Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T48069 | Target Info | |||
| Target Name | Insulin-like growth factor I receptor (IGF1R) | ||||
| Synonyms |
Type 1 insulin-like growth factor receptor; Insulin-like growth factor 1 receptor; IGF-IR; IGF-I receptor; IGF-1R; IGF-1 receptor; CD221 antigen; CD221
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| Target Type | Successful Target | ||||
| Gene Name | IGF1R | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 109 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Dasatinib
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Approved | Compound Info | ||
| Synonyms |
Sprycel (TN); BMS 354825; BMS-354825; BMS-354825, Sprycel, BMS354825, Dasatinib; BMS354825; Dasatinib (USAN); Dasatinib [USAN]; Dasatinib anhydrous; Dasatinib, BMS 354825; Dasatinibum; Sprycel; Spyrcel
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Romiplostim
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Approved | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
oxindole i; CHEMBL86755; 3-(1H-Pyrrol-2-ylmethylene)-1,3-dihydroindol-2-one; oxindole 1; AC1NZGXV; K00027; (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one; Indolinone based inhibitor, 1; SCHEMBL1162655; SCHEMBL13819612; BDBM17015; MolPort-023-197-743; SEZFNTZQMWJIAI-FLIBITNWSA-N; ZINC3874586; HSCI1_000049; NCGC00343760-01; BRD-K51816706-001-01-7; (3Z)-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one; 3-[(1H-Pyrrole-2-yl)methylene]-1H-indole-2(3H)-one; Z-(1H-Pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one; Oxindole I
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
VEGF receptor 2 kinase inhibitor I
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Investigative | Compound Info | ||
| Synonyms |
VEGF Receptor 2 Kinase Inhibitor I; UNII-U07H877HUF; CHEMBL86943; U07H877HUF; 15966-93-5; (Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one; Vegfr-2 inhi; ethyl 2,4-dimethyl-5-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrole-3-carboxylate; Ethyl 2,4-dimethyl-5-(((3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene)methyl)-1H-pyrrole-3-carboxylate; AC1O4WEX; K00004; Vegfr 2 kinase inhibitor I; SCHEMBL378979; VEGFR2 KiN/Ase Inhibitor I; GTPL6053; MolPort-044-561-167; HMS3229O05; ZINC3875265
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-Benzyl-2-(1H-indol-3-yl)-2-oxo-acetamide
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Investigative | Compound Info | ||
| Synonyms |
N-benzyl-2-(1H-indol-3-yl)-2-oxoacetamide
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
SU5402
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Investigative | Compound Info | ||
| Synonyms |
su5402; 215543-92-3; SU 5402; SU-5402; 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone; (Z)-3-(4-methyl-2-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid; CHEMBL89363; 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE; J-502595; 3-{[3-(2-carboxyethyl)-4-methylpyrrol-2-yl]methylene}-2-indolinone; 3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid; (Z)-3-(4-Methyl-2-((2-oxoindolin-3-ylidene)-methyl)-1H-pyrrol-3-yl)propanoic acid
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
SU4984
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Investigative | Compound Info | ||
| Synonyms |
SU-4984; CHEMBL315546; 3[4-(1-Formylpiperazin-4-yl)benzylidenyl]-2-indolinone; (Z)-4-(4-((2-Oxoindolin-3-ylidene)methyl)phenyl)piperazine-1-carbaldehyde; 186610-89-9; AC1NZT45; SCHEMBL141892; BDBM50065306; ZINC12832813; 4-[4-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]phenyl]piperazine-1-carbaldehyde
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL357756; CHEMBL3822972; BDBM206104; DB-085143; US9255110, 17
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-[4-(5-Bromo-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-phenyl]-piperazine-1-carbaldehyde
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL88405; BDBM50065299; 4-{4-[5-Bromo-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-phenyl}-piperazine-1-carbaldehyde
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949788; SCHEMBL12134179; BDBM50364832; CH-4932748
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-(2-Methoxyethyl)phenol
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Investigative | Compound Info | ||
| Synonyms |
p-(2-Methoxyethyl)phenol; p-(2-Methoxyethyl) phenol; Phenol, 4-(2-methoxyethyl)-; 4-METHOXYETHYLPHENOL; UNII-PY1W0AKW8I; Metoprolol Impurity B; Metoprolol IMpurity 02; MFCD00017537; PY1W0AKW8I; CHEMBL1094369; 4-Hydroxyphenylethyl methyl ether; 4-(2'-METHOXYETHYL)PHENOL; Metoprolol Impurity I; 4-(2-methoxyethyl)-phenol; 4-(2-Methoxy ethyl)-phenol; EINECS 260-354-9; 4-Methoxy ethyl phenol; ACMC-1AUK5; 4-(2'Methoxyethyl)Phenol; EC 260-354-9; 4-(2-methoxy ethyl)phenol; 4-(2-methoxyethyl) phenol; 4-(2-methoxy ethyl) phenol; 4-(2-methoxy-ethyl)-phenol; KSC495I9L; SCHEMBL303516; p-Hydroxyphenethyl methyl ether; DTXSID2073564; CTK3J5495; ATTERCOP-CHM AT108983; 4-(2-Methoxyethyl)phenol, 97%; CS-M3678; KS-000009AQ; ZINC2566176; ANW-32571; BDBM50316786; AKOS000120544; AS00207; MCULE-8081983402; NE10781; AC-23553; TS-02027; DB-052961; FT-0616546; FT-0652026; M1167; ST50824360; W-105505; Q27286814
