Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T47510 Target Info
Target Name Angiomotin (AMOT)
Synonyms KIAA1071
Target Type Literature-reported Target
Gene Name AMOT
UniProt ID
AMOT_HUMAN
Ligand General Information  Top
Ligand Name 5-[3-(2-Azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide Ligand Info
Canonical SMILES C1=CC=C(C=C1)C2=C(SC(=C2)C(=N)N)C3=CN=CN3CCN
InChI 1S/C16H17N5S/c17-6-7-21-10-20-9-13(21)15-12(8-14(22-15)16(18)19)11-4-2-1-3-5-11/h1-5,8-10H,6-7,17H2,(H3,18,19)
InChIKey NTJUXVTZPMWWMS-UHFFFAOYSA-N
PubChem Compound ID 146170561
Drug Binding Sites of Target  Top
PDB ID: 7NPG      Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 22
Method X-ray diffraction Resolution 1.37 Å Mutation No [1]
PDB Sequence
RSLERLM
Residue
Distance (Å)
LEU178
4.518
Residue
Distance (Å)
MET179
3.110
PDB ID: 7NNE      Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 22
Method X-ray diffraction Resolution 1.96 Å Mutation No [1]
PDB Sequence
HVRSLERLMQ
180
Residue
Distance (Å)
LEU178
4.538
MET179
2.787
Residue
Distance (Å)
GLN180
4.783
References  Top
REF 1 Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol. 2021 Dec 29;4:21-28.

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