Biomarker General Infomation
Biomarker ID
Biomarker Name
5-HT 2A receptor (HTR2A)
Disease Schizophrenia
ICD Code ICD-11: 6A20
Biomarker Type Pharmacodynamic; theragnostic
Molecular Type Protein
Biomarker Location striatum; cortex
Biomarker Measure Occupancy
Specific Aim Target occupancy; help dose decision
Conclusion D2 or 5-HT2 receptor occupancy in striatum or cortex as measured using PET or SP ECT, currently considered the most reliable biomarker of target engagements for current antipsychotics.
Treatment antipsychotics
UniProt ID
REF 1 Biomarkers for antipsychotic therapies. Handb Exp Pharmacol. 2012;(212):339-60.

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