Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99685 | Target Info | |||
| Target Name | HUMAN mammalian target of rapamycin (mTOR) | ||||
| Synonyms |
Target of rapamycin; TOR kinase; Rapamycin target protein 1; Rapamycin target protein; Rapamycin and FKBP12 target 1; RAPT1; RAFT1; Mechanistic target of rapamycin; Mammalian target of rapamycin; FRAP2; FRAP1; FRAP; FKBP12-rapamycin complex-associated protein; FKBP-rapamycin associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1
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| Gene Name | MTOR | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 63 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Sorafenib
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Approved | Compound Info | ||
| Synonyms |
Nexavar; Sorafenibum; Sorafenib [INN]; Nexavar (TN); Sorafenib (INN); N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea; N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea; N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea; 4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide; 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate; 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide; 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE; Sorafenib (Pan-TK inhibitor)
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
PMID28460551-Compound-2
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Patented | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
AMA37
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Investigative | Compound Info | ||
| Synonyms |
arylmorpholine analog 37
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Imidazo[1,2-a]pyridine, 3-(5,6-dimethoxy-3-pyridinyl)-
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL380343; CHEMBL3649443; BDBM122466; DB-122408; US8729074, 10; 3-(5,6-dimethoxypyridin-3-yl)imidazo[1,2-a]pyridine
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Tert-Butyl {4-[4-Amino-1-(Propan-2-Yl)-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl]-2-Methoxyphenyl}carbamate
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Investigative | Compound Info | ||
| Synonyms |
tert-butyl 4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenylcarbamate; SCHEMBL2429870; CHEMBL1241481; Q27467124; tert-butyl 4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d] pyrimidin-3-yl)-2-methoxyphenylcarbamate; tert-butyl N-[4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl]carbamate
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-(Phenylethynyl)-1H-indazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631889; SCHEMBL7982776; 3-(2-phenylethynyl)-2H-indazole; BDBM50333030
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(3-(9H-Purin-6-yl)pyridin-2-yl)-1H-indol-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL167289; CHEMBL3643919; BDBM125229; US8772480, 19; N-[3-(7H-purin-6-yl)pyridin-2-yl]-1H-indol-4-amine
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-[3-(6-Amino-2-methylpyrimidin-4-yl)pyridin-2-yl]-1H-indazol-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165271; SCHEMBL168583; BDBM50394886; US8772480, 27
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-(3-(4-Amino-6-methyl-1,3,5-triazin-2-YL)-5-methylpyridine-2-YL)-1H-indazol-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL168849; CHEMBL3643927; BDBM125240; US8772480, 47; N-[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-methylpyridin-2-yl]-1H-indazol-4-amine
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-(3-(6-Amino-2-methylpyrimidin-4-yl)pyridin-4-yl)-1H-indazol-4-amine
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Investigative | Compound Info | ||
| Synonyms |
N-[3-(6-amino-2-methylpyrimidin-4-yl)pyridin-4-yl]-1H-indazol-4-amine; SCHEMBL168179; CHEMBL3646452; BDBM125294; US8772480, 107
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3616915; CHEMBL1241391; US9765037, Compound 18; BDBM340891; 1-propan-2-yl-3-pyrimidin-5-ylpyrazolo[3,4-d]pyrimidin-4-amine; 1-isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4- d]pyrimidin-4-amine
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
8-[(8-Fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3799831; BDBM50500914
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
5-(4-Amino-1-((5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242845
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
4-((1H-Indazol-3-yl)ethynyl)benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631901; SCHEMBL12269664; BDBM50333018; ZINC66251573
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-Methyl-6-[5-methyl-2-(pyridin-3-ylamino)pyridin-3-yl]-1,3,5-triazin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL167475; CHEMBL3643921; BDBM125232; US8772480, 32
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| Activity |
IC50 ~ 50000 nM
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[5] | |||
