Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T35264 | Target Info | |||
| Target Name | P2Y purinoceptor (P2RY) | ||||
| Synonyms |
Platelet adenosine diphosphatereceptor; P2Y receptor; Adenosine diphosphate (ADP) receptor; Adenosine 5'-Diphosphate Receptor; ADP receptor
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| Target Type | Literature-reported Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 84 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Suramin
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|
Phase 1 | Compound Info | ||
| Synonyms |
Antrypol; Belganyl; Farma; Fourneau; Germanin; Moranyl; Naganil; Naganin; Naganine; Naganol; Naphuride; SVR; Suramine; SURAMIN SODIUM; Sodium suramin; Suramine sodium; Farma 939; Naganol 6 Na; Germanin (TN); SGCTO-001
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| Activity | Purinergic receptor P2Y2 |
IC50 = 50000 nM
|
[1] | ||
| Compound Name |
INS 316
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Discontinued in Phase 3 | Compound Info | ||
| Synonyms |
Uridine 5'-triphosphate; uridine 5'-triphosphate; uridine triphosphate; 63-39-8; Uteplex; UTP; Uridine 5'-(tetrahydrogen triphosphate); 5'-UTP; Uridine 5'-triphosphoric acid; H4utp; UNII-UT0S826Z60; BRN 0071520; INS316; EINECS 200-558-7; uridine-5'-triphosphate; CHEMBL336296; CHEBI:15713; UT0S826Z60; Uridine5'-(tetrahydrogen triphosphate); [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate; uridine5'-triphosphate; uridintriphosphat; uridine tetrahydrogen
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| Activity | Purinergic receptor P2Y1 |
EC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
PMID:23368907C16
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Investigative | Compound Info | ||
| Synonyms |
BPTU; 870544-59-5; GTPL5808; BMS-646786; MolPort-046-033-632; BCP29138; EX-A2593; ZINC95588286; BDBM50429537; AKOS032962872; CS-8114; HY-13831; DS-20243; AK689499; 1-(2-[2-
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| Activity | Purinergic receptor P2Y12 |
Ki ~ 70000 nM
|
[3] | ||
| Compound Name |
2-amino-uridine-5'-monophosphate
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Investigative | Compound Info | ||
| Synonyms |
iso-CMP; compound 13g [PMID: 21417463]
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| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
Uridine-5'-Diphosphate
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Investigative | Compound Info | ||
| Synonyms |
Uridine 5'-diphosphate; URIDINE DIPHOSPHATE; 58-98-0; Uridine 5'-(trihydrogen diphosphate); uridine-5'-diphosphate; UDP; UNII-5G0F599A1Y; 5'-UDP; Uridine 5'-pyrophosphate; EINECS 200-409-6; Uridine 5'-pyrophosphoric acid; CHEMBL130266; CHEBI:17659; 5G0F599A1Y; uridine-diphosphate; ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate; [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate; Uridine Pyrophosp
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| Activity | Purinergic receptor P2Y1 |
EC50 ~ 100000 nM
|
[2] | ||
| Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[2] | |||
| Purinergic receptor P2Y14 |
EC50 = 160000 nM
|
[6] | |||
| Compound Name |
adenosine diphosphate
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Investigative | Compound Info | ||
| Synonyms |
Adenosine diphosphate; 58-64-0; ADP; Adenosine 5'-(trihydrogen diphosphate); adenosine pyrophosphate; adenosine 5'-pyrophosphate; ADP (nucleotide); adenosine-diphosphate; 5'-Adenylphosphoric acid; 5'-Adp; Adenosindiphosphorsaeure; Adenosine 5'-pyrophosphoric acid; Adenosine-5'-diphosphat; Adenosine 5'-diphosphoric acid; Adenosine diphosphoric acid; Ado-5'-P-P; UNII-61D2G4IYVH; H3adp; BRN 0067722; CHEBI:16761; EINECS 200-392-5; 61D2G4IYVH; CHEMBL14830
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| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
RB 2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223344; Cibacron Blue 3GA Agarose; Cibacron Blue 3GA Agarose, saline suspension; Cibacron Blue 3GA Agarose, Type 300, saline suspension; Cibacron Blue 3GA Agarose, Type 100, saline suspension; Cibacron Blue 3GA Agarose, saline suspension, Fast flow; Cibacron Blue 3GA Agarose, Type 1000, saline suspension; Cibacron Blue 3GA Agarose, Type 3000, saline suspension; Cibacron Blue 3GA Agarose, Type 3000-CL, saline suspension; Cibacron Blue 3GA Agarose, Type 3000-L, lyophilized powder
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| Activity | Purinergic receptor P2Y11 |
EC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
2MeSADP
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Investigative | Compound Info | ||
| Synonyms |
2-Methylthio-adenosine-5'-diphosphate; 2-MeSADP; 2-methylthio-ADP; 2-Mes-ADP; 2-methylthio-adenosine-5'-diphosphate; CHEMBL435402; 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate); methylthio-ADP; [(2R,3S,4R,5R)-5-(6-amino-2-methylsulfanylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate; 2-(Methylthio)adenosine 5'-diphosphate; [3H]2-methylthio-ADP; [3H]2MeSADP; (3H)2-Mes-ADP; AC1L3TRY; SCHEMBL195864; GTPL1763; GTPL1710; AC1Q6S18; adenosine, 2-(methylthio)-, 5'-(trihydrogen diphosphate); 2-(Methylthio)-Adenosinediphosphate; 2-methylthio-ADP
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| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
6-Hydroxyuridine-5'-Phosphate
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Investigative | Compound Info | ||
| Synonyms |
6-hydroxy-UMP; 6-HYDROXYURIDINE-5'-PHOSPHATE; 6-hydroxyuridine 5'-(dihydrogen phosphate); CHEMBL383923; 29741-00-2; Prfb acid; 1lor; 1dqx; 1eix; 6-hydroxyuridine 5'-phosphate; AC1Q69HY; AC1L4PT5; 5'-Uridylic acid,6-hydroxy-; SCHEMBL2130675; 5'-Uridylic acid, 6-hydroxy-; CTK4G3746; DTXSID50183892; Phosphoribofuranosylbarbituric acid; BDBM50199178; 6-Hydroxyuridine 5'-phosphoric acid; DB02890; 6-HYDROXYURIDINE-5''-PHOSPHATE; Barbituric acid ribonucleoside 5'-phosphate; 1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione 5''-monophosp
