Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | Arzoxifene | Drug Info |
| MMP1 --- MMP3 | [(S)-3-((2R,3R)-3-Hydroxycarbamoyl-2-isobutyl-hexanoylamino)-2-oxo-azepan-1-yl]-acetic acid methyl ester | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-benzyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 6-(3-Fluoro-4-hydroxy-phenyl)-8-prop-1-ynyl-naphthalen-2-ol | Drug Info |
| MMP1 --- MMP9 | Benzo[1,3]dioxole-5-carboxylic acid [(R)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-mercapto-ethyl]-amide | Drug Info |
| S5AR --- SRD5A2 | 2-Cyano-17-diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Erbeta --- ER | (2S,3S)-7-Hydroxy-2,3-bis-(4-hydroxy-phenyl)-chroman-4-one | Drug Info |
| MMP13 --- MMP1 | 4-(4-Benzyloxy-benzenesulfonylamino)-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (3-trifluoromethyl-phenyl)-amide | Drug Info |
| Erbeta --- ER | 3-benzyl-2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| MMP13 --- MMP1 | 3-(4-Methoxy-benzenesulfonyl)-hexane-1-thiol | Drug Info |
| S5AR --- SRD5A2 | CHEMBL1201841 | Drug Info |
| Erbeta --- ER | 7-hydroxy-4-methyl-9a-phenyl-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| MMP13 --- MMP1 | 4-[4-(Naphthalen-2-yloxy)-benzenesulfonylamino]-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (3-benzoyl-phenyl)-amide | Drug Info |
| Erbeta --- ER | (13S,17S)-2-Hydroxymethyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol | Drug Info |
| MMP13 --- MMP1 | (3S,6S)-6-(2-amino-2-oxoethyl)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (3R,8S,9S,10R,13S,14S,17S)-17-(diisopropylcarbamoyl)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Erbeta --- ER | 3-(4-hydroxy-3-propylphenyl)benzo[d]isoxazol-6-ol | Drug Info |
| MMP13 --- MMP1 | 4-(4-But-2-ynyloxy-benzenesulfonyl)-1-(pyridine-3-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | Drug Info |
| ABL --- Src | 4-(4-Chloro-5-methoxy-2-methyl-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 3,7,8-trihydroxy-4-methyl-6H-benzo[c]chromen-6-one | Drug Info |
| MMP13 --- MMP14 | N-((2S,4S)-1-(4-(2,4-dichlorobenzyloxy)piperidin-1-ylsulfonyl)-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl)-N-hydroxyformamide | Drug Info |
| ABL --- Src | 4-(2-Chloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-4-ylmethoxy)-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | (2R,3R,4S)-3-(4-Hydroxy-phenyl)-4-methyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-7-ol | Drug Info |
| MMP13 --- MMP9 | 5-Bromo-4-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-thiophene-3-carboxylic acid hydroxyamide | Drug Info |
| PDGFR --- Src | 8-Methyl-2-phenylamino-6-thiophen-3-yl-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| Erbeta --- ER | (R)-N-(4-(4-hydroxyphenyl)butan-2-yl)-2-(2-phenyl-7-(3-(piperidin-1-yl)propoxy)-1H-indol-3-yl)acetamide | Drug Info |
| MMP2 --- HER2 | (2S,3S)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-((R)-3-phenylpyrrolidine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID50085782 | Drug Info |
| Erbeta --- ER | 2-(2-Fluoro-4-hydroxy-phenyl)-7-propenyl-benzooxazol-5-ol | Drug Info |
| MMP2 --- MMP1 | 2-(R)-1-Hydrazinocarbonylmethyl-4-methyl-pentanoic acid [2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-amide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-4-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)butan-1-one | Drug Info |
| Erbeta --- Mcl1 | SID860234 | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentyl-6-methoxynaphthalene-2-sulfonamido)-3-methylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(benzo[b]thiophen-3-ylmethyl)-2-(4-sulfamoylphenylamino)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-{[1-((R)-2-Amino-3-mercapto-propionyl)-4-phenyl-piperidine-4-carbonyl]-amino}-4-methyl-pentanoic acid | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(4-isopropylpiperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-(methylsulfonyl)phenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxylic acid | Drug Info |
| Ftase --- FPTase | 8-Chloro-11-(1-ethenesulfonyl-piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine | Drug Info |
| MMP2 --- MMP13 | 2-Dimethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benzenesulfonyl)-propionamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4'-(trifluoromethyl)biphenyl-4-carbonitrile | Drug Info |
| Ftase --- FPTase | 17-oxo-16-(2-thienylmethyl)-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| MMP2 --- MMP13 | (S)-N-(3,4-dimethoxybenzyl)-4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Methyl-1-(indol-3-yl)-2-acetyl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| Ftase --- FPTase | {2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| MMP2 --- MMP13 | (S)-2-{4'-[(5-Acetyl-4-hydroxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[4-(2,2-difluoro-1,3-benzodioxol-5-yl)phenyl]sulfamide | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[Benzyl-(1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | 2-(4'-Methoxy-biphenyl-4-sulfonylamino)-6-pyrrolidin-1-yl-hex-4-ynoic acid | Drug Info |
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