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086065; SCHEMBL959662; BDBM50443366
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
(R)-3-(6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL602471; BDBM50306677
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949789; SCHEMBL12134185; BDBM50364833; CH-4932750
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL600795; BDBM50306683
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
CID 49806721
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823221; SCHEMBL896410; BDBM50352760; 9-ethyl-6,6-dimethyl-8-[4-(oxetan-3-yl)piperazin-1-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
Serotonin hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
5-Hydroxytryptamine hydrochloride; Serotonin HCl; 3-(2-aminoethyl)-1H-indol-5-ol hydrochloride; 5-Hydroxytryptamine HCl; 1H-Indol-5-ol, 3-(2-aminoethyl)-, monohydrochloride; UNII-GKN429M9VS; MFCD00012686; 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride; GKN429M9VS; CHEMBL535832; 5-Hydroxytryptamine hydrochioride; 3-(2-aminoethyl)indol-5-ol, chloride; 3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride; Serotonin hydrochloride, 98+%; SMR000875214; Prestwick_447; CCRIS 4420; SR-01000075577; Serotonin, HCl; 5-HT hydrochloride; 3-(2-Aminoethyl)indol-5-ol hydrochloride; MLS001332607; MLS001332608; MLS002153834; SCHEMBL379650; Serotonin hydrochloride(5-HT); Serotonin hydrochloride, powder; 3-(2-AMINO-ETHYL)-1H-INDOL-5-OL HYDROCHLORIDE; CTK3J3022; DTXSID80165186; 5-hydroxy tryptamine hydrochloride; HMS1569B03; 3-(2-Aminoethyl)indol-5-ol HCl; BCP20357; HY-B1473; KS-00000FV4; EINECS 244-464-4; Tox21_500607; ANW-43151; s4244; SBB003418; 5-Hydroxytryptamine Hydrochloride,(S); AKOS016010442; CCG-214216; GS-3130; LP00607; MCULE-8194058321; QC-1340; 3-(2-Aminoethyl)-1H-indol-5-ol HCl; NCGC00093982-01; NCGC00093982-02; NCGC00261292-01; SC-80561; ST056223; SY061788; AB0013658; DB-043206; CS-0013171; EU-0100607; FT-0631852; S0370; SW196666-3; A16699; H 9523; H-8140; X-1770; 3-(2-aminoethyl)-1H-indol-5-ol, hydrochloride; 3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride.; 3-(2-azanylethyl)-1H-indol-5-ol hydrochloride; 153S980; A809482; 5-Hydroxytryptamine hydrochloride;5-HT hydrochloride; SR-01000075577-1; SR-01000075577-5; Q27279146
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-4-methyl-N-(1,2-oxazol-3-yl)benzamide; CHEMBL383172; 5-Cyanopyrimidine Derivative 3b; SCHEMBL16576397; BDBM16326; 3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-N-isoxazol-3-yl-4-methylbenzamide
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| Activity |
IC50 ~ 50000 nM
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[10] | |||
| Compound Name |
5-Amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl)-1H-pyrazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290746; SCHEMBL14097139; BDBM50331629
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| Activity |
IC50 ~ 50000 nM
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[11] | |||
| Compound Name |
N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089082; SCHEMBL4656083; BDBM50314051; N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
Tert-Butyl-2-{5-(4-hydroxyphenethoxy)-1-{5-[4-(methylthio)phenyl]pentyl}-1H-indole-3-yl}ethyl carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1099339; BDBM50316778
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| Activity |
IC50 ~ 50000 nM
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[6] | |||
| Compound Name |
CID 60154336
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2088106; BDBM50420944; 5-bromo-4-N-(5-methyl-1H-pyrazol-3-yl)-2-N-[(3-methylpyridin-2-yl)methyl]pyrimidine-2,4-diamine
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| Activity |
IC50 = 50118.72 nM
|
[13] | |||
| Compound Name |
2-(1H-Indol-3-yl)-N-[2-(4-methylphenyl)ethyl]-2-oxoacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796175; BDBM50346824
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| Activity |
IC50 = 52000 nM
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[3] | |||
| Compound Name |
N'-[2-(1H-Indol-3-yl)-2-oxoacetyl]-4-methoxybenzohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796179; BDBM50346846
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| Activity |
IC50 = 54000 nM
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[3] | |||
| Compound Name |
2-(1H-Indol-3-yl)-N-(4-methylbenzyl)-2-oxoacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL220737; ZINC4163156; BDBM50346845; AKOS000423609; MCULE-4050371716; NCGC00294126-01; AB01258772-02; F0675-0091
