Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 17-benzyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-N-(3-methoxyphenyl)-4-methylbenzamide | Drug Info |
| MMP2 --- MMP13 | (S)-4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)-N-(3-(methylsulfonyl)benzyl)benzamide | Drug Info |
| Ftase --- FPTase | (R)-17-Acetyl-2-bromo-6-chloro-17-hydroxy-10,13-dimethyl-16-methylene-1,2,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[2-fluoro-1-(fluoromethyl)ethoxy]-3,6-dioxocyclohexa-1,4-dien-1-yl}amino)quinazolin-6-yl]but-2-enamide | Drug Info |
| MMP2 --- MMP13 | 1-(benzo[d]oxazol-2-yl)-4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxypiperidine-4-carboxamide | Drug Info |
| Ftase --- FPTase | 15,16-dimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| VEGFR2 --- FGFR1 | 1-tert-Butyl-3-[3-(3,5-dimethoxy-phenyl)-7-(4-phenoxy-butylamino)-[1,6]naphthyridin-2-yl]-urea | Drug Info |
| MMP2 --- MMP13 | N1-ethyl-N4-hydroxy-4-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)piperidine-1,4-dicarboxamide | Drug Info |
| Ftase --- FPTase | 4-methyl-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| VEGFR2 --- TEK | GW673715X | Drug Info |
| MMP2 --- MMP13 | 1-(4-acetylpiperazin-1-ylsulfonyl)-4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxypiperidine-4-carboxamide | Drug Info |
| Ftase --- FPTase | N-[7-Bromo-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-benzamide | Drug Info |
| VEGFR2 --- TEK | 3-butyl-7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| MMP2 --- MMP13 | 2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-(4-morpholin-4-yl-phenyl)-pent-4-ynoic acid | Drug Info |
| Ftase --- FPTase | 4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-[3-(1-methyl-2-oxo-azepan-3-yl)-phenoxy]-benzonitrile | Drug Info |
| VEGFR2 --- TEK | 5,6-bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine | Drug Info |
| MMP2 --- MMP14 | 1-(benzylsulfonyl)-3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxypiperidine-3-carboxamide | Drug Info |
| Ftase --- FPTase | 4'-(2-Amino-3-mercapto-propylamino)-2'-propoxy-biphenyl-3-carboxylic acid 13 (FTI-288) | Drug Info |
| VEGFR2 --- TEK | 3-(2-(2-aminopyrimidin-5-yl)ethynyl)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-[1,1';4',1'']terphenyl-4-yl-hexanoic acid | Drug Info |
| Ftase --- FPTase | 2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-naphthalen-1-yl-benzoylamino]-4-methyl-pentanoic acid | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenylcarbonyl)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| MMP2 --- MMP3 | 2-[4-(3'-ethoxy-2-methyl-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-N-hydroxy-acetamide | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-[1-(2-morpholin-4-yl-2-oxo-ethyl)-piperidin-4-yl]-ethanone | Drug Info |
| VEGFR2 --- TEK | 7-[(furan-2-yl)carbonyl]-19-methyl-3-(2-methylpropyl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| MMP2 --- MMP3 | (R)-3-(((S)-3-cyclohexyl-1-oxo-1-(phenethylamino)propan-2-yl)carbamoyl)-6-p-tolylhexanoic acid | Drug Info |
| Ftase --- FPTase | [2-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienylcarbamoyl)-ethyl]-phosphonic acid | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-N-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-amine | Drug Info |
| MMP2 --- MMP3 | (R)-3-(((S)-3-cyclohexyl-1-(3-methoxy-3-oxopropylamino)-1-oxopropan-2-yl)carbamoyl)-6-p-tolylhexanoic acid | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-(4-trifluoromethoxy-phenyl)-piperidine-1-carboxamidine | Drug Info |
| VEGFR2 --- VEGFR1 | GW575533A | Drug Info |
| MMP2 --- MMP9 | 3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylsulfamoyl]-5-phenyl-pentanoic acid | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | N-[4-(2-Fluoro-5-hydroxy-4-methyl-phenylamino)-6-methoxy-quinazolin-7-yl]-2-methoxy-acetamide | Drug Info |
| MMP2 --- MMP9 | 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4'-isopropyl-biphenyl-4-sulfonyl)-butyric acid | Drug Info |
| Ftase --- FPTase | N-[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-N-thiophen-3-ylmethyl-benzenesulfonamide | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Chloro-N-(4-chloro-benzoyl)-benzenesulfonamide | Drug Info |
| MMP2 --- MMP9 | N-Hydroxy-2-{4-[5-(4-methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyramide | Drug Info |
| Ftase --- FPTase | 4-(2,3-dihydroxypropyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dichlorophenyl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(3-(N-(5-methylisoxazol-3-yl)sulfamoyl)benzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Ftase --- FPTase | 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-methyl-3-(trifluoromethyl)phenyl)-5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| MMP2 --- MMP9 | 11-(2',6'-Difluoro-biphenyl-4-ylmethyl)-2,10-dioxo-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-morpholin-4-yl-2-oxo-ethyl)-amide] | Drug Info |
| Ftase --- FPTase | (S)-2-[((S)-2-{(S)-2-[(S)-2-((R)-2,6-Diamino-hexanoylamino)-2-mercapto-acetylamino]-3-methyl-butyryl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- VEGFR1 | 3-(2-chlorophenyl)-1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)urea | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-((8-(dimethylamino)napththalen-4-yl)sulfonyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-5-fluoro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| VEGFR2 --- VEGFR1 | 1-methyl-4-(pyridin-3-ylmethylamino)-N-(3-(trifluoromethyl)phenyl)-1H-pyrazole-5-carboxamide | Drug Info |
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