Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
Chemical Structure based Activity Landscape of Target
Co-Targets
Target Poor or Non Binders
Target Affiliated Biological Pathways
References
Drug Binding Sites of Target  Top
Ligand Name: 5-[2-amino-3-(4-morpholin-4-ylphenyl)benzimidazol-5-yl]-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide Ligand Info
Structure Description Human PI4KIIIa lipid kinase complex PDB:6BQ1
Method Electron microscopy Resolution 3.60 Å Mutation No [2]
PDB Sequence
.
Residue [Chain]
Distance (Å)
GLN1796[A]
4.451
SER1797[A]
3.329
ALA1798[A]
4.625
PRO1802[A]
3.847
LEU1804[A]
4.552
ILE1848[A]
4.269
LYS1850[A]
2.590
ASP1853[A]
4.790
TYR1884[A]
3.736
ILE1896[A]
2.656
GLU1897[A]
3.223
CYS1898[A]
3.195
ILE1899[A]
2.751
PRO1900[A]
4.953
ASP1901[A]
2.681
CYS1902[A]
4.614
THR1903[A]
3.649
SER1904[A]
2.690
GLN1907[A]
2.650
GLY1961[A]
4.242
ASN1962[A]
2.603
MET1964[A]
2.634
ILE1974[A]
3.169
GLN1796[E]
3.749
Residue [Chain]
Distance (Å)
SER1797[E]
3.380
ALA1798[E]
4.654
LYS1800[E]
4.860
PRO1802[E]
3.863
LEU1804[E]
4.547
ILE1848[E]
4.373
LYS1850[E]
2.680
ASP1853[E]
4.747
ASP1858[E]
4.853
TYR1884[E]
3.241
ILE1896[E]
2.802
GLU1897[E]
3.005
CYS1898[E]
3.359
ILE1899[E]
2.614
PRO1900[E]
4.838
ASP1901[E]
3.187
THR1903[E]
4.029
SER1904[E]
2.757
GLN1907[E]
3.274
GLY1961[E]
4.290
ASN1962[E]
2.890
MET1964[E]
2.554
ILE1974[E]
3.135
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
Biological Network Descriptors
There is no similarity protein (E value < 0.005) for this target
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
 Download Picture         KEGG Link      
 Download Picture         KEGG Link      
KEGG Pathway Pathway ID Affiliated Target Pathway Map
Inositol phosphate metabolism hsa00562 Affiliated Target
  Class: Metabolism => Carbohydrate metabolism Pathway Hierarchy
Phosphatidylinositol signaling system hsa04070 Affiliated Target
  Class: Environmental Information Processing => Signal transduction Pathway Hierarchy
Degree 10 Degree centrality 1.07E-03 Betweenness centrality 2.77E-04
Closeness centrality 1.81E-01 Radiality 1.30E+01 Clustering coefficient 3.56E-01
Neighborhood connectivity 7.80E+00 Topological coefficient 1.90E-01 Eccentricity 13
Download Click to Download the Full PPI Network of This Target

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