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| Activity |
IC50 = 63000 nM
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[3] | |||
| Compound Name |
(Z)-5-(4-Ethoxy-3-isobutoxybenzylidene)thiazolidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL590521; BDBM50308372
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| Activity |
IC50 = 63900 nM
|
[14] | |||
| Compound Name |
N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmethyl)-amino]-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL347537; n-(3-isoquinolin-4-ylphenyl)-2-[(pyridin-4-ylmethyl)amino]-benzamide; BDBM50121980; ZINC27644428
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| Activity |
IC50 = 64000 nM
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[15] | |||
| Compound Name |
(Z)-4-(4-((4-Methyl-2-oxoindolin-3-ylidene)methyl)phenyl)piperazine-1-carbaldehyde
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL89040; BDBM50065290; 4-[4-(4-Methyl-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-phenyl]-piperazine-1-carbaldehyde; 4-{4-[4-Methyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-phenyl}-piperazine-1-carbaldehyde
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| Activity |
IC50 = 67600 nM
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[2] | |||
| Compound Name |
N-Cyclopentyl-4-[4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3421974; BDBM50081176
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| Activity |
IC50 = 67727 nM
|
[16] | |||
| Compound Name |
(Z)-3-(4-Hydroxyphenyl)-2-pyridin-2-ylprop-2-enenitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL43689; ZINC4347852; BDBM50409195; AKOS001301581; AB00757746-01
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| Activity |
IC50 = 72800 nM
|
[17] | |||
| Compound Name |
CID 42602949
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2088259; SCHEMBL3982541; BDBM50420968
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| Activity |
IC50 = 79432.82 nM
|
[13] | |||
| Compound Name |
N'-[2-(1H-Indol-3-yl)-2-oxoacetyl]-4-methylbenzohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796178; BDBM50346842
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| Activity |
IC50 = 82000 nM
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[3] | |||
| Compound Name |
2-Fluoro-N'-[2-(1H-indol-3-yl)-2-oxoacetyl]benzohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796184; BDBM50346831
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| Activity |
IC50 = 91000 nM
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[3] | |||
| Compound Name |
3-[(Z)-(4-Bromo-2-thienyl)methylidene]-1H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL316268; (3Z)-3-[(4-bromothiophen-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one; SCHEMBL5728269; ZINC5903417; BDBM50065319; MFCD03012811; AKOS005094253; 5T-0045; 3-[1-(4-Bromo-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(Z)-1-Methyl-3-(4-dimethylaminobenzylidene)indoline-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL86921; SCHEMBL14589616; ZINC586193; BDBM50065315; MCULE-4166796331; 3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-methyl-1,3-dihydro-indol-2-one
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456294; Calicoferol I; USFQLAVWHQCNDG-AYEIPMSGSA-; BDBM50358248; LMST03020180
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| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N'-Phenyl-2-(1H-indole-3-yl)-2-oxoacetohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL72505; BDBM50066940; (1H-Indol-3-yl)-oxo-acetic acid N''-phenyl-hydrazide
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
5-[2-(2,4-Dichloro-benzyloxy)-benzylidene]-thiazolidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL591020; ZINC1013701; BDBM50308359; STL282825; AKOS000409111; (E)-5-(2-(2,4-dichlorobenzyloxy)benzylidene)thiazolidine-2,4-dione; (5E)-5-{2-[(2,4-dichlorobenzyl)oxy]benzylidene}-1,3-thiazolidine-2,4-dione
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-(3-Tert-Butyl-4-methoxy-benzylidene)-5-chloro-1,3-dihydro-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL86326; BDBM50065278; 3-[1-(3-tert-Butyl-4-methoxy-phenyl)-meth-(Z)-ylidene]-5-chloro-1,3-dihydro-indol-2-one
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3361128; BDBM50038423; ZINC16052822; (E)-2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one
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| Activity |
IC50 = 100000 nM
|
[19] | |||
| Compound Name |
3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
