Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
Chemical Structure based Activity Landscape of Target
References
Drug Binding Sites of Target  Top
Ligand Name: Vemurafenib Ligand Info
Structure Description Human leucine zipper- and sterile alpha motif-containing kinase (ZAK, MLT, HCCS-4, MRK, AZK, MLTK) in complex with vemurafenib PDB:5HES
Method X-ray diffraction Resolution 2.14 Å Mutation No [2]
PDB Sequence
ASFVQIKFDD
15
LQFFENCGGG
25
SFGSVYRAKW
35
ISQDKEVAVK
45
KLLKIEKEAE
55

ILSVLSHRNI
65
IQFYGVILEP
75
PNYGIVTEYA
85
SLGSLYDYIN
95
SNRSEEMDMD
105

HIMTWATDVA
115
KGMHYLHMEA
125
PVKVIHRDLK
135
SRNVVIAADG
145
VLKICDFGAS
155

RFHNHGTFPW
172
MAPEVIQSLP
182
VSETCDTYSY
192
GVVLWEMLTR
202
EVPFKGLEGL
212

QVAWLVVEKN
222
ERLTIPSSCP
232
RSFAELLHQC
242
WEADAKKRPS
252
FKQIISILES
262

MSNDTSLPDK
272
CNSFLHNKAE
282
WRCEIEATLE
292
RLKKLER
Residue
Distance (Å)
CYS22
4.039
GLY23
3.513
PHE27
3.629
VAL30
3.518
ALA43
3.257
VAL44
3.831
LYS45
3.530
LEU57
4.185
ILE66
3.663
GLN67
4.535
PHE68
3.982
ILE80
3.598
THR82
3.224
Residue
Distance (Å)
GLU83
2.855
TYR84
3.496
ALA85
2.971
GLY88
4.048
SER89
3.979
ASP92
3.404
VAL140
3.887
CYS150
3.320
ASP151
3.114
PHE152
2.999
GLY153
2.868
ALA154
4.053
Ligand Name: Phosphonothreonine Ligand Info
Structure Description Human leucine zipper- and sterile alpha motif-containing kinase (ZAK, MLT, HCCS-4, MRK, AZK, MLTK) in complex with vemurafenib PDB:5HES
Method X-ray diffraction Resolution 2.14 Å Mutation No [2]
PDB Sequence
ASFVQIKFDD
15
LQFFENCGGG
25
SFGSVYRAKW
35
ISQDKEVAVK
45
KLLKIEKEAE
55

ILSVLSHRNI
65
IQFYGVILEP
75
PNYGIVTEYA
85
SLGSLYDYIN
95
SNRSEEMDMD
105

HIMTWATDVA
115
KGMHYLHMEA
125
PVKVIHRDLK
135
SRNVVIAADG
145
VLKICDFGAS
155

RFHNHGTFPW
172
MAPEVIQSLP
182
VSETCDTYSY
192
GVVLWEMLTR
202
EVPFKGLEGL
212

QVAWLVVEKN
222
ERLTIPSSCP
232
RSFAELLHQC
242
WEADAKKRPS
252
FKQIISILES
262

MSNDTSLPDK
272
CNSFLHNKAE
282
WRCEIEATLE
292
RLKKLER
Residue
Distance (Å)
LYS49
3.286
GLU51
2.090
SER155
4.937
ARG156
4.102
Residue
Distance (Å)
HIS158
2.138
ASN159
4.423
HIS160
1.336
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
Biological Network Descriptors
Protein Name Pfam ID Percentage of Identity (%) E value
Mixed lineage kinase 1 (MAP3K9)
PF00069 ; 
PF14604
39.130 (135/345) 4.35E-66
Serine/threonine-protein kinase Nek5 (NEK5)
PF00069
29.070 (75/258) 5.75E-28
Aurora kinase A (AURKA)
PF00069
27.076 (75/277) 1.19E-26
PAK-1 protein kinase (PAK1)
PF00786 ; 
PF00069
30.400 (76/250) 3.11E-26
Serine/threonine-protein kinase 26 (STK26)
PF00069
29.856 (83/278) 4.13E-26
Serine/threonine-protein kinase PAK 3 (PAK3)
PF00786 ; 
PF00069
30.400 (76/250) 1.59E-25
PKC-delta-interacting protein kinase (RIPK4)
PF12796 ; 
PF00069
30.337 (81/267) 3.71E-25
PAK-2 protein kinase (PAK2)
PF00786 ; 
PF00069
29.600 (74/250) 6.28E-25
Serine/threonine-protein kinase 25 (STK25)
PF00069
29.880 (75/251) 1.00E-24
MST-1 protein kinase (STK4)
PF11629 ; 
PF00069
29.317 (73/249) 1.43E-24
Serine/threonine-protein kinase 24 (STK24)
PF00069
28.777 (80/278) 5.46E-24
NUAK family SNF1-like kinase 2 (NUAK2)
PF00069
32.683 (67/205) 5.79E-24
NIMA-related kinase 7 (NEK7)
PF00069
29.771 (78/262) 7.41E-24
Serine/threonine-protein kinase Nek11 (NEK11)
PF00069
28.740 (73/254) 1.90E-23
Aurora kinase C (AURKC)
PF00069
28.571 (74/259) 2.02E-23
Fused homolog (STK36)
PF13646 ; 
PF00069
27.490 (69/251) 2.77E-23
Proto-oncogene serine/threonine-protein kinase mos (MOS)
PF00069
24.916 (74/297) 3.85E-23
Serine/threonine-protein kinase 3 (STK3)
PF11629 ; 
PF00069
28.514 (71/249) 4.74E-23
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)
PF00069 ; 
PF12721
28.727 (79/275) 6.62E-23
Serine/threonine-protein kinase MARK2 (MARK2)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 28.897 (76/263) 1.42E-22
Serine/threonine-protein kinase Nek3 (NEK3)
PF00069
26.848 (69/257) 1.58E-22
