| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T19760 | ||||
| Target Name | Mitogen-activated protein kinase kinase kinase 9 | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | CEP-6331 | Drug Info | IC50 = 33 nM | [529647] | |
| CEP-5104 | Drug Info | IC50 = 127 nM | [529647] | ||
| References | |||||
| Ref 529647 | J Med Chem. 2008 Sep 25;51(18):5680-9. Epub 2008 Aug 21.Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models. | ||||
| Ref 529647 | J Med Chem. 2008 Sep 25;51(18):5680-9. Epub 2008 Aug 21.Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models. | ||||
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