SU 4312; SU-4312; NSC86429; NSC 86429; CHEMBL328710; 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one; SU4312; SR-01000076222; BiomolKI_000054; BiomolKI2_000060; UPCMLD-DP118; cis-SU 4312; Lopac0_001121; BMK1-F6; BSPBio_000998; SCHEMBL1982207; UPCMLD-DP118:001; UPCMLD-DP118:002; BDBM17747; HMS1362B19; HMS1792B19; HMS1990B19; HMS3263B03; HMS3403B19; HMS3412D03; HMS3676D03; BCP20743; Tox21_501121; NSC-86429; STK946565; ZINC12339625; AKOS005640946; CCG-100658; LP01121; SDCCGSBI-0051089.P002; SU4312(NSC86429); IDI1_002094; NCGC00025170-02; NCGC00025170-03; NCGC00025170-04; NCGC00025170-05; NCGC00025170-06; NCGC00025170-07; NCGC00025170-08; NCGC00025170-09; NCGC00025170-10; NCGC00025170-11; NCGC00025170-12; NCGC00025170-14; NCGC00261806-01; B6746; EU-0101121; EC-000.2453; S 8567; (Z)-3-(4-(dimethylamino)benzylidene)indolin-2-one; SR-01000076222-1; SR-01000076222-3; BRD-K20287671-001-01-0; (3Z)-3-[(4-dimethylaminophenyl)methylene]indolin-2-one; DMBI; (Z)-3-(4-(dimethylamino)benzylidene)indolin-2-one; (3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one; (3Z)-3-[4-(dimethylamino)benzylidene]-1,3-dihydro-2H-indol-2-one; (3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-dihydro-1H-indol-2-one; SU-4312; SU4312. DMBI; NSC 86429; NSC-86429; NSC86429
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[1-(3-Tert-Butyl-4-methoxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86945; BDBM50065318; ZINC13780159
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3Z)-3-[(4-Bromophenyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU 4942; CHEMBL86837; 3-(4-Bromobenzylidene)-1,3-dihydroindol-2-one; 3-(4-Bromobenzylidene)indolin-2-one; SU4942; SCHEMBL5465141; ZINC574906; BCP20736; BDBM50065305; MFCD00435354; 3-(4-Bromobenzylidene)indoline-2-one; AKOS001575405; (3Z)-3-(4-bromobenzylidene)-1,3-dihydro-2H-indol-2-one; 3-[1-(4-Bromo-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[1-(4-Piperidin-1-yl-phenyl)-ethylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314798; SCHEMBL19451599; BDBM50065293; 3-[1-(4-Piperidin-1-yl-phenyl)-eth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[2-(3-Chlorophenyl)ethyl]-2-(1H-indol-3-yl)-2-oxoacetamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796176; BDBM50346825
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(4-Dimethylamino-benzylidene)-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89809; BDBM50065294; 3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N'-(4-Chlorophenyl)-2-(1H-indole-3-yl)-2-oxoacetohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL124871; BDBM50066943; (1H-Indol-3-yl)-oxo-acetic acid N''-(4-chloro-phenyl)-hydrazide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[1-(4-Piperidin-1-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315701; SCHEMBL6001605; BDBM50065276
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3Z)-3-[4-(Morpholin-4-yl)benzylidene]-1,3-dihydro-2H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86480; SCHEMBL1452713; HMS1404H09; ZINC3262621; BDBM50065280; STK114426; AKOS005399481; IDI1_007326; 3-(4-Morpholinobenzylidene)indolin-2-one; (Z)-3-(4-Morpholinobenzylidene)indolin-2-one; 3-[1-(4-Morpholin-4-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-Nitro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87325; SCHEMBL6000878; BDBM50065287; 5-Nitro-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
AZ-Dyrk1B-33
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3421980; 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine; AZ Dyrk1B 33; BDBM50081189; AKOS030210999; Cc1nccc(n1)c2cn(Cc3ccccc3)c4cnccc24; HY-117391; CS-0065849
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
3-(5-Methyl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89697; BDBM50065309; 3-[1-(5-Methyl-furan-2-yl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3Z)-4-Methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL85403; Indolinone based inhibitor, 1a; SCHEMBL5728466; BDBM17016
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[(Z)-(3-Bromo-2-thienyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87783; (3Z)-3-[(3-bromothiophen-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one; ZINC4038356; BDBM50065272; MFCD05975006; AKOS005076668; 10X-0879; 3-[1-(3-Bromo-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-Chloro-3-(4-hydroxy-3,5-diisopropyl-benzylidene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89723; BDBM50065307; 5-Chloro-3-[1-(4-hydroxy-3,5-diisopropyl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N'-[2-(1H-Indol-3-yl)-2-oxoacetyl]benzohydrazide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796177; BDBM50346826
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(E)-5-(3-Fluoro-4-(pyrrolidin-1-yl)benzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602315; ZINC982241; BDBM50308371; AKOS003208107; AH-487/41660440; SR-01000261930; SR-01000261930-1; 5-[3-fluoro-4-(1-pyrrolidinyl)benzylidene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
5-(4-Benzyloxy-3-methoxy-benzylidene)-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590285; MLS001210478; HMS2830A10; ZINC9012037; BDBM50308370; AKOS000542320; SMR000513491; ST50299477; (E)-5-(4-(benzyloxy)-3-methoxybenzylidene)thiazolidine-2,4-dione; 5-{[3-methoxy-4-(phenylmethoxy)phenyl]methylene}-1,3-thiazolidine-2,4-dione