SPS1/STE20-related protein kinase YSK4 (YSK4)
PF00069
27.419 (68/248) 2.28E-22
Serine/threonine-protein kinase WNK4 (WNK4)
PF12202 ; 
PF00069
33.495 (69/206) 2.95E-22
NIMA-related kinase 6 (NEK6)
PF00069
29.811 (79/265) 4.71E-22
MAP/microtubule affinity-regulating kinase 4 (MARK4)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 30.374 (65/214) 6.93E-22
Myosin-IIIa (MYO3A)
PF00612 ; 
PF00063 ; 
PF00069
More >>
 28.866 (84/291) 7.92E-22
Microtubule affinity regulating kinase 3 (MARK3)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 27.376 (72/263) 9.16E-22
NIMA-related kinase 1 (NEK1)
PF00069
25.296 (64/253) 9.94E-22
Serine/threonine-protein kinase PAK 5 (PAK5)
PF00786 ; 
PF00069
33.971 (71/209) 1.18E-21
WNK lysine-deficient protein kinase 3 (WNK3)
PF12202 ; 
PF00069
30.583 (63/206) 1.27E-21
Omphalocele kinase 1 (NUAK1)
PF00069
30.288 (63/208) 2.29E-21
Oxidative stress responsive 1 (OXSR1)
PF12202 ; 
PF00069
25.806 (72/279) 2.48E-21
Serine/threonine-protein kinase ULK2 (ULK2)
PF12063 ; 
PF00069
31.839 (71/223) 2.76E-21
Serine/threonine-protein kinase WNK1 (WNK1)
PF12202 ; 
PF00069
27.376 (72/263) 3.07E-21
MAPK/ERK kinase kinase 2 (MAP3K2)
PF00564 ; 
PF00069
26.667 (68/255) 3.47E-21
ERK activator kinase 5 (MAP2K5)
PF00564 ; 
PF00069
27.547 (73/265) 5.02E-21
STE20-related serine/threonine-protein kinase (SLK)
PF00069 ; 
PF12474
30.078 (77/256) 5.47E-21
Serine/threonine-protein kinase Nek4 (NEK4)
PF00069
25.483 (66/259) 7.10E-21
TGF-beta receptor type I (TGFBR1)
PF01064 ; 
PF00069 ; 
PF08515
More >>
 29.392 (87/296) 8.81E-21
TRAF2 and NCK interacting kinase (TNIK)
PF00780 ; 
PF00069
25.095 (66/263) 9.73E-21
MEK kinase kinase 1 (MAP4K1)
PF00780 ; 
PF00069
28.897 (76/263) 1.13E-20
Ste-20-related kinase (STK39)
PF12202 ; 
PF00069
26.909 (74/275) 1.15E-20
NIMA-related kinase 2 (NEK2)
PF00069
27.928 (93/333) 1.16E-20
MAPK/ERK kinase kinase 3 (MAP3K3)
PF00564 ; 
PF00069
26.172 (67/256) 1.31E-20
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)
PF16579 ; 
PF00069
30.651 (80/261) 1.45E-20
Misshapen-like kinase 1 (MINK1)
PF00780 ; 
PF00069
25.095 (66/263) 1.67E-20
Serine/threonine-protein kinase WNK2 (WNK2)
PF12202 ; 
PF00069
31.884 (66/207) 1.71E-20
PAK-4 protein kinase (PAK4)
PF00786 ; 
PF00069
33.333 (67/201) 2.14E-20
TAO kinase 1 (TAOK1)
PF00069
27.692 (72/260) 2.23E-20
MAPK/ERK kinase kinase 1 (MAP3K1)
PF00069
25.869 (67/259) 3.48E-20
Serine/threonine-protein kinase TAO2 (TAOK2)
PF00069
27.027 (70/259) 4.03E-20
Protein kinase C gamma (PRKCG)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 29.317 (73/249) 4.21E-20
Aurora kinase B (AURKB)
PF00069
29.020 (74/255) 4.64E-20
Serine/threonine-protein kinase Nek9 (NEK9)
PF00069 ; 
PF00415
25.000 (62/248) 5.51E-20
Serine/threonine-protein kinase MARK1 (MARK1)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 28.972 (62/214) 7.15E-20
Serine/threonine-protein kinase ULK1 (ULK1)
PF12063 ; 
PF00069
31.579 (72/228) 9.40E-20
MEK kinase kinase 4 (MAP4K4)
PF00780 ; 
PF00069
25.926 (70/270) 1.33E-19
TAO kinase 3 (TAOK3)
PF00069
27.200 (68/250) 2.56E-19
MEK kinase kinase 3 (MAP4K3)
PF00780 ; 
PF00069
25.191 (66/262) 3.96E-19
Bone morphogenetic protein receptor (BMPR2)
PF01064 ; 
PF00069
27.796 (87/313) 6.05E-19
Serine/threonine-protein kinase Nek10 (NEK10)
PF00069
22.924 (69/301) 6.13E-19
Testis-specific serine/threonine-protein kinase 4 (TSSK4)
PF00069
27.037 (73/270) 9.10E-19
Leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1)
PF12796 ; 
PF16095 ; 
PF00069 ; 
PF08477
More >>
 29.218 (71/243) 9.20E-19
Protein kinase C epsilon (PRKCE)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 28.638 (61/213) 1.06E-18
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
PF00069
25.547 (70/274) 1.09E-18
Salt-inducible kinase 1 (SIK1)
PF00069
26.923 (70/260) 1.60E-18
