Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T14928 Target Info
Target Name Protein FAM83B (FA83B)
Synonyms C6orf143
Target Type Literature-reported Target
Gene Name FAM83B
UniProt ID
FA83B_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 1,1'-Carbonyldipiperidine Ligand Info
Structure Description PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000010a PDB:5QHK
Method X-ray diffraction Resolution 1.61 Å Mutation No [1]
PDB Sequence
GTHIDLLFHP
127
PRAHLLTIKE
137
TIRKMIKEAR
147
KVIALVMDIF
157
TDVDIFKEIV
167

EASTRGVSVY
177
ILLDESNFNH
187
FLNMTEKQGC
197
SVQRLRNIRV
207
RTVKGQDYLS
217

KTGAKFHGKM
227
EQKFLLVDCQ
237
KVMYGSYSYM
247
WSFEKAHLSM
257
VQIITGQLVE
267

SFDEEFRTLY
277
ARSCVPSSF
Residue
Distance (Å)
VAL149
3.837
ALA151
4.131
TYR177
3.525
LEU233
3.339
CYS236
3.323
Residue
Distance (Å)
ASP270
2.544
PHE273
3.815
ARG274
3.916
TYR277
3.384
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: (2S)-1-{[(2H-1,3-benzodioxol-5-yl)methyl]amino}propan-2-ol Ligand Info
Structure Description PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000709a PDB:5QHJ
Method X-ray diffraction Resolution 1.68 Å Mutation No [2]
PDB Sequence
GTHIDLLFHP
127
PRAHLLTIKE
137
TIRKMIKEAR
147
KVIALVMDIF
157
TDVDIFKEIV
167

EASTRGVSVY
177
ILLDESNFNH
187
FLNMTEKQGC
197
SVQRLRNIRV
207
RTVKGQDYLS
217

KTGAKFHGKM
227
EQKFLLVDCQ
237
KVMYGSYSYM
247
WSFEKAHLSM
257
VQIITGQLVE
267

SFDEEFRTLY
277
ARSCVPSSF
Residue
Distance (Å)
LYS144
3.423
LYS164
2.975
Residue
Distance (Å)
GLU165
3.289
GLU168
3.133
Ligand Name: N-(3-fluorophenyl)-5-methyl-1,3,4-thiadiazol-2-amine Ligand Info
Structure Description PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000635a PDB:5QHR
Method X-ray diffraction Resolution 1.68 Å Mutation No [3]
PDB Sequence
GGTHIDLLFH
12
PPRAHLLTIK
22
ETIRKMIKEA
32
RKVIALVMDI
42
FTDVDIFKEI
52

VEASTRGVSV
62
YILLDESNFN
72
HFLNMTEKQG
82
CSVQRLRNIR
92
VRTVKGQDYF
109

HGKMEQKFLL
119
VDCQKVMYGS
129
YSYMWSFEKA
139
HLSMVQIITG
149
QLVESFDEEF
159

RTLYARSCVP
169
SSFA
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GQS or .GQS2 or .GQS3 or :3GQS;style chemicals stick;color identity;select .A:35 or .A:37 or .A:63 or .A:119 or .A:122 or .A:156 or .A:159 or .A:160 or .A:163; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
VAL35
4.200
ALA37
4.218
TYR63
4.020
LEU119
3.195
CYS122
3.832
Residue
Distance (Å)
ASP156
3.647
PHE159
3.834
ARG160
3.405
TYR163
2.738
Ligand Name: [5-(4-Amino-phenyl)-furan-2-yl]-methanol Ligand Info
Structure Description PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000551a PDB:5QHL
Method X-ray diffraction Resolution 1.68 Å Mutation No [4]
PDB Sequence
GTHIDLLFHP
127
PRAHLLTIKE
137
TIRKMIKEAR
147
KVIALVMDIF
157
TDVDIFKEIV
167

