Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP9 | 2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmethyl)-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-methylcarbamoylmethyl-amide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-6-Chloro-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (2,5-bis-trifluoromethyl-phenyl)-amide | Drug Info |
| Ftase --- FPTase | 3'-chloro-6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(4-methyl-2-(methylsulfonamido)benzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| S5AR --- SRD5A2 | 7-Chloro-4a-methyl-3,4,4a,9-tetrahydro-phenanthrene-2-carboxylic acid | Drug Info |
| Ftase --- FPTase | 3'-chloro-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylsulfamoyl]-nonanoic acid | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-(2-tert-butylphenyl)-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-[(R)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-thiophen-2-ylmethyl-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | 5-(4-Acetyl-piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| S5AR --- SRD5A2 | (10R,13S)-10,13-Dimethyl-4-trifluoromethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-2H-cyclopenta[a]phenanthrene-3,17-dione | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[(4-Cyano-benzyl)-(3H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylamino]-3-(1H-indol-3-yl)-propionic acid | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-N',N'-diphenyl-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carbohydrazide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-hydroxy-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP9 | (S)-N,2-dihydroxy-3-(N-(4-(p-tolyloxy)phenyl)ethan-15-ylsulfonamido)propanamide | Drug Info |
| S5AR --- SRD5A2 | ((10R,13S,17S)-17-tert-Butylcarbamoyl-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)-phosphinic acid | Drug Info |
| Ftase --- FPTase | 2-(3-tert-Butyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2-(4-oxo-2-(phenylimino)thizolidin-5-yl)acetyl)-)-1,4-diazepan-1-yl)pyrimidine-2,4,6-(1H,3H,5H)-trione | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid methyl ester | Drug Info |
| Ftase --- FPTase | (E)-4-(4-benzoylbenzyloxy)-3-methylbut-2-enyl diphosphate | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2,6-dichloro-5-fluoronicotinoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| S5AR --- SRD5A2 | 4-[2-(6-{[Bis-(4-methoxy-phenyl)-methyl]-carbamoyl}-benzofuran-2-yl)-phenoxy]-butyric acid | Drug Info |
| Ftase --- FPTase | 1-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-4-carboxylic acid pyridin-4-ylamide | Drug Info |
| MMP2 --- MMP9 | 4-(4-chlorophenoxy)-N-(1-hydroxy-4-methyl-2-oxo-1,2-dihydropyridin-3-yl)-N-methylbenzenesulfonamide | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 3'-chloro-6-[(4-cyano-phenyl)-(2,3-dimethyl-3H-imidazol-4-yl)-methoxymethyl]-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 5-(4-(6-Chloropyridine-3-carbonyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| ABL --- Src | CHEMBL84803 | Drug Info |
| Ftase --- FPTase | 4-{5-[((S)-1-Benzyl-2-oxo-azepan-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| MMP2 --- MMP9 | (S)-2-(4-fluorophenylamino)-N-hydroxy-3-(N-(4-(p-tolyloxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| FGFR --- Src | 6-(2,6-Dichloro-phenyl)-pyrido[2,3-d]pyrimidin-7-ylamine | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(naphthalen-1-yloxy)-benzonitrile | Drug Info |
| MMP3 --- MMP8 | [7-Amino-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-2-amino-1-((S)-4-(2,5-difluorophenyl)-2-(3-hydroxyphenyl)-2H-pyrrol-1(5H)-yl)-3-methylbutan-1-one | Drug Info |
| Ftase --- FPTase | (Sch-207758)(+)-4-(2-{4-[4-chloro-1-methyl-(12R)-3,6,7,12-tetrahydropyrido[2',3':4,5]cyclohepta[e]indol-12-yl]hexahydro-1-pyridinyl}-2-oxoethyl)-1-pyridiniumolate | Drug Info |
| MMP3 --- MMP8 | 2-(Biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Chloro-1-(3-hydroxyphenyl)-2-(3-aminopropyl)-1,2,3,4-tetrahydro-beta-carboline hydrochloride | Drug Info |
| Ftase --- FPTase | 1-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| MMP3 --- MMP8 | 2-(4-Morpholin-4-yl-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | rac-2-benzyl-3-phenyl-6-(pyrrolidin-1-yl)-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3-ethoxy-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP9 --- MMP8 | N-Hydroxy-N'-[(S)-2-(1H-indol-3-yl)-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-oxalamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-tert-butyl-7-(trifluoromethyl)-9H-carbazole | Drug Info |
| Ftase --- FPTase | 2-[11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,8R,9S,13S)-11-azatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6-trien-9-ylcarboxamido]acetic acid (RPR113258) | Drug Info |
| mTOR --- AKT | N-(6-(2-(4-Methoxyphenylsulfonamido)pyridin-4-yl)benzo-[d]thiazol-2-yl)acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)quinoxaline-6-carboxamide | Drug Info |
| Ftase --- FPTase | {2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid benzyl ester | Drug Info |
| mTOR --- PI3K gamma | (S)-1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-phenylpyrazolo[1,5-c]quinazolin-5(6H)-one | Drug Info |
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