Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-(3-iodo-propyl)-phenyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| PR --- mRNA of AR | {2-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidenemethyl]-phenyl}-dimethyl-amine | Drug Info |
| MMP2 --- MMP9 | (S)-N,2-dihydroxy-3-(N-(4-(p-tolylthio)phenyl)methan-15-ylsulfonamido)propanamide | Drug Info |
| Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1H-quinolin-2-one | Drug Info |
| PR --- mRNA of AR | 15-methyl-N-(1,3,4-thiadiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | Drug Info |
| MMP2 --- MMP9 | (R)-3-Methyl-2-(5-p-tolylethynyl-thiophene-2-sulfonylamino)-butyric acid | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-methyl-2-pyridin-3-yl-propan-1-one | Drug Info |
| Renin --- Cathepsin D | (S)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-(difluoromethoxy)-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2,6-dichlorobenzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Ftase --- FPTase | [3-Benzyl-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-naphthalen-1-yl-methanone | Drug Info |
| S5AR --- SRD5A2 | N-Phenyl-N-((4aR,6aS,7S,11aR)-1,4a,6a-trimethyl-2-oxo-hexadecahydro-indeno[5,4-f]quinolin-7-yl)-isobutyramide | Drug Info |
| MMP3 --- MMP8 | [2-(4'-Chloro-biphenyl-4-sulfonyl)-6-nitro-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid tert-butyl ester | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS,7S)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (2-chloro-6-trifluoromethyl-phenyl)-amide | Drug Info |
| MMP3 --- MMP8 | 2-[3-(2-Hydroxy-benzoylamino)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | (S)-2-Amino-1-(4-{2-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-4-methylsulfanyl-butan-1-one | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-7-(3,4-Dihydro-2H-quinoline-1-carbonyl)-4a,6a-dimethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
| MMP3 --- MMP8 | [(R)-2-methyl-1-(4'-pyrrolidin-1-yl-biphenyl-4-sulfonylamino)-propyl]-phosphonic acid | Drug Info |
| Ftase --- FPTase | 4-[(5-chloro-3'-methoxy-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aR)-7-(1,5-Dimethyl-hexyl)-4a,6a-dimethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
| MMP9 --- MMP8 | N-Hydroxy-N'-{(S)-1-((S)-1-phenyl-ethylcarbamoyl)-2-[4-(3-phenyl-ureido)-phenyl]-ethyl}-oxalamide | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-isopropyl-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| S5AR --- SRD5A2 | 7-chloro-4a-methyl-3,4,4a,9-tetrahydrophenanthren-2-ylphosphonous acid | Drug Info |
| mTOR --- AKT | N-(5-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)-1H-benzo[d]imidazol-2-yl)acetamide | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-piperidin-4-yl-ethanone | Drug Info |
| S5AR --- SRD5A2 | (8S,9S,10R,13S,14S,17S)-17-(diisopropylcarbamoyl)-10,13-dimethyl-8,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-phenyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| Ftase --- FPTase | 2-(Biphenyl-4-yloxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| S5AR --- SRD5A2 | 3-(17-Diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)-propionic acid | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-methyl-1-(3-(4-methylpiperazin-1-yl)propyl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid p-tolyl ester | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-pyridazin-4-ylurea | Drug Info |
| Ftase --- FPTase | (R)-2-{3-[((R)-2-Amino-3-mercapto-propionylamino)-methyl]-benzoylamino}-3-methylsulfanyl-propionic acid | Drug Info |
| ABL --- Src | (2,4-Dichloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-hydroxyethyl)phenyl)urea | Drug Info |
| Ftase --- FPTase | N-Benzo[1,3]dioxol-5-ylmethyl-4-(3-bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| ABL --- Src | (4-tert-Butoxy-3,5-dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine | Drug Info |
| NET --- SERT | 2-(1-Ethyl-6-methyl-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine | Drug Info |
| Ftase --- FPTase | 1-{4-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carbonyl]-cyclohexyl}-ethanone | Drug Info |
| FGFR --- Src | N-{6-(2,6-Dichloro-phenyl)-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrido[2,3-d]pyrimidin-7-yl}-3,3-dimethyl-butyramide | Drug Info |
| NET --- SERT | 1-(4-Chloro-2,3-dihydro-1H-indol-5-ylmethyl)-propylamine | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-1-oxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-3-yl)-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(trifluoromethyl)-9H-carbazole | Drug Info |
| NET --- SERT | 2-(2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-6-Chloro-3-(3,4-dichloro-benzyloxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-2-(thiophene-2-carboxamido)-5,7-dihydro-4H-thieno[2,3-c]thiopyran-3-carboxamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-pyridin-2-ylmethyl-piperidine-1-carboxamidine | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Methyl-1-(indol-3-yl)-2-butyryl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
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