Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T98269 | Target Info | |||
| Target Name | Caspase-1 (CASP1) | ||||
| Synonyms |
P45; Interleukin-1 beta-converting enzyme; Interleukin-1 beta converting enzyme; Interleukin-1 beta convertase; IL1BCE; IL1BC; IL-1BC; IL-1 beta-converting enzyme; IL-1 beta converting enzyme; ICE; CASP-1
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| Target Type | Clinical trial Target | ||||
| Gene Name | CASP1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Caspase-8 (CASP8) | Patented-recorded Target | ||||
| UniProt ID | CASP8_HUMAN | |||||
| Gene Name | CASP8 | |||||
| Synonyms |
MORT1-associated CED-3 homolog; MCH5; MACH; ICE-like apoptotic protease 5; FLICE; FADD-like ICE; FADD-homologous ICE/CED-3-like protease; CASP-8; CAP4; Apoptotic protease Mch-5; Apoptotic cysteine protease
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| Representative Drug(s) | PRALNACASAN | Drug Info | IC50 = 40 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4233-6. | ||||
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