Putative serine/threonine-protein kinase SIK1B (SIK1B)
PF00069
26.923 (70/260) 1.67E-18
Activin receptor type IB (ACVR1B)
PF01064 ; 
PF00069 ; 
PF08515
More >>
 27.458 (81/295) 2.09E-18
Serine/threonine-protein kinase 10 (STK10)
PF00069 ; 
PF12474
27.490 (69/251) 2.10E-18
Mitogen-activated protein kinase kinase kinase 15 (MAP3K15)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 28.800 (72/250) 2.55E-18
Myosin light chain kinase 2 (MYLK2)
PF00069
29.000 (58/200) 2.83E-18
Serine/threonine-protein kinase PAK 6 (PAK6)
PF00786 ; 
PF00069
31.188 (63/202) 2.86E-18
Cyclin-dependent kinase 3 (CDK3)
PF00069
30.769 (64/208) 2.97E-18
Protein kinase C theta (PRKCQ)
PF00130 ; 
PF00069 ; 
PF00433
More >>
 27.103 (58/214) 3.30E-18
Protein kinase C beta (PRKCB)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 27.706 (64/231) 3.40E-18
cAMP-dependent protein kinase catalytic subunit gamma (PRKACG)
PF00069
27.309 (68/249) 4.01E-18
Salt-inducible kinase 2 (SIK2)
PF00069
28.736 (75/261) 5.07E-18
Apoptosis signal-regulating kinase 1 (MAP3K5)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 29.482 (74/251) 5.33E-18
Myosin light chain kinase 3 (MYLK3)
PF00069
30.000 (60/200) 6.00E-18
Protein kinase C alpha (PRKCA)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 27.753 (63/227) 6.57E-18
Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)
PF00780 ; 
PF00069
25.573 (67/262) 8.10E-18
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
PF16579 ; 
PF00069
29.885 (78/261) 9.32E-18
SNF-related serine/threonine-protein kinase (SNRK)
PF00069
25.101 (62/247) 1.52E-17
SIK family kinase 3 (SIK3)
PF00069
28.685 (72/251) 1.68E-17
Tyrosine-protein kinase EIF2AK2 (p68)
PF00035 ; 
PF00069
28.182 (62/220) 1.80E-17
Serine/threonine-protein kinase Nek8 (NEK8)
PF00069 ; 
PF00415
26.904 (53/197) 1.92E-17
MEK kinase kinase 2 (MAP4K2)
PF00780 ; 
PF00069
25.455 (70/275) 2.46E-17
Nik-related protein kinase (NRK)
PF00780 ; 
PF00069
27.273 (57/209) 3.02E-17
Death-associated protein kinase 3 (DAPK3)
PF00069
26.636 (57/214) 3.85E-17
Serine/threonine-protein kinase Sgk1 (SGK1)
PF00069 ; 
PF00433
28.685 (72/251) 5.74E-17
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
PF00069
26.000 (65/250) 7.21E-17
Activin receptor type IIB (ACVR2B)
PF01064 ; 
PF00069
28.296 (88/311) 8.21E-17
IL-1 receptor-associated kinase 3 (IRAK3)
PF00531 ; 
PF00069
26.848 (69/257) 9.45E-17
Ribosomal protein S6 kinase alpha-1 (RSK1)
PF00069 ; 
PF00433
22.400 (56/250) 9.87E-17
cAMP-dependent protein kinase catalytic subunit beta (PRKACB)
PF00069
26.000 (65/250) 1.32E-16
Cytoplasmic DRAK1 (STK17A)
PF00069
28.713 (58/202) 1.42E-16
Myosin-IIIb (MYO3B)
PF00612 ; 
PF00063 ; 
PF00069
More >>
 26.449 (73/276) 1.45E-16
Polo-like kinase 2 (PLK2)
PF00069 ; 
PF00659
26.957 (62/230) 1.56E-16
Checkpoint kinase-1 (CHK1)
PF00069
29.952 (62/207) 2.14E-16
Protein kinase C eta type (PRKCH)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 28.169 (60/213) 2.22E-16
Leucine-rich repeat kinase 2 (LRRK2)
PF16095 ; 
PF12799 ; 
PF13855 ; 
PF00069 ; 
PF08477
More >>
 29.078 (82/282) 3.09E-16
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
PF00069
24.906 (66/265) 3.28E-16
RAC-alpha serine/threonine-protein kinase (AKT1)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 25.197 (64/254) 3.44E-16
Death-associated protein kinase 2 (DAPK2)
PF00069
26.667 (52/195) 4.46E-16
Myosin light chain kinase family member 4 (MYLK4)
PF00069
27.000 (54/200) 5.07E-16
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)
PF08332 ; 
PF00069
26.794 (56/209) 5.79E-16
PDZ binding kinase (PBK)
PF00069
28.279 (69/244) 5.84E-16
Extracellular signal-regulated kinase 1 (ERK1)
PF00069
29.167 (63/216) 5.95E-16
Polo-like kinase 4 (PLK4)
PF00069 ; 
PF18190 ; 
PF18409
More >>
 25.283 (67/265) 6.73E-16
Putative 3-phosphoinositide-dependent protein kinase 2 (PDPK2P)
