Target Information

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Target General Information
Different Human System Profiles of Target
References
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
Protein Name Pfam ID Percentage of Identity (%) E value
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
PF00619 ; 
PF07714
44.444 (120/270) 9.68E-56
Receptor-interacting protein 1 (RIPK1)
PF00531 ; 
PF07714 ; 
PF12721
More >>
 32.975 (92/279) 7.82E-35
TGF-beta-activated kinase 1 (MAP3K7)
PF07714
35.662 (97/272) 6.08E-30
MLK-related kinase (MLTK)
PF07714 ; 
PF00536
30.337 (81/267) 2.68E-25
Mixed lineage kinase 2 (MAP3K10)
PF07714 ; 
PF14604
30.241 (88/291) 1.13E-22
Mixed lineage kinase 3 (MAP3K11)
PF07714 ; 
PF14604
30.420 (87/286) 4.34E-21
Renal carcinoma antigen NY-REN-64 (IRAK-4)
PF07714
33.663 (68/202) 1.11E-20
Tyrosine-protein kinase Tec (PSCTK4)
PF00779 ; 
PF00169 ; 
PF07714 ; 
PF00017 ; 
PF00018
More >>
 28.679 (76/265) 1.88E-20
Serine/threonine-protein kinase B-raf (BRAF)
PF00130 ; 
PF07714 ; 
PF02196
More >>
 30.418 (80/263) 6.36E-20
Atrial natriuretic peptide receptor B (NPR2)
PF01094 ; 
PF00211 ; 
PF07714
More >>
 32.035 (74/231) 8.99E-20
Tyrosine-protein kinase TXK (TXK)
PF07714 ; 
PF00017 ; 
PF00018
More >>
 28.114 (79/281) 1.55E-19
Testis-specific kinase 2 (TESK2)
PF07714
28.261 (78/276) 1.80E-19
Tyrosine-protein kinase ZAP-70 (ZAP-70)
PF07714 ; 
PF00017
29.070 (75/258) 2.12E-19
Hematopoietic cell kinase (HCK)
PF07714 ; 
PF00017 ; 
PF00018
More >>
 29.537 (83/281) 3.01E-19
Ephrin type-B receptor 1 (EPHB1)
PF14575 ; 
PF01404 ; 
PF00041 ; 
PF07714 ; 
PF00536
More >>
 30.827 (82/266) 3.68E-19
Ephrin type-A receptor 2 (EPHA2)
PF14575 ; 
PF01404 ; 
PF00041 ; 
PF07714 ; 
PF00536
More >>
 29.389 (77/262) 9.73E-19
Ephrin type-A receptor 3 (EPHA3)
PF14575 ; 
PF01404 ; 
PF07699 ; 
PF00041 ; 
PF07714 ; 
PF07647
More >>
 30.216 (84/278) 1.21E-18
Ephrin type-A receptor 1 (EPHA1)
PF14575 ; 
PF01404 ; 
PF07699 ; 
PF00041 ; 
PF07714 ; 
PF00536
More >>
 31.930 (91/285) 2.02E-18
LCK tyrosine protein kinase (LCK)
PF07714 ; 
PF00017 ; 
PF00018
More >>
 28.470 (80/281) 2.31E-18
Ephrin type-B receptor 4 (EPHB4)
PF14575 ; 
PF01404 ; 
PF07699 ; 
PF00041 ; 
PF07714 ; 
PF00536
More >>
 29.699 (79/266) 2.45E-18
Proto-oncogene c-RAF (c-RAF)
PF00130 ; 
PF07714 ; 
PF02196
More >>
 28.302 (75/265) 2.46E-18
Focal adhesion kinase 1 (FAK)
PF00373 ; 
PF18038 ; 
PF03623 ; 
PF07714
More >>
 27.953 (71/254) 4.44E-18
Mixed lineage kinase 4 (MAP3K21)
PF07714 ; 
PF14604
29.329 (83/283) 7.04E-18
Ephrin type-A receptor 4 (EPHA4)
PF14575 ; 
PF01404 ; 
PF00041 ; 
PF07714 ; 
PF07647
More >>
