Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PPAR gamma --- PPAR delta | (S)-2-methoxy-3-(4-(4-(4-phenoxyphenoxy)but-1-ynyl)phenyl)propanoic acid | Drug Info |
| Erbeta --- ER | SID859273 | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(3-fluoroquinolin-5-yl)acetamide | Drug Info |
| PR --- mRNA of AR | (S)-3-(3-Bromo-4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)propanamide | Drug Info |
| Erbeta --- ER | SID50112959 | Drug Info |
| MEP --- Cathepsin B | 1-(1-(3,5-bis(trifluoromethyl)phenyl)-3-phenylpropylidene)thiosemicarbazide | Drug Info |
| PR --- mRNA of AR | 2-chloro-4-((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropylamino)-3-methylbenzonitrile | Drug Info |
| Erbeta --- ER | 4-bromo-6-hydroxy-2-(4-hydroxyphenyl)isoindoline-1,3-dione | Drug Info |
| MEP --- Cathepsin B | {3-Methyl-1-[2-oxo-1-phenethyl-3-(3-phenyl-propylsulfanyl)-propylcarbamoyl]-butyl}-carbamic acid pyridin-3-ylmethyl ester | Drug Info |
| PR --- mRNA of AR | 5-(3,3-Difluoro-allyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| Erbeta --- ER | 1-{2-[4-((3S,4R)-7-Methoxy-3-phenyl-isochroman-4-yl)-phenoxy]-ethyl}-pyrrolidine | Drug Info |
| MEP --- Cathepsin B | 2-(4-Bromo-thiophen-3-ylamino)-4-methyl-pentanoic acid cyanomethyl-amide | Drug Info |
| PR --- mRNA of AR | Acetic acid 5-bromo-2-((1S,6R)-4,6-dimethyl-2-methylene-cyclohex-3-enylmethyl)-4-methoxy-phenyl ester | Drug Info |
| Erbeta --- ER | (S)(-)-9a-Butyl-6-ethyl-8,9,9a,10-tetrahydro-3H-1,2,3-triaza-cyclopenta[a]fluoren-7-one | Drug Info |
| Erbeta --- ER | (2S,3R)-2-[3-Bromo-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]dithiin-6-ol | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-(3-naphthalen-1-yl-thioureido)-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| PR --- mRNA of AR | 5-(3-cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile | Drug Info |
| Erbeta --- ER | 3-hydroxy-8-methoxy-4,7-dimethyl-6H-benzo[c]chromen-6-one | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-isopropyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-1-phenylpyrrolidine-3-carboxamide | Drug Info |
| PR --- mRNA of AR | 5-[1-(3-Fluoro-phenyl)-meth-(Z)-ylidene]-2,2,4-trimethyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one | Drug Info |
| Erbeta --- ER | (2R,3S)-8-Chloro-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| Met --- VEGFR | 7-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-N,N-dimethylthieno[3,2-b]pyridine-2-carboxamide | Drug Info |
| PR --- mRNA of AR | (+)-(S)-3-(4-Nitrophenylamino)-3-(3-fluorophenyl)-1-p-tolylpropan-1-one | Drug Info |
| Erbeta --- ER | 1-[4-(4-Ethyl-3-methyl-piperazin-1-yl)-phenyl]-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(4-(piperazin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| Renin --- Cathepsin D | {1-[1-[2-(1-Butyl-5,5-dimethyl-2-oxo-pyrrolidin-3-yl)-1-cyclohexylmethyl-2-hydroxy-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| Erbeta --- ER | 4-{6-Hydroxy-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-N,N-dimethyl-benzamide | Drug Info |
| MMP1 --- MMP3 | (S)-2-Cyclohexyl-N*4*-hydroxy-N*1*-[(S)-3-methyl-1-(5-phenyl-1H-imidazol-2-yl)-butyl]-succinamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-(bis(4-fluorophenyl)methyl)-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 4-(2-{4-[2-(4-Chloro-phenoxy)-ethylsulfanyl]-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino}-ethyl)-phenol | Drug Info |
| MMP1 --- MMP3 | 1-(4-Butoxy-benzenesulfonyl)-4-(1-methyl-1H-imidazole-4-sulfonylamino)-pyrrolidine-2-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | 4-(3-{4-[1-(4-Propyl-phenoxy)-ethyl]-benzoyl}-indol-1-yl)-butyric acid | Drug Info |
| Erbeta --- ER | Dimethyl-{2-[4-(4-phenyl-2,3-dihydro-benzo[b]oxepin-5-yl)-phenoxy]-ethyl}-amine | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-(4-phenoxy-butyl)-succinamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid naphthalen-2-ylamide | Drug Info |
| Erbeta --- ER | 4-[2-(4-(4-Benzyl-piperazin-1-yl)-6-{[3-(4-chloro-phenyl)-propyl]-methyl-amino}-[1,3,5]triazin-2-ylamino)-ethyl]-phenol | Drug Info |
| MMP1 --- MMP9 | (3R,6S)-3-Mercaptomethyl-6-(4-nitro-benzyl)-1-quinolin-2-ylmethyl-piperazine-2,5-dione | Drug Info |
| S5AR --- SRD5A2 | 4-{3-[(R)-2-(4-Isobutyl-phenyl)-2-methyl-benzo[1,3]dioxole-5-carbonyl]-indol-1-yl}-butyric acid | Drug Info |
| Erbeta --- ER | 4-{2-[4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-(4-phenyl-piperazin-1-yl)-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
| MMP13 --- MMP1 | 4-{(R)-Carboxy-[5-(4'-ethoxyphenyl)-thiophene-2-sulfonylamino]-methyl}-piperidine-1-carboxylic Acid 4-Tetrahydropyranyl Ester | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aR,10S)-7-(1,5-Dimethyl-hexyl)-4a,6a-dimethyl-10-propyl-hexadecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
| Erbeta --- ER | 4-{6-Hydroxy-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-benzamide | Drug Info |
| MMP13 --- MMP1 | (2R,5R)-5-Hydroxy-1-[4-(2-isopropyl-benzyloxy)-benzenesulfonyl]-3,3-dimethyl-piperidine-2-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-N-trityl-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 5'-(2-hexahydro-1-pyridinylethoxy)-5-hydroxy-2-(4-hydroxyphenyl)-1,2'-spirobi[1H-indene]-1',3'-dione | Drug Info |
| MMP13 --- MMP1 | (R)-[5-(4'-Methoxyphenyl)-thiophene-2-sulfonylamino]-(1-tertbutylcarbamoyl-piperidin-4-yl)-acetic Acid | Drug Info |
| S5AR --- SRD5A2 | 4-Cyano-17-diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Erbeta --- ER | 5-(5-Hydroxy-2-naphthyl)biphenyl-2-ol | Drug Info |
| MMP13 --- MMP1 | 1-(4-But-2-ynyloxy-benzenesulfonyl)-4-(thiophene-2-carbonyl)-[1,4]diazepane-2-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-5-benzyl-N,N-diethyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
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