Target Information
| Target General Information | Top | |||||
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| Target ID |
T14928
(Former ID: TTDNR00733)
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| Target Name |
Protein FAM83B (FA83B)
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| Synonyms |
C6orf143
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| Gene Name |
FAM83B
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades.
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| UniProt ID | ||||||
| Sequence |
METSSMLSSLNDECKSDNYIEPHYKEWYRVAIDILIEHGLEAYQEFLVQERVSDFLAEEE
INYILKNVQKVAQSTAHGTDDSCDDTLSSGTYWPVESDVEAPNLDLGWPYVMPGLLGGTH IDLLFHPPRAHLLTIKETIRKMIKEARKVIALVMDIFTDVDIFKEIVEASTRGVSVYILL DESNFNHFLNMTEKQGCSVQRLRNIRVRTVKGQDYLSKTGAKFHGKMEQKFLLVDCQKVM YGSYSYMWSFEKAHLSMVQIITGQLVESFDEEFRTLYARSCVPSSFAQEESARVKHGKAL WENGTYQHSVSSLASVSSQRNLFGRQDKIHKLDSSYFKNRGIYTLNEHDKYNIRSHGYKP HFVPNFNGPNAIRQFQPNQINENWKRHSYAGEQPETVPYLLLNRALNRTNNPPGNWKKPS DSLSVASSSREGYVSHHNTPAQSFANRLAQRKTTNLADRNSNVRRSFNGTDNHIRFLQQR MPTLEHTTKSFLRNWRIESYLNDHSEATPDSNGSALGDRFEGYDNPENLKANALYTHSRL RSSLVFKPTLPEQKEVNSCTTGSSNSTIIGSQGSETPKEVPDTPTNVQHLTDKPLPESIP KLPLQSEAPKMHTLQVPENHSVALNQTTNGHTESNNYIYKTLGVNKQTENLKNQQTENLL KRRSFPLFDNSKANLDPGNSKHYVYSTLTRNRVRQPEKPKEDLLKSSKSMHNVTHNLEED EEEVTKRNSPSGTTTKSVSIAALLDVNKEESNKELASKKEVKGSPSFLKKGSQKLRSLLS LTPDKKENLSKNKAPAFYRLCSSSDTLVSEGEENQKPKKSDTKVDSSPRRKHSSSSNSQG SIHKSKEDVTVSPSQEINAPPDENKRTPSPGPVESKFLERAGDASAPRFNTEQIQYRDSR EINAVVTPERRPTSSPRPTSSELLRSHSTDRRVYSRFEPFCKIESSIQPTSNMPNTSINR PEIKSATMGNSYGRSSPLLNYNTGVYRSYQPNENKFRGFMQKFGNFIHKNK Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | AlphaFold | ||||
| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: 1,1'-Carbonyldipiperidine | Ligand Info | |||||
| Structure Description | PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000010a | PDB:5QHK | ||||
| Method | X-ray diffraction | Resolution | 1.61 Å | Mutation | No | [2] |
| PDB Sequence |
GTHIDLLFHP
127 PRAHLLTIKE137 TIRKMIKEAR147 KVIALVMDIF157 TDVDIFKEIV167 EASTRGVSVY 177 ILLDESNFNH187 FLNMTEKQGC197 SVQRLRNIRV207 RTVKGQDYLS217 KTGAKFHGKM 227 EQKFLLVDCQ237 KVMYGSYSYM247 WSFEKAHLSM257 VQIITGQLVE267 SFDEEFRTLY 277 ARSCVPSSF
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (2S)-1-{[(2H-1,3-benzodioxol-5-yl)methyl]amino}propan-2-ol | Ligand Info | |||||
| Structure Description | PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000709a | PDB:5QHJ | ||||
| Method | X-ray diffraction | Resolution | 1.68 Å | Mutation | No | [3] |
| PDB Sequence |
GTHIDLLFHP
127 PRAHLLTIKE137 TIRKMIKEAR147 KVIALVMDIF157 TDVDIFKEIV167 EASTRGVSVY 177 ILLDESNFNH187 FLNMTEKQGC197 SVQRLRNIRV207 RTVKGQDYLS217 KTGAKFHGKM 227 EQKFLLVDCQ237 KVMYGSYSYM247 WSFEKAHLSM257 VQIITGQLVE267 SFDEEFRTLY 277 ARSCVPSSF
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution
of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects
(Nat Rev Drug Discov, 20: 64-81, 2021).
Human Similarity Proteins
Human Tissue Distribution
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There is no similarity protein (E value < 0.005) for this target
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Note:
If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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| References | Top | |||||
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| REF 1 | FAM83A and FAM83B as Prognostic Biomarkers and Potential New Therapeutic Targets in NSCLC. Cancers (Basel). 2019 May 11;11(5). pii: E652. | |||||
| REF 2 | PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) | |||||
| REF 3 | PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) | |||||
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