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| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
(S)-4-(2,6-Diphenylisonicotinamido)-5-oxo-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL549594; BDBM50298121
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| Activity | Purinergic receptor P2Y12 |
IC50 ~ 50000 nM
|
[7] | ||
| Compound Name |
4-(2-(4,6-Diphenylpicolinamido)acetyl)piperazin-1-yl propionate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL549797; BDBM50298122
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| Activity | Purinergic receptor P2Y12 |
IC50 ~ 50000 nM
|
[7] | ||
| Compound Name |
Chembl4206162
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456177
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| Activity | Purinergic receptor P2Y14 |
IC50 ~ 50000 nM
|
[8] | ||
| Compound Name |
Chembl4215280
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Investigative | Compound Info | ||
| Synonyms |
BDBM50458838
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| Activity | Purinergic receptor P2Y2 |
EC50 ~ 50000 nM
|
[9] | ||
| Compound Name |
(S)-4-(4-(4-(Methoxymethyl)piperidin-1-yl)-6-phenylpicolinamido)-5-oxo-5-(4-(pentyloxycarbonyl)piperazin-1-yl)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL539733; BDBM50298132
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| Activity | Purinergic receptor P2Y12 |
IC50 ~ 50000 nM
|
[7] | ||
| Compound Name |
7-(3-Benzenesulfonyl-propoxy)-1-methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL88698; SCHEMBL10655614; BDBM50000911; 7-[3-(benzenesulfonyl)propoxy]-1-methyl-3H-imidazo[4,5-b]quinolin-2-one; 1-Methyl-1,3-dihydro-7-[3-(phenylsulfonyl)propoxy]-2H-imidazo[4,5-b]quinolin-2-one
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| Activity | Purinergic receptor P2Y12 |
EC50 = 50300 nM
|
[10] | ||
| Compound Name |
1,3-Dihydro-7-[4-(1H-tetrazol-5-yl)butoxy]-2H-imidazo[4,5-b]quinolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL90120; BDBM50000943; 7-[4-(1H-Tetrazol-5-yl)-butoxy]-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
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| Activity | Purinergic receptor P2Y12 |
EC50 = 51000 nM
|
[10] | ||
| Compound Name |
Chembl4205258
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456180
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| Activity | Purinergic receptor P2Y14 |
IC50 = 53000 nM
|
[8] | ||
| Compound Name |
2-Morpholin-4-yl-7-(pyridin-2-ylmethoxy)-chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL64555; SCHEMBL7362287; BDBM50044222; 2-morpholin-4-yl-7-(pyridin-2-ylmethoxy)chromen-4-one
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| Activity | Purinergic receptor P2Y12 |
IC50 = 53000 nM
|
[11] | ||
| Compound Name |
Methyl 1-[2-[[4-(trifluoromethoxy)phenyl]carbamoylamino]phenyl]spiro[2H-indole-3,4'-piperidine]-1'-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3104630; BDBM50445204
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| Activity | Purinergic receptor P2Y1 |
IC50 = 54200 nM
|
[12] | ||
| Compound Name |
Chembl4208103
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456175
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| Activity | Purinergic receptor P2Y14 |
IC50 = 54700 nM
|
[8] | ||
| Compound Name |
(S)-5-(4-(Heptyloxycarbonyl)piperazin-1-yl)-5-oxo-4-(6-phenylpicolinamido)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL564981; BDBM50298148
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| Activity | Purinergic receptor P2Y12 |
IC50 = 56000 nM
|
[7] | ||
| Compound Name |
[(3Ar,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2-(2-phenylethynyl)-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methyl dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1162187; BDBM50371586
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| Activity | Purinergic receptor P2Y12 |
IC50 = 57070 nM
|
[13] | ||
| Compound Name |
(S)-5-(4-((2-Cyclopentylethoxy)carbonyl)piperazin-1-yl)-4-(4-(4-hydroxypiperidin-1-yl)-6-phenylpicolinamido)-5-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL540736; BDBM50298162
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| Activity | Purinergic receptor P2Y12 |
IC50 = 57800 nM
|
[7] | ||
| Compound Name |
7-Allyloxy-8-methyl-2-morpholin-4-yl-chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL302875; SCHEMBL7316808; BDBM50044205; 8-methyl-2-morpholin-4-yl-7-prop-2-enoxychromen-4-one; 2-Morpholino-7-[(2-propenyl)oxy]-8-methyl-4H-1-benzopyran-4-one
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| Activity | Purinergic receptor P2Y12 |
IC50 = 58000 nM
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[11] | ||
| Compound Name |
(3,8-Dimethyl-2-morpholin-4-yl-4-oxo-4H-chromen-7-yloxy)-acetic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL292047; SCHEMBL7324297; BDBM50044195; methyl 2-(3,8-dimethyl-2-morpholin-4-yl-4-oxochromen-7-yl)oxyacetate
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| Activity | Purinergic receptor P2Y12 |
IC50 = 59000 nM
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[11] | ||
| Compound Name |
N,4-Dimethyl-N-(2-(thiophene-3-carbonyl)phenyl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL604583; BDBM50305731
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| Activity | Purinergic receptor P2Y2 |
IC50 ~ 60000 nM
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[14] | ||
| Compound Name |
[(4-Methylphenyl)sulfonyl](2-{[(4-methylphenyl)sulfonyl]prop-2-enylamino}pheny l)prop-2-enylamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL604277; ZINC2573080; BDBM50305737; SBB057090; AKOS024364667; MCULE-3639320640; ST50997002; N,N'-Diallyl-N,N'-ditosyl-1,2-benzenediamine; N,N''-(1,2-phenylene)bis(N-allyl-4-methylbenzenesulfonamide)
