Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T79027 Target Info
Target Name Cytidine deaminase (CDA)
Synonyms Cytidine aminohydrolase; CDA
Target Type Clinical trial Target
Gene Name CDA
Biochemical Class Carbon-nitrogen hydrolase
UniProt ID
CDD_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 1-beta-Ribofuranosyl-1,3-diazepinone Ligand Info
Structure Description Crystal Structure of Human Cytidine Deaminase PDB:1MQ0
Method X-ray diffraction Resolution 2.40 Å Mutation Yes [1]
PDB Sequence
ECVQQLLVCS
22
QEAKQSAYCP
32
YSHFPVGAAL
42
LTQEGRIFKG
52
CNIENACYPL
62

GICAERTAIQ
72
KAVSEGYKDF
82
RAIAIASDMQ
92
DDFISPCGAC
102
RQVMREFGTN
112

WPVYMTKPDG
122
TYIVMTVQEL
132
LPSSFGPEDL
142
Residue
Distance (Å)
SER34
3.999
PHE36
3.452
VAL38
3.524
ASN54
3.233
GLU56
2.719
ILE64
3.433
CYS65
3.135
Residue
Distance (Å)
ALA66
2.788
GLU67
2.688
ILE87
4.401
ILE96
4.069
SER97
3.706
PRO98
4.496
CYS99
4.754
References  Top
REF 1 Structure of human cytidine deaminase bound to a potent inhibitor. J Med Chem. 2005 Feb 10;48(3):658-60.

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