| Compound Name |
N-[5-[(4-Methoxyphenyl)methoxymethyl]-3-(2-methyl-7H-purin-6-yl)pyridin-2-yl]-1H-indol-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL114392; CHEMBL3643936; BDBM125259; US8772480, 71; N-(5-((4-methoxybenzyloxy)methyl)-3-(2-methyl-9H-purin-6-yl)pyridin-2-yl)-1H-indol-4-amine
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| Activity |
IC50 ~ 50000 nM
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[5] | |||
| Compound Name |
N-(3-(4-Amino-6-methyl-1,3,5-triazin-2-YL)pyridin-2-YL)-1H-indazol-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165053; N-[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]-1H-indazol-4-amine; SCHEMBL167442; BDBM50394890; US8772480, 24
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-(3-(6-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)pyridin-2-yl)-1H-indazol-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165042; N-[3-(6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)pyridin-2-yl]-1H-indazol-4-amine; SCHEMBL168036; BDBM50394878; US8772480, 55
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-(4-Amino-6-methyl-1,3,5-triazin-2-yl)-N-(2-methylpyrazol-3-yl)benzimidazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1760164; SCHEMBL9948507; BDBM50341046; 1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1-methyl-1H-pyrazol-5-yl)-1H-benzo[d]imidazol-2-amine
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N-[3-[6-Amino-2-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-yl]-1H-indazol-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165036; SCHEMBL166401; BDBM50394884; US8772480, 21
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-((4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
PIK-294; PIK294; PIK 294; C28H23N7O2; cc-610; MLS006010993; SCHEMBL1952680; CHEMBL1241767; BDBM36411; AOB6611; DTXSID20648004; SYN1098; HMS3244E13; HMS3244E14; HMS3244F13; HMS3655P12; BCP01970; EX-A2568; s2227; ZINC62260316; AKOS026750411; CCG-269607; CS-3528; CID24905149; NCGC00346614-01; NCGC00346614-02; NCGC00346614-07; AC-32796; AK176035; AS-16244; HY-10303; QC-11467; SMR004702793; PIK-294, >=98% (HPLC); FT-0699808; SW220212-1; X7436; Z-3176; J-505227
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
4-[2-[(6-Methoxypyridin-3-yl)amino]-5-methylpyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165024; SCHEMBL116368; BDBM50394866; US8772480, 31
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| Activity |
IC50 ~ 50000 nM
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[5] | |||
| Compound Name |
N-(3-(6-Amino-2-methylpyrimidin-4-yl)pyridin-4-yl)-1H-indol-4-amine
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Investigative | Compound Info | ||
| Synonyms |
N-[3-(6-amino-2-methylpyrimidin-4-yl)pyridin-4-yl]-1H-indol-4-amine; SCHEMBL166585; CHEMBL3649476; BDBM125515; US8772480, 109
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| Activity |
IC50 ~ 50000 nM
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[5] | |||
| Compound Name |
N-[3-(6-Amino-5-fluoro-2-methylpyrimidin-4-yl)pyridin-2-yl]-1H-indazol-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165035; SCHEMBL168182; BDBM50394885; US8772480, 29
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| Activity |
IC50 ~ 50000 nM
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[5] | |||
| Compound Name |
3-(Pyridin-3-ylethynyl)-1h-indazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631891; SCHEMBL12269820; BDBM50333028; ZINC66263425; 3-(2-pyridin-3-ylethynyl)-2H-indazole
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3-[3-(Dimethylamino)-1-propynyl]-1H-indazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631893; BDBM50333026; 3-(1H-Indazol-3-yl)-N,N-dimethylprop-2-yn-1-amine
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
N-(2-Chloro-5-imidazo[1,2-a]pyrimidin-3-ylpyridin-3-yl)-4-fluorobenzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL379979; CHEMBL3649447; BDBM122470; US8729074, 24; N-(2-chloro-5-(imidazo[1,2-a]pyrimidin-3-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
N-(6-(4-(1H-Indol-4-ylamino)pyridin-3-yl)-2-methylpyrimidin-4-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
N-[6-[4-(1H-indol-4-ylamino)pyridin-3-yl]-2-methylpyrimidin-4-yl]acetamide; SCHEMBL114269; CHEMBL3646453; BDBM125295; US8772480, 108
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| Activity |
IC50 ~ 50000 nM
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[5] | |||
| Compound Name |
3-(1-(4-(2,2,2-Trifluoroethylamino)-1,3,5-triazin-2-yl)-1H-benzo[d]imidazol-2-ylamino)phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762776; BDBM50341070
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| Activity |
IC50 ~ 50000 nM
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[7] | |||
| Compound Name |