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| Activity | Purinergic receptor P2Y2 |
IC50 ~ 60000 nM
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[14] | ||
| Compound Name |
n,n'-1,2-Phenylenebis(n,4-dimethylbenzenesulfonamide)
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL595990; NSC101062; Oprea1_370376; CBDivE_001423; DTXSID20295299; ZINC636919; BDBM50305735; AKOS002161609; MCULE-1311888097; NSC-101062; N,N-o-phenylene-bis(p-toluenesulfonamide); ST50036099; p-Toluenesulfonamide,N'-o-phenylenebis[N-methyl-; N,N'-Ditosyl-N,N'-dimethyl-1,2-phenylenediamine; N,N''-(1,2-phenylene)bis(N-methyl-1-phenylmethanesulfonamide)
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| Activity | Purinergic receptor P2Y2 |
IC50 ~ 60000 nM
|
[14] | ||
| Compound Name |
(S)-5-(4-(Allyloxycarbonyl)piperazin-1-yl)-4-(4-butoxy-6-phenylpicolinamido)-5-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL563429; BDBM50298163
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| Activity | Purinergic receptor P2Y12 |
IC50 = 61700 nM
|
[7] | ||
| Compound Name |
(S)-5-Oxo-4-(6-phenylpicolinamido)-5-(4-(propoxycarbonyl)piperazin-1-yl)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL563041; BDBM50298164
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| Activity | Purinergic receptor P2Y12 |
IC50 = 62000 nM
|
[7] | ||
| Compound Name |
5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yl)-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL88265; BDBM50000922
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| Activity | Purinergic receptor P2Y12 |
EC50 = 63100 nM
|
[10] | ||
| Compound Name |
CID 70692052
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029009
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| Activity | Purinergic receptor P2Y2 |
EC50 = 64200 nM
|
[15] | ||
| Compound Name |
CID 70694094
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029005
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| Activity | Purinergic receptor P2Y2 |
EC50 = 64200 nM
|
[15] | ||
| Compound Name |
2-Morpholino-7-(2-naphthylmethoxy)-8-methyl-4H-1-benzopyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62470; BDBM50044198; 8-methyl-2-morpholin-4-yl-7-(naphthalen-2-ylmethoxy)chromen-4-one; 8-Methyl-2-morpholin-4-yl-7-(naphthalen-2-ylmethoxy)-chromen-4-one
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| Activity | Purinergic receptor P2Y12 |
IC50 = 65000 nM
|
[11] | ||
| Compound Name |
Chembl4205655
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456195
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| Activity | Purinergic receptor P2Y14 |
IC50 = 67200 nM
|
[8] | ||
| Compound Name |
7-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-2-morpholin-4-yl-8-propyl-chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62500; SCHEMBL9533715; BDBM50044201; 7-[2-(4-methylpiperazin-1-yl)ethoxy]-2-morpholin-4-yl-8-propylchromen-4-one
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| Activity | Purinergic receptor P2Y12 |
IC50 = 69000 nM
|
[11] | ||
| Compound Name |
1-(2,4-Difluorophenyl)-3-[2-[3-(trifluoromethyl)phenoxy]pyridin-3-yl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333774; SCHEMBL3150129; BDBM50429569
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| Activity | Purinergic receptor P2Y12 |
Ki ~ 70000 nM
|
[3] | ||
| Compound Name |
1-[2-(2-Tert-butylphenoxy)pyridin-3-yl]-3-(4-tert-butylphenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333771; SCHEMBL3154400; BDBM50429536
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| Activity | Purinergic receptor P2Y12 |
Ki ~ 70000 nM
|
[3] | ||
| Compound Name |
1-[2-(2-Tert-butylphenyl)sulfanylpyridin-3-yl]-3-(4-methylphenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333767; SCHEMBL3150533; BDBM50429538
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| Activity | Purinergic receptor P2Y12 |
Ki ~ 70000 nM
|
[3] | ||
| Compound Name |
1-(4-Tert-butylphenyl)-3-[2-(2-propan-2-ylphenoxy)pyridin-3-yl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333772; SCHEMBL3257113; BDBM50429535
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| Activity | Purinergic receptor P2Y12 |
Ki ~ 70000 nM
|
[3] | ||
| Compound Name |
1-[2-(2-Propan-2-ylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethoxy)phenyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333773; SCHEMBL3151339; BDBM50429534
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| Activity | Purinergic receptor P2Y12 |
Ki ~ 70000 nM
|
[3] | ||
| Compound Name |
(S)-5-Oxo-4-(6-phenylpicolinamido)-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL557062; BDBM50298114
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| Activity | Purinergic receptor P2Y12 |
IC50 = 71000 nM
|
[7] | ||
| Compound Name |
N-Methyl-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL90168; BDBM50000888; N-Methyl-4-[[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]butyramide
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| Activity | Purinergic receptor P2Y12 |
EC50 = 71600 nM
|
[10] | ||
| Compound Name |
(S)-5-Oxo-4-(4-phenylpyrimidine-2-carboxamido)-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL559689; BDBM50298123
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| Activity | Purinergic receptor P2Y12 |
IC50 = 74000 nM
|
[7] | ||
| Compound Name |
2-Morpholino-7-[[2-(4-phenylpiperazino)ethyl]oxy]-8-methyl-4H-1-benzopyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL60443; SCHEMBL8881859; BDBM50044212; 8-Methyl-2-morpholin-4-yl-7-[2-(4-phenyl-piperazin-1-yl)-ethoxy]-chromen-4-one; 8-methyl-2-morpholin-4-yl-7-[2-(4-phenylpiperazin-1-yl)ethoxy]chromen-4-one
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| Activity | Purinergic receptor P2Y12 |
IC50 ~ 75000 nM
|
[11] | ||
| Compound Name |
