Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 4-((5-((1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | (4-Chloro-phenyl)-[4-(1-pyridin-4-yl-ethyl)-phthalazin-1-yl]-amine | Drug Info |
| MMP2 --- MMP9 | (R)-4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxopiperidin-3-yl)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | 10-(tert-butyl)-2,6-dimethyl-(6E,10Z)-2,6,10-dodecatriene1-diphosphate (3-tbFPP) | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3-tert-butylphenyl)-4-(pyridin-4-ylmethylamino)isothiazole-3-carboxamide | Drug Info |
| MMP2 --- MMP9 | (ethylamino)carbonylphosphonic acid | Drug Info |
| Ftase --- FPTase | (S)-2-[3-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP3 --- MMP8 | 2-(4-Methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-methanesulfonyl-phenyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP3 --- MMP8 | 2-(4-Butoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | 4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-(6-methyl-pyridin-3-yl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile | Drug Info |
| MMP3 --- MMP8 | 2-(4-Acetylamino-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | 8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-6-(3-chloro-phenyl)-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one | Drug Info |
| MMP9 --- MMP8 | N-Hydroxy-N'-[(S)-2-naphthalen-2-yl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-oxalamide | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({2'-methyl-5-[5-(4-methylsulfanyl-phenyl)-furan-2-ylmethoxymethyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| mTOR --- AKT | N-(6-(6-Cyano-5-(4-methoxyphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| Ftase --- FPTase | 6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethyl]-3''-methoxy-biphenyl-3-carbonitrile | Drug Info |
| mTOR --- PI3K gamma | CHEMBL592465 | Drug Info |
| Ftase --- FPTase | 5-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-biphenyl-2-carboxylic acid benzylamide | Drug Info |
| mTOR --- PI3K gamma | 5-(6-morpholino-9H-purin-2-yl)pyridin-3-ol | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(3-Isopropyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-pyridin-3-ylurea | Drug Info |
| Ftase --- FPTase | 5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(2,3-dimethyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(3-Cyclopropyl-7-morpholino-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl)-3-(thiophen-2-yl)urea | Drug Info |
| Ftase --- FPTase | 4-(3,3-dimethyl-1-butynyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-4-pyridin-4-ylurea | Drug Info |
| Ftase --- FPTase | Cyanoguanidine derivative | Drug Info |
| NET --- SERT | 3-(4-Iodo-phenyl)-8-(3-methanesulfonyloxy-propyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| Ftase --- FPTase | 2-Chloro-3-((2R,3R)-6-chloro-2-imidazol-1-ylmethyl-2,3-dihydro-benzo[b]thiophen-3-yloxymethyl)-pyridine | Drug Info |
| NET --- SERT | SID49648945 | Drug Info |
| Ftase --- FPTase | 1-[4-((S)-3-Bromo-8,10-dichloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-(thiomorpholinomethyl)furan-2-yl)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-6-Chloro-3-(2-chloro-benzo[b]thiophen-3-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(4-methoxystyryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | (R)-2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiol | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(4-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)-3'-(trifluoromethoxy)biphenyl-3-carbonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 5-{(1E)-4-[4-(Ethylsulfonyl)piperazin-1-yl]but-1-en-1-yl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(4-(3-(2-benzoyl-4-ethylphenoxy)pentyloxy)-2-methylphenyl)propanoic acid | Drug Info |
| Ftase --- FPTase | (2S)-2-(2-(3-(2-(1H-imidazol-5-yl)ethyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetamido)-4-(methylthio)butanoic acid | Drug Info |
| CAII --- CAI | 2,6-Diisopropyl-4-phenyl-1-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-pyridinium; perchlorate | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(4-((4-(dimethylamino)piperidin-1-yl)methyl)styryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| PPAR gamma --- PPAR delta | 2-[4-[5-(3,4-dichloro-phenyl)-[1,2,4]thiadiazol-3-ylmethylsulfanyl]-2-methyl-phenoxy}-2-methyl-propionic acid | Drug Info |
| H3 --- SERT | (4-(3-(dimethylamino)-1-(4-(trifluoromethyl)phenoxy)propyl)phenyl)(4-isopropylpiperazin-1-yl)methanone | Drug Info |
| EGFR3 --- HER2 | 5-((4-aminopiperidin-1-yl)methyl)-N-(3-fluorophenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(2-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| PR --- mRNA of AR | (R)-5-bromo-2-((2,2-dimethyl-6-methylenecyclohexyl)methyl)-4-methoxyphenol | Drug Info |
| H3 --- SERT | 7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(4-(methylsulfonyl)phenyl)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 3-[4-(3-Bromo-phenylamino)-quinazolin-6-ylcarbamoyl]-acrylic acid 3-dimethylamino-propyl ester | Drug Info |
| PI3K gamma --- PI3K delta | 3-((4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl)phenol | Drug Info |
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