Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T08280 | Target Info | |||
| Target Name | Trypanosoma Pyrophosphate-dependent phosphofructokinase (Trypano pfk) | ||||
| Synonyms |
Pyrophosphate-dependent 6-phosphofructose-1-kinase; Pyrophosphate--fructose 6-phosphate 1-phosphotransferase alpha subunit; PPi-PFK; PFP-ALPHA; PFP; 6-phosphofructokinase, pyrophosphate dependent
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| Target Type | Literature-reported Target | ||||
| Gene Name | Trypano pfk | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Sulfamethoxazole
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Approved | Compound Info | ||
| Synonyms |
sulfamethoxazole; 723-46-6; Gantanol; Sulphamethoxazole; Sulfisomezole; Sulfamethoxazol; Metoxal; Sulfamethylisoxazole; Simsinomin; Radonil; Sinomin; Sulphamethoxazol; 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide; Sulpha-methoxizole; Sulfamethalazole; Azo-gantanol; Sulphamethylisoxazole; Urobak; Sulfamethoxizole; 3-Sulfanilamido-5-methylisoxazole; Gantanol-DS; 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide; Bactrimel; Gamazole; Sulphisomezole; Sulfametoxazol; Solfametossazolo; Sulfamethoxazolum; Ro 4-2130; SMX; Septran; Sulphamethalazole; Trib; Solfametossazolo [DCIT]; Sulfamethoxazole sodium; MS 53; Sulphamethoxazole BP 98; ALBB-002089; Apo-Sulfamethoxazole; Bactrim (TN); Septra (TN); Septrin (TN); Sulfamethoxazolum [INN-Latin]; Sulfametoxazol [INN-Spanish]; Ro 6-2580/11; Ro-4-2130; Sulfamethoxazole [USAN:INN:JAN]; Sulfamethoxazole (JP15/USP/INN); N1-(5-Methyl-3-isoxazolyl)sulfanilamide; N1-(5-Methylisoxazol-3-yl)sulfanilamide; SULFAMETHOXAZOLE (8064-90-2 (TRIMETHOPRIM/SULFAMETHOXAZOLE); N'-(5-Methyl-3-isoxazole)sulfanilamide; N'-(5-Methyl-3-isoxazolyl)sulfanilamide; N'-(5-Methylisoxazol-3-yl)sulphanilamide; N(sup 1)-(5-Methyl-3-isoxazolyl)sulfanilamide; N(sup 1)-(5-Methyl-3-isoxazolyl)sulphanilamide; N(sup1)-(5-Methyl-3-isoxazolyl)sulfanilamide; Sulfanilamide, N1-(5-methyl-3-isoxazolyl)-(8CI); 3-(p-Aminophenylsulfonamido)-5-methylisoxazole; 3-(para-Aminophenylsulphonamido)-5-methylisoxazole; 3-Sulphanilamido-5-methylisoxazole; 4-Amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonamide; 4-Amino-N-[5-methyl-3-isoxazolyl]benzenesulfonamide; 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide; 5-Methyl-3-sulfanilamidoisoxazole; 5-Methyl-3-sulfanylamidoisoxazole; 5-Methyl-3-sulphanil-amidoisoxazole; Sulphameth oxazole
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| Activity |
IC50 ~ 57000 nM
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[1] | |||
| Compound Name |
(2S,3S,4S,5R)-5-((3,4-Dichlorobenzylamino)methyl)-N-allyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL477106; BDBM50270348
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
Ethyl 3-[[4-[[2-(3,4-dichlorophenyl)acetyl]amino]phenyl]sulfonylamino]benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3108862; BDBM50446096; NCGC00248361-01
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| Activity |
IC50 ~ 57000 nM
|
[1] | |||
| Compound Name |
2-(4-Methoxy-3-methylphenyl)-N-[4-[(5-methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3108851; BDBM50446108; NCGC00244861-01
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| Activity |
IC50 ~ 57000 nM
|
[1] | |||
| Compound Name |
4-[[2-(3,4-Dichlorophenyl)acetyl]amino]-N-(5-methyl-1,2-oxazol-3-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3108840; BDBM50446119; NCGC00244108-01
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| Activity |
IC50 ~ 57000 nM
|
[1] | |||
| Compound Name |
2-[[2-(3,4-Dichlorophenyl)acetyl]amino]-N-(5-methyl-1,2-oxazol-3-yl)-1,3-thiazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3108834; BDBM50446125; NCGC00244106-01
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| Activity |
IC50 ~ 57000 nM
|
[1] | |||
| Compound Name |
2-(3,4-Dimethoxyphenyl)-N-{4-[(5-methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl}acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1873990; SMR000154742; MLS000568593; MLS002633214; HMS2275C06; ZINC3318852; BDBM50446107; AKOS034184124; MCULE-2656380217; NCGC00244881-01; AB00489560-08; Z32430323
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| Activity |
IC50 ~ 57000 nM
|
[1] | |||
| Compound Name |
(2S,3S,4S,5R)-5-((3,4-Dichlorobenzylamino)methyl)-N-cycloheptyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL479202; BDBM50270351
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| Activity |
IC50 = 80000 nM
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[2] | |||
| Compound Name |
3-O-Acetylgreenwayodendrin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1083629; BDBM50320386
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| Activity |
IC50 = 170000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2,5-Anhydro-1-deoxy-1-(3,4-dichlorobenzylamino)-D-mannitol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL518269; BDBM50270460; 2,5-anhydro-1-deoxy-1-(3,4-dichlorobenzylamino) -d-mannitol
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| Activity |
IC50 = 410000 nM
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[2] | |||
| Compound Name |
(2R,3S,4S,5R)-2-[(3,4-Dichloroanilino)methyl]-5-(hydroxymethyl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3220031
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| Activity |
IC50 = 410000 nM
|
[4] | |||
| Compound Name |
(2R,3S,4S,5R)-2-(Hydroxymethyl)-5-[(naphthalen-2-ylamino)methyl]oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3220030
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| Activity |
IC50 = 900000 nM
|
[4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett. 2013 Oct 30;5(1):12-7. | ||||
| REF 2 | Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis. Bioorg Med Chem. 2008 May 1;16(9):5050-61. | ||||
| REF 3 | Antitrypanosomal alkaloids from Polyalthia suaveolens (Annonaceae): their effects on three selected glycolytic enzymes of Trypanosoma brucei. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3495-8. | ||||
| REF 4 | Phosphofructokinase: structural and functional aspects and design of selective inhibitors. Medchemcomm. 2012;3:1219-27. | ||||
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