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(5Z)-5-(3-Bromo-5-ethoxy-4-propoxybenzylidene)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL599975; BDBM50308376; STK244871; ZINC13843846; AKOS005422230; AN-989/41696701; (Z)-5-(3-bromo-5-ethoxy-4-propoxybenzylidene)thiazolidine-2,4-dione; 5-(3-bromo-5-ethoxy-4-propoxybenzylidene)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-[2-(4-Chlorophenyl)ethyl]-2-(1H-indol-3-yl)-2-oxoacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL71184; MLS001198399; HMS2885H18; ZINC2873929; BDBM50000767; STK734898; AKOS003356295; MCULE-8231753624; SMR000559268; ST4081619; SR-01000293292; SR-01000293292-1; N-[2-(4-chlorophenyl)ethyl]-2-indol-3-yl-2-oxoacetamide; N~1~-(4-chlorophenethyl)-2-(1H-indol-3-yl)-2-oxoacetamide; 2-(1H-Indol-3-yl)-2-oxo-N-[2-(4-chlorophenyl)ethyl]acetamide; Acetamide, N-[2-(4-chlorophenyl)ethyl]-2-(1H-indol-3-yl)-2-oxo-; N-[2-(4-Chloro-phenyl)-ethyl]-2-(1H-indol-3-yl)-2-oxo-acetamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3Z)-3-(4-Hydroxybenzylidene)-1,3-dihydro-2H-indol-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL313578; SCHEMBL5470603; ZINC2939076; BDBM50065304; STK946564; AKOS002131864; 3-(4-Hydroxybenzylidenyl)-indolin-2-one; 3-[(Z)-4-Hydroxybenzylidene]indoline-2-one; J3.666.327H; SR-01000594632; J-017472; SR-01000594632-1; 3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N'-(4-Bromophenyl)-2-(1H-indol-3-yl)-2-oxoacetohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796173; BDBM50346840
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(1H-Indol-3-yl)-N'-(4-iodophenyl)-2-oxoacetohydrazide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796174; BDBM50346841
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(Z)-4-Methyl-3-(4-morpholinobenzylidene)indolin-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL90277; BDBM50065312; 4-Methyl-3-(4-morpholin-4-yl-benzylidene)-1,3-dihydro-indol-2-one; 4-Methyl-3-[1-(4-morpholin-4-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3Z)-3-[(4-Methoxyphenyl)methylidene]-1H-indol-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL87810; 3-(4-Methoxybenzylidene)-2-indolinone; SCHEMBL5475861; BDBM50065296; STL553883; ZINC12339635; AKOS016032064; 3-(4-Methoxybenzylidene)indoline-2-one; (Z)-3-(4-methoxybenzylidene)indolin-2-one; 3-[(Z)-4-Methoxybenzylidene]-1H-indol-2(3H)-one; (3Z)-3-(4-methoxybenzylidene)-1,3-dihydro-2H-indol-2-one; 3-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Methyl-3-(5-methylsulfanyl-thiophen-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL86432; BDBM50065274; 4-Methyl-3-[1-(5-methylsulfanyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3Z)-3-[(4-Chloro-1-methylpyrazol-3-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL89646; SCHEMBL5999800; BDBM50065279; 3-[1-(4-Chloro-1-methyl-1H-pyrazol-3-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-[4-[3-Methoxy-4-[[6-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-4-yl]amino]phenyl]piperazin-1-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3421965; BDBM50081183
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
3-[1-(5-Ethyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314146; SCHEMBL6001148; BDBM50065295; ZINC12352634
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Calicoferol C
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL515982; BDBM50358249
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-(4-Chlorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL73288; MLS000674387; HMS2608G07; ZINC4268552; BDBM50055241; STK710824; AKOS000346802; MCULE-8563552712; SMR000297338; ST4127583; N-[(4-chlorophenyl)methyl]-2-indol-3-yl-2-oxoacetamide; N-(4-Chloro-benzyl)-2-(1H-indol-3-yl)-2-oxo-acetamide; 1H-Indole-3-acetamide, N-[(4-chlorophenyl)methyl]-.alpha.-oxo-
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-(1H-indol-3-yl)-2-oxoacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL71999; N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(1H-indol-3-yl)-2-oxo-acetamide; N-(3,4-dimethoxyphenethyl)-2-(1H-indol-3-yl)-2-oxoacetamide; N-(2-(3,4-DIMETHOXYPHENYL)ETHYL)-2-INDOL-3-YL-2-OXOETHANAMIDE; NSC377714; MLS001211757; CTK6J7761; HMS2831M21; ZINC1590445; BDBM50000761; MFCD00245698; STK710823; AKOS001695117; MCULE-6186184263; MS-7224; NSC-377714; KS-0000290Q; SMR000518987; ST058888; N-[2-(3,4-dimethoxyphenyl)ethyl]-2-indol-3-yl-2-oxoacetamide; 2-(1H-Indol-3-yl)-2-oxo-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide; Acetamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(1H-indol-3-yl)-2-oxo-
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Calicoferol B
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL464351; BDBM50358250