 31.179 (82/263) 8.55E-18
Ephrin type-B receptor 2 (EPHB2)
PF14575 ; 
PF01404 ; 
PF07699 ; 
PF00041 ; 
PF07714 ; 
PF00536
More >>
 30.566 (81/265) 9.93E-18
Tropomyosin-related kinase A (TrkA)
PF13855 ; 
PF16920 ; 
PF07714 ; 
PF18613
More >>
 27.737 (76/274) 2.25E-17
Proto-oncogene c-Fes (FES)
PF07714 ; 
PF00017
26.415 (70/265) 2.43E-17
Proto-oncogene c-Src (SRC)
PF07714 ; 
PF00017 ; 
PF00018
More >>
 29.961 (77/257) 2.59E-17
Testis-specific kinase 1 (TESK1)
PF07714
31.068 (64/206) 4.37E-17
Tyrosine-protein kinase SYK (SYK)
PF07714 ; 
PF00017
31.628 (68/215) 4.45E-17
Fyn tyrosine protein kinase (FYN)
PF07714 ; 
PF00017 ; 
PF00018
More >>
 28.521 (81/284) 4.97E-17
Atrial natriuretic peptide receptor A (NPR1)
PF01094 ; 
PF00211 ; 
PF07714
More >>
 30.303 (70/231) 5.42E-17
T-cell-specific kinase (ITK)
PF00779 ; 
PF00169 ; 
PF07714 ; 
PF00017 ; 
PF00018
More >>
 28.571 (82/287) 5.95E-17
Insulin-like growth factor I receptor (IGF1R)
PF00757 ; 
PF07714 ; 
PF01030
More >>
 27.509 (74/269) 6.13E-17
Proto-oncogene c-Met (MET)
PF07714 ; 
PF01437 ; 
PF01403 ; 
PF01833
More >>
 27.879 (92/330) 6.66E-17
Ephrin type-B receptor 3 (EPHB3)
PF14575 ; 
PF01404 ; 
PF07699 ; 
PF00041 ; 
PF07714 ; 
PF00536
More >>
 30.075 (80/266) 9.63E-17
Epidermal growth factor receptor (EGFR)
PF00757 ; 
PF14843 ; 
PF07714 ; 
PF01030
More >>
 29.286 (82/280) 1.03E-16
Inactive tyrosine-protein kinase 7 (PTK7)
PF07679 ; 
PF13927 ; 
PF07714
More >>
 27.706 (64/231) 1.08E-16
Mitogen-activated protein kinase kinase kinase 12 (MAP3K12)
PF07714
30.315 (77/254) 1.13E-16
BDNF/NT-3 growth factors receptor (TrkB)
PF07679 ; 
PF13855 ; 
PF16920 ; 
PF01462 ; 
PF07714
More >>
 28.159 (78/277) 1.19E-16
Insulin receptor-related protein (INSRR)
PF00757 ; 
PF07714 ; 
PF01030
More >>
 28.519 (77/270) 1.47E-16
Janus kinase 3 (JAK-3)
PF18379 ; 
PF18377 ; 
PF17887 ; 
PF07714
More >>
 26.715 (74/277) 1.78E-16
Ephrin type-A receptor 5 (EPHA5)
PF14575 ; 
PF01404 ; 
PF00041 ; 
PF07714 ; 
PF00536
More >>
 30.268 (79/261) 1.98E-16
Macrophage-stimulating protein receptor (RON)
PF07714 ; 
PF01403 ; 
PF01833
More >>
 29.965 (86/287) 2.11E-16
Insulin receptor (INSR)
PF00757 ; 
PF17870 ; 
PF07714 ; 
PF01030
More >>
 27.941 (76/272) 2.51E-16
Focal adhesion kinase 2 (PTK2B)
PF00373 ; 
PF18038 ; 
PF03623 ; 
PF07714
More >>
 28.295 (73/258) 2.63E-16
Tyrosine-protein kinase FRK (FRK)
PF07714 ; 
PF00017 ; 
PF00018
More >>
 25.379 (67/264) 2.74E-16
Yes tyrosine kinase (YES)
PF07714 ; 
PF00017 ; 
PF00018
More >>
 29.225 (83/284) 3.85E-16
Tyrosine-protein kinase Lyn (JTK8)
PF07714 ; 
PF00017 ; 
PF00018
More >>
 28.462 (74/260) 4.07E-16
Tyrosine-protein kinase Fgr (FGR)