EASTRGVSVY
177
ILLDESNFNH
187
FLNMTEKQGC
197
SVQRLRNIRV
207
RTVKGQDYLS
217

KTGAKFHGKM
227
EQKFLLVDCQ
237
KVMYGSYSYM
247
WSFEKAHLSM
257
VQIITGQLVE
267

SFDEEFRTLY
277
ARSCVPSSF
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GQ7 or .GQ72 or .GQ73 or :3GQ7;style chemicals stick;color identity;select .A:229 or .A:272 or .A:275 or .A:276 or .A:279; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLN229
2.957
GLU272
2.484
THR275
3.781
Residue
Distance (Å)
LEU276
3.524
ARG279
3.218
Ligand Name: Ethyl 4-pyrazolecarboxylate Ligand Info
Structure Description PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000271a PDB:5QHI
Method X-ray diffraction Resolution 1.73 Å Mutation No [5]
PDB Sequence
GTHIDLLFHP
127
PRAHLLTIKE
137
TIRKMIKEAR
147
KVIALVMDIF
157
TDVDIFKEIV
167

EASTRGVSVY
177
ILLDESNFNH
187
FLNMTEKQGC
197
SVQRLRNIRV
207
RTVKGQDYLS
217

KTGAKFHGKM
227
EQKFLLVDCQ
237
KVMYGSYSYM
247
WSFEKAHLSM
257
VQIITGQLVE
267

SFDEEFRTLY
277
ARSCVPSSF
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GOJ or .GOJ2 or .GOJ3 or :3GOJ;style chemicals stick;color identity;select .A:149 or .A:151 or .A:177 or .A:233 or .A:236 or .A:270 or .A:273 or .A:274 or .A:277; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
VAL149
3.770
ALA151
3.851
TYR177
3.570
LEU233
3.683
CYS236
3.394
Residue
Distance (Å)
ASP270
2.514
PHE273
3.531
ARG274
3.364
TYR277
3.215
Ligand Name: methyl (2~{S},4~{R})-1-(furan-2-ylcarbonyl)-4-oxidanyl-pyrrolidine-2-carboxylate Ligand Info
Structure Description PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000622a PDB:5QHN
Method X-ray diffraction Resolution 1.73 Å Mutation No [6]
PDB Sequence
GGTHIDLLFH
12
PPRAHLLTIK
22
ETIRKMIKEA
32
RKVIALVMDI
42
FTDVDIFKEI
52

VEASTRGVSV
62
YILLDESNFN
72
HFLNMTEKQG
82
CSVQRLRNIR
92
VRTVKGQDYF
109

HGKMEQKFLL
119
VDCQKVMYGS
129
YSYMWSFEKA
139
HLSMVQIITG
149
QLVESFDEEF
159

RTLYARSCVP
169
SSFA
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GQJ or .GQJ2 or .GQJ3 or :3GQJ;style chemicals stick;color identity;select .A:98 or .A:99 or .A:165; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLY98
4.355
GLN99
4.001
Residue
Distance (Å)
ARG165
4.639
Ligand Name: 3-Hydroxy-1-methyl-2(1h)-pyridinethione Ligand Info
Structure Description PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with OX-145 PDB:5QHM
Method X-ray diffraction Resolution 1.79 Å Mutation No [7]
PDB Sequence
GGTHIDLLFH
12
PPRAHLLTIK
22
ETIRKMIKEA
32
RKVIALVMDI
42
FTDVDIFKEI
52

VEASTRGVSV
62
YILLDESNFN
72
HFLNMTEKQG
82
CSVQRLRNIR
92
VRTVKGQDYF
109

HGKMEQKFLL
119
VDCQKVMYGS
129
YSYMWSFEKA
139
HLSMVQIITG
149
QLVESFDEEF
159

RTLYARSCVP
169
SSFA
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GQA or .GQA2 or .GQA3 or :3GQA;style chemicals stick;color identity;select .A:115 or .A:116 or .A:127 or .A:128 or .A:129; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLN115
4.525
LYS116
3.683
TYR127
3.602
Residue
Distance (Å)
GLY128
3.205
SER129
3.579
Ligand Name: 1-Methyl-3-hydroxy-2(1H)-pyridinone Ligand Info
Structure Description PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FF000014a PDB:5QHS
Method X-ray diffraction Resolution 1.95 Å Mutation No [8]
PDB Sequence
GGTHIDLLFH
12
PPRAHLLTIK
22
ETIRKMIKEA
32
RKVIALVMDI
42
FTDVDIFKEI
52

