Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T47510 Target Info
Target Name Angiomotin (AMOT)
Synonyms KIAA1071
Target Type Literature-reported Target
Gene Name AMOT
UniProt ID
AMOT_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: L-serine-O-phosphate Ligand Info
Structure Description Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ177 PDB:7OQS
Method X-ray diffraction Resolution 1.34 Å Mutation No [1]
PDB Sequence
VRSLERL
Residue
Distance (Å)
SER173
3.755
LEU174
1.330
Residue
Distance (Å)
GLU176
1.321
ARG177
2.681
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: 5-[1-(2-Azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide Ligand Info
Structure Description Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 09 PDB:7NPB
Method X-ray diffraction Resolution 1.37 Å Mutation No [2]
PDB Sequence
VRSLERLM
Residue
Distance (Å)
MET179
2.583
Residue
Distance (Å)
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: 5-[3-(2-Azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide Ligand Info
Structure Description Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 22 PDB:7NPG
Method X-ray diffraction Resolution 1.37 Å Mutation No [2]
PDB Sequence
RSLERLM
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K92 or .K922 or .K923 or :3K92;style chemicals stick;color identity;select .P:178 or .P:179; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
LEU178
4.518
Residue
Distance (Å)
MET179
3.110
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: 2-(1,3-benzodioxol-5-yl)-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]ethanamide Ligand Info
Structure Description Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ177 PDB:7OQS
Method X-ray diffraction Resolution 1.34 Å Mutation No [1]
PDB Sequence
VRSLERL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .0BS or .0BS2 or .0BS3 or :30BS;style chemicals stick;color identity;select .P:177 or .P:178; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG177
4.018
Residue
Distance (Å)
LEU178
4.334
Ligand Name: (2~{S},3~{S})-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-3-methyl-2,3-dihydro-1-benzofuran-2-carboxamide Ligand Info
Structure Description Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ180 PDB:7OQU
Method X-ray diffraction Resolution 1.40 Å Mutation No [3]
PDB Sequence
RSLER
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .0BL or .0BL2 or .0BL3 or :30BL;style chemicals stick;color identity;select .P:176 or .P:177; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLU176
4.996
Residue
Distance (Å)
ARG177
3.840
Ligand Name: N-[(5-carbamimidoyl-3-phenylthiophen-2-yl)methyl]-2,3-dihydro-1-benzofuran-7-carboxamide Ligand Info
Structure Description Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ162 PDB:7OQJ
Method X-ray diffraction Resolution 1.40 Å Mutation No [4]
PDB Sequence
RSLER
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .09W or .09W2 or .09W3 or :309W;style chemicals stick;color identity;select .P:176 or .P:177; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLU176
3.827
Residue
Distance (Å)
ARG177
2.652
Ligand Name: 5-(2-Azanylethyl)-4-phenyl-thiophene-2-carboximidamide Ligand Info
Structure Description Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 40 PDB:7NMW
Method X-ray diffraction Resolution 1.50 Å Mutation No [2]
PDB Sequence
RSLERL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .UJW or .UJW2 or .UJW3 or :3UJW;style chemicals stick;color identity;select .P:178; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
LEU178
4.325
Residue
Distance (Å)
Ligand Name: N-[(5-carbamimidoyl-3-phenylthiophen-2-yl)methyl]-2,3-dihydro-1-benzofuran-5-carboxamide Ligand Info
Structure Description Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ136 PDB:7OQG
Method X-ray diffraction Resolution 1.50 Å Mutation No [5]
PDB Sequence
RSLER
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .0AW or .0AW2 or .0AW3 or :30AW;style chemicals stick;color identity;select .P:176 or .P:177; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLU176
2.031
Residue
Distance (Å)
ARG177
3.324
Ligand Name: 7-(6-Azanyl-5-methyl-pyridin-2-yl)-1-benzothiophene-2-carboximidamide Ligand Info
Structure Description Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 41 PDB:7NN2
Method X-ray diffraction Resolution 1.80 Å Mutation No [2]
PDB Sequence
RSLERL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K8W or .K8W2 or .K8W3 or :3K8W;style chemicals stick;color identity;select .P:178; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
LEU178
3.706
Residue
Distance (Å)
Ligand Name: N-[(5-carbamimidoyl-3-phenylthiophen-2-yl)methyl]-1H-indole-6-carboxamide Ligand Info
Structure Description Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ178 PDB:7OQW
Method X-ray diffraction Resolution 1.90 Å Mutation No [6]
PDB Sequence
SLER
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .0B7 or .0B72 or .0B73 or :30B7;style chemicals stick;color identity;select .P:176 or .P:177; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLU176
3.983
Residue
Distance (Å)
ARG177
3.690
Ligand Name: N-(2-aminoethyl)-2-carbamimidoyl-7-methoxy-1-benzothiophene-4-carboxamide Ligand Info
Structure Description Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 12 PDB:7NMX
Method X-ray diffraction Resolution 2.30 Å Mutation No [2]
PDB Sequence
RSLERL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K7Q or .K7Q2 or .K7Q3 or :3K7Q;style chemicals stick;color identity;select .P:178; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
LEU178
4.791
Residue
Distance (Å)
References  Top
REF 1 A crystallography-based study of fragment extensions
REF 2 Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol. 2021 Dec 29;4:21-28.
REF 3 A crystallography-based study of fragment extensions
REF 4 A crystallography-based study of fragment extensions into the 14-3-3 binding groove
REF 5 A crystallography-based study of fragment extensions into the 14-3-3 binding groove
REF 6 A crystallography-based study of fragment extensions

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.