Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T57818 | Target Info | |||
| Target Name | Arginyl aminopeptidase (RNPEP) | ||||
| Synonyms |
Arginine aminopeptidase; Aminopeptidase B; APB; AP-B
Click to Show/Hide
|
||||
| Target Type | Literature-reported Target | ||||
| Gene Name | RNPEP | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(5S)-5-Amino-2,7-dimethyl-4-oxooctanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL341941; 5-Amino-2,7-dimethyl-4-oxo-octanoic acid; BDBM50008427
Click to Show/Hide
|
||||
| Activity |
Ki = 130000 nM
|
[1] | |||
| Compound Name |
Ubenimex
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Bestatin; Ubenimex (Bestatin); UNII-I0J33N5627; MFCD00083262; NK-421; CHEMBL29292; 58970-76-6 (free base); I0J33N5627; Ubenimexum [Latin]; Ubenimexum; Ubenimex [INN:JAN]; Ubenimex(Bestatin); SMR000059165; EINECS 261-529-2; NK 421; NSC 265489; BRN 4704312; Ubestatin; Ubenimex, solid; NSC-265489; Ubenimex, Bestatin; Ubenimex,(S); SCHEMBL7944; (3-Amino-2-hydroxy-4-phenylbutanoyl)-L-leucine; Lopac0_000214; BSPBio_001553; KBioGR_000273; KBioSS_000273; MLS000028649; MLS001424177; MLS006010137; BCBcMAP01_000178; BDBM23971; KBio2_000273; KBio2_002841; KBio2_005409; KBio3_000545; KBio3_000546; Bio2_000273; Bio2_000753; HMS1361N15; HMS1791N15; HMS1989N15; HMS2052A03; HMS2232H13; HMS3268O06; HMS3402N15; HMS3412N16; HMS3676N16; HMS3715B20; EX-A1292; HY-B0134; KS-00000JJ0; ZINC1542895; BDBM50367209; KM0266; s1591; AKOS016339610; CCG-101071; CS-1910; DB03424; KS-5207; NC00321; QC-8204; SDCCGSBI-0050202.P003; IDI1_034023; SMP1_000030; NCGC00025323-01; NCGC00025323-02; NCGC00025323-03; NCGC00025323-04; NCGC00025323-05; NCGC00025323-06; NCGC00025323-08; NCGC00025323-14; AT-11558; BCP0726000308; AB0010690; ST50405897; AB00698345_05; 970B766; SR-01000075724-3; W-105351; BRD-K59574735-001-02-7; BRD-K59574735-001-05-0; Q10909912
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[2] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-Amino-2-hydroxy-5-methyl-hexanoic acid (3-methyl-butyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL142010; SCHEMBL12609442; BDBM50008428; (2S,3R)-3-Amino-2-hydroxy-5-methyl-N-(3-methylbutyl)hexanamide
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[1] | |||
| Compound Name |
(3S)-3-Amino-5-methylhexan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL342867; Leu-CH..3..; SCHEMBL5522530; ZINC1764161; (S)-3-Amino-5-methylhexan-2-one; BDBM50008429; AKOS006340965; Q27462439
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Alpha-Keto amide inhibitors of aminopeptidases. J Med Chem. 1992 Feb 7;35(3):451-6. | ||||
| REF 2 | Stacking with No Planarity?. ACS Med Chem Lett. 2016 Apr 6;7(4):341-4. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.