VEASTRGVSV
62
YILLDESNFN
72
HFLNMTEKQG
82
CSVQRLRNIR
92
VRTVKGQDYF
109

HGKMEQKFLL
119
VDCQKVMYGS
129
YSYMWSFEKA
139
HLSMVQIITG
149
QLVESFDEEF
159

RTLYARSCVP
169
SSFA
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GQV or .GQV2 or .GQV3 or :3GQV;style chemicals stick;color identity;select .A:116 or .A:127 or .A:128 or .A:129; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
LYS116
2.724
TYR127
3.485
Residue
Distance (Å)
GLY128
2.973
SER129
3.619
Ligand Name: 1-[(4-Fluorophenyl)methyl]benzimidazole Ligand Info
Structure Description PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000574a PDB:5QHQ
Method X-ray diffraction Resolution 1.96 Å Mutation No [9]
PDB Sequence
GGTHIDLLFH
12
PPRAHLLTIK
22
ETIRKMIKEA
32
RKVIALVMDI
42
FTDVDIFKEI
52

VEASTRGVSV
62
YILLDESNFN
72
HFLNMTEKQG
82
CSVQRLRNIR
92
VRTVKGQDYF
109

HGKMEQKFLL
119
VDCQKVMYGS
129
YSYMWSFEKA
139
HLSMVQIITG
149
QLVESFDEEF
159

RTLYARSCVP
169
SSFA
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GQP or .GQP2 or .GQP3 or :3GQP;style chemicals stick;color identity;select .A:12 or .A:13 or .A:14 or .A:20 or .A:63 or .A:64 or .A:65 or .A:92 or .A:93 or .A:94 or .A:137 or .A:138 or .A:139 or .A:140 or .A:141 or .A:159 or .A:160 or .A:163; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
HIS12
3.347
PRO13
3.657
PRO14
3.566
THR20
3.104
TYR63
3.162
ILE64
3.684
LEU65
3.284
ARG92
3.172
VAL93
4.317
Residue
Distance (Å)
ARG94
3.530
GLU137
3.612
LYS138
3.529
ALA139
3.713
HIS140
3.601
LEU141
3.669
PHE159
3.292
ARG160
3.375
TYR163
3.216
Ligand Name: 5-Methoxy-2-(1H-pyrazol-5-yl)phenol Ligand Info
Structure Description PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000554a PDB:5QHP
Method X-ray diffraction Resolution 2.06 Å Mutation No [10]
PDB Sequence
GGTHIDLLFH
12
PPRAHLLTIK
22
ETIRKMIKEA
32
RKVIALVMDI
42
FTDVDIFKEI
52

VEASTRGVSV
62
YILLDESNFN
72
HFLNMTEKQG
82
CSVQRLRNIR
92
VRTVKGQDYF
109

HGKMEQKFLL
119
VDCQKVMYGS
129
YSYMWSFEKA
139
HLSMVQIITG
149
QLVESFDEEF
159

RTLYARSCVP
169
SSFA
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GQM or .GQM2 or .GQM3 or :3GQM;style chemicals stick;color identity;select .A:35 or .A:36 or .A:37 or .A:63 or .A:119 or .A:120 or .A:121 or .A:122 or .A:156 or .A:159 or .A:160 or .A:163; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
VAL35
3.162
ILE36
3.759
ALA37
3.138
TYR63
3.492
LEU119
3.410
VAL120
3.976
Residue
Distance (Å)
ASP121
3.287
CYS122
3.323
ASP156
2.295
PHE159
3.688
ARG160
3.509
TYR163
3.527
References  Top
REF 1 PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
REF 2 PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
REF 3 PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
REF 4 PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
REF 5 PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
REF 6 PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
REF 7 PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
REF 8 PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
REF 9 PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
REF 10 PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)

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