Target Information

Target General Information

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Target ID

T95033

Target Name

Oxidoreductase HTATIP2 (HTATIP2)

Synonyms

HIV-1 TAT-interactive protein 2; 30 kDa HIV-1 TAT-interacting protein

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Gene Name

HTATIP2

Target Type

Literature-reported target

[1]

Function

Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

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UniProt ID

HTAI2_HUMAN

EC Number

EC 1.1.1.-

Sequence

MAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEE
AYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRGKAGAEGFVRVDRDYVLKSAELAK
AGGCKHFNLLSSKGADKSSNFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPG
EWLVRKFFGSLPDSWASGHSVPVVTVVRAMLNNVVRPRDKQMELLENKAIHDLGKAHGSL
KP

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3D Structure

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PDB

Cell-based Target Expression Variations

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Cell-based Target Expression Variations

Cell-based Target Expression Variations Info

Drug Binding Sites of Target

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Ligand Name: NADPH

Ligand Info

Structure Description

CC3(TIP30)Crystal Structure

PDB:2BKA

Method

X-ray diffraction

Resolution

1.70 Å

Mutation

[2]

PDB Sequence

EALSKLREDF

¹⁴

RMQNKSVFIL

²⁴

GASGETGRVL

³⁴

LKEILEQGLF

⁴⁴

SKVTLIGRRK

⁵⁴

LTFDEEAYKN

⁶⁴

VNQEVVDFEK

⁷⁴

LDDYASAFQG

⁸⁴

HDVGFCCLGT

⁹⁴

TRGKAGAEGF

¹⁰⁴

VRVDRDYVLK

¹¹⁴

SAELAKAGGC

¹²⁴

KHFNLLSSKG

¹³⁴

ADKSSNFLYL

¹⁴⁴

QVKGEVEAKV

¹⁵⁴

EELKFDRYSV

¹⁶⁴

FRPGVLLCDR

¹⁷⁴

QESRPGEWLV

¹⁸⁴

RKFFGSLPDS

¹⁹⁴

WASGHSVPVV

²⁰⁴

TVVRAMLNNV

²¹⁴

VRPRDKQMEL

²²⁴

LENKAIHDLG

²³⁴

Residue

Distance (Å)

GLY25

3.172

ALA26

4.264

SER27

2.621

GLY28

3.128

GLU29

2.823

THR30

2.899

GLY31

4.637

ARG52

2.784

ARG53

2.881

PHE72

3.789

CYS91

3.346

LEU92

2.733

GLY93

3.109

THR94

3.800

Residue

Distance (Å)

LYS98

4.005

VAL107

3.362

ASP108

4.092

TYR111

3.854

LEU130

3.235

SER131

3.126

SER132

3.853

TYR143

2.677

LYS147

2.789

PRO167

3.610

GLY168

3.618

VAL169

3.723

LEU170

2.900

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Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues. The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021). Human Similarity Proteins Human Tissue Distribution

Different Human System Profiles of Target

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Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.

The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).

Human Similarity Proteins

Human Tissue Distribution

There is no similarity protein (E value < 0.005) for this target


Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.

References

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REF 1

Inhibition of nuclear import by the proapoptotic protein CC3. Mol Cell Biol. 2004 Aug;24(16):7091-101.

REF 2

Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor. J Biol Chem. 2005 May 6;280(18):18229-36.

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