Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
Chemical Structure based Activity Landscape of Target
References
Drug Binding Sites of Target  Top
Ligand Name: Batimastat Ligand Info
Structure Description ADAM-8 metalloproteinase domain with bound batimastat PDB:4DD8
Method X-ray diffraction Resolution 2.10 Å Mutation No [2]
PDB Sequence
RETRYVELYV
206
VVDNAEFQML
216
GSEAAVRHRV
226
LEVVNHVDKL
236
YQKLNFRVVL
246

VGLEIWNSQD
256
RFHVSPDPSV
266
TLENLLTWQA
276
RRHLHDNVQL
290
ITGVDFTGTT
300

VGFARVSAMC
310
SHSSGAVNQD
320
HSKNPVGVAC
330
TMAHEMGHNL
340
GMDHDENVQG
350

CRCQERFEAG
360
RCIMAGSIGS
370
SFPRMFSDCS
380
QAYLESFLER
390
PQSVCLANAP
400

D
Residue
Distance (Å)
THR299
2.693
THR300
2.716
VAL301
2.865
GLY302
3.006
PHE303
3.532
ALA304
4.971
THR331
3.976
HIS334
3.019
Residue
Distance (Å)
GLU335
2.300
HIS338
2.919
HIS344
2.801
ALA365
3.488
GLY366
3.132
SER367
3.282
ILE368
2.982
GLY369
4.725
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Similarity Proteins
Human Tissue Distribution
Protein Name Pfam ID Percentage of Identity (%) E value
Microtubule-actin cross-linking factor 1, isoforms 6/7 (MACF1)
PF13499 ; 
PF02187 ; 
PF00435
More >>
 29.545 (39/132) 1.65E-04
Teneurin-3 (TENM3)
PF06484 ; 
PF15636
32.710 (35/107) 1.00E-03
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.

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