2-(4-(2-(3-Hydroxyphenylamino)-1H-benzo[d]imidazol-1-yl)-6-methoxy-1,3,5-triazin-2-ylamino)acetonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762787; BDBM50341068
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| Activity |
IC50 ~ 50000 nM
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[7] | |||
| Compound Name |
2-((1H-Indazol-3-yl)ethynyl)aniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631898; BDBM50333021
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3-(Pyridin-2-ylethynyl)-1H-indazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631894; SCHEMBL12269783; BDBM50333025; ZINC66251528
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3-(Cyclopropylethynyl)-1H-indazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631897; SCHEMBL12269671; BDBM50333022
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
N-[3-(7H-Purin-6-yl)pyridin-2-yl]-1H-indazol-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165040; SCHEMBL3116812; BDBM50394880; US8772480, 18
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| Activity |
IC50 ~ 50000 nM
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[5] | |||
| Compound Name |
N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089082; SCHEMBL4656083; BDBM50314051; N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide
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| Activity |
IC50 ~ 50000 nM
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[8] | |||
| Compound Name |
3-(Cyclopentylethynyl)-1H-indazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631896; SCHEMBL12269835; BDBM50333023
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3-(1-(4-Methoxy-1,3,5-triazin-2-yl)-1H-benzo[d]imidazol-2-ylamino)phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762780; BDBM50341061
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| Activity |
IC50 ~ 50000 nM
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[7] | |||
| Compound Name |
2-[4-({4-[4-Methyl-3-(methylsulfamoyl)phenyl]phthalazin-1-yl}amino)phenoxy]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3113389; Oprea1_292441; Oprea1_562221; SCHEMBL3026202; BDBM50447250; STK042169; STK845810; ZINC17994073; AKOS000664805; AKOS005626283; MCULE-8639539916; SR-01000476880; SR-01000476880-1
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| Activity |
IC50 = 52200 nM
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[9] | |||
| Compound Name |
7-(2-Furylmethyl)-N-[3-(1H-imidazol-1-yl)propyl]-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
MLS000535058; SMR000142495; MLS002541336; CHEMBL1539483; SCHEMBL15038000; BDBM39677; cid_2930286; REGID_for_CID_2930286; HMS1614H10; HMS2350G13; ZINC8670778; CCG-22113; STK033622; AKOS001677315; MCULE-1769124409
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| Activity |
IC50 = 54100 nM
|
[9] | |||
| Compound Name |
3-Amino-N-[2-(3,4-dimethoxyphenyl)ethyl]-4,6-diphenylthieno[2,3-b]pyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3113388; Oprea1_525226; ZINC9463229; BDBM50447249; STK166531; AKOS005409286; MCULE-9522161972; 3-amino-N-(3,4-dimethoxyphenethyl)-4,6-diphenylthieno[2,3-b]pyridine-2-carboxamide
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| Activity |
IC50 = 57600 nM
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[9] | |||
| Compound Name |
1-Tert-butyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL6055041; CHEMBL1242379; 1-tert-butyl-3-(3,4-dimethoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(2-Ethoxynaphthalen-6-yl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242661; SCHEMBL12608279
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-((3,5-Bis(trifluoromethyl)phenyl)ethynyl)-1Hindazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631899; SCHEMBL12269739; BDBM50333020
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-(4-Amino-3-methoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2433214; CHEMBL1241485; 3-(4-amino-3-methoxyphenyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-((3,5-Difluorophenyl)ethynyl)-1H-indazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631890; SCHEMBL12269817; BDBM50333029
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[4-Amino-3-(3-ethoxy-4-methoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242753
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Isopropyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242660; SCHEMBL3602391; BDBM50345734; 1-propan-2-yl-3-(3,4,5-trimethoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(Thiophen-3-ylethynyl)-1H-indazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631900; SCHEMBL12269771; BDBM50333019; ZINC66252788
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2466148; CHEMBL1241773; 1-[4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]ethanone
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(Benzo[c][1,2,5]oxadiazol-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3610515; CHEMBL1241492; 3-(2,1,3-benzoxadiazol-5-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241864