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(3E)-3-(Furan-2-ylmethylidene)-1H-indol-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL312826; SCHEMBL20838; HMS1433A06; ZINC4693315; BDBM50065301; IDI1_012097; 3-Furan-2-ylmethylene-1,3-dihydro-indol-2-one; 3-[1-Furan-2-yl-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330321; SCHEMBL13432277; BDBM50065288; 3-[1-(3,5-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(5E)-5-{4-[(2-Chlorobenzyl)oxy]benzylidene}-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591471; ZINC1005057; BDBM50308363; STK040454; AKOS003239427; (E)-5-(4-(2-chlorobenzyloxy)benzylidene)thiazolidine-2,4-dione
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N'-[1H-Indol-3-yl(oxo)acetyl]-4-nitrobenzohydrazide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796172; ZINC2251508; BDBM50346844; STK536234; AKOS005467227; MCULE-2202306145
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2,3-[Ethyliminobis[ethyleneoxyethylene(1H-indole-1,3-diyl)]]maleimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL103055; SCHEMBL4346022; BDBM50132310
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
6-Fluoro-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL87208; SCHEMBL5728248; BDBM50065302
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89483; BDBM50065292; (Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-methyl-1,3-dihydro-indol-2-one; 3-[1-(3,5-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-5-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[1-(4-Bromo-phenyl)-meth-(Z)-ylidene]-1-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314021; ZINC575064; BDBM50065316; AKOS001097016; AB00736582-01; SR-01000072622; SR-01000072622-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[1-(4-Chloro-1H-pyrazol-3-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87402; SCHEMBL6001442; BDBM50065284
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-[2-Oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-benzoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL313259; BDBM50065281
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[1-(3,4-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316020; SCHEMBL6001449; BDBM50065311
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(Z)-5-(2-Bromo-5-ethoxy-4-methoxybenzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599974; BDBM50308374
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(Z)-5-(4-Butoxybenzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591704; (5Z)-5-(4-butoxybenzylidene)-1,3-thiazolidine-2,4-dione; BDBM50308364; STK092229; ZINC13894889; AKOS003203616; AN-989/41696607; 5-(4-butoxybenzylidene)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
CID 60154345
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2088258; SCHEMBL3935753; BDBM50420952
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[13] | |||
| Compound Name |
3-(5-Ethyl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328452; SCHEMBL5728117; BDBM50065291; 3-[1-(5-Ethyl-furan-2-yl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3Z)-3-[[4-(Dimethylamino)phenyl]methylidene]-6-fluoro-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329367; BDBM50065298; 3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-6-fluoro-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Methyl 3-[4-methyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316009; SCHEMBL14519114; BDBM50065289
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3Z)-3-[(5-Methylsulfanylthiophen-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89721; BDBM50065273; 3-[1-(5-Methylsulfanyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3Z)-3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-6-fluoro-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87324; BDBM50065282; 3-[1-(3,5-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-6-fluoro-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-Chloro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431025; SCHEMBL3912682; BDBM50065317; ZINC33034247; AKOS001473500; 5-Chloro-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(3-Chloro-benzyl)-2-(1H-indol-3-yl)-2-oxo-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL358147; BDBM50055248
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[1-(4-Pyrrolidin-1-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314217; SCHEMBL6001567; SCHEMBL14519135; ZINC574986; BDBM50065314
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3Z)-3-[(1-Methylpyrrol-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86631; SCHEMBL21465; BDBM50065300; 3-[1-(1-Methyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[4-(4-Methylpiperazin-1-yl)phenyl]-6-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3421962; BDBM50081186