PF00069
24.286 (51/210) 6.77E-16
Extracellular signal-regulated kinase 5 (ERK5)
PF00069
28.017 (65/232) 7.00E-16
Maternal embryonic leucine zipper kinase (MELK)
PF02149 ; 
PF00069
26.996 (71/263) 8.13E-16
Serine/threonine-protein kinase NLK (NLK)
PF00069
28.440 (62/218) 9.08E-16
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G)
PF08332 ; 
PF00069
26.794 (56/209) 9.50E-16
Ribosomal protein S6 kinase alpha-3 (RSK3)
PF00069 ; 
PF00433
22.400 (56/250) 9.65E-16
Cyclin-dependent kinase 14 (CDK14)
PF00069
27.570 (59/214) 1.04E-15
Calcium/calmodulin-dependent protein kinase type IV (CAMK4)
PF00069
31.373 (64/204) 1.10E-15
MAPK/ERK kinase kinase 4 (MAP3K4)
PF19431 ; 
PF00069
25.490 (65/255) 1.29E-15
Striated muscle preferentially expressed protein kinase (SPEG)
PF07679 ; 
PF00069 ; 
PF16650
More >>
 26.131 (52/199) 1.31E-15
Myosin light kinase (MYLK)
PF16620 ; 
PF00041 ; 
PF07679 ; 
PF00069
More >>
 28.502 (59/207) 1.60E-15
Phosphoinositide dependent protein kinase-1 (PDPK1)
PF14593 ; 
PF00069
24.286 (51/210) 1.82E-15
Protein kinase G2 (PRKG2)
PF00027 ; 
PF00069
24.800 (62/250) 1.87E-15
Activin receptor type IIA (ACVR2A)
PF01064 ; 
PF00069
27.090 (81/299) 2.05E-15
Cyclin-dependent kinase 2 (CDK2)
PF00069
27.885 (58/208) 2.13E-15
Serine/threonine-protein kinase Sgk3 (SGK3)
PF00069 ; 
PF00433 ; 
PF00787
More >>
 29.126 (60/206) 3.04E-15
Apoptosis signal-regulating kinase 2 (MAP3K6)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 27.600 (69/250) 3.14E-15
Extracellular signal-regulated kinase 2 (ERK2)
PF00069
28.641 (59/206) 3.73E-15
Serine/threonine-protein kinase 17B (STK17B)
PF00069
25.098 (64/255) 4.78E-15
Mitogen-activated protein kinase 13 (MAPK13)
PF00069
30.516 (65/213) 4.98E-15
Serine/threonine-protein kinase 33 (STK33)
PF00069
29.126 (60/206) 5.33E-15
Stress-activated protein kinase JNK3 (JNK3)
PF00069
26.255 (68/259) 5.55E-15
Serine/threonine-protein kinase Sgk2 (SGK2)
PF00069 ; 
PF00433
26.800 (67/250) 6.35E-15
Serine/threonine-protein kinase Chk2 (RAD53)
PF00498 ; 
PF00069
30.918 (64/207) 6.66E-15
Calcium/calmodulin-dependent protein kinase type 1D (CAMK1D)
PF00069
30.244 (62/205) 8.70E-15
ERK activator kinase 1 (MEK1)
PF00069
29.327 (61/208) 8.74E-15
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)
PF00069
24.088 (66/274) 9.22E-15
Stress-activated protein kinase JNK1 (JNK1)
PF00069
25.869 (67/259) 9.89E-15
Ribosomal protein S6 kinase alpha-2 (RSK2)
PF00069 ; 
PF00433
22.273 (49/220) 1.07E-14
Inhibitor of nuclear factor kappa-B kinase alpha (IKKA)
PF18397 ; 
PF12179 ; 
PF00069
More >>
 28.986 (60/207) 1.21E-14
Protein kinase C delta (PRKCD)
PF00130 ; 
PF00069 ; 
PF00433
More >>
 26.316 (55/209) 1.22E-14
RAC-beta serine/threonine-protein kinase (AKT2)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 22.353 (57/255) 1.34E-14
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)
PF08332 ; 
PF00069
25.837 (54/209) 1.46E-14
Serine/threonine-protein kinase PLK3 (PLK3)
PF00069 ; 
PF00659
28.879 (67/232) 1.62E-14
RAC-gamma serine/threonine-protein kinase (AKT3)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 23.200 (58/250) 1.71E-14
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)
PF08332 ; 
PF00069
25.837 (54/209) 2.03E-14
Protein kinase N1 (PKN1)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 27.315 (59/216) 2.31E-14
Calcium/calmodulin-dependent protein kinase type 1B (PNCK)
PF00069
28.000 (56/200) 2.37E-14
Calcium/calmodulin-dependent protein kinase type 1G (CAMK1G)
PF00069
27.861 (56/201) 2.51E-14
Cyclin-dependent kinase 16 (CDK16)
PF12330 ; 
PF00069
26.941 (59/219) 2.70E-14
PAS domain-containing serine/threonine-protein kinase (PASK)
PF13426 ; 
PF00069
29.952 (62/207) 3.14E-14
Cyclin-dependent kinase 1 (CDK1)
PF00069
27.014 (57/211) 3.34E-14
MAP kinase p38 (MAPK12)
