Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PDE --- TNF alpha | (R)-Rolipram | Drug Info |
| VEGFR2 --- VEGFR1 | GW627834A | Drug Info |
| H3 --- SERT | 7-(3-(4-isopropylpiperazin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | CHEMBL429760 | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(6-(dimethylamino)pyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-tert-butylphenyl)-4-(2-(quinolin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| H3 --- SERT | 4-phenyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-imidazol-1-yl-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-7-(2-(hydroxymethyl)morpholino)imidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3-methyl-4-(trifluoromethyl)phenyl)-4-(pyridin-4-ylmethylamino)isothiazole-3-carboxamide | Drug Info |
| H3 --- SERT | 4-(3-(dimethylamino)-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)propoxy)benzonitrile | Drug Info |
| EGFR3 --- HER2 | 4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-[3-(2-ethoxycarbonylethylamino)phenoxy]pyrimidine | Drug Info |
| PI3K gamma --- PI3K delta | (R)-1-(2-methyl-3-(trifluoromethyl)benzyl)-7-(2-methylmorpholino)imidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chlorophenyl)-4-(2-(isoxazol-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| HD6 --- HDAC2 | 4-(((R)-3-(3,4-difluorobenzyl)-2,3-dihydro-2-oxoquinoxalin-4(1H)-yl)methyl)-N-hydroxybenzamide | Drug Info |
| EGFR3 --- HER2 | 1-(5-Chloro-2-hydroxybenzyl)-1-(4-fluorobenzyl)-3-phenylthiourea | Drug Info |
| PKCA --- NPKC delta | 18-methylaminomethyl-(18S)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione | Drug Info |
| VEGFR2 --- VEGFR1 | (5-Ethanesulfonyl-2-methoxy-phenyl)-{5-[3-(3-methyl-3H-imidazol-4-yl)-phenyl]-oxazol-2-yl}-amine | Drug Info |
| HDAC1 --- HD6 | 2-[4-(3-Benzodioxyl-sulfamoyl)-phenyl]-2-oxoethyl ethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | [3-Chloro-4-(pyridin-2-ylmethoxy)-phenyl]-[7-methoxy-5-(4-methyl-piperidin-1-yloxy)-quinazolin-4-yl]-amine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid 2-dimethylamino-3-(4-hydroxy-phenyl)-propyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-N-m-tolyl-1,3,4-oxadiazol-2-amine | Drug Info |
| HDAC1 --- HD6 | N-Ethyl S-2-(4-acetamidophenyl)-2-oxoethyl dithiocarbamate | Drug Info |
| EGFR3 --- HER2 | 2-Chloro-N-[4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-6-yl]-acetamide | Drug Info |
| PKCA --- NPKC delta | SID103905239 | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-isopropylphenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | Thailandepsin A | Drug Info |
| EGFR3 --- HER2 | N4-(3-methylphenyl)-4,6-quinazolinediamine | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Dichloro-benzoyl)-4-fluoro-benzenesulfonamide | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(3-(1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | 4-(3-azidophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| PPAR gamma --- mRNA of PTP1B | (S)-2-[(2E,4E)-Hexadienoyl]-7-{2-[5-methyl-2-(5-methylhexyl)oxazol-4-yl]ethoxy}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(3-(1-(3-phenylpropyl)-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-imidazol-1-ylmethyl-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-(4-(4-fluorobenzoyl)-2-propylphenoxy)propoxy)-1H-indol-1-yl)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | 7-(4-(3-bromophenyl)thiazol-2-yl)-N-hydroxyheptanamide | Drug Info |
| EGFR3 --- VEGFR1 | 3-{4-[7-(2-Methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzylamino}-propan-1-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | 7-(4-(2,6-dimethoxyphenyl)thiazol-2-yl)-N-hydroxyheptanamide | Drug Info |
| Erbeta --- ER | 2-(3-Hydroxy-phenyl)-1-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | methyl 2-(2-methyl-4-(3-(2-propyl-4-(trifluoromethyl)phenoxy)propoxy)phenoxy)acetate | Drug Info |
| HDAC1 --- HDAC2 | 7-Phenoxy-heptanoic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 2,2,2-Trichloro-1-(6-hydroxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-(5-methoxy-4-methyl-1H-indol-1-ylsulfonyl)benzamido)-5-methylbenzoic acid | Drug Info |
| HDAC1 --- HDAC2 | 4-(3-(4-(4-Chlorobenzyloxy)-3-methoxyphenyl)propanamido)-N-hydroxybenzamide | Drug Info |
| Erbeta --- ER | 4-{3-Ethyl-5-phenyl-4-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-furan-2-yl}-phenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(1-{3-[4-(4-Methoxy-benzoyl)-2-propyl-phenoxy]-propyl}-1H-indol-5-yloxy)-2-methyl-propionic acid | Drug Info |
| HDAC1 --- HDAC2 | 1H-Indole-6-carboxylic acid (5-hydroxycarbamoyl-pentyl)-amide | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethylamino)-phenyl]-methanone | Drug Info |
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