PF07714 ; 
PF00017 ; 
PF00018
More >>
 28.906 (74/256) 6.01E-16
Tyrosine-protein kinase ABL1 (ABL)
PF08919 ; 
PF07714 ; 
PF00017 ; 
PF00018
More >>
 25.969 (67/258) 7.55E-16
Tyrosine-protein kinase ABL2 (ABL2)
PF08919 ; 
PF07714 ; 
PF00017 ; 
PF00018
More >>
 25.882 (66/255) 7.69E-16
Ephrin type-A receptor 7 (EPHA7)
PF14575 ; 
PF01404 ; 
PF07699 ; 
PF00041 ; 
PF07714 ; 
PF00536
More >>
 28.467 (78/274) 8.67E-16
Tyrosine-protein kinase BMX (BMX)
PF00779 ; 
PF00169 ; 
PF07714 ; 
PF00017
More >>
 27.203 (71/261) 8.78E-16
Mitogen-activated protein kinase kinase kinase 13 (MAP3K13)
PF07714
32.883 (73/222) 9.37E-16
Mixed lineage kinase domain-like protein (MLKL)
PF07714
29.596 (66/223) 9.88E-16
LIM domain kinase-1 (LIMK-1)
PF00412 ; 
PF00595 ; 
PF07714
More >>
 25.723 (80/311) 1.07E-15
Erbb2 tyrosine kinase receptor (HER2)
PF00757 ; 
PF14843 ; 
PF07714 ; 
PF01030
More >>
 28.929 (81/280) 1.75E-15
Ephrin type-A receptor 8 (EPHA8)
PF14575 ; 
PF01404 ; 
PF00041 ; 
PF07714 ; 
PF00536
More >>
 31.004 (71/229) 2.58E-15
Tyrosine-protein kinase BRK (PTK6)
PF07714 ; 
PF00017 ; 
PF00018
More >>
 29.520 (80/271) 7.04E-15
B lymphocyte kinase (BLK)
PF07714 ; 
PF00017 ; 
PF00018
More >>
 29.123 (83/285) 1.35E-14
NT-3 growth factor receptor (TrkC)
PF07679 ; 
PF00047 ; 
PF13855 ; 
PF16920 ; 
PF01462 ; 
PF07714
More >>
 26.948 (83/308) 1.40E-14
Tyrosine-protein kinase UFO (AXL)
PF00041 ; 
PF13927 ; 
PF07714
More >>
 27.083 (78/288) 1.55E-14
Proto-oncogene c-Ros (ROS1)
PF00041 ; 
PF07714
29.137 (81/278) 1.59E-14
Tyrosine-protein kinase CSK (CSK)
PF07714 ; 
PF00017 ; 
PF00018
More >>
 27.969 (73/261) 2.21E-14
Fibroblast growth factor receptor 2 (FGFR2)
PF07679 ; 
PF13927 ; 
PF07714
More >>
 25.000 (72/288) 2.71E-14
Fibroblast growth factor receptor 4 (FGFR4)
PF07679 ; 
PF13927 ; 
PF07714
More >>
 23.843 (67/281) 3.76E-14
Tyrosine-protein kinase Srms (SRMS)
PF07714 ; 
PF00017
28.364 (78/275) 4.32E-14
Fibroblast growth factor receptor 3 (FGFR3)
PF07679 ; 
PF13927 ; 
PF07714
More >>
 24.910 (69/277) 4.40E-14
Discoidin domain-containing receptor 2 (DDR2)
PF00754 ; 
PF07714
26.778 (64/239) 4.89E-14
Ephrin type-A receptor 6 (EPHA6)
PF14575 ; 
PF01404 ; 
PF07699 ; 
PF00041 ; 
PF07714 ; 
PF00536
More >>
 31.088 (60/193) 6.11E-14
Megakaryocyte-associated tyrosine-protein kinase (MATK)
PF07714 ; 
PF00017 ; 
PF00018
More >>
 26.335 (74/281) 9.08E-14
Proto-oncogene c-Fer (FER)
PF00611 ; 
PF07714 ; 
PF00017
More >>
 27.799 (72/259) 1.21E-13
Erbb4 tyrosine kinase receptor (Erbb-4)
PF00757 ; 
PF14843 ; 
PF07714 ; 
PF01030
More >>
 27.957 (78/279) 1.74E-13
Serine/threonine-protein kinase A-Raf (ARAF)
PF00130 ; 
PF07714 ; 
