| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T93062 | ||||
| Target Name | Multidrug resistance protein 3 (ABCB4) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | LY335979 | Drug Info | IC50 = 59 nM | [2] | |
| Action against Disease Model | LY335979 | Drug Info | LY335979 could effectively block Pgp function on isolated CD56(+) lymphocytes (IC(50) = 1.2 nM) or CD56(+) lymphocytes in whole blood (IC(50) = 174 nM) | [1] | |
| References | |||||
| REF 1 | Modulation by LY335979 of P-glycoprotein function in multidrug-resistant cell lines and human natural killer cells. Biochem Pharmacol. 2001 Jun 1;61(11):1393-9. | ||||
| REF 2 | Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. | ||||
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