| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T23761 | ||||
| Target Name | Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Artemisinin SP | Drug Info | EC50 = 20000 nM | [2] | |
| OZ277 | Drug Info | pKi = 5.7 | [3] | ||
| THAPSIGARGIN | Drug Info | IC50 = 0.2 nM | [1] | ||
| References | |||||
| REF 1 | Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase. Bioorg Med Chem. 2010 Aug 1;18(15):5634-46. | ||||
| REF 2 | GABA(A) receptor ligands and their therapeutic potentials. Curr Top Med Chem. 2002 Aug;2(8):817-32. | ||||
| REF 3 | Selective agents for serotonin2C (5-HT2C) receptor. Curr Top Med Chem. 2006;6(18):1927-70. | ||||
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