PF02196
More >>
 25.271 (70/277) 1.79E-13
Dual serine/threonine and tyrosine protein kinase (DSTYK)
PF07714
32.447 (61/188) 2.36E-13
LIM domain kinase-2 (LIMK-2)
PF00412 ; 
PF00595 ; 
PF07714
More >>
 27.570 (59/214) 2.47E-13
TYRO3 tyrosine kinase receptor (TYRO3)
PF00041 ; 
PF07679 ; 
PF07714
More >>
 26.071 (73/280) 3.28E-13
Proto-oncogene c-Ret (RET)
PF00028 ; 
PF07714 ; 
PF17756 ; 
PF17812 ; 
PF17813
More >>
 26.027 (76/292) 3.43E-13
Tyrosine-protein kinase BTK (ATK)
PF00779 ; 
PF00169 ; 
PF07714 ; 
PF00017 ; 
PF00018
More >>
 25.912 (71/274) 4.97E-13
Tyrosine-protein kinase Mer (MERTK)
PF00041 ; 
PF00047 ; 
PF07714
More >>
 27.309 (68/249) 6.24E-13
Fibroblast growth factor receptor 1 (FGFR1)
PF07679 ; 
PF00047 ; 
PF07714
More >>
 24.595 (76/309) 7.92E-13
TYK2 tyrosine kinase (TYK2)
PF18379 ; 
PF18377 ; 
PF17887 ; 
PF07714
More >>
 26.619 (74/278) 1.14E-12
Epithelial discoidin domain receptor 1 (DDR1)
PF00754 ; 
PF07714
27.347 (67/245) 1.29E-12
Activated CDC42 kinase 1 (ACK-1)
PF09027 ; 
PF11555 ; 
PF07714 ; 
PF14604
More >>
 28.302 (75/265) 1.32E-12
Guanylyl cyclase C (GUCY2C)
PF00211 ; 
PF07714
26.840 (62/231) 1.80E-12
Leukocyte receptor tyrosine kinase (LTK)
PF12810 ; 
PF07714
26.199 (71/271) 3.25E-12
Janus kinase 1 (JAK-1)
PF18379 ; 
PF18377 ; 
PF17887 ; 
PF07714
More >>
 24.286 (68/280) 4.52E-12
Ankyrin repeat domain-containing protein 62 (ANKRD62)
PF13606 ; 
PF13857 ; 
PF14915
More >>
 29.646 (67/226) 5.73E-12
Platelet-derived growth factor receptor alpha (PDGFRA)
PF07679 ; 
PF07714
27.895 (53/190) 6.67E-12
Serine/threonine-protein kinase LMTK1 (AATK)
PF07714
29.310 (85/290) 8.70E-12
Janus kinase 2 (JAK-2)
PF18379 ; 
PF18377 ; 
PF17887 ; 
PF07714 ; 
PF00017
More >>
 25.939 (76/293) 1.35E-11
Ankyrin and armadillo repeat-containing protein (ANKAR)
PF00514
28.934 (57/197) 1.59E-11
Muscle-specific kinase receptor (MUSK)
PF01392 ; 
PF07679 ; 
PF13927 ; 
PF07714
More >>
 24.828 (72/290) 2.93E-11
Krev interaction trapped protein 1 (KRIT1)
PF13857 ; 
PF00373 ; 
PF16705
More >>
 34.426 (42/122) 4.70E-11
Activin receptor-like kinase 2 (ALK-2)
PF01064 ; 
PF07714 ; 
PF08515
More >>
 30.288 (63/208) 5.38E-11
Vascular endothelial growth factor receptor 3 (FLT-4)
PF07679 ; 
PF13927 ; 
PF07714 ; 
PF17988
More >>
 29.885 (52/174) 6.91E-11
Platelet-derived growth factor receptor beta (PDGFRB)
PF07679 ; 
PF00047 ; 
PF13927 ; 
PF07714
More >>
 29.487 (46/156) 9.65E-11
TGF-beta receptor type II (TGFBR2)
PF08917 ; 
PF07714
24.497 (73/298) 1.53E-10
Activin receptor-like kinase-1 (ACVRL1)
PF07714 ; 
PF08515
26.291 (56/213) 1.95E-10
Neurotrophic tyrosine kinase ROR1 (ROR1)
PF01392 ; 
PF07679 ; 
