| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T96721 | ||||
| Target Name | Vascular endothelial growth factor (VEGF) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Avastin+/-Tarceva | Drug Info | IC50 = 95000 nM | [2] | |
| Bevasiranib | Drug Info | IC50 = 0.95~3.2 nM | |||
| Romiplostim | Drug Info | IC50 = 40 nM | [1] | ||
| TAK-593 | Drug Info | Ki = 0.95~3.2 nM | [3] | ||
| References | |||||
| REF 1 | SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodyspl... Blood. 2003 Aug 1;102(3):795-801. | ||||
| REF 2 | Recent advances in the research of HIV-1 RNase H inhibitors. Mini Rev Med Chem. 2008 Oct;8(12):1243-51. | ||||
| REF 3 | Biochemical characterization of TAK-593, a novel VEGFR/PDGFR inhibitor with a two-step slow binding mechanism. Biochemistry. 2011 Feb 8;50(5):738-51. | ||||
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