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
4-[2-(1-Methylindol-5-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030441; BDBM50384246
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
6-(4-Amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-4H-chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242117
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
5-(4-Amino-1-((piperidin-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242844
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3616930; CHEMBL1241771; ZINC43465534; 4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(4-Ethoxy-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242471; SCHEMBL16665685
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3608290; CHEMBL1241680; 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile
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||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
Chembl4276946
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Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
3-((1H-Indazol-3-yl)ethynyl)aniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631895; SCHEMBL12269751; BDBM50333024; ZINC66263695
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-Methyl-3-Naphthalen-2-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-Amine
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Investigative | Compound Info | ||
| Synonyms |
1-methyl-3-(naphthalen-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; CHEMBL1234815; SCHEMBL12551789; BDBM123756; DB08300; Q27097521; 1-Methyl-3-(2-naphthyl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine; 1-methyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (15)
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| Activity |
IC50 = 100000 nM
|
[12] | |||
| Compound Name |
5-(4-Amino-1-((4-phenyloxazol-5-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241482
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| Activity |
IC50 = 100000 nM
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[1] | |||
| Compound Name |
4-[4-[6-Chloro-4-(trifluoromethyl)pyridin-3-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100862; BDBM50240988
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| Activity |
Ki = 110000 nM
|
[13] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID28870136-Compound-52
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Patented | Compound Info | ||
| Activity |
IC50 = 400000 nM
|
[14] | |||
| Compound Name |
4-[4-[6-Bromo-4-(trifluoromethyl)pyridin-3-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062723; BDBM50240987
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| Activity |
Ki = 660000 nM
|
[13] | |||
| Compound Name |
5-[2-[(4-Methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]-4-(trifluoromethyl)pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2087479; SCHEMBL15603064; BDBM50420719
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| Activity |
IC50 = 10000000 nM
|
[15] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. | ||||
| REF 2 | Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem. 2007 Aug 17;282(33):24463-70. | ||||
| REF 3 | US patent application no. 8729074B2, Inhibitors of PI3 kinase | ||||
| REF 4 | Design, synthesis, and structure-activity relationships of 3-ethynyl-1H-indazoles as inhibitors of the phosphatidylinositol 3-kinase signaling pathway. J Med Chem. 2010 Dec 9;53(23):8368-75. | ||||
| REF 5 | US patent application no. 8772480B2, Inhibitors of PI3 kinase and/or mTOR | ||||
| REF 6 | Discovery of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides as PI3K/ inhibitors for the treatment of PTEN-deficient tumours. Bioorg Med Chem Lett. 2016 May 1;26(9):2318-23. | ||||
| REF 7 | Discovery of triazine-benzimidazoles as selective inhibitors of mTOR. Bioorg Med Chem Lett. 2011 Apr 1;21(7):2064-70. | ||||
| REF 8 | Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. | ||||
| REF 9 | Virtual screening and biochemical evaluation to identify new inhibitors of mammalian target of rapamycin (mTOR). Bioorg Med Chem Lett. 2014 Feb 1;24(3):835-8. | ||||
| REF 10 | Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4163-8. | ||||
| REF 11 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
| REF 12 | Small molecules targeting phosphoinositide 3-kinases. Medchemcomm. 2012;3:1337-55. | ||||
| REF 13 | 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. J Med Chem. 2017 Sep 14;60(17):7524-7538. | ||||
| REF 14 | Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. J Med Chem. 2011 Apr 14;54(7):2320-30. | ||||
| REF 15 | Identification of ETP-46321, a potent and orally bioavailable PI3K alpha, inhibitor. Bioorg Med Chem Lett. 2012 May 15;22(10):3460-6. | ||||
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