PF00069
26.939 (66/245) 3.38E-14
Cyclin-dependent kinase 11B (CDK11B)
PF00069
30.841 (66/214) 3.99E-14
Inhibitor of nuclear factor kappa-B kinase beta (IKKB)
PF18397 ; 
PF12179 ; 
PF00069
More >>
 28.708 (60/209) 4.07E-14
ERK activator kinase 7 (MAP2K7)
PF00069
22.909 (63/275) 4.18E-14
Testis-specific serine/threonine-protein kinase 3 (TSSK3)
PF00069
27.203 (71/261) 4.93E-14
Ribosomal protein S6 kinase alpha-6 (RSK6)
PF00069 ; 
PF00433
24.766 (53/214) 5.07E-14
Protein kinase G1 (PRKG1)
PF00027 ; 
PF16808 ; 
PF00069
More >>
 22.656 (58/256) 5.19E-14
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)
PF00069
26.471 (54/204) 5.75E-14
Putative serine/threonine-protein kinase PRKY (PRKY)
PF00069
26.570 (55/207) 5.97E-14
Cyclin-G-associated kinase (GAK)
PF00069 ; 
PF10409
26.280 (77/293) 6.86E-14
Stress-activated protein kinase 2a (p38 alpha)
PF00069
28.037 (60/214) 8.39E-14
Serine/threonine-protein kinase H2 (PSKH2)
PF00069
29.000 (58/200) 9.47E-14
Mitogen-activated protein kinase 6 (MAPK6)
PF00069
28.761 (65/226) 1.11E-13
Cyclin-dependent kinase 11A (CDK11A)
PF00069
30.841 (66/214) 1.21E-13
Serine/threonine-protein kinase D2 (PRKD2)
PF00130 ; 
PF00069
28.856 (58/201) 1.27E-13
Polo-like kinase 1 (PLK1)
PF00069 ; 
PF00659
26.887 (57/212) 1.60E-13
Stress-activated protein kinase 2b (p38 beta)
PF00069
27.670 (57/206) 1.67E-13
Ribosomal protein S6 kinase alpha-4 (RPS6KA4)
PF00069 ; 
PF00433
29.703 (60/202) 1.71E-13
Glycogen synthase kinase-3 beta (GSK-3B)
PF00069
27.488 (58/211) 1.79E-13
Testis-specific serine/threonine-protein kinase 1 (TSSK1B)
PF00069
26.054 (68/261) 1.98E-13
ERK activator kinase 2 (MEK2)
PF00069
27.014 (57/211) 2.11E-13
Serine/threonine-protein kinase H1 (PSKH1)
PF00069
28.500 (57/200) 2.16E-13
Serine/threonine-protein kinase STK11 (STK11)
PF00069
26.047 (56/215) 2.46E-13
Protein kinase N2 (PKN2)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 28.837 (62/215) 2.48E-13
Serine/threonine-protein kinase D3 (PRKD3)
PF00130 ; 
PF00169 ; 
PF00069
More >>
 27.861 (56/201) 2.60E-13
Testis-specific serine kinase 2 (TSSK2)
PF00069
25.287 (66/261) 2.77E-13
Death-associated protein kinase 1 (DAPK1)
PF00023 ; 
PF12796 ; 
PF13637 ; 
PF00531 ; 
PF00069
More >>
 26.154 (51/195) 2.89E-13
IL-1 receptor-associated kinase 1 (IRAK1)
PF00531 ; 
PF00069
28.431 (58/204) 2.96E-13
CDC42 binding protein kinase alpha (DMPK-like alpha)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF15796 ; 
PF00069 ; 
PF00433
More >>
 25.417 (61/240) 3.29E-13
Protein kinase D (PRKD1)
PF00130 ; 
PF00169 ; 
PF00069
More >>
 28.713 (58/202) 3.37E-13
Serine/threonine-protein kinase NIK (MAP3K14)
PF00069
28.279 (69/244) 4.36E-13
Hormonally up-regulated neu tumor-associated kinase (HUNK)
PF00069
23.622 (60/254) 4.41E-13
Ribosomal protein S6 kinase beta-1 (S6K1)
PF00069 ; 
PF00433
24.074 (52/216) 4.42E-13
Serine/threonine-protein kinase MRCK beta (CDC42BPB)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF15796 ; 
PF00069
More >>
 25.714 (63/245) 5.76E-13
Glycogen synthase kinase-3 alpha (GSK-3A)
PF00069
27.064 (59/218) 5.89E-13
Serine/threonine-protein kinase cot (COT)
PF00069
31.579 (60/190) 6.60E-13
Unc-51 like kinase 3 (ULK3)
PF04212 ; 
PF00069
25.784 (74/287) 7.39E-13
Doublecortin-like kinase 2 (DCLK2)
PF03607 ; 
PF00069
26.482 (67/253) 7.86E-13
Triple functional domain protein (TRIO)
PF00650 ; 
PF07679 ; 
PF00169 ; 
PF00069 ; 
PF00621 ; 
PF16609 ; 
PF00018 ; 
PF00435
More >>
 30.256 (59/195) 8.12E-13
Protein kinase N3 (PKN3)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 29.302 (63/215) 9.45E-13
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)
PF00069
27.536 (57/207) 9.80E-13
CaM-kinase IV kinase (CAMKK1)
PF00069
29.000 (58/200) 1.00E-12
Stress-activated protein kinase JNK2 (JNK2)
PF00069
27.805 (57/205) 1.16E-12
