Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T41201 Target Info
Target Name Dehydropeptidase I (DPEP1)
Synonyms hRDP; Renal dipeptidase; RDP; Microsomal dipeptidase; MDP; Dipeptidase 1; Dehydropeptidase-I
Target Type Successful Target
Gene Name DPEP1
Biochemical Class Peptidase
UniProt ID
DPEP1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Cilastatin Ligand Info
Structure Description HUMAN RENAL DIPEPTIDASE COMPLEXED WITH CILASTATIN PDB:1ITU
Method X-ray diffraction Resolution 2.00 Å Mutation No [1]
PDB Sequence
DFFRDEAERI
10
MRDSPVIDGH
20
NDLPWQLLDM
30
FNNRLQDERA
40
NLTTLAGTHT
50

NIPKLRAGFV
60
GGQFWSVYTP
70
CDTQNKDAVR
80
RTLEQMDVVH
90
RMCRMYPETF
100

LYVTSSAGIR
110
QAFREGKVAS
120
LIGVEGGHSI
130
DSSLGVLRAL
140
YQLGMRYLTL
150

THSCNTPWAD
160
NWLVDTGDSE
170
PQSQGLSPFG
180
QRVVKELNRL
190
GVLIDLAHVS
200

VATMKATLQL
210
SRAPVIFSHS
220
SAYSVCASRR
230
NVPDDVLRLV
240
KQTDSLVMVN
250

FYNNYISCTN
260
KANLSQVADH
270
LDHIKEVAGA
280
RAVGFGGDFD
290
GVPRVPEGLE
300

DVSKYPDLIA
310
ELLRRNWTEA
320
EVKGALADNL
330
LRVFEAVEQA
340
SNLTQAPEEE
350

PIPLDQLGGS
360
CRTHYGYSS
Residue
Distance (Å)
ASP22
3.568
TRP25
3.882
TYR68
3.435
GLU125
3.735
HIS152
2.837
HIS198
3.050
HIS219
3.219
ARG230
2.872
Residue
Distance (Å)
ASN250
3.952
TYR252
3.564
TYR255
2.951
ASP288
2.816
GLY291
3.004
VAL292
3.818
PRO293
3.602
References  Top
REF 1 Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis. J Mol Biol. 2002 Aug 9;321(2):177-84.

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