Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- TEK | SID124349812 | Drug Info |
| Erbeta --- ER | geldanamycin-estradiol hybrid | Drug Info |
| MMP2 --- HER2 | isopropyl-(5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidin-3-yl(methyl)carbamate | Drug Info |
| VEGFR2 --- TEK | N-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}thiophene-2-carboxamide | Drug Info |
| Erbeta --- Mcl1 | 2,3-Bis(2-furyl)quinoxaline-6-{1-[(2-pyridyl)methyl]aminocarbonyl} | Drug Info |
| MMP2 --- MMP13 | (S)-3-methyl-2-(4'-(3-methyl-4-(methylsulfonamido)benzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)butanoic acid | Drug Info |
| VEGFR2 --- TEK | N-(5-((2-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)-2-methylphenyl)-4-methoxy-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidine-5-carboxamide | Drug Info |
| FGFR --- PDGFR | 4-Benzoimidazol-1-yl-phenol | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentylnaphthalene-2-sulfonamido)-3-methylbutanamide | Drug Info |
| VEGFR2 --- TEK | 1-methyl-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-methoxy-benzyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP13 | (S)-4-(4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)benzamido)-N-methylpiperidine-1-carboxamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2-fluoro-4-methylphenyl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(3-methoxy-phenoxy)-benzonitrile | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-2-(N-isobutylnaphthalene-2-sulfonamido)acetamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Dichloro-benzoyl)-3,4-dimethoxy-benzenesulfonamide | Drug Info |
| Ftase --- FPTase | (S)-2-[((S)-2-{(S)-2-[2-(3H-Imidazol-4-yl)-ethylamino]-3-methyl-butyryl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | (S)-N-(1-(cyclopropanecarbonyl)piperidin-4-yl)-4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)benzamide | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-(chlorodifluoromethoxy)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | 4-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(2-(trifluoromethyl)phenyl)piperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-bromophenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| Ftase --- FPTase | 4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N-cyano-N'-(1-oxy-pyridin-3-ylmethyl)-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(4-acetylpiperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(2-(2-(pyridin-3-yl)ethyl)pyridin-3-yl)-N-(3-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-amine | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(3-imidazol-1-yl-propyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4'-formyl-biphenyl-4-yl)-hexanoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-tert-butylphenyl)benzamide | Drug Info |
| Ftase --- FPTase | N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)-N-(4-methoxyphenethyl)quinoline-2-carboxamide | Drug Info |
| MMP2 --- MMP3 | 2-[4-(2-fluoro-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-N-hydroxy-acetamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dimethoxyphenyl)-3-methyl-5-(pyridin-4-ylmethylamino)isoxazole-4-carboxamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid methylamide | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-1-(cyclopentylamino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dimethoxyphenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| Ftase --- FPTase | (20R)-14-chloro-19,20,21,22-tetrahydro-19-oxo-17H-18,20-etheno-6,10:12,16-dimetheno-16H-imidazo[3,4-h][1,8,11,14]oxatriazacycloeicosine-9-carbonitrile | Drug Info |
| MMP2 --- MMP3 | (R)-1-(1-(methylamino)-1-oxo-3-phenylpropan-2-yl)-3-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)urea | Drug Info |
| VEGFR2 --- VEGFR1 | (2-((1H-indazol-5-yl)methylamino)phenyl)(1H-indazol-3-yl)methanone | Drug Info |
| Ftase --- FPTase | 2-[1-(2-Amino-acetyl)-piperidin-4-yl]-1-[4-((R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone | Drug Info |
| MMP2 --- MMP9 | (R)-2-(4-Benzoylamino-benzenesulfonylamino)-3-phenyl-propionic acid | Drug Info |
| VEGFR2 --- VEGFR1 | 1-[3-(4-Methyl-piperazin-1-yl)-propyl]-4-(3-phenyl-pyrazolo[1,5-a]pyrimidin-6-yl)-1H-pyridin-2-one | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-methyl-2-pyridin-3-yl-propan-1-one | Drug Info |
| MMP2 --- MMP9 | 2-[7-(3,5-Dichloro-benzyloxy)-1,1-dioxo-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl]-N-hydroxy-propionamide | Drug Info |
| Ftase --- FPTase | 1-((2R,3R)-3-Allyloxy-6-chloro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl)-1H-imidazole | Drug Info |
| MMP2 --- MMP9 | (S)-1-(biphenyl-4-ylsulfonyl)-N-hydroxy-5-oxopyrrolidine-2-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(2-Methyl-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | (S)-N,2-dihydroxy-3-(N-(4-(2-(4-methoxyphenyl)ethynyl)phenyl)methan-8-ylsulfonamido)propanamide | Drug Info |
| Ftase --- FPTase | (2E,6E)-3-ethyl-7,11-dimethyldodeca-2,6,10-trienyl trihydrogen diphosphate | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-((R)-1-phenylethylamino)-3-(N-(4-(p-tolyloxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP9 | 2-(4'-chloro-biphenyl-4-sulfonyl)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentanoic acid | Drug Info |
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