Serine/threonine-protein kinase NIM1 (NIM1K)
PF00069
27.638 (55/199) 1.39E-12
Cyclin-dependent kinase 18 (CDK18)
PF00069
26.484 (58/219) 1.40E-12
Cyclin-dependent kinase 17 (CDK17)
PF12330 ; 
PF00069
26.601 (54/203) 1.44E-12
Kalirin (KALRN)
PF13716 ; 
PF00041 ; 
PF07679 ; 
PF00169 ; 
PF00069 ; 
PF00621 ; 
PF16609 ; 
PF00435
More >>
 28.718 (56/195) 1.47E-12
Cyclin-dependent kinase 7 (CDK7)
PF00069
27.014 (57/211) 1.59E-12
Serine/threonine-protein kinase 32A (STK32A)
PF00069
22.222 (68/306) 1.91E-12
Obscurin (OBSCN)
PF00041 ; 
PF07679 ; 
PF00612 ; 
PF00069 ; 
PF00621
More >>
 25.424 (75/295) 2.16E-12
Cyclin-dependent kinase-like 5 (CDKL5)
PF00069
23.188 (48/207) 3.27E-12
Cyclin-dependent kinase 12 (CDK12)
PF00069
23.762 (72/303) 3.36E-12
Rho-associated protein kinase 2 (ROCK2)
PF00069 ; 
PF08912
26.364 (58/220) 3.57E-12
Calmodulin-dependent kinase II (CAMKK2)
PF00069
29.310 (51/174) 3.60E-12
Doublecortin-like kinase 1 (DCLK1)
PF03607 ; 
PF00069
28.000 (56/200) 4.07E-12
Ribosomal protein S6 kinase alpha-5 (RSK5)
PF00069 ; 
PF00433
27.919 (55/197) 4.76E-12
Cyclin-dependent kinase 6 (CDK6)
PF00069
22.967 (48/209) 4.82E-12
Serine/threonine-protein kinase 32C (STK32C)
PF00069
23.944 (51/213) 4.96E-12
Ribosomal protein S6 kinase beta-2 (RPS6KB2)
PF00069 ; 
PF00433
24.731 (46/186) 5.55E-12
Yet another novel kinase 2 (STK32B)
PF00069
22.961 (76/331) 5.73E-12
Cyclin-dependent kinase-like 4 (CDKL4)
PF00069
26.190 (55/210) 5.77E-12
NF-kappa-B-activating kinase (TBK1)
PF00069 ; 
PF18394 ; 
PF18396
More >>
 26.168 (56/214) 6.35E-12
Mitogen-activated protein kinase 4 (MAPK4)
PF00069
28.112 (70/249) 7.57E-12
BR serine/threonine kinase 2 (BRSK2)
PF00069
24.299 (52/214) 8.19E-12
Serine/threonine-protein kinase ICK (CILK1)
PF00069
24.373 (68/279) 9.56E-12
BR serine/threonine kinase 1 (BRSK1)
PF00069
24.766 (53/214) 9.87E-12
Citron Rho-interacting kinase (CIT)
PF00780 ; 
PF00169 ; 
PF00069
More >>
 25.532 (48/188) 1.22E-11
Cyclin-dependent kinase 9 (CDK9)
PF00069
26.761 (57/213) 1.23E-11
Dual specificity protein kinase TTK (MPS1)
PF00069
23.158 (66/285) 1.23E-11
Cyclin-dependent kinase-like 2 (CDKL2)
PF00069
24.752 (50/202) 1.34E-11
Titin (TTN) 25.000 (51/204) 1.87E-11
Rho-associated protein kinase 1 (ROCK1)
PF00069 ; 
PF08912
26.364 (58/220) 1.93E-11
Dual-specificity tyrosine-phosphorylation regulated kinase 3 (DYRK3)
PF00069
25.641 (60/234) 2.60E-11
Cyclin-dependent kinase 5 (CDK5)
PF00069
25.510 (50/196) 2.64E-11
Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2)
PF00069
26.531 (65/245) 3.04E-11
Serine/threonine-protein kinase MRCK gamma (CDC42BPG)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF00069
More >>
 22.222 (54/243) 3.31E-11
Serine/threonine-protein kinase SBK1 (SBK1)
PF00069
25.592 (54/211) 3.73E-11
Protein kinase C zeta (PRKCZ)
PF00130 ; 
PF00564 ; 
PF00069 ; 
PF00433
More >>
 22.381 (47/210) 3.90E-11
Cyclin-dependent kinase-like 1 (CDKL1)
PF00069
26.531 (52/196) 4.00E-11
Microtubule-associated serine/threonine-protein kinase 2 (MAST2)
PF08926 ; 
PF17820 ; 
PF00069
More >>
 24.107 (54/224) 4.59E-11
Cyclin-dependent kinase 15 (CDK15)
PF00069
27.397 (60/219) 4.71E-11
Doublecortin-like kinase 3 (DCLK3)
PF00069
25.743 (52/202) 4.91E-11
Microtubule-associated serine/threonine-protein kinase 4 (MAST4)
PF08926 ; 
PF17820 ; 
PF02163 ; 
PF00069
More >>
 25.000 (56/224) 5.31E-11
Cyclin-dependent kinase 4 (CDK4)
PF00069
24.038 (50/208) 5.37E-11
CDC-like kinase 1 (CLK1)
PF00069
26.977 (58/215) 5.52E-11
Anti-mullerian hormone II receptor (AMHR2)
PF00069
26.316 (80/304) 6.82E-11
Cyclin-dependent kinase 19 (CDK19)
PF00069
26.786 (60/224) 7.46E-11
Microtubule-associated serine/threonine-protein kinase 3 (MAST3)
PF08926 ; 
PF17820 ; 
PF02163 ; 
PF00069
More >>
 25.000 (56/224) 7.52E-11
Protein kinase C iota (PRKCI)
PF00130 ; 
PF00564 ; 
PF00069 ; 
PF00433
