Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 3'-hydroxy-1,1':2',1''-terphenyl-4'-carbaldehyde oxime | Drug Info |
| PPAR gamma --- PPAR delta | 3-[4-(3-Phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-butoxy]-benzoic acid | Drug Info |
| HDAC1 --- HDAC2 | 7-(4-(4-bromophenyl)thiazol-2-yl)-N-hydroxyheptanamide | Drug Info |
| Erbeta --- ER | 10-[4-(2-Dimethylamino-ethoxy)-benzyl]-10H-benzo[4,5]thieno[3,2-b]indol-7-ol | Drug Info |
| PPAR gamma --- PPAR delta | (E)-2-(2-Methyl-4-(1-(((5-methyl-2-(p-tolyl)oxazol-4-yl)-methoxy)imino)ethyl)phenoxy)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | 1H-Indole-2-carboxylic acid (5-hydroxycarbamoyl-pentyl)-amide | Drug Info |
| Erbeta --- ER | (2S,3R)-3-Cyclopentyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(4-((cyclopropylmethoxy)methyl)-2-(pent-2-ynyloxy)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | 4-(3-(4-(2-Bromobenzyloxy)-3-methoxyphenyl)propanamido)-N-hydroxybenzamide | Drug Info |
| Erbeta --- ER | (R)-6-chloro-9a-ethyl-9,9a-dihydroindeno[2,1-e]indazole-7,10(3H,8H)-dione | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(2-methyl-4'-(trifluoromethyl)biphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| HDAC1 --- HDAC4 | (S)-methyl 1-(cyclopentylamino)-7-mercapto-1-oxoheptan-2-ylcarbamate | Drug Info |
| Erbeta --- ER | (2S,3R)-2-{4-[2-(3-Aza-bicyclo[3.1.0]hex-3-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(2-ethyl-4-(3-(4-ethyl-2-(pyridin-2-yl)phenoxy)butoxy)phenyl)propanoic acid | Drug Info |
| HER2 --- CD221 | 2,6-difluoro-N-(3-(5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide | Drug Info |
| Erbeta --- ER | 2-(3-tert-butyl-4-hydroxyphenyl)benzo[d]oxazol-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-ethoxy-3-(1-((5-methyl-2-o-tolyloxazol-4-yl)methyl)-1H-indol-5-yl)propanoic acid | Drug Info |
| HER2 --- MMP-2 | (3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phenylpiperazine-1-carbonyl)piperidin-3-yl pyrrolidine-1-carboxylate | Drug Info |
| Erbeta --- ER | (S)-N-(1-(1-(4-(2-(piperidin-1-yl)ethoxy)benzyl)-5-hydroxy-3-methyl-1H-indol-2-yl)ethyl)-2-(2-phenyl-1H-indol-3-yl)acetamide | Drug Info |
| PPAR gamma --- PPAR delta | 3-(4-((5-(3-fluorophenyl)-1,2,4-oxadiazol-3-yl)methoxy)phenyl)-2-isopropoxypropanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(3-hydroxypropylamino)picolinamide | Drug Info |
| Erbeta --- ER | 2-Bromo-4-((1R,2R,5R)-5-hydroxymethyl-8-methyl-3-oxa-bicyclo[3.3.1]non-7-en-2-yl)-phenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-[2-(5,6,7,8-Tetrahydro-naphthalen-2-yloxy)-ethoxy]-benzyl}-malonic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(2-methoxyethylamino)picolinamide | Drug Info |
| Erbeta --- ER | 3,4-bis(4-hydroxyphenyl)butan-2-one | Drug Info |
| PPAR gamma --- PPAR delta | SID26754830 | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(8-fluoroisoquinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | (1S,4R,5S)-4-(4-Hydroxy-phenyl)-6,9,9-trimethyl-3-oxa-bicyclo[3.3.1]non-6-en-1-ol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(3-propylbiphenyl-4-yloxy)propoxy)phenyl)oxazolidine-2,4-dione | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | 1-[4-(2,3-Diphenyl-pent-2-enyl)-phenoxymethyl]-piperidine | Drug Info |
| PPAR gamma --- PPAR delta | 2-[4-(4,4''-bis-trifluoromethyl-[1,1';3',1'']terphenyl-5'-ylmethoxy)-phenoxy]-2-methyl-propionic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(5-amino-1H-1,2,4-triazol-3-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide | Drug Info |
| Erbeta --- ER | 7-(2-bromovinyl)-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(4-benzoyl-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
| JNK1 --- JNK3 | 4-(4-(naphthalen-2-yl)-1H-1,2,3-triazol-5-yl)pyridine | Drug Info |
| Erbeta --- ER | 3'-[4-(2-hexahydro-1-pyridinylethoxy)phenyl]-1,1'-spirobi[2,3-dihydro-1H-indene]-5,5'-diol; with hydrochloride | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclopentylmethoxy)picolinamide | Drug Info |
| Erbeta --- ER | SID14726689 | Drug Info |
| JNK1 --- JNK3 | 2-(2-(3-methoxyphenoxy)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-isopropoxy-3-(4-(2-(5-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)ethoxy)phenyl)propanoic acid | Drug Info |
| Erbeta --- ER | 6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol | Drug Info |
| JNK1 --- JNK3 | 4-(3-fluoro-5-morpholinophenyl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)pyrimidin-2-amine | Drug Info |
| PR --- mRNA of AR | 9-Chloro-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| Erbeta --- ER | 10-ethyl-3-hydroxy-8-methoxy-4-methyl-6H-benzo[c]chromen-6-one | Drug Info |
| MEP --- Cathepsin B | Bis(3-bromophenyl)(4-hydroxy)thiosemicarbazone | Drug Info |
| PR --- mRNA of AR | N-(1-Ethoxy-6-phenyl-6H-benzo[c]chromen-8-yl)-methanesulfonamide | Drug Info |
| Erbeta --- ER | CHEMBL242818 | Drug Info |
| MEP --- Cathepsin B | 6-(3-(furan-2-yl)benzylamino)-9-(3-hydroxypropyl)-9H-purine-2-carbonitrile | Drug Info |
| PR --- mRNA of AR | 5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
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