Target Information
| Target General Information | Top | |||||
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| Target ID |
T94823
(Former ID: TTDR00759)
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| Target Name |
Xaa-Pro dipeptidase (PEPD)
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| Synonyms |
X-Pro dipeptidase; Proline dipeptidase; Prolidase; PEPD; Imidodipeptidase
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| Gene Name |
PEPD
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Splits dipeptides with a prolyl or hydroxyprolyl residuein the carboxyl terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.
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| BioChemical Class |
Peptidase
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| UniProt ID | ||||||
| EC Number |
EC 3.4.13.9
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| Sequence |
MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTD
TGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEK YAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEI VECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSS YTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTA DQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLG AVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDH LLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMA GCDKAFTPFSGPK Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: L-leucine | Ligand Info | |||||
| Structure Description | Crystal Structure of Wild-Type Human Prolidase with Mg ions and LeuPro ligand | PDB:5M4L | ||||
| Method | X-ray diffraction | Resolution | 1.49 Å | Mutation | No | [2] |
| PDB Sequence |
GPSFWLGNET
15 LKVPLALFAL25 NRQRLCERLR35 KNPAVQAGSI45 VVLQGGEETQ55 RYCTDTGVLF 65 RQESFFHWAF75 GVTEPGCYGV85 IDVDTGKSTL95 FVPRLPASHA105 TWMGKIHSKE 115 HFKEKYAVDD125 VQYVDEIASV135 LTSQKPSVLL145 TLRGVNTDSG155 SVCREASFDG 165 ISKFEVNNTI175 LHPEIVECRV185 FKTDMELEVL195 RYTNKISSEA205 HREVMKAVKV 215 GMKEYELESL225 FEHYCYSRGG235 MRHSSYTCIC245 GSGENSAVLH255 YGHAGAPNDR 265 TIQNGDMCLF275 DMGGEYYCFA285 SDITCSFPAN295 GKFTADQKAV305 YEAVLRSSRA 315 VMGAMKPGVW325 WPDMHRLADR335 IHLEELAHMG345 ILSGSVDAMV355 QAHLGAVFMP 365 HGLGHFLGID375 VHDVGGYPEG385 VERIDEPGLR395 SLRTARHLQP405 GMVLTVEPGI 415 YFIDHLLDEA425 LADPARASFL435 NREVLQRFRG445 FGGVRIEEDV455 VVTDSGIELL 465 TCVPRTVEEI475 EACMAGCDKA485 FTPF
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution
of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects
(Nat Rev Drug Discov, 20: 64-81, 2021).
Human Similarity Proteins
Human Tissue Distribution
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There is no similarity protein (E value < 0.005) for this target
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Note:
If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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| Chemical Structure based Activity Landscape of Target | Top |
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| Target Poor or Non Binders | Top | |||||
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| Target Poor or Non Binders | ||||||
| References | Top | |||||
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| REF 1 | Prolidase as a prodrug converting enzyme. II. Synthesis of proline analogue of anthraquinone-2-carboxylic acid and its susceptibility to the action... Rocz Akad Med Bialymst. 1998;43:201-9. | |||||
| REF 2 | Substrate specificity and reaction mechanism of human prolidase. FEBS J. 2017 Sep;284(17):2870-2885. | |||||
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