More >>
 21.759 (47/216) 7.54E-11
Serine/threonine-protein kinase SBK2 (SBK2)
PF00069
25.664 (58/226) 9.53E-11
Serine/threonine-protein kinase LATS1 (LATS1)
PF00069 ; 
PF00627
23.759 (67/282) 1.11E-10
Microtubule-associated serine/threonine-protein kinase 1 (MAST1)
PF08926 ; 
PF17820 ; 
PF00069
More >>
 25.000 (56/224) 1.26E-10
CDC-like kinase 4 (CLK4)
PF00069
27.907 (60/215) 2.56E-10
Serine/threonine-protein kinase pim-1 (PIM1)
PF00069
23.320 (59/253) 2.97E-10
Beta-adrenergic receptor kinase 1 (ADRBK1)
PF00169 ; 
PF00069 ; 
PF00615
More >>
 25.926 (56/216) 3.78E-10
PIM-3 protein kinase (PIM3)
PF00069
23.162 (63/272) 3.88E-10
Serine/threonine-protein kinase/endoribonuclease IRE2 (ERN2)
PF00069 ; 
PF06479
25.943 (55/212) 4.05E-10
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)
PF00069 ; 
PF18394 ; 
PF18396
More >>
 27.523 (60/218) 4.31E-10
Cyclin-dependent kinase 10 (CDK10)
PF00069
26.852 (58/216) 4.54E-10
Cyclin-dependent kinase 13 (CDK13)
PF12330 ; 
PF00069
21.951 (54/246) 4.71E-10
Homeodomain-interacting protein kinase 1 (HIPK1)
PF00069
25.980 (53/204) 5.40E-10
CaM kinase-like vesicle-associated protein (CAMKV)
PF00069
26.425 (51/193) 6.81E-10
Dual-specificity tyrosine-phosphorylation regulated kinase 4 (DYRK4)
PF00069
25.792 (57/221) 7.05E-10
Cyclin-dependent kinase-like 3 (CDKL3)
PF00069
24.615 (48/195) 7.18E-10
TGF-beta-stimulated factor 1 (STK16)
PF00069
23.297 (65/279) 1.22E-09
G protein-coupled receptor kinase 5 (GRK5)
PF00069 ; 
PF00615
24.747 (49/198) 1.37E-09
NDR2 protein kinase (STK38L)
PF00069 ; 
PF00433
20.513 (56/273) 1.46E-09
Ribosomal protein S6 kinase-related protein (RSKR)
PF00069
32.000 (40/125) 1.83E-09
MAP kinase signal-integrating kinase 2 (MKNK2)
PF00069
26.068 (61/234) 2.02E-09
Serine/threonine-protein kinase MAK (MAK)
PF00069
23.551 (65/276) 2.35E-09
STE20-related kinase adapter protein alpha (STRADA)
PF00069
23.864 (42/176) 2.50E-09
Homeodomain-interacting protein kinase 3 (HIPK3)
PF00069
23.263 (77/331) 3.34E-09
Myotonin-protein kinase (DMPK)
PF08826 ; 
PF00069
21.488 (52/242) 3.48E-09
Rhodopsin kinase GRK7 (GRK7)
PF00069 ; 
PF00615
25.478 (40/157) 4.96E-09
Large tumor suppressor homolog 2 (LATS2)
PF00069 ; 
PF00433
22.185 (67/302) 5.32E-09
Rhodopsin kinase GRK1 (GRK1)
PF00069 ; 
PF00615
24.183 (37/153) 5.34E-09
Beta-adrenergic receptor kinase 2 (ADRBK2)
PF00169 ; 
PF00069 ; 
PF00615
More >>
 26.961 (55/204) 6.68E-09
G protein-coupled receptor kinase 6 (GRK6)
PF00069 ; 
PF00615
31.313 (31/99) 9.09E-09
Serine/threonine-protein kinase greatwall (MASTL)
PF00069
28.481 (45/158) 9.84E-09
MAPK signal-integrating kinase 1 (MKNK1)
PF00069
24.265 (66/272) 1.66E-08
Cyclin-dependent kinase 20 (CDK20)
PF00069
25.000 (54/216) 1.66E-08
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1)
PF00069
26.425 (51/193) 2.05E-08
STE20-related kinase adapter protein beta (STRADB)
PF00069
25.967 (47/181) 2.46E-08
BMP-2-inducible protein kinase (BMP2K)
PF15282 ; 
PF00069
24.229 (55/227) 2.77E-08
Homeodomain interacting protein kinase 2 (HIPK2)
PF00069
24.510 (50/204) 2.91E-08
Cyclin-dependent kinase 8 (CDK8)
PF00069
25.893 (58/224) 3.64E-08
Serine/threonine-protein kinase tousled-like 2 (TLK2)
PF00069
26.415 (56/212) 3.80E-08
MAPK-activated protein kinase 2 (MAPKAPK2)
PF00069
26.761 (38/142) 4.02E-08
Homeodomain-interacting protein kinase 4 (HIPK4)
PF00069
23.585 (50/212) 5.57E-08
Mitogen-activated protein kinase 15 (MAPK15)
PF00069
25.410 (62/244) 5.63E-08
Serine/threonine-protein kinase 35 (STK35)
PF00069
23.622 (60/254) 6.43E-08
Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B)
PF00069
26.238 (53/202) 6.80E-08
NDR1 protein kinase (STK38)
PF00069 ; 
PF00433
19.780 (54/273) 8.39E-08
TBC domain-containing protein kinase-like protein (TBCK)
PF00069 ; 
PF00566 ; 
PF00581
More >>
 21.429 (51/238) 9.82E-08