7-Benzyloxy-3,8-dimethyl-2-morpholin-4-yl-chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL291376; SCHEMBL7322397; BDBM50044187; 3,8-dimethyl-2-morpholin-4-yl-7-phenylmethoxychromen-4-one
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| Activity | Purinergic receptor P2Y12 |
IC50 ~ 75000 nM
|
[11] | ||
| Compound Name |
3,8-Dimethyl-2-morpholin-4-yl-7-(naphthalen-1-ylmethoxy)-chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62064; SCHEMBL7325246; BDBM50044203; 3,8-dimethyl-2-morpholin-4-yl-7-(naphthalen-1-ylmethoxy)chromen-4-one
Click to Show/Hide
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||||
| Activity | Purinergic receptor P2Y12 |
IC50 ~ 75000 nM
|
[11] | ||
| Compound Name |
(S)-4-(4,6-Diphenylpicolinamido)-5-oxo-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551484; BDBM50298167
Click to Show/Hide
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||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 76000 nM
|
[7] | ||
| Compound Name |
Diadenosine tetraphosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AppppA; 5',5'''-Diadenosine tetraphosphate; P(1),P(4)-bis(5'-adenosyl) tetraphosphate; (ppA)2; BIS(ADENOSINE)-5'-TETRAPHOSPHATE; CHEMBL339385; adenosine(5')tetraphospho(5')adenosine; P1,P4-Bis(5'-adenosyl) tetraphosphate; A(5')p4(5')A; Diadenosine 5',5'''-P(sup 1),P(sup 2)-tetraphosphate; ADENOSINE 5'-(PENTAHYDROGEN TETRAPHOSPHATE), 5'-5'-ESTER with ADENOSINE; SCHEMBL849869; Adenosine 5'-tetraphosphate, 5'-ester with adenosine; bis(5''-adenylyl) diphosphate; DTXSID60203994; BDBM50118220; ZINC96014967; P1,P4-Diadenosine-5'-tetraphosphate; P1,P4-bis(5'-adenosyl)tetraphosphate; A(5'')p4(5'')A; P1,P4-Di(adenosin-5'-yl)tetraphosphate; adenosine(5'')tetraphospho(5'')adenosine; adenosine-(5')-tetraphospho-(5')-adenosine; Diadenosine 5',5'''-P1,P4-tetraphosphate; C01260; P(1),P(4)-bis(5''-adenosyl) tetraphosphate; Q27102391; Adenosine 5'-tetraphosphate, 5'-ester with adenosine (7CI)
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y2 |
EC50 = 81000 nM
|
[16] | ||
| Compound Name |
(S)-4-(4-(Benzylamino)-6-phenylpicolinamido)-5-(4-(ethoxycarbonyl)piperazin-1-yl)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553572; BDBM50298169
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 81000 nM
|
[7] | ||
| Compound Name |
Methyl 4-(1,3-dimethyl-2-oxoimidazo[4,5-b]quinolin-7-yl)oxybutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90102; BDBM50000924; 4-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid methyl ester(HCl); 4-[[(1,3-Dimethyl-2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]butyric acid methyl ester
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
EC50 ~ 87500 nM
|
[10] | ||
| Compound Name |
((2R,3S,4R,5R)-3,4-Dihydroxy-5-(2-(methylamino)-4-oxopyrimidin-1(4H)-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767423; BDBM50341894
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
(S)-5-Oxo-4-(4-phenylpicolinamido)-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL562546; BDBM50298128
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 ~ 100000 nM
|
[7] | ||
| Compound Name |
1-(beta-D-Ribofuranosyl)-2-thio-uracil-5'-phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Thiouridine 5'-phosphate; CHEMBL384771; Polys2U; Poly-2-thiouridylic acid; 2-Thiouridine5'-phosphate; 2-thiouridine-5'-phosphate; SCHEMBL1881780; DTXSID60961901; 2-Thiouridine 5'-phosphoric acid; BDBM50199180; ZINC13517211; 5'-Uridylic acid, 2-thio-, homopolymer; Q27465498; 1-(BETA-D-RIBOFURANOSYL)-2-THIO-URACIL-5''-PHOSPHATE; 4-Hydroxy-1-(5-O-phosphonopentofuranosyl)pyrimidine-2(1H)-thione; 2-thio-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-dione 5''-monophosphate; 1-(5-O-phosphono-beta-D-ribofuranosyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
Click to Show/Hide
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||||
| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
5'-Uridylic acid, 3-(2-oxo-2-phenylethyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215381; CTK3I0370; DTXSID20475413; BDBM50199174; 3-phenacyl-1-beta-D-ribofuranosylpyrimidine-2,4-dione 5''-monophosphate
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
6-Propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-dione 5''-diphosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL385506; BDBM50199181
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
(S)-5-Oxo-4-(2-phenylpyrimidine-4-carboxamido)-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552921; BDBM50298118
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 ~ 100000 nM
|
[7] | ||
| Compound Name |
(S)-5-Oxo-4-(picolinamido)-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560809; BDBM50298127
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 ~ 100000 nM
|
[7] | ||
| Compound Name |
7-[3-(1H-Tetrazol-5-yl)-propoxy]-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88835; BDBM50000878; 1,3-Dihydro-7-[3-(1H-tetrazol-5-yl)propoxy]-2H-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
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||||
| Activity | Purinergic receptor P2Y12 |
EC50 ~ 100000 nM
|
[10] | ||
| Compound Name |
6-Propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-dione 5''-monophosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217391; BDBM50199182
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
[(2R,3S,5R)-5-[6-(Methylamino)purin-9-yl]-2-(phosphonooxymethyl)oxolan-3-yl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129841; MRS 2179; MRS-2179; CHEMBL1096400; MRS 2179 ammonium salt; Lopac0_000756; SCHEMBL134008; DTXSID701016926; ZINC3985980; BDBM50118229; BDBM50318029; n6-methyl-2'-deoxyadenosine-3',5'-bisphosphate; J-000339
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
2-Benzylthio-1-beta-D-ribofuranosylpyrimidine-4-one-5''-monophosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767420; BDBM50341903
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