PF00051 ; 
PF07714
More >>
 25.540 (71/278) 3.28E-10
Non-receptor tyrosine-protein kinase TNK1 (TNK1)
PF07714
28.571 (76/266) 3.44E-10
ALK tyrosine kinase receptor (ALK)
PF12810 ; 
PF00629 ; 
PF07714
More >>
 24.164 (65/269) 6.42E-10
Vascular endothelial growth factor receptor 1 (FLT-1)
PF07679 ; 
PF00047 ; 
PF13927 ; 
PF07714 ; 
PF17988
More >>
 27.976 (47/168) 1.30E-09
Ephrin type-A receptor 10 (EPHA10)
PF14575 ; 
PF01404 ; 
PF00041 ; 
PF07714 ; 
PF00536
More >>
 28.251 (63/223) 1.80E-09
Vascular endothelial growth factor receptor 2 (KDR)
PF07679 ; 
PF13927 ; 
PF07714 ; 
PF17988
More >>
 29.221 (45/154) 2.93E-09
Angiopoietin 1 receptor (TEK)
PF00041 ; 
PF10430 ; 
PF07714
More >>
 25.000 (68/272) 3.05E-09
DNA-binding protein RFXANK (RFXANK)
PF13606 ; 
PF13857
31.250 (40/128) 3.74E-09
Bone morphogenetic protein receptor type-1A (BMPR1A)
PF01064 ; 
PF07714 ; 
PF08515
More >>
 26.267 (57/217) 5.89E-09
Tie-1 tyrosine kinase receptor (TIE1)
PF00041 ; 
PF00047 ; 
PF07714
More >>
 25.090 (70/279) 6.14E-09
Retinal guanylyl cyclase 2 (GUCY2F)
PF01094 ; 
PF00211 ; 
PF07701 ; 
PF07714
More >>
 26.768 (53/198) 1.33E-08
Kinase suppressor of Ras 2 (KSR2)
PF07714 ; 
PF13543 ; 
PF20406
More >>
 23.774 (63/265) 2.57E-08
Bone morphogenetic protein receptor type-1B (BMPR1B)
PF01064 ; 
PF07714 ; 
PF08515
More >>
 26.636 (57/214) 2.69E-08
Fms-like tyrosine kinase 3 (FLT-3)
PF00047 ; 
PF07714
27.215 (43/158) 3.59E-08
Soluble guanylyl cyclase (GUCY2D)
PF01094 ; 
PF00211 ; 
PF07701 ; 
PF07714
More >>
 26.667 (52/195) 5.15E-08
Serine/threonine-protein kinase LMTK3 (LMTK3)
PF07714
25.352 (72/284) 5.56E-08
KN motif and ankyrin repeat domain-containing protein 4 (KANK4)
PF00023 ; 
PF13857 ; 
PF12075
More >>
 29.341 (49/167) 8.36E-08
Tyrosine-protein kinase Kit (KIT)
PF00047 ; 
PF07714
28.824 (49/170) 1.85E-07
Protein phosphatase 1 regulatory subunit 27 (PPP1R27)
PF13637
31.818 (28/88) 1.90E-07
Activin receptor type-1C (ACVR1C)
PF01064 ; 
PF07714 ; 
PF08515
More >>
 25.517 (74/290) 2.16E-07
Tyrosine-protein kinase RYK (RYK)
PF07714 ; 
PF02019
25.439 (58/228) 2.24E-07
Macrophage colony-stimulating factor 1 receptor (CSF1R)
PF00047 ; 
PF13927 ; 
PF07714
More >>
 26.752 (42/157) 3.03E-07
CDK inhibitor 4C p18-INK4c (CDKN2C)
PF13637
40.909 (36/88) 4.18E-07
Serine/threonine-protein kinase LMTK2 (LMTK2)
PF07714
23.774 (63/265) 1.67E-06
Neurotrophic tyrosine kinase ROR2 (ROR2)
PF01392 ; 
PF07679 ; 
PF00051 ; 
PF07714
More >>
 24.460 (68/278) 1.68E-06
Erbb3 tyrosine kinase receptor (Erbb-3)
PF00757 ; 
PF14843 ; 
PF07714 ; 
PF01030
More >>
 23.741 (66/278) 3.57E-06
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