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(Z)-5-(4-(2,4-Dichlorobenzyloxy)-3-methoxybenzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL601494; SCHEMBL13479549; BDBM50308369; ZINC13549723; AKOS000542028; ST50166577; 5-({4-[(2,4-dichlorophenyl)methoxy]-3-methoxyphenyl}methylene)-1,3-thiazolidin e-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(3Z)-3-[(3-Ethyl-4,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313433; SCHEMBL6000845; BDBM50065303; 3-[1-(3-Ethyl-4,5-dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[2-(4-Methylsulfonylphenyl)pyrimidin-4-yl]-1H-pyrrolo[2,3-c]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3421975; BDBM50081175
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
3-(2-Methylpyrimidin-4-yl)-1H-pyrrolo[2,3-c]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3421979; BDBM50081190
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(5Z)-5-[3,4-Dimethoxy-5-(prop-2-en-1-yl)benzylidene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591014; BDBM50308377; STK244887; ZINC13843879; AKOS005422313; (Z)-5-(3-allyl-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(3Z)-3-[(4-Ethyl-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL420411; SCHEMBL5728018; BDBM50065286; 3-[1-(4-Ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-(3-Bromo-5-tert-butyl-4-methoxy-benzylidene)-5-chloro-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86944; BDBM50065313; 3-[1-(3-Bromo-5-tert-butyl-4-methoxy-phenyl)-meth-(Z)-ylidene]-5-chloro-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358966
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(3Z)-3-[(3-Bromo-5-tert-butyl-4-methoxyphenyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87746; BDBM50065285; 3-[1-(3-Bromo-5-tert-butyl-4-methoxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-1H-pyrrole-3-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316008; SCHEMBL5388917; BDBM50065283
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-(5-(1H-Imidazol-1-yl)-7-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-(2-chlorophenyl)-2-hydroxyethylamino)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL387794; SCHEMBL14510269; BDBM50201141
Click to Show/Hide
|
||||
| Activity |
IC50 = 180000 nM
|
[22] | |||
| Compound Name |
N-(2-{2-Dimethylaminoethyl-methylamino}-4-methoxy-5-{[5-methyl-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353409; SCHEMBL14719501; BDBM50029688
Click to Show/Hide
|
||||
| Activity |
IC50 = 196000 nM
|
[23] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 10 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ro-0505124
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
RO0505124
Click to Show/Hide
|
||||
| Activity |
IC50 = 22000000 nM
|
[24] | |||
| Compound Name |
1421373-98-9
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AZ5104; AZ-5104; UNII-2DWZ6SE1E1; 2DWZ6SE1E1; CHEMBL3353411; AZD5104; AZ 5104; Osimertinib metabolite M6; SCHEMBL14663428; EX-A824; AOB87166; BCP08428; HY-B0793; BDBM50029689; MFCD28899992; s7298; AKOS025404698; ZINC147059673; CCG-269587; CS-5192; NCGC00387805-01; AK174234; AS-55926; DA-45003; QC-11825; B5836; FT-0733191
Click to Show/Hide
|
||||
| Activity |
IC50 = 263000 nM
|
[23] | |||
| Compound Name |
Chembl4213021
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 > 1000000 nM
|
[25] | |||
| Compound Name |
N-(Pyridin-3-ylmethyl)benzofuro[2,3-b]pyridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290178; BDBM50331614
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[26] | |||
| Compound Name |
Chembl4209296
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 > 1000000 nM
|
[25] | |||
| Compound Name |
Indirubin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Indigo Red; Couroupitine B; Indigopurpurin; (Z)-[2,3'-biindolinylidene]-2',3-dione; 3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; UNII-V86L8P74GI; NSC 105327; NSC-105327; C.I. 73200; UNII-1LXW6D3W2Z; 1LXW6D3W2Z; V86L8P74GI; (E)-[2,3'-biindolinylidene]-2',3-dione; MFCD00956441; (3E)-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; [2,3'-Biindolinylidene]-2',3-dione; C.I. 75790; MFCD00221745; SMR000466311; BRN 0088279; Isoindirubin; Isoindirubine; Isoindogotin; Indirubin/; Indirubin [MI]; Indirubin,(S); INDARUBICIN; CPD000466311; Indirubin derivative, 1; BiomolKI_000069; EM-A05-INDIRUBIN; [.DELTA.2,3-dione; Indirubin 3E-form [MI]; BiomolKI2_000073; Indirubin 479-41-4; (3Z)-3-(3-oxoindolin-2-ylidene)indolin-2-one; (delta(sup 2,3')-BIINDOLINE)-2',3-DIONE; SCHEMBL27678; BMK1-G9; BSPBio_001110; KBioGR_000450; KBioSS_000450; 5-24-08-00507 (Beilstein Handbook Reference); MLS000759416; MLS001424211; MLS002473308; MLS006010732; CHEMBL35349; BDBM7392; CHEMBL259664; SCHEMBL9899338; (3Z)-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; CHEMBL1276127; CHEMBL3185783; cid_5318433; KBio2_000450; KBio2_003018; KBio2_005586; KBio3_000839; KBio3_000840; EX-A347; Bio2_000395; Bio2_000875; HMS1362H11; HMS1792H11; HMS1990H11; HMS2051H20; HMS2234G06; HMS3369O15; HMS3393H20; HMS3403H11; HMS3656O13; ACT03264; BCP28869; HY-N0117; KS-000000OC; ABP000850; BDBM50023867; BDBM50349806; NSC105327; s2386; ZINC18825333; AKOS015895136; AKOS028108775; AKOS032455876; ZINC100015416; AC-8003; BCP9000788; CCG-100673; CCG-101058; CCG-267073; CS-3682; DB12379; NC00308; IDI1_002150; (2'Z)-Indirubin, >=98% (HPLC); NCGC00163356-01; NCGC00163356-02; NCGC00163356-03; NCGC00163356-04; NCGC00179302-02; AC-29931; AK128411; CS-12423; SMR004701694; SY058396; 