[(1R,2R,4S,5S)-4-[2-Chloro-6-(methylamino)purin-9-yl]-2-phosphonooxy-1-bicyclo[3.1.0]hexanyl]methyl dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3085531; BDBM50026893
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[2] | ||
| Purinergic receptor P2Y11 |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(2-(6-Phenylpicolinamido)acetyl)piperazin-1-yl propionate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549307; BDBM50298124
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 ~ 100000 nM
|
[7] | ||
| Compound Name |
1-(3,5-Difluorophenyl)-3-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2071536
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y1 |
Ki ~ 100000 nM
|
[17] | ||
| Compound Name |
[(4-{[(3,4-Dimethylisoxazol-5-yl)amino]sulfonyl}phenyl)amino]-N-(3-chloropheny l)carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2071533; ZINC950164; STL482234; AKOS001680091; MCULE-7789404844; ST50202762; SR-01000150770; SR-01000150770-1; 4-{[(3-chlorophenyl)carbamoyl]amino}-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide
Click to Show/Hide
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||||
| Activity | Purinergic receptor P2Y1 |
Ki ~ 100000 nM
|
[17] | ||
| Compound Name |
N(3)-Methyluridine 5'-monophosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215940; N(3)-methyl-UMP; 3-N-methyluridine-5 '-phosphate; N(3)-methyluridine 5'-phosphate; BDBM50199190; 3-METHYLURIDINE-5'-MONOPHOSHATE; 3-METHYLURIDINE-5''-MONOPHOSHATE; 3-methyluridine 5'-(dihydrogen phosphate); Q27105026; 3-methyl-1-beta-D-ribofuranosyl-pyrimidine-2,4-dione 5''-monophosphate
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
(S)-4-(4,6-Diphenylpicolinamido)-5-oxo-5-(4-m-tolylpiperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557553; BDBM50298129
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 ~ 100000 nM
|
[7] | ||
| Compound Name |
(S)-5-(4-(Methoxycarbonyl)piperazin-1-yl)-5-oxo-4-(6-phenylpicolinamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549308; BDBM50298125
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 ~ 100000 nM
|
[7] | ||
| Compound Name |
(S)-4-(4-(Diethylamino)-6-phenylpicolinamido)-5-(4-(ethoxycarbonyl)piperazin-1-yl)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL561406; BDBM50298173
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 100000 nM
|
[7] | ||
| Compound Name |
(4S)-5-Oxo-4-[(3-phenylbenzoyl)amino]-5-(4-propanoyloxypiperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551750; BDBM50298126; (S)-4-biphenyl-3-ylcarboxamido-5-oxo-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 ~ 100000 nM
|
[7] | ||
| Compound Name |
(S)-5-Oxo-4-(6-phenylpicolinamido)-5-(4-m-tolylpiperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560084; BDBM50298130
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 ~ 100000 nM
|
[7] | ||
| Compound Name |
4-(2-Oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313609; SCHEMBL10374710; BDBM50000898; 4-[(2-oxo-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-7-yl)oxy]butanoic acid
Click to Show/Hide
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||||
| Activity | Purinergic receptor P2Y12 |
EC50 ~ 100000 nM
|
[10] | ||
| Compound Name |
4-Thiouridine-5'-monophosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1230331; 1-(5-O-Phosphono-beta-D-ribofuranosyl)-4-thioxo-3,4-dihydropyrimidin-2(1H)-one; 4-Thiouridylic acid; 4-thio-UMP; S4UMP; 4-thiouridine monophosphate; 5'-Uridylic acid, 4-thio-; 4-Thiouracil 5'-monophosphate; SCHEMBL1402556; 4-Thiouridine 5'-phosphoric acid; 4-THIOURIDINE-5''-PHOSPHATE; BDBM50341895; ZINC13518042; 4-THIOURIDINE-5''-MONOPHOSPHATE; Q27454935
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
(S)-5-(4-(Octyloxycarbonyl)piperazin-1-yl)-5-oxo-4-(6-phenylpicolinamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL564150; BDBM50298131
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 ~ 100000 nM
|
[7] | ||
| Compound Name |
6-Methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-dione 5''-monophosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215263; BDBM50199179
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y2 |
EC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
4-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91579; BDBM50000895; 4-[[(1,3-Dimethyl-2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]butyric acid
Click to Show/Hide
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||||
| Activity | Purinergic receptor P2Y12 |
EC50 ~ 100000 nM
|
[10] | ||
| Compound Name |
(4S)-4-[(3,5-Diphenylbenzoyl)amino]-5-oxo-5-(4-propanoyloxypiperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL561692; BDBM50298119
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 ~ 100000 nM
|
[7] | ||
| Compound Name |
5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90601; SCHEMBL10657313; BDBM50000904; 5-[(1-methyl-2-oxo-3H-imidazo[4,5-b]quinolin-7-yl)oxy]pentanoic acid; 5-[[(1-Methyl-2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]valeric acid
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
EC50 ~ 100000 nM
|
[10] | ||
| Compound Name |
5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91224; SCHEMBL10657144; BDBM50000889; 5-[(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]pentanoic Acid; 5-[(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)oxy]pentanoic acid; 5-[[(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]valeric acid
Click to Show/Hide
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||||
| Activity | Purinergic receptor P2Y12 |
EC50 ~ 106000 nM
|
[10] | ||
| Compound Name |
4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL421885; SCHEMBL10658509; BDBM50000930; 4-[(1-methyl-2-oxo-3H-imidazo[4,5-b]quinolin-7-yl)oxy]butanoic acid; 4-[(2,3-dihydro-1-methyl-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]butanoic acid; 4-[[(1-Methyl-2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]butyric acid
