]-formamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID534102 | Drug Info |
| Erbeta --- mRNA of AR | SID4243681 | Drug Info |
| MMP2 --- MMP13 | 2-(4'-Methoxy-biphenyl-4-sulfonylamino)-6-(4-phenyl-piperazin-1-yl)-hex-4-ynoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL254192 | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-10,10-dioxo-10,11-dihydro-10lambda*6*-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4'-(4-methoxy-3-methylbenzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829250 | Drug Info |
| Ftase --- FPTase | 4-(1-Carboxy-3-methylsulfanyl-propylcarbamoyl)-5-o-tolyl-3,6-dihydro-2H-pyridine-1-carboxylic acid 3-cyclohexyl-1-thiazol-5-yl-propyl ester | Drug Info |
| MMP2 --- MMP13 | N-benzyl-1-(4-(1-cyclopropyl-4-(hydroxycarbamoyl)piperidin-4-ylsulfonyl)phenyl)-N-methylpiperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 7-(trifluoromethyl)-9H-pyrido[3,4-b]indole | Drug Info |
| Ftase --- FPTase | 3-(2-Cyano-5-imidazol-1-ylmethyl-phenoxy)-N-phenyl-benzamide | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentylnaphthalene-2-sulfonamido)-2-(tetrahydro-2H-pyran-4-yl)acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(3-chlorophenyl)-N,N,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1H)-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-(5-((R)-2-amino-3-mercaptopropylamino)biphenyl-2-ylcarboxamido)-4-methylpentanoic acid | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(2,5-dimethoxyphenyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
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