3-(3-oxoindolin-2-ylidene)indolin-2-one; 3-(3-indolinone-2-ylidene)-indolin-2-one; AB0020115; UNM-0000305766; FT-0627199; I0868; SW197688-2; V0881; (delta2,3'-Biindoline)-2',3-dione (8CI); W-2665; (E)-[2,3-BIINDOLINYLIDENE]-2,3-DIONE; AB00639939-06; 2-(2-oxo-1H-indol-3-ylidene)-1H-indol-3-one; 479I414; A827403; SR-01000759396; Q-100514; Q1661452; SR-01000759396-5; BRD-K17894950-001-03-6; BRD-K17894950-001-04-4; Q27164070; Indigo Red; Couroupitine B; (3E)-3-(3-Oxo-1H-indol-2-ylidene)-1H-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[27] | |||
| Compound Name |
Chembl4216200
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 > 1000000 nM
|
[25] | |||
| Compound Name |
Chembl4202409
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 > 1000000 nM
|
[25] | |||
| Compound Name |
[4-Amino-2-[[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]amino]-5-thiazolyl](3-methoxyphenyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956069; SCHEMBL5741716; HMS3401E09; BDBM50365217; Ro-0506220; [4-amino-2-[4-(4-propan-2-ylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(3-methoxyphenyl)methanone
Click to Show/Hide
|
||||
| Activity |
IC50 = 20000000 nM
|
[24] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 = 2900000 nM
|
[23] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004 Dec 30;47(27):6658-61. | ||||
| REF 2 | Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603. | ||||
| REF 3 | Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure. Eur J Med Chem. 2011 Jul;46(7):2759-69. | ||||
| REF 4 | Identification of a selective inhibitor of transforming growth factor -activated kinase 1 by biosensor-based screening of focused libraries. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1031-1036. | ||||
| REF 5 | Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation. Bioorg Med Chem. 2012 Feb 15;20(4):1442-60. | ||||
| REF 6 | Serotonin derivatives as a new class of non-ATP-competitive receptor tyrosine kinase inhibitors. Bioorg Med Chem. 2010 May 15;18(10):3387-402. | ||||
| REF 7 | The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6223-7. | ||||
| REF 8 | Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1405-9. | ||||
| REF 9 | 9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors. J Med Chem. 2011 Sep 22;54(18):6286-94. | ||||
| REF 10 | 5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase. J Med Chem. 2005 Oct 6;48(20):6261-70. | ||||
| REF 11 | 5-amino-pyrazoles as potent and selective p38alpha inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6886-9. | ||||
| REF 12 | Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. | ||||
| REF 13 | Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase. J Med Chem. 2012 Jun 14;55(11):5003-12. | ||||
| REF 14 | Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening. J Med Chem. 2010 Mar 25;53(6):2661-5. | ||||
| REF 15 | Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J Med Chem. 2002 Dec 19;45(26):5687-93. | ||||
| REF 16 | Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J Med Chem. 2015 Mar 26;58(6):2834-44. | ||||
| REF 17 | Structural studies on bioactive compounds. 32. Oxidation of tyrphostin protein tyrosine kinase inhibitors with hypervalent iodine reagents. J Med Chem. 2000 Apr 20;43(8):1550-62. | ||||
| REF 18 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. Bioorg Med Chem. 2011 Nov 15;19(22):6873-80. | ||||
| REF 19 | In vitro and in vivo characterization of a benzofuran derivative, a potential anticancer agent, as a novel Aurora B kinase inhibitor. Eur J Med Chem. 2015 Jan 7;89:310-9. | ||||
| REF 20 | Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3049-53. | ||||
| REF 21 | Optimization of potent DFG-in inhibitors of platelet derived growth factor receptor (PDGF-R) guided by water thermodynamics. J Med Chem. 2015 Jan 8;58(1):170-82. | ||||
| REF 22 | Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach. J Med Chem. 2009 Aug 27;52(16):4981-5004. | ||||
| REF 23 | Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67. | ||||
| REF 24 | Inhibition of S/G2 phase CDK4 reduces mitotic fidelity. J Biol Chem. 2006 Apr 14;281(15):9987-95. | ||||
| REF 25 | Discovery of dually acting small-molecule inhibitors of cancer-resistance relevant receptor tyrosine kinases EGFR and IGF-1R. Medchemcomm. 2016;7:2159-66. | ||||
| REF 26 | Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. | ||||
| REF 27 | Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule. J Med Chem. 2017 Jun 22;60(12):4949-4962. | ||||
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