Click to Show/Hide
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||||
| Activity | Purinergic receptor P2Y12 |
EC50 ~ 106000 nM
|
[10] | ||
| Compound Name |
Tetrasodium;[chloro-[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(propylamino)purin-9-yl]oxolan-2-yl]methoxy-oxidophosphinothioyl]oxy-oxidophosphoryl]methyl]-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(propylamino)purin-9-yl]oxolan-2-yl]methoxy-oxidophosphinothioyl]oxyphosphinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3746451; BDBM50500437
Click to Show/Hide
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||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 156000 nM
|
[18] | ||
| Compound Name |
Hexasodium;8-[[4-fluoro-3-[[3-[[3-[[2-fluoro-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NF157; CHEMBL413145
Click to Show/Hide
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||||
| Activity | Purinergic receptor P2Y2 |
IC50 = 169824.37 nM
|
[19] | ||
| Compound Name |
Trypan blue
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Direct Blue 14; VisionBlue; C.I. Direct Blue 14; Niagara Blue; Niagara Blue 3B; trypan-blue; Diamineblue; Dianilblau; Pyrotropblau; Parkibleu; Parkipan; Benzamine Blue; Bleu diamine; Chloramine Blue; Dianil blue; Diphenyl Blue; Trypane Blue; Tripan Blue; Benzaminblau 3B; Benzo Blue; Chloramiblau 3B; Congo Blue; Bleu trypane N; Benzanil Blue R; Diaminblau 3B; Directblau 3B; Triazolblau 3BX; Benzoblau 3B; Congoblau 3B; Dianilblau H3G; Renolblau 3B; Bleu directe 3B; Naphthylamine Blue; Azidine Blue 3B; C.I. 23850; Diamine Blue 3B; Diazine Blue 3B; Pyrazol Blue 3B; Trypan Blue BPC; Bleue diretto 3B; Bencidal Blue 3B; Dianil Blue H3G; Diazol Blue 3B; Diphenyl Blue 3B; Direct Blue 3B; Direct Blue 3BX; Direct Blue D3B; Direct Blue H3G; Direct Blue M3B; Paramine Blue 3B; Azurro diretto 3B; Benzo Blue 3B; Benzo Blue 3BS; Blue EMB; Naphthaminblau 3BX; Orion Blue 3B; Benzamine Blue 3B; Chlorazol Blue 3B; Cresotine Blue 3B; UNII-I2ZWO3LS3M; Amanil Sky Blue R; Benzanil Blue 3BN; Centraline Blue 3B; Chloramine Blue 3B; Hispamin Blue 3BX; I2ZWO3LS3M; Diaphtamine Blue TH; Bleu diazole N 3B; Blue 3B; Pontamine Blue 3BX; Brasilamina Blue 3B; Brasilazina Blue 3B; Directakol Blue 3BL; Naphthamine Blue 3BX; C.I. Direct Blue 14, tetrasodium salt; Chrome Leather Blue 3B; Trianol Direct Blue 3B; Trypanblau; MFCD00003969; C34H24N6O14S4.4Na; Diaminine Blue; Vision Blue; Azidinblau 3B; Trypanblau [German]; Trypan (Congo) Blue; Modr Trypanova [Czech]; NCGC00167554-01; Modr Prima 14 [Czech]; RCRA waste no. U236; RCRA waste number U236; Membraneblue; CCRIS 616; Modr Trypanova; Trypan blue (commercial grade); HSDB 2945; NCI C61289; EINECS 200-786-7; Modr Prima 14; NSC 11247; Trypan Blue solution; AI3-26698; DSSTox_CID_6268; CHEMBL1640; DSSTox_RID_78083; DSSTox_GSID_26268; CHEMBL177987; Trypan Blue, dye content 60%; DTXSID4026268; KS-00000YE3; Tox21_112549; 2084AH; 6952AF; AKOS015902434; AKOS030228627; FT-0690008; C19307; C.I. Direct Blue 14, tetrasodium salt (8CI)
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y2 |
IC50 = 171000 nM
|
[2] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 35 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Tetrasodium;[chloro-[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methoxy-oxidophosphinothioyl]oxy-oxidophosphoryl]methyl]-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methoxy-oxidophosphinothioyl]oxyphosphinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3746177; BDBM50500448
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 > 200000 nM
|
[18] | ||
| Compound Name |
Adenosine 5'-[dichloro-[beta,gamma-methylene]triphosphoric acid]
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160356; BDBM50167269; 5'-Adenylic acid, anhydride with (dichloromethylene)bis[phosphonic acid]
Click to Show/Hide
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||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 316227.77 nM
|
[20] | ||
| Compound Name |
Uridine 5'-diphosphoric acid beta-(3-fluoro-3-deoxy-alpha-D-glucopyranosyl) ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594064; MRS-2825; BDBM50304033
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y14 |
EC50 = 361000 nM
|
[6] | ||
| Compound Name |
Chembl4209172
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454135; uridine 5'-(tetrahydrogen triphosphate), 4-O-hexyl-
Click to Show/Hide
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||||
| Activity | Purinergic receptor P2Y2 |
EC50 = 489300 nM
|
[21] | ||
| Compound Name |
Uridine-5'-diphosphate-4-deoxy-4-fluoro-alpha-D-galactose
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593125; UDP-4-fluoro-4-deoxy-alpha-D-glucose; BDBM50304034; DB04097; URIDINE-5''-DIPHOSPHATE-4-DEOXY-4-FLUORO-ALPHA-D-GALACTOSE
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y14 |
EC50 = 567000 nM
|
[6] | ||
| Compound Name |
(4-Nitrobenzotriazol-1-yl)-phenylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077194; BDBM50260841
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 650000 nM
|
[22] | ||
| Compound Name |
1-Benzyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075841; BDBM50260812
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 810000 nM
|
[22] | ||
| Compound Name |
2-Benzyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065540; BDBM50260835
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 820000 nM
|
[22] | ||
| Compound Name |
1-(4-Methylphenyl)sulfonyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087693; BDBM50260836
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 860000 nM
|
[22] | ||
| Compound Name |
[[(2R,3S,4R,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6S)-6-(fluoromethyl)-3,4,5-trihydroxyoxan-2-yl] hydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593126; BDBM50304035
