Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09ZSC
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| Drug Name |
Everolimus
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| Synonyms |
Afinitor; Afinitor (TN); CERTICAN(R); Certican; Certican (TN); Everolimus (JAN/USAN/INN); Everolimus [USAN]; MTOR kinase inhibitors; NVP-RAD-001; RAD 001; RAD-001; RAD-001C; RAD001; RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus; SDZ-RAD; Zortress
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| Drug Type |
Small molecular drug
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| Indication | Advanced/metastatic breast cancer [ICD-11: 2C60] | Approved | [1] | |
| Middle East Respiratory Syndrome (MERS) [ICD-11: 1D64] | Investigative | [2] | ||
| Severe acute respiratory syndrome (SARS) [ICD-11: 1D65] | Investigative | [2] | ||
| Therapeutic Class |
Antiviral Agents
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| Company |
Novartis
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| Structure |
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Download2D MOL |
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| Formula |
C53H83NO14
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| Canonical SMILES |
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC
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| InChI |
1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
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| InChIKey |
HKVAMNSJSFKALM-GKUWKFKPSA-N
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| CAS Number |
CAS 159351-69-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
12014881, 14767667, 14865574, 50044230, 50112765, 56311446, 56312241, 56312580, 56313164, 91613187, 104178966, 134338463, 135156085, 136340120, 136929859, 137140572, 139754909, 143493384, 144206063, 151990396, 152236848, 152258132, 160645716, 160646971, 162189189, 174527790, 175265707, 177748738, 179150022, 203355779, 226396389
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| ChEBI ID |
CHEBI:68478
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HUMAN mammalian target of rapamycin (mTOR) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. | |||
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