Adaptor-associated kinase 1 (AAK1)
PF00069
21.970 (58/264) 1.07E-07
Endoplasmic reticulum to nucleus signaling 1 (ERN1)
PF00069 ; 
PF06479
26.316 (70/266) 1.18E-07
CDC-like kinase 3 (CLK3)
PF00069
22.857 (40/175) 1.22E-07
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A)
PF00069
25.352 (54/213) 1.45E-07
G protein-coupled receptor kinase 4 (GRK4)
PF00069 ; 
PF00615
24.359 (38/156) 1.53E-07
MAPK-activated protein kinase 3 (MAPKAPK3)
PF00069
25.385 (33/130) 1.79E-07
Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)
PF00069
29.012 (47/162) 2.01E-07
Serine/threonine-protein kinase ULK4 (ULK4)
PF00069
21.786 (61/280) 2.41E-07
Testis-specific serine/threonine-protein kinase 6 (TSSK6)
PF00069
27.189 (59/217) 3.05E-07
PRKR-like endoplasmic reticulum kinase (PERK)
PF00069
27.559 (35/127) 3.32E-07
Serine/threonine-protein kinase tousled-like 1 (TLK1)
PF00069
26.901 (46/171) 3.98E-07
MAPK/MAK/MRK overlapping kinase (MOK)
PF00069
24.020 (49/204) 7.45E-07
MAPK-activated protein kinase 5 (MAPKAPK5)
PF00069
24.775 (55/222) 1.25E-06
Wee1-like protein kinase 2 (WEE2)
PF00069
23.929 (67/280) 3.35E-06
Serine/threonine-protein kinase Kist (UHMK1)
PF00069 ; 
PF00076
27.230 (58/213) 3.79E-06
CDC-like kinase 2 (CLK2)
PF00069
24.806 (32/129) 4.44E-06
Serine/threonine-protein kinase pim-2 (PIM2)
PF00069
20.385 (53/260) 5.48E-06
Casein kinase I alpha (CSNK1A1)
PF00069
25.373 (68/268) 7.85E-06
Phosphorylase kinase testis gamma 2 (PHKG2)
PF00069
22.936 (50/218) 9.68E-06
Wee1-like protein kinase (WEE1)
PF00069
21.959 (65/296) 9.86E-06
Peripheral plasma membrane protein CASK (CASK)
PF00625 ; 
PF02828 ; 
PF00595 ; 
PF00069 ; 
PF00018
More >>
 22.374 (49/219) 1.48E-05
Serine/threonine-protein kinase PRP4 homolog (PRPF4B)
PF00069
32.927 (27/82) 1.53E-05
Eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4)
PF12745 ; 
PF00069 ; 
PF05773 ; 
PF13393
More >>
 26.389 (38/144) 1.60E-05
Serine/threonine-protein kinase PDIK1L (PDIK1L)
PF00069
23.828 (61/256) 2.04E-05
Casein kinase I delta (CSNK1D)
PF00069
22.642 (60/265) 4.78E-05
Nuclear receptor-binding protein 2 (NRBP2)
PF00069
24.157 (43/178) 8.26E-05
Casein kinase I epsilon (CSNK1E)
PF00069
21.887 (58/265) 1.79E-04
Tau-tubulin kinase (TTBK1)
PF00069
20.664 (56/271) 2.08E-04
Casein kinase II alpha prime (CSNK2A2)
PF00069
24.155 (50/207) 2.72E-04
Serine/threonine-protein kinase 31 (STK31)
PF00069 ; 
PF00567
33.333 (29/87) 3.20E-04
Diacylglycerol kinase delta (DGKD)
PF00130 ; 
PF00609 ; 
PF00781 ; 
PF00169 ; 
PF07647
More >>
 30.000 (21/70) 4.18E-04
Casein kinase I isoform alpha-like (CSNK1A1L)
PF00069
23.333 (63/270) 4.86E-04
Ribosomal protein S6 kinase delta-1 (RPS6KC1)
PF04212 ; 
PF00069 ; 
PF00787
More >>
 27.368 (26/95) 2.00E-03
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)
PF00069
25.166 (38/151) 2.00E-03
Ribosomal protein S6 kinase-like 1 (RPS6KL1)
PF04212 ; 
PF00069
23.973 (35/146) 2.00E-03
Diacylglycerol kinase eta (DGKH)
PF00130 ; 
PF00609 ; 
PF00781 ; 
PF00169 ; 
PF07647
More >>
 30.556 (22/72) 3.00E-03
Casein kinase II alpha (CSNK2A1)
PF00069
23.188 (48/207) 3.00E-03
Sterile alpha motif domain-containing protein 12 (SAMD12)
PF07647
29.167 (21/72) 4.00E-03
  Click to Show/Hide the Information of Human Similarity Proteins
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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KEGG Pathway Pathway ID Affiliated Target Pathway Map
MAPK signaling pathway hsa04010 Affiliated Target
  Class: Environmental Information Processing => Signal transduction Pathway Hierarchy
Degree 1 Degree centrality 1.07E-04 Betweenness centrality 0.00E+00
Closeness centrality 1.80E-01 Radiality 1.30E+01 Clustering coefficient 0.00E+00
Neighborhood connectivity 4.00E+00 Topological coefficient 1.00E+00 Eccentricity 13
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