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y14 |
EC50 = 905000 nM
|
[6] | ||
| Compound Name |
1-(3-Chloropropyl)-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079813; BDBM50260833
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 910000 nM
|
[22] | ||
| Compound Name |
4-Nitro-2-octylbenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077654; BDBM50260840
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 920000 nM
|
[22] | ||
| Compound Name |
2-Heptyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075411; BDBM50260831
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 930000 nM
|
[22] | ||
| Compound Name |
4-Nitro-1-octylbenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067755; BDBM50260832
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 940000 nM
|
[22] | ||
| Compound Name |
2-Hexyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087845; BDBM50260839
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 940000 nM
|
[22] | ||
| Compound Name |
1-Heptyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075331; BDBM50260830
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 950000 nM
|
[22] | ||
| Compound Name |
4-Nitro-2-pentylbenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071889; BDBM50260820
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 1020000 nM
|
[22] | ||
| Compound Name |
1-Hexyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093411; BDBM50260821
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 1040000 nM
|
[22] | ||
| Compound Name |
1-Butyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075142; BDBM50260818
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 1050000 nM
|
[22] | ||
| Compound Name |
2-Butyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078992; BDBM50260838
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 1070000 nM
|
[22] | ||
| Compound Name |
4-Nitro-1-pentylbenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076196; SCHEMBL11596553; BDBM50260819
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 1070000 nM
|
[22] | ||
| Compound Name |
2-(3-Chloropropyl)-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060620; BDBM50260834
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 1260000 nM
|
[22] | ||
| Compound Name |
4-Nitro-1-propylbenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100042; BDBM50260817
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 1300000 nM
|
[22] | ||
| Compound Name |
4-Nitro-2-propylbenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062156; BDBM50260811
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 1320000 nM
|
[22] | ||
| Compound Name |
1-Ethyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102781; BDBM50260837
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 1500000 nM
|
[22] | ||
| Compound Name |
2-Ethyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076556; BDBM50260816
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 1620000 nM
|
[22] | ||
| Compound Name |
1-Methyl-7-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-nitro-1-methylbenzotriazole; CHEMBL4084826; 1-methyl-7-nitro-1H-benzotriazole; 1H-Benzotriazole, 1-methyl-7-nitro-; CTK8G9387; ZINC3163041; BDBM50260815; STK370132; AKOS005445427; MCULE-4755695417; ST51060899; 1-Methyl-7-nitro-1H-1,2,3-benzotriazole #
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 1800000 nM
|
[22] | ||
| Compound Name |
Hexasodium;8-[[4-fluoro-3-[[3-[[3-[[2-fluoro-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NF157; CHEMBL413145
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y1 |
IC50 = 1819700.86 nM
|
[19] | ||
| Compound Name |
1-Methyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073608; 1-Methyl-4-nitro-1H-benzotriazole; 1H-Benzotriazole, 1-methyl-4-nitro-; SCHEMBL11593131; DTXSID70345016; BDBM50260813; MFCD00464867; 1-Methyl-4-nitro-1H-1,2,3-benzotriazole #
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 1840000 nM
|
[22] | ||
| Compound Name |
2-Methyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099652; SCHEMBL2494303; ZINC2532334; BDBM50260814; MFCD04122507; AKOS006292943; MCULE-8437171942; 2-methyl-4-nitro-2h-1,2,3-benzotriazole
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 1960000 nM
|
[22] | ||
| Compound Name |
4-Nitro-1H-1,2,3-benzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-Nitro-1H-benzotriazole; 4-nitro-2H-benzotriazole; 4-Nitrobenzotriazole; nitro-1h-benzotriazole; 4-nitro-1h-benzo[d][1,2,3]triazole; UNII-S75GE4B24J; MLS000540987; S75GE4B24J; SMR000126045; nitrobenzotriazole; 7-Nitro-1H-benzotriazole; 2H-Benzotriazole, 4-nitro-; NSC44657; EINECS 228-579-7; 7-Nitrobenzotriazole; Benzotriazole, 4-nitro-; 4-Nitro 1H-benzotriazole; 1H-Benzotriazole,7-nitro-; 1H-Benzotriazole, 4-nitro-; cid_80533; SCHEMBL103130; SCHEMBL854375; CHEMBL1456115; BDBM70499; CTK5B6965; DTXSID70212198; HMS2334D24; ALBB-016077; BCP04118; KS-00000O7P; ZINC5425412; ANW-55970; MFCD00160033; NSC-44657; SBB017079; STK523155; 1H-1,2,3-benzotriazole, 4-nitro-; 7-Nitro-1H-1,2,3-benzotriazole #; AKOS003193925; MCULE-6970289510; NCGC00246589-01; AK-46489; ST026570; DB-058100; CS-0043845; FT-0680465; R2362; 5R-0658; AE-641/30196004; J-515858; Z2235413189
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 2060000 nM
|
[22] | ||
| Compound Name |
Uridine-5'-Diphosphate-2-Deoxy-2-Fluoro-alpha-D-Glucose
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593830; URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GALACTOSE; BDBM50304032; DB03488; Q27466809; URIDINE-5''-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE; Uridine 5'-(trihydrogen diphosphate) P'-(2-deoxy-2-fluoro-; A-D-glucopyranosyl) ester
Click to Show/Hide
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||||
| Activity | Purinergic receptor P2Y14 |
EC50 = 2500000 nM
|
[6] | ||
| Compound Name |
