Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
References
Drug Binding Sites of Target  Top
Ligand Name: 3-iodotyrosine Ligand Info
Structure Description X-ray Crystal Structure of PGC-1beta C-terminus bound to the CBP80-CBP20 Cap Binding Complex PDB:6D0Y
Method X-ray diffraction Resolution 2.68 Å Mutation No [2]
PDB Sequence
SKEAMDFDSL
11
LKEAQQSL
Residue
Distance (Å)
SER1
3.277
LYS2
1.328
GLU4
1.329
ALA5
3.035
Residue
Distance (Å)
MET6
3.098
LEU11
2.566
GLU14
4.033
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Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Biological Network Descriptors
There is no similarity protein (E value < 0.005) for this target
Degree 1 Degree centrality 1.07E-04 Betweenness centrality 0.00E+00
Closeness centrality 1.67E-01 Radiality 1.26E+01 Clustering coefficient 0.00E+00
Neighborhood connectivity 2.00E+00 Topological coefficient 1.00E+00 Eccentricity 12
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