Cyclohexyl [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1199733; BDBM50097952
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y14 |
EC50 = 5160000 nM
|
[6] | ||
| Compound Name |
1H-Benzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Benzotriazole; 2H-Benzotriazole; 1H-Benzo[d][1,2,3]triazole; 1,2,3-BENZOTRIAZOLE; 1H-1,2,3-Benzotriazole; Azimidobenzene; Aziminobenzene; Benztriazole; Benzisotriazole; Benzene azimide; 2,3-Diazaindole; Cobratec #99; 1,2-Aminoazophenylene; Cobratec 99; 1,2,3-Triaza-1H-indene; 1,2,3-Triazaindene; 1,2,-Aminozophenylene; NCI-C03521; NSC-3058; 1,2,3-1h-benzotriazole; U-6233; UNII-86110UXM5Y; 1,2,3-Benztriazole; MFCD00005699; 2H-benzo[d][1,2,3]triazole; 86110UXM5Y; 1H-Benzotriazol; DSSTox_CID_147; 1H-Benzotriazole, 99%; DSSTox_RID_75400; DSSTox_GSID_20147; Benzotriazole (VAN); benzotriazol; CCRIS 78; Pseudoazimidobenzene; Cobratec 35G; HSDB 4143; 1,2,3-Benzotriazole,1H-benzo[d][1,2,3]triazole; EINECS 202-394-1; azaindazole; BRN 0112133; aza-indazole; AI3-15984; 1 h-benzotriazole; 1,3-Triazaindene; 1,3-Benzotriazole; Cobratec No. 99; 1,2-Aminozophenylene; PubChem16004; ACMC-209ruz; 1H-1,3-Benzotriazole; 1,3-Triaza-1H-indene; 1H-Benzotriazole (VAN8C; EC 202-394-1; WLN: T56 BMNNJ; SCHEMBL8956; 1,2,3-Benzotriazole(BTA); 4-26-00-00093 (Beilstein Handbook Reference); KSC486M6D; MLS002302971; CHEMBL84963; 1H-benzo-[1,2,3]triazole; DTXSID6020147; BDBM36293; CTK1A4424; CTK3I6661; NSC3058; Benzotriazole, analytical standard; HMS3091M10; ZINC332008; Benzotriazole, reagent grade, 97%; CS-D1407; KS-00000K8O; STR01561; Tox21_201501; Tox21_302934; ANW-40377; BDBM50234613; SBB060070; STL281967; Benzotriazole, ReagentPlus(R), 99%; 1H-Benzotriazole, >=98.0% (N); AKOS000119181; AKOS025396849; MCULE-2848618742; PS-3644; NCGC00091322-01; NCGC00091322-02; NCGC00091322-03; NCGC00256574-01; NCGC00259052-01; AK-44446; BP-21454; SC-15698; SMR001252218; AB0008382; DB-022595; B0094; BB 0243857; FT-0606217; FT-0698151; ST51046317; Benzotriazole, Vetec(TM) reagent grade, 98%; 3334-EP2270010A1; 3334-EP2270113A1; 3334-EP2272828A1; 3334-EP2272935A1; 3334-EP2280000A1; 3334-EP2281563A1; 3334-EP2281818A1; 3334-EP2284920A1; 3334-EP2289883A1; 3334-EP2292586A2; 3334-EP2292593A2; 3334-EP2292597A1; 3334-EP2292611A1; 3334-EP2298753A1; 3334-EP2301918A1; 3334-EP2301921A1; 3334-EP2301924A1; 3334-EP2301926A1; 3334-EP2305651A1; 3334-EP2308562A2; 3334-EP2308839A1; 3334-EP2308840A1; 3334-EP2308849A1; 3334-EP2308850A1; 3334-EP2308854A1; 3334-EP2314575A1; 3334-EP2315502A1; 3334-EP2316459A1; 3334-EP2371811A2; 3334-EP2372804A1; 3334-EP2377847A1; 3334-EP2378585A1; Z-2915; 22608-EP2315502A1; 81449-EP2275411A2; 81449-EP2305687A1; AB00374479-06; AC-907/34124039; Q220672; W-100172; Z57127352; F2190-0645
Click to Show/Hide
|
||||
| Activity | Purinergic receptor P2Y12 |
IC50 = 7430000 nM
|
[22] | ||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity | Purinergic receptor P2Y12 |
IC50 = 251188.64 nM
|
[20] | ||
| Purinergic receptor P2Y2 |
EC50 > 300000 nM
|
[16] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide. J Med Chem. 2008 Aug 14;51(15):4518-28. | ||||
| REF 2 | Purine and pyrimidine (P2) receptors as drug targets. J Med Chem. 2002 Sep 12;45(19):4057-93. | ||||
| REF 3 | Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists. J Med Chem. 2013 Feb 28;56(4):1704-14 | ||||
| REF 4 | Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2011 Apr 28;54(8):2878-90. | ||||
| REF 5 | Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87. | ||||
| REF 6 | Molecular modeling of the human P2Y14 receptor: A template for structure-based design of selective agonist ligands. Bioorg Med Chem. 2015 Jul 15;23(14):4056-64. | ||||
| REF 7 | Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4657-63. | ||||
| REF 8 | Structure-Guided Modification of Heterocyclic Antagonists of the P2Y 14 Receptor. J Med Chem. 2018 Jun 14;61(11):4860-4882. | ||||
| REF 9 | 3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17. J Med Chem. 2018 Sep 27;61(18):8136-8154. | ||||
| REF 10 | Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains. J Med Chem. 1992 Jul 10;35(14):2672-87. | ||||
| REF 11 | Synthesis and biological evaluation of antiplatelet 2-aminochromones. J Med Chem. 1993 Jul 9;36(14):2026-32. | ||||
| REF 12 | Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist. J Med Chem. 2013 Nov 27;56(22):9275-95. | ||||
| REF 13 | Lipophilic modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor. J Med Chem. 2008 Feb 28;51(4):1007-25. | ||||
| REF 14 | Identification of a new class of small molecule C5a receptor antagonists. Bioorg Med Chem Lett. 2010 Jan 15;20(2):662-4. | ||||
| REF 15 | Boranophosphate isoster controls P2Y-receptor subtype selectivity and metabolic stability of dinucleoside polyphosphate analogues. J Med Chem. 2012 Jan 12;55(1):437-48. | ||||
| REF 16 | Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling. J Med Chem. 2009 May 14;52(9):2762-75. | ||||
| REF 17 | Virtual screening leads to the discovery of novel non-nucleotide P2Y receptor antagonists. Bioorg Med Chem. 2012 Sep 1;20(17):5254-61. | ||||
| REF 18 | New highly active antiplatelet agents with dual specificity for platelet P2Y1 and P2Y12 adenosine diphosphate receptors. Eur J Med Chem. 2016 Jan 1;107:204-18. | ||||
| REF 19 | Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. J Med Chem. 2005 Nov 3;48(22):7040-8. | ||||
| REF 20 | State of affairs: Design and structure-activity relationships of reversible P2Y12 receptor antagonists. Bioorg Med Chem Lett. 2016 Jun 15;26(12):2739-2754. | ||||
| REF 21 | Current knowledge on the nucleotide agonists for the P2Y2 receptor. Bioorg Med Chem. 2018 Jan 15;26(2):366-375. | ||||
| REF 22 | Facile alkylation of 4-nitrobenzotriazole and its platelet aggregation inhibitory activity. Bioorg Med Chem. 2017 